ES8500742A1 - Procedimiento para la preparacion de derivados de acido fenilacetico - Google Patents

Procedimiento para la preparacion de derivados de acido fenilacetico

Info

Publication number
ES8500742A1
ES8500742A1 ES529808A ES529808A ES8500742A1 ES 8500742 A1 ES8500742 A1 ES 8500742A1 ES 529808 A ES529808 A ES 529808A ES 529808 A ES529808 A ES 529808A ES 8500742 A1 ES8500742 A1 ES 8500742A1
Authority
ES
Spain
Prior art keywords
preparation
acetic
phenyl
acid derivatives
pharmaceutical compostions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529808A
Other languages
English (en)
Other versions
ES529808A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19823225155 external-priority patent/DE3225155A1/de
Priority claimed from DE19823225188 external-priority patent/DE3225188A1/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES8500742A1 publication Critical patent/ES8500742A1/es
Publication of ES529808A0 publication Critical patent/ES529808A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fertilizers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO FENILACETICO, DE SUS ANTIPODAS OPTICAMENTE ACTIVOS, DE SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES Y DE SUS BASES, DE FORMULA (I), EN LA QUE A, W, R1, R2 Y R3 PUEDEN SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III); TODOS LOS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE EFECTUA EN PRESENCIA DE UN ACIDO FUERTE, EN UN DISOLVENTE INERTE A TEMPERATURAS ENTRE 0JC Y 150JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO HIPOGLUCEMICO.
ES529808A 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico Granted ES529808A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823225155 DE3225155A1 (de) 1982-07-06 1982-07-06 Neue n-benzylamide und deren salze, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE19823225188 DE3225188A1 (de) 1982-07-06 1982-07-06 Neue phenylessigsaeurederivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8500742A1 true ES8500742A1 (es) 1984-11-01
ES529808A0 ES529808A0 (es) 1984-11-01

Family

ID=25802849

Family Applications (4)

Application Number Title Priority Date Filing Date
ES523869A Granted ES523869A0 (es) 1982-07-06 1983-07-05 Procedimiento para la preparacion de derivados de acido fenilacetico.
ES529807A Granted ES529807A0 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico
ES529808A Granted ES529808A0 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico
ES529806A Granted ES529806A0 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES523869A Granted ES523869A0 (es) 1982-07-06 1983-07-05 Procedimiento para la preparacion de derivados de acido fenilacetico.
ES529807A Granted ES529807A0 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES529806A Granted ES529806A0 (es) 1982-07-06 1984-02-17 Procedimiento para la preparacion de derivados de acido fenilacetico

Country Status (21)

Country Link
EP (1) EP0099017B1 (es)
KR (1) KR900004925B1 (es)
AU (1) AU561274B2 (es)
CA (1) CA1214773A (es)
CS (1) CS240970B2 (es)
DD (1) DD210907A5 (es)
DE (1) DE3375783D1 (es)
DK (1) DK159850C (es)
ES (4) ES523869A0 (es)
FI (1) FI78477C (es)
GB (1) GB2124220B (es)
GR (1) GR78661B (es)
HU (1) HU195651B (es)
IE (1) IE56171B1 (es)
IL (1) IL69172A (es)
NO (1) NO159590C (es)
NZ (1) NZ204814A (es)
PL (1) PL143992B1 (es)
PT (1) PT76986B (es)
SU (1) SU1170969A3 (es)
YU (1) YU146883A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312924A (en) * 1983-12-30 1994-05-17 Dr. Karl Thomae Gmbh Phenylacetic acid benzylamides
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
FR2763590B1 (fr) * 1997-05-22 2000-03-24 Synthelabo Derives d'acides[[[(arylmethyl)amino]carbonyl] alkyl]- aromatiques, leur preparation et leur application en therapeutique
WO2004108673A2 (en) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE764238A (fr) * 1971-03-17 1971-09-13 Lilly Industries Ltd Derives de phenylalkylamine
NL7305171A (es) * 1973-04-13 1974-10-15
DE3100575A1 (de) * 1981-01-10 1982-09-02 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benzoesaeuren, ihre herstellung und ihre verwendung als arzneimittel"

Also Published As

Publication number Publication date
PL143992B1 (en) 1988-04-30
CA1214773A (en) 1986-12-02
FI832374A0 (fi) 1983-06-29
FI832374L (fi) 1984-01-07
DD210907A5 (de) 1984-06-27
GR78661B (es) 1984-09-27
FI78477C (fi) 1989-08-10
IE56171B1 (en) 1991-05-08
NO159590B (no) 1988-10-10
KR840005438A (ko) 1984-11-12
GB2124220B (en) 1985-11-13
DK159850C (da) 1991-05-06
IL69172A (en) 1987-10-20
AU561274B2 (en) 1987-05-07
EP0099017B1 (de) 1988-03-02
DK310883D0 (da) 1983-07-05
NZ204814A (en) 1986-10-08
DE3375783D1 (en) 1988-04-07
FI78477B (fi) 1989-04-28
GB2124220A (en) 1984-02-15
NO159590C (no) 1989-01-18
DK310883A (da) 1984-01-07
CS240970B2 (en) 1986-03-13
PT76986B (de) 1986-04-11
EP0099017A2 (de) 1984-01-25
DK159850B (da) 1990-12-17
IL69172A0 (en) 1983-11-30
ES8501382A1 (es) 1984-11-16
KR900004925B1 (ko) 1990-07-12
ES523869A0 (es) 1984-11-16
ES8500923A1 (es) 1984-11-01
EP0099017A3 (en) 1984-02-22
YU146883A (en) 1986-04-30
AU1657683A (en) 1984-01-12
PT76986A (de) 1983-08-01
IE831573L (en) 1984-01-06
NO832430L (no) 1984-01-09
PL242873A1 (en) 1984-09-10
SU1170969A3 (ru) 1985-07-30
ES529808A0 (es) 1984-11-01
ES529806A0 (es) 1984-11-01
HU195651B (en) 1988-06-28
GB8318250D0 (en) 1983-08-10
ES8500924A1 (es) 1984-11-01
ES529807A0 (es) 1984-11-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303