ES8707243A1 - Un procedimiento para preparar derivados de tienopiridona - Google Patents

Un procedimiento para preparar derivados de tienopiridona

Info

Publication number
ES8707243A1
ES8707243A1 ES556026A ES556026A ES8707243A1 ES 8707243 A1 ES8707243 A1 ES 8707243A1 ES 556026 A ES556026 A ES 556026A ES 556026 A ES556026 A ES 556026A ES 8707243 A1 ES8707243 A1 ES 8707243A1
Authority
ES
Spain
Prior art keywords
thienopyridones
thieno
formula
processes
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556026A
Other languages
English (en)
Other versions
ES556026A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Publication of ES8707243A1 publication Critical patent/ES8707243A1/es
Publication of ES556026A0 publication Critical patent/ES556026A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TIENOPIRIDONA, DE FORMULA (I). COMPRENDE LA REACCION DE ALQUILACION DE UN COMPUESTO DE FORMULA (II), POR TRATAMIENTO CON UN AGENTE ALQUILANTE EN CONDICIONES CONVENCIONALES, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE A REPRESENTA ANILLO DE TIOFENO, R Y R1 SON ALQUILO INFERIOR, M VALE 0 O 1 Y N VALE 0-2. TAMBIEN SE PUEDEN EMPLEAR OTROS COMPUESTOS DE PARTIDA Y SOMETERLOS A LAS REACCIONES ADECUADAS PARA OBTENER EL COMPUESTO DE FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIHIPERTENSORES.
ES556026A 1985-06-15 1986-06-13 Un procedimiento para preparar derivados de tienopiridona Expired ES8707243A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858515207A GB8515207D0 (en) 1985-06-15 1985-06-15 Therapeutic agents

Publications (2)

Publication Number Publication Date
ES8707243A1 true ES8707243A1 (es) 1987-07-16
ES556026A0 ES556026A0 (es) 1987-07-16

Family

ID=10580803

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556026A Expired ES8707243A1 (es) 1985-06-15 1986-06-13 Un procedimiento para preparar derivados de tienopiridona

Country Status (20)

Country Link
US (1) US4710506A (es)
EP (1) EP0209977A3 (es)
JP (1) JPS6236382A (es)
KR (1) KR870000339A (es)
AU (1) AU581595B2 (es)
CS (1) CS258483B2 (es)
DD (1) DD253823A5 (es)
DK (1) DK272486A (es)
ES (1) ES8707243A1 (es)
FI (1) FI862520A (es)
GB (1) GB8515207D0 (es)
GR (1) GR861527B (es)
HU (1) HU195661B (es)
JO (1) JO1482B1 (es)
NO (1) NO862373L (es)
PH (1) PH22293A (es)
PL (1) PL266392A1 (es)
PT (1) PT82759B (es)
YU (2) YU99386A (es)
ZA (1) ZA864396B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
US4767766A (en) * 1987-01-30 1988-08-30 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors
US4904672A (en) * 1987-01-30 1990-02-27 Merck & Co., Inc. Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
CA2339484A1 (en) * 1998-08-03 2000-02-17 Robert A. O'brien Pyridinones for the treatment of sexual dysfunction
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
OA12622A (en) * 2001-06-11 2006-06-12 Shire Biochem Inc Thiophene derivatives as antiviral agents for flavivirus infection.
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
AU2002345792A1 (en) * 2001-06-21 2003-01-08 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents
DE60332482D1 (de) 2002-12-10 2010-06-17 Virochem Pharma Inc Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen
US7973050B2 (en) * 2006-09-26 2011-07-05 Crestone, Inc. Enantiomeric compounds with antibacterial activity
US8697720B2 (en) 2006-09-26 2014-04-15 Crestone, Inc. Substituted phenylether-thienopyridone compounds with antibacterial activity
JP5247705B2 (ja) * 2006-09-26 2013-07-24 クレストーン・インコーポレーテッド 抗細菌活性を持つ置換チエノピリドン化合物
US7994192B2 (en) * 2006-09-26 2011-08-09 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
US8658670B2 (en) * 2006-09-26 2014-02-25 Crestone, Inc. Methods and compounds for treatment of clostridium based infection
JP5290186B2 (ja) * 2006-11-15 2013-09-18 ヴァイロケム ファーマ インコーポレイテッド フラビウイルス感染症の治療または予防用のチオフェン類似体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997545A (en) * 1973-07-23 1976-12-14 Takeda Chemical Industries, Ltd. Thienopyridine-carboxylic acid derivatives
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
JPS5742690A (en) * 1980-08-28 1982-03-10 Kanebo Ltd Thieno 3,2-b pyridinecarboxylic acid derivative
GB2085441B (en) * 1980-09-26 1984-10-17 Boots The Co Ltd Therapeutic agents
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
DE3412947A1 (de) * 1984-04-06 1985-10-17 Bayer Ag, 5090 Leverkusen Tetrahydothienopyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
EP0209977A3 (en) 1988-06-08
GR861527B (en) 1986-10-14
JO1482B1 (en) 1988-03-10
DK272486D0 (da) 1986-06-10
CS436286A2 (en) 1987-12-17
YU99386A (en) 1988-04-30
ZA864396B (en) 1987-08-26
US4710506A (en) 1987-12-01
HUT42775A (en) 1987-08-28
PH22293A (en) 1988-07-22
CS258483B2 (en) 1988-08-16
AU581595B2 (en) 1989-02-23
KR870000339A (ko) 1987-02-17
PT82759B (en) 1988-05-12
PT82759A (en) 1986-07-01
NO862373L (no) 1986-12-16
ES556026A0 (es) 1987-07-16
NO862373D0 (no) 1986-06-13
PL266392A1 (en) 1988-02-18
FI862520A0 (fi) 1986-06-12
DD253823A5 (de) 1988-02-03
EP0209977A2 (en) 1987-01-28
HU195661B (en) 1988-06-28
DK272486A (da) 1986-12-16
FI862520A (fi) 1986-12-16
GB8515207D0 (en) 1985-07-17
YU121187A (en) 1988-04-30
JPS6236382A (ja) 1987-02-17
AU5838386A (en) 1986-12-18

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