FI46259B - - Google Patents

Info

Publication number
FI46259B
FI46259B FI3710/69A FI371069A FI46259B FI 46259 B FI46259 B FI 46259B FI 3710/69 A FI3710/69 A FI 3710/69A FI 371069 A FI371069 A FI 371069A FI 46259 B FI46259 B FI 46259B
Authority
FI
Finland
Application number
FI3710/69A
Other languages
Finnish (fi)
Other versions
FI46259C (en
Inventor
K Arima
H Yazawa
M Kohsaka
K Kariyone
G Tamura
H Sakai
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of FI46259B publication Critical patent/FI46259B/fi
Publication of FI46259C publication Critical patent/FI46259C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI693710A 1968-12-30 1969-12-22 Method for the preparation of new therapeutically valuable 11-alkyloxy-1,2,3,10,11,11a-hexahydro-2-ethylidene-7-methoxy-8-hydroxy-5H-pyrrolo [2,1-c] / 1,4 / to prepare benzodiazepin-5-ones. FI46259C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8368 1968-12-30
JP44050780A JPS4843755B1 (en) 1969-06-26 1969-06-26

Publications (2)

Publication Number Publication Date
FI46259B true FI46259B (en) 1972-10-31
FI46259C FI46259C (en) 1973-02-12

Family

ID=26332992

Family Applications (1)

Application Number Title Priority Date Filing Date
FI693710A FI46259C (en) 1968-12-30 1969-12-22 Method for the preparation of new therapeutically valuable 11-alkyloxy-1,2,3,10,11,11a-hexahydro-2-ethylidene-7-methoxy-8-hydroxy-5H-pyrrolo [2,1-c] / 1,4 / to prepare benzodiazepin-5-ones.

Country Status (6)

Country Link
ES (1) ES375013A1 (en)
FI (1) FI46259C (en)
GB (1) GB1299198A (en)
IE (1) IE33906B1 (en)
IL (1) IL33558A (en)
RO (1) RO55813A (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
ES2244210T3 (en) * 1998-08-27 2005-12-01 Spirogen Limited PIRROLOBENZODIAZEPINAS.
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
ES2381858T3 (en) 2004-03-01 2012-06-01 Spirogen Limited 11-Hydroxy-5H-pyrrolo [2,1-C] [1,4] benzodiazepin-5-one derivatives as key intermediates for the preparation of C2 substituted pyrrolobenzodiazepines
EP1723152B1 (en) 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
US8697688B2 (en) 2010-04-15 2014-04-15 Seattle Genetics Inc. Pyrrolobenzodiazepines used to treat proliferative diseases
AU2011239522B2 (en) 2010-04-15 2014-10-23 Medimmune Limited Targeted pyrrolobenzodiazapine conjugates
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
AU2012311505B2 (en) 2011-09-20 2016-09-29 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
WO2013053871A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines
JP6399930B2 (en) 2011-10-14 2018-10-03 シアトル ジェネティクス，インコーポレーテッド Pyrrolobenzodiazepine and target conjugates
EP2755642B1 (en) 2011-10-14 2018-07-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
EP2751111B1 (en) 2011-10-14 2017-04-26 MedImmune Limited Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
JP6166728B2 (en) 2011-10-14 2017-07-19 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Synthetic methods and intermediates useful for the preparation of pyrrolobenzodiazepines
EP2906250B1 (en) 2012-10-12 2018-05-30 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-psma antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
CA2887895C (en) 2012-10-12 2019-10-29 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd19 antibody conjugates
SI2906248T1 (en) 2012-10-12 2019-02-28 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
AU2013328619B2 (en) 2012-10-12 2016-11-17 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-PSMA antibody conjugates
PL2839860T3 (en) 2012-10-12 2019-10-31 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
JP6367204B2 (en) 2012-10-12 2018-08-01 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
RS57104B1 (en) 2012-10-12 2018-06-29 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
MX364327B (en) 2012-10-12 2019-04-23 Medimmune Ltd Pyrrolobenzodiazepine-anti-cd22 antibody conjugates.
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
KR20170101895A (en) 2014-11-25 2017-09-06 에이디씨 테라퓨틱스 에스에이 Pyrrolobenzodiazepine-antibody conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
WO2018146189A1 (en) 2017-02-08 2018-08-16 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
RS63502B1 (en) 2017-04-18 2022-09-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
EP3612234B1 (en) 2017-04-20 2024-03-13 ADC Therapeutics SA Combination therapy with an anti-axl antibody-drug conjugate
JP7145891B2 (en) 2017-06-14 2022-10-03 アーデーセー セラピューティクス ソシエテ アノニム Dosing Regimens for Administering Anti-CD19 ADCs
HRP20220311T1 (en) 2017-08-18 2022-05-13 Medimmune Limited Pyrrolobenzodiazepine conjugates
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof

Also Published As

Publication number Publication date
FI46259C (en) 1973-02-12
ES375013A1 (en) 1972-03-01
RO55813A (en) 1974-02-01
IE33906L (en) 1970-06-30
IL33558A (en) 1973-10-25
IE33906B1 (en) 1974-12-11
IL33558A0 (en) 1970-04-20
GB1299198A (en) 1972-12-06

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