FI101678B - Happolabiileja kytkentämolekyylejä - Google Patents
Happolabiileja kytkentämolekyylejäInfo
- Publication number
- FI101678B FI101678B FI916131A FI916131A FI101678B FI 101678 B FI101678 B FI 101678B FI 916131 A FI916131 A FI 916131A FI 916131 A FI916131 A FI 916131A FI 101678 B FI101678 B FI 101678B
- Authority
- FI
- Finland
- Prior art keywords
- aralkyl
- aryl
- lower alkyl
- alkylene
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Mushroom Cultivation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90203526 | 1990-12-31 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI916131A0 FI916131A0 (fi) | 1991-12-27 |
FI916131A FI916131A (fi) | 1992-07-01 |
FI101678B1 FI101678B1 (fi) | 1998-08-14 |
FI101678B true FI101678B (fi) | 1998-08-14 |
Family
ID=8205218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI916131A FI101678B (fi) | 1990-12-31 | 1991-12-27 | Happolabiileja kytkentämolekyylejä |
Country Status (17)
Country | Link |
---|---|
US (1) | US5306809A (fi) |
EP (1) | EP0495265B1 (fi) |
JP (1) | JPH04334377A (fi) |
KR (1) | KR920012063A (fi) |
AT (1) | ATE109476T1 (fi) |
AU (1) | AU646121B2 (fi) |
CA (1) | CA2058595A1 (fi) |
DE (1) | DE69103255T2 (fi) |
DK (1) | DK0495265T3 (fi) |
ES (1) | ES2061166T3 (fi) |
FI (1) | FI101678B (fi) |
HU (1) | HUT60484A (fi) |
IE (1) | IE65406B1 (fi) |
NO (1) | NO180417C (fi) |
NZ (1) | NZ241217A (fi) |
PT (1) | PT99954B (fi) |
ZA (1) | ZA9110203B (fi) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5505931A (en) * | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
EP0638583A1 (en) * | 1993-08-13 | 1995-02-15 | Hoechst Aktiengesellschaft | Aminosugar active substances, a process for their preparation and use as pharmaceuticals |
DE4433890C2 (de) * | 1994-09-22 | 1999-02-18 | Deutsches Krebsforsch | Konjugat aus einem Wirkstoff und einem nicht als körperfremd angesehenen, nativen Protein |
PT871490E (pt) * | 1995-12-22 | 2003-07-31 | Bristol Myers Squibb Co | Ligantes de hidrazona ramificada |
DE19636889A1 (de) | 1996-09-11 | 1998-03-12 | Felix Dr Kratz | Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel |
US6030997A (en) * | 1998-01-21 | 2000-02-29 | Eilat; Eran | Acid labile prodrugs |
US6800616B2 (en) | 1998-02-26 | 2004-10-05 | Supergen, Inc. | Treatment of HIV infections |
CA2248592A1 (en) | 1998-08-31 | 2000-02-29 | Christopher D. Batich | Microspheres for use in the treatment of cancer |
TWI242000B (en) * | 1998-12-10 | 2005-10-21 | Univ Southern California | Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use |
US6140015A (en) * | 1998-12-10 | 2000-10-31 | International Business Machines Corporation | Photoresist compositions with pendant polar-functionalized aromatic groups and acid-labile branching |
CA2358420C (en) * | 1999-03-11 | 2010-03-16 | Ardenia Investments Ltd. | New compounds for the treatment of cancer |
US6706892B1 (en) * | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
BRPI0003386B8 (pt) * | 2000-08-08 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | pró-droga homo ou heterodiméricas úteis no tratamento de doenças ou disfunções mediadas por fosfodiesterases; composições farmacêuticas contendo a pró-droga ou seus sais farmacêuticos aceitáveis; processo de obtenção destas pró-drogas |
WO2002032400A1 (en) * | 2000-10-16 | 2002-04-25 | Neopharm, Inc. | Liposomal formulation of mitoxantrone |
EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
GB0116143D0 (en) * | 2001-07-02 | 2001-08-22 | Amersham Pharm Biotech Uk Ltd | Chemical capture reagent |
KR100507968B1 (ko) * | 2001-08-18 | 2005-08-17 | 한국과학기술연구원 | 자기집합체를 형성하는 항암제-키토산 복합체 및 그의제조방법 |
AU2002351388A1 (en) * | 2001-12-14 | 2003-06-30 | The University Of Wyoming | Methods and compositions for controlled release of drugs |
US8361464B2 (en) | 2002-03-01 | 2013-01-29 | Immunomedics, Inc. | Anthracycline-Antibody Conjugates for Cancer Therapy |
US20050069551A1 (en) * | 2002-03-08 | 2005-03-31 | Emory University | Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis |
US20060229239A9 (en) * | 2002-03-08 | 2006-10-12 | Mamoru Shoji | Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis |
JP2005529931A (ja) * | 2002-05-24 | 2005-10-06 | マイラス コーポレイション | 膜相互作用の可逆的改質 |
CN1733314A (zh) * | 2004-08-11 | 2006-02-15 | 张阳德 | 半乳糖化白蛋白磁性阿霉素纳米粒的制备方法 |
WO2006052900A2 (en) * | 2004-11-09 | 2006-05-18 | University Of Southern California | Targeted innate immunity |
NZ556788A (en) | 2005-01-05 | 2011-03-31 | Biogen Idec Inc | Humanized CRIPTO binding molecules with CDRs from murine B3F6 |
KR20090091145A (ko) | 2006-10-27 | 2009-08-26 | 웨이-치앙 션 | 지질화된 인터페론 및 이의 용도 |
ES2609094T3 (es) * | 2007-01-25 | 2017-04-18 | Dana-Farber Cancer Institute, Inc. | Uso de anticuerpos anti-EGFR en el tratamiento de enfermedades mediadas por un EGFR mutante |
CA2680854C (en) * | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
MX2010001757A (es) | 2007-08-14 | 2010-09-14 | Ludwig Inst Cancer Res | Anticuerpo monoclonal 175 que activa el receptor egf y derivados y usos del mismo. |
WO2010011684A2 (en) * | 2008-07-21 | 2010-01-28 | The Regents Of The University Of California | Prodrug and fluoregenic compositions and methods for using the same |
JP5472288B2 (ja) * | 2009-03-17 | 2014-04-16 | 国立大学法人 東京大学 | タンパク質の電荷調節剤、及びタンパク質内包高分子ミセル複合体 |
US8535948B2 (en) * | 2009-03-26 | 2013-09-17 | Institute For Systems Biology | Method to determine protein interaction sites |
US9290577B2 (en) | 2009-07-03 | 2016-03-22 | Avipep Pty Limited | Immuno-conjugates and methods for producing them |
US20110076232A1 (en) * | 2009-09-29 | 2011-03-31 | Ludwig Institute For Cancer Research | Specific binding proteins and uses thereof |
WO2011075786A1 (en) | 2009-12-23 | 2011-06-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
AU2011274229A1 (en) | 2010-07-02 | 2013-01-10 | Angiochem Inc. | Short and D-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
CN103890246A (zh) | 2011-08-18 | 2014-06-25 | 亲和生物科学公司 | 可溶性多肽 |
HUE039033T2 (hu) | 2012-01-10 | 2018-12-28 | Biogen Ma Inc | Terápiás molekulák transzportjának fokozása a vér-agy gáton keresztül |
GB201202268D0 (en) | 2012-02-09 | 2012-03-28 | Medical Res Council | Intracellular immunity |
WO2014057436A2 (en) | 2012-10-10 | 2014-04-17 | Adamed Sp. Z O.O. | Anticancer conjugate |
CN105209068A (zh) | 2013-02-07 | 2015-12-30 | 免疫医疗公司 | 用于靶向癌症治疗的缀合至抗体的高效2-吡咯啉多柔比星的前药形式(p2pdox) |
WO2014141094A1 (en) | 2013-03-14 | 2014-09-18 | Adamed Sp. Z O.O. | Anticancer conjugate |
EP3104857A4 (en) | 2014-02-14 | 2017-10-11 | The Regents of The University of California | Cyclic peroxides as prodrugs for selective delivery of agents |
AU2015326407C1 (en) | 2014-10-03 | 2021-06-24 | Engeneic Molecular Delivery Pty Ltd | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
BR102016018074A2 (pt) | 2015-08-07 | 2021-11-16 | ALX Oncology Inc. | Construção variante de sirp-alfa, seu método de preparação e seus usos, molécula de ácido nucleico, vetor, célula hospedeira, e composição farmacêutica |
GEP20217326B (en) | 2015-08-07 | 2021-11-25 | Alx Oncology Inc | Constructs having a sirp-alpha domain or variant thereof |
PT3380495T (pt) | 2015-11-24 | 2021-08-19 | Transfert Plus Sec | Compostos peptídicos e conjugados peptídicos para o tratamento de cancro através de quimioterapia mediada por recetores |
US10800817B2 (en) | 2016-12-19 | 2020-10-13 | Morehouse School Of Medicine | Compositions and methods for treating diseases by inhibiting exosome release |
EP3554638B1 (en) | 2016-12-19 | 2022-02-02 | Morehouse School of Medicine | Compositions and methods for treating diseases by inhibiting exosome release |
SG11202112733XA (en) | 2019-05-31 | 2021-12-30 | Alx Oncology Inc | Methods of treating cancer with sirp alpha fc fusion in combination with an immune checkpoint inhibitor |
KR20240007913A (ko) | 2021-05-13 | 2024-01-17 | 알렉소 온콜로지 인크. | 암 치료를 위한 병용 요법 |
US11180534B1 (en) | 2021-06-04 | 2021-11-23 | Morehouse School Of Medicine | Compositions and methods for treating SARS-CoV-2 infections |
AU2023208050A1 (en) * | 2022-01-14 | 2024-07-04 | Regeneron Pharmaceuticals, Inc. | Verrucarin a derivatives and antibody drug conjugates thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4631190A (en) * | 1981-06-26 | 1986-12-23 | Shen Wei C | Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers |
US4542225A (en) * | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4744981A (en) * | 1985-10-17 | 1988-05-17 | Neorx Corporation | Trichothecene antibody conjugates |
US4997913A (en) * | 1986-06-30 | 1991-03-05 | Oncogen | pH-sensitive immunoconjugates and methods for their use in tumor therapy |
US5140013A (en) * | 1989-11-28 | 1992-08-18 | Universite Laval | Maleic anhydride derivatives used as conjugation agents of anti-tumor agents on desired carriers |
-
1991
- 1991-12-27 JP JP3361486A patent/JPH04334377A/ja active Pending
- 1991-12-27 FI FI916131A patent/FI101678B/fi active
- 1991-12-28 HU HU914133A patent/HUT60484A/hu unknown
- 1991-12-30 AU AU90098/91A patent/AU646121B2/en not_active Ceased
- 1991-12-30 EP EP91203439A patent/EP0495265B1/en not_active Expired - Lifetime
- 1991-12-30 ES ES91203439T patent/ES2061166T3/es not_active Expired - Lifetime
- 1991-12-30 KR KR1019910025982A patent/KR920012063A/ko not_active Application Discontinuation
- 1991-12-30 CA CA002058595A patent/CA2058595A1/en not_active Abandoned
- 1991-12-30 DK DK91203439.4T patent/DK0495265T3/da active
- 1991-12-30 IE IE456791A patent/IE65406B1/en not_active IP Right Cessation
- 1991-12-30 ZA ZA9110203A patent/ZA9110203B/xx unknown
- 1991-12-30 PT PT99954A patent/PT99954B/pt not_active IP Right Cessation
- 1991-12-30 DE DE69103255T patent/DE69103255T2/de not_active Expired - Fee Related
- 1991-12-30 AT AT91203439T patent/ATE109476T1/de active
- 1991-12-31 US US07/815,671 patent/US5306809A/en not_active Expired - Fee Related
-
1992
- 1992-01-02 NO NO920040A patent/NO180417C/no unknown
- 1992-01-06 NZ NZ241217A patent/NZ241217A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US5306809A (en) | 1994-04-26 |
KR920012063A (ko) | 1992-07-25 |
DK0495265T3 (da) | 1995-01-02 |
NO180417C (no) | 1997-04-16 |
IE65406B1 (en) | 1995-10-18 |
FI101678B1 (fi) | 1998-08-14 |
FI916131A (fi) | 1992-07-01 |
DE69103255D1 (de) | 1994-09-08 |
PT99954A (pt) | 1993-06-30 |
NO180417B (no) | 1997-01-06 |
ZA9110203B (en) | 1993-01-27 |
NO920040D0 (no) | 1992-01-02 |
JPH04334377A (ja) | 1992-11-20 |
DE69103255T2 (de) | 1994-12-08 |
ES2061166T3 (es) | 1994-12-01 |
NZ241217A (en) | 1993-12-23 |
HUT60484A (en) | 1992-09-28 |
IE914567A1 (en) | 1992-07-01 |
AU9009891A (en) | 1993-01-28 |
AU646121B2 (en) | 1994-02-10 |
PT99954B (pt) | 1999-06-30 |
EP0495265B1 (en) | 1994-08-03 |
CA2058595A1 (en) | 1992-07-01 |
HU914133D0 (en) | 1992-03-30 |
NO920040L (no) | 1992-07-01 |
ATE109476T1 (de) | 1994-08-15 |
FI916131A0 (fi) | 1991-12-27 |
EP0495265A1 (en) | 1992-07-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI101678B (fi) | Happolabiileja kytkentämolekyylejä | |
MXPA03010432A (es) | Inmunoconjugados del anticuerpo cd44 citotoxico. | |
KR900002803A (ko) | 세포독성 약물 결합체 | |
FI912285A0 (fi) | Nya bifunktionella kopplingsfoereningar, konjugat och foerfaranden foer framstaellning av dessa. | |
ATE294592T1 (de) | Thioether enthaltende konjugate | |
US4263279A (en) | Pharmaceutically active compositions containing adriamycin and daunomycin | |
PT76394A (fr) | Procede de preparation de nouveaux conjugues associant par liaison covalente une enzyme et un anticorps | |
IL64722A (en) | Immunoglobulin conjugates,their preparation and pharmaceutical compositions containing them | |
FI915780A0 (fi) | Maerktae, modifierade oligonukleotider. | |
WO2004041307A3 (en) | Compositions and methods for treating cancer using cytotoxic cd44 antibody immunoconjugates and radiotherapy | |
HU9500585D0 (en) | Hepatotropic conjugates of antiviral drugs, carriers thereof and pharmaceutical compositions containing them |