FI890283A0 - Process for the preparation of therapeutically useful 25-hydroxy vitamin D derivatives - Google Patents

Process for the preparation of therapeutically useful 25-hydroxy vitamin D derivatives

Info

Publication number: FI890283A0
Authority: FI; Finland
Prior art keywords: derivatives; preparation; therapeutically useful; hydroxy vitamin; vitamin
Prior art date: 1988-01-20

Application number

FI890283A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI90764B (en

FI890283A (en

FI90764C (en

Inventor

Enrico Giuseppe Baggiolini

Bernard Michael Hennessy

Shian-Jan Shiuey

Gary Arthur Truitt

Milan Radoje Uskokovic

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-20

Filing date

1989-01-19

Publication date

1989-01-19

1989-01-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1989-01-19 Publication of FI890283A0 publication Critical patent/FI890283A0/en

1989-07-21 Publication of FI890283A publication Critical patent/FI890283A/en

1993-12-15 Publication of FI90764B publication Critical patent/FI90764B/en

1994-03-25 Application granted granted Critical

1994-03-25 Publication of FI90764C publication Critical patent/FI90764C/en

Links

JWUBBDSIWDLEOM-XHQRYOPUSA-N (3e)-3-[(2e)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical class C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2\C1=C\C=C1/CC(O)CCC1=C JWUBBDSIWDLEOM-XHQRYOPUSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nutrition Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI890283A 1988-01-20 1989-01-19 Process for the preparation of therapeutically useful 25-hydroxy vitamin D derivatives FI90764C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14593288A	1988-01-20	1988-01-20
US14593288		1988-01-20

Publications (4)

Publication Number	Publication Date
FI890283A0 true FI890283A0 (en)	1989-01-19
FI890283A FI890283A (en)	1989-07-21
FI90764B FI90764B (en)	1993-12-15
FI90764C FI90764C (en)	1994-03-25

Family

ID=22515181

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI890283A FI90764C (en)	1988-01-20	1989-01-19	Process for the preparation of therapeutically useful 25-hydroxy vitamin D derivatives

Country Status (23)

Country	Link
EP (1)	EP0325279B1 (en)
JP (1)	JPH0764806B2 (en)
KR (1)	KR960009119B1 (en)
AR (1)	AR247551A1 (en)
AT (1)	ATE74350T1 (en)
AU (1)	AU622139B2 (en)
BG (1)	BG60530B2 (en)
CA (1)	CA1337529C (en)
DE (1)	DE58901056D1 (en)
DK (1)	DK169945B1 (en)
ES (1)	ES2033467T3 (en)
FI (1)	FI90764C (en)
GR (1)	GR3004786T3 (en)
HU (1)	HU201007B (en)
IE (1)	IE60921B1 (en)
IL (1)	IL88989A (en)
MC (1)	MC1998A1 (en)
NO (1)	NO175429C (en)
NZ (1)	NZ227641A (en)
PH (1)	PH25605A (en)
PT (1)	PT89486B (en)
YU (1)	YU47298B (en)
ZA (1)	ZA8923B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
EP0398217B1 (en) *	1989-05-18	1994-01-12	F. Hoffmann-La Roche Ag	Dehydrocholecalciferol derivatives
AU650751B2 (en) *	1991-05-28	1994-06-30	Wisconsin Alumni Research Foundation	Novel synthesis of 19-nor vitamin D compounds
ES2091515T3 (en) *	1992-05-20	1996-11-01	Hoffmann La Roche	FLUORATED ANALOGS OF VITAMIN D3.
US5753638A (en) *	1992-10-07	1998-05-19	Hoffmann-La Roche Inc.	Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
CA2096105A1 (en) *	1992-10-07	1994-04-08	Enrico Giuseppe Baggiolini (Deceased)	Vitamin d3 fluorinated analogs
TW267161B (en) *	1992-11-20	1996-01-01	Hoffmann La Roche
US5401733A (en) *	1993-10-01	1995-03-28	Hoffmann-La Roche Inc.	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
TW403735B (en) *	1995-11-22	2000-09-01	Hoffmann La Roche	25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
AU708679B2 (en) *	1996-03-21	1999-08-12	F. Hoffmann-La Roche Ag	1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
SG70009A1 (en) *	1996-05-23	2000-01-25	Hoffmann La Roche	Vitamin d3 analogs
US5939408A (en) *	1996-05-23	1999-08-17	Hoffman-La Roche Inc.	Vitamin D3 analogs
ATE237586T1 (en) *	1997-05-02	2003-05-15	Duphar Int Res	METHOD FOR PRODUCING 16-DEHYDRO VITAMIN D COMPOUNDS
US6331642B1 (en) *	1999-07-12	2001-12-18	Hoffmann-La Roche Inc.	Vitamin D3 analogs
US9221753B2 (en) *	2004-02-03	2015-12-29	Chugai Seiyaku Kabushiki Kaisha	Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
CA2605815A1 (en) *	2005-04-25	2006-11-02	Cytochroma Inc.	Low-calcemic 16,23-diene 25-oxime analogs of 1alpha,25-dihydroxy vitamin d3
WO2007022433A2 (en) *	2005-08-18	2007-02-22	Bioxell S.P.A.	SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7803154A (en) *	1977-03-24	1978-09-26	Wisconsin Alumni Res Found	VITAMIN D ANTAGONISTS, METHOD OF PREPARATION THEREOF, AND PREPARATIONS CONTAINING THEY.
DE2920092A1 (en) *	1978-05-19	1979-11-29	Wisconsin Alumni Res Found	ANTIVITAMIN D COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
US4360471A (en) *	1981-12-11	1982-11-23	Wisconsin Alumni Research Foundation	23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) *	1983-03-21	1985-04-02	Hoffmann-La Roche Inc.	Synthesis of 1α,25-dihydroxyergocalciferol
US4505906A (en) *	1984-01-30	1985-03-19	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 isomers
US4612308A (en) *	1984-11-29	1986-09-16	Hoffmann-La Roche Inc.	25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) *	1987-09-14	1990-02-06	Hoffman-La Roche Inc.	Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) *	1988-01-20	1989-02-14	Hoffmann-La Roche Inc.	Vitamin D compounds
EP0398217B1 (en) *	1989-05-18	1994-01-12	F. Hoffmann-La Roche Ag	Dehydrocholecalciferol derivatives

1989
- 1989-01-03 ZA ZA8923A patent/ZA8923B/en unknown
- 1989-01-17 PH PH38057A patent/PH25605A/en unknown
- 1989-01-17 DK DK019789A patent/DK169945B1/en not_active IP Right Cessation
- 1989-01-17 NZ NZ227641A patent/NZ227641A/en unknown
- 1989-01-17 CA CA000588384A patent/CA1337529C/en not_active Expired - Fee Related
- 1989-01-18 AR AR89313011A patent/AR247551A1/en active
- 1989-01-18 HU HU89175A patent/HU201007B/en not_active IP Right Cessation
- 1989-01-18 IL IL88989A patent/IL88989A/en not_active IP Right Cessation
- 1989-01-19 YU YU11789A patent/YU47298B/en unknown
- 1989-01-19 IE IE15789A patent/IE60921B1/en not_active IP Right Cessation
- 1989-01-19 AU AU28644/89A patent/AU622139B2/en not_active Ceased
- 1989-01-19 NO NO890239A patent/NO175429C/en unknown
- 1989-01-19 KR KR89000514A patent/KR960009119B1/en not_active IP Right Cessation
- 1989-01-19 FI FI890283A patent/FI90764C/en not_active IP Right Cessation
- 1989-01-19 PT PT89486A patent/PT89486B/en not_active IP Right Cessation
- 1989-01-19 JP JP1008782A patent/JPH0764806B2/en not_active Expired - Fee Related
- 1989-01-19 MC MC902029A patent/MC1998A1/en unknown
- 1989-01-20 DE DE8989100974T patent/DE58901056D1/en not_active Expired - Fee Related
- 1989-01-20 ES ES198989100974T patent/ES2033467T3/en not_active Expired - Lifetime
- 1989-01-20 AT AT89100974T patent/ATE74350T1/en not_active IP Right Cessation
- 1989-01-20 EP EP89100974A patent/EP0325279B1/en not_active Expired - Lifetime
1992
- 1992-06-03 GR GR920401138T patent/GR3004786T3/el unknown
1994
- 1994-02-24 BG BG098544A patent/BG60530B2/en unknown

Also Published As

Publication number	Publication date
KR890011838A (en)	1989-08-22
IL88989A0 (en)	1989-08-15
YU47298B (en)	1995-01-31
DK19789D0 (en)	1989-01-17
NO890239L (en)	1989-07-21
AU622139B2 (en)	1992-04-02
EP0325279B1 (en)	1992-04-01
FI90764B (en)	1993-12-15
HUT49317A (en)	1989-09-28
IE890157L (en)	1989-07-20
JPH0764806B2 (en)	1995-07-12
ES2033467T3 (en)	1993-03-16
IE60921B1 (en)	1994-09-07
PT89486B (en)	1993-12-31
NO175429B (en)	1994-07-04
FI890283A (en)	1989-07-21
AR247551A1 (en)	1995-01-31
NO890239D0 (en)	1989-01-19
IL88989A (en)	1993-08-18
MC1998A1 (en)	1990-01-26
HU201007B (en)	1990-09-28
DE58901056D1 (en)	1992-05-07
BG60530B2 (en)	1995-07-28
FI90764C (en)	1994-03-25
PT89486A (en)	1989-10-04
DK169945B1 (en)	1995-04-10
YU11789A (en)	1991-04-30
ATE74350T1 (en)	1992-04-15
NO175429C (en)	1994-10-12
NZ227641A (en)	1991-06-25
GR3004786T3 (en)	1993-04-28
EP0325279A1 (en)	1989-07-26
KR960009119B1 (en)	1996-07-13
CA1337529C (en)	1995-11-07
DK19789A (en)	1989-07-21
ZA8923B (en)	1989-09-27
AU2864489A (en)	1989-07-20
JPH029861A (en)	1990-01-12
PH25605A (en)	1991-08-08

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Legal Events

Date	Code	Title	Description
1993-11-16	BB	Publication of examined application
2004-08-31	FG	Patent granted	Owner name: F. HOFFMANN-LA ROCHE AG
2007-07-31	MA	Patent expired