ES8603408A1 - Un procedimiento para la preparacion de un compuesto de 2-oxindol-1-carboxamida - Google Patents

Un procedimiento para la preparacion de un compuesto de 2-oxindol-1-carboxamida

Info

Publication number
ES8603408A1
ES8603408A1 ES541372A ES541372A ES8603408A1 ES 8603408 A1 ES8603408 A1 ES 8603408A1 ES 541372 A ES541372 A ES 541372A ES 541372 A ES541372 A ES 541372A ES 8603408 A1 ES8603408 A1 ES 8603408A1
Authority
ES
Spain
Prior art keywords
formula
analgesic
inflammatory agents
reaction
oxindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541372A
Other languages
English (en)
Other versions
ES541372A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8603408A1 publication Critical patent/ES8603408A1/es
Publication of ES541372A0 publication Critical patent/ES541372A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 2-OXINDOL-1-CARBOXAMIDA Y DE SUS SALES CON BASES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X, Y Y R1 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE SUSTITUCION DE UN COMPUESTO DE FORMULA (II) CON UN DERIVADO ACTIVO DE ACIDO CARBOXILICO, DE FORMULA R1COOH, EN LAS QUE X, Y Y R1 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE 1 A 4 EQUIVALENTES MOLARES DE UN AGENTE BASICO, TAL COMO UNA AMINA TERCIARIA, A UNA TEMPERATURA ENTRE C10JC Y 25JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANALGESICOS Y ANTIINFLAMATORIOS.
ES541372A 1984-03-19 1985-03-18 Un procedimiento para la preparacion de un compuesto de 2-oxindol-1-carboxamida Granted ES541372A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Publications (2)

Publication Number Publication Date
ES8603408A1 true ES8603408A1 (es) 1985-12-16
ES541372A0 ES541372A0 (es) 1985-12-16

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541372A Granted ES541372A0 (es) 1984-03-19 1985-03-18 Un procedimiento para la preparacion de un compuesto de 2-oxindol-1-carboxamida

Country Status (36)

Country Link
US (1) US4556672A (es)
EP (1) EP0156603B1 (es)
JP (1) JPH04235165A (es)
KR (1) KR860001873B1 (es)
AT (1) ATE45731T1 (es)
AU (1) AU549927B2 (es)
BG (1) BG60347B2 (es)
CA (2) CA1251441A (es)
CS (1) CS249539B2 (es)
CY (1) CY1668A (es)
DE (1) DE3572481D1 (es)
DK (1) DK162090C (es)
EG (1) EG17795A (es)
ES (1) ES541372A0 (es)
FI (2) FI82042C (es)
GR (1) GR850668B (es)
HK (1) HK78392A (es)
HU (1) HU196178B (es)
IE (1) IE57743B1 (es)
IL (3) IL85130A (es)
LV (1) LV5618A3 (es)
MA (1) MA20380A1 (es)
MY (1) MY101987A (es)
NL (1) NL940025I2 (es)
NO (1) NO165799C (es)
NZ (2) NZ224134A (es)
OA (1) OA07966A (es)
PH (2) PH21323A (es)
PL (1) PL145951B1 (es)
PT (1) PT80117B (es)
RO (1) RO90952B (es)
SI (1) SI8510440A8 (es)
SU (1) SU1445556A3 (es)
UA (1) UA6343A1 (es)
YU (1) YU43870B (es)
ZW (1) ZW4785A1 (es)

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DE68923673T2 (de) * 1988-10-18 1996-01-18 Pfizer Prodrogen von antiinflammatorischen 3-Acyl-2-oxindol-1-carboxamiden.
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Also Published As

Publication number Publication date
FI82042C (fi) 1991-01-10
MY101987A (en) 1992-02-29
DK121385A (da) 1985-09-20
IL74631A (en) 1988-07-31
HU196178B (en) 1988-10-28
CS249539B2 (en) 1987-03-12
OA07966A (fr) 1987-01-31
DK121385D0 (da) 1985-03-18
IL85130A (en) 1988-07-31
NO165799C (no) 1991-04-10
DK162090C (da) 1992-02-24
EP0156603B1 (en) 1989-08-23
US4556672A (en) 1985-12-03
IL74631A0 (en) 1985-06-30
PH21470A (en) 1987-10-28
PH21323A (en) 1987-09-28
LV5618A3 (lv) 1994-05-10
HUT37398A (en) 1985-12-28
EP0156603A3 (en) 1986-02-12
ATE45731T1 (de) 1989-09-15
GR850668B (es) 1985-07-16
EP0156603A2 (en) 1985-10-02
YU43870B (en) 1989-12-31
CY1668A (en) 1993-05-14
FI851069L (fi) 1985-09-20
DE3572481D1 (en) 1989-09-28
NO851054L (no) 1985-09-20
ES541372A0 (es) 1985-12-16
FI82042B (fi) 1990-09-28
CA1251441A (en) 1989-03-21
KR860001873B1 (ko) 1986-10-24
FI894540A (fi) 1989-09-26
JPH04235165A (ja) 1992-08-24
PL252434A1 (en) 1985-12-03
KR850006173A (ko) 1985-10-02
UA6343A1 (uk) 1994-12-29
CA1288422C (en) 1991-09-03
NZ211486A (en) 1988-10-28
PT80117A (en) 1985-04-01
JPH0561269B2 (es) 1993-09-06
ZW4785A1 (en) 1985-06-19
RO90952B (ro) 1987-03-01
FI894540A0 (fi) 1989-09-26
AU549927B2 (en) 1986-02-20
YU44085A (en) 1988-02-29
FI82449B (fi) 1990-11-30
SI8510440A8 (sl) 1996-06-30
FI851069A0 (fi) 1985-03-18
IE57743B1 (en) 1993-03-24
IL85130A0 (en) 1988-06-30
BG60347B2 (bg) 1994-09-30
SU1445556A3 (ru) 1988-12-15
PL145951B1 (en) 1988-12-31
EG17795A (en) 1990-08-30
NZ224134A (en) 1988-10-28
IE850684L (en) 1985-09-19
HK78392A (en) 1992-10-23
NO165799B (no) 1991-01-02
MA20380A1 (fr) 1985-10-01
FI82449C (fi) 1991-03-11
RO90952A (ro) 1987-02-27
NL940025I1 (nl) 1995-02-01
PT80117B (pt) 1987-10-20
DK162090B (da) 1991-09-16
NL940025I2 (nl) 2000-01-03
AU4005985A (en) 1985-09-26

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