ES514877A0 - "un procedimiento para preparar derivados de purina". - Google Patents

"un procedimiento para preparar derivados de purina".

Info

Publication number
ES514877A0
ES514877A0 ES514877A ES514877A ES514877A0 ES 514877 A0 ES514877 A0 ES 514877A0 ES 514877 A ES514877 A ES 514877A ES 514877 A ES514877 A ES 514877A ES 514877 A0 ES514877 A0 ES 514877A0
Authority
ES
Spain
Prior art keywords
compounds
purine
procedure
preparing derivatives
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES514877A
Other languages
English (en)
Other versions
ES8403128A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES8403128A1 publication Critical patent/ES8403128A1/es
Publication of ES514877A0 publication Critical patent/ES514877A0/es
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/061,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
ES514877A 1981-08-11 1982-08-10 "un procedimiento para preparar derivados de purina". Granted ES514877A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8124444 1981-08-11

Publications (2)

Publication Number Publication Date
ES8403128A1 ES8403128A1 (es) 1983-10-01
ES514877A0 true ES514877A0 (es) 1983-10-01

Family

ID=10523843

Family Applications (3)

Application Number Title Priority Date Filing Date
ES514877A Granted ES514877A0 (es) 1981-08-11 1982-08-10 "un procedimiento para preparar derivados de purina".
ES521550A Expired ES8504802A1 (es) 1981-08-11 1983-04-15 Un procedimiento para preparar derivados de purina.
ES521551A Granted ES521551A0 (es) 1981-08-11 1983-04-15 Un procedimiento para preparar derivados de purina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES521550A Expired ES8504802A1 (es) 1981-08-11 1983-04-15 Un procedimiento para preparar derivados de purina.
ES521551A Granted ES521551A0 (es) 1981-08-11 1983-04-15 Un procedimiento para preparar derivados de purina.

Country Status (25)

Country Link
EP (1) EP0072027B1 (es)
JP (1) JPS5841879A (es)
KR (1) KR880002276B1 (es)
AT (2) ATE34393T1 (es)
AU (1) AU569462B2 (es)
CA (1) CA1305138C (es)
CS (1) CS594082A2 (es)
DD (1) DD202717A5 (es)
DE (1) DE3278501D1 (es)
DK (1) DK154561C (es)
ES (3) ES514877A0 (es)
FI (1) FI76086C (es)
GB (1) GB2104070B (es)
GR (1) GR76891B (es)
HU (1) HU189609B (es)
IE (1) IE54148B1 (es)
MC (1) MC1475A1 (es)
NO (1) NO158539C (es)
NZ (1) NZ201547A (es)
PH (3) PH19940A (es)
PL (3) PL247394A1 (es)
PT (1) PT75406B (es)
ZA (1) ZA825792B (es)
ZM (1) ZM6082A1 (es)
ZW (1) ZW16882A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
SU1537138A3 (ru) * 1982-02-01 1990-01-15 Синтекс (Ю.С.А.) Инк (Фирма) Способ получени производных пуринов или их солей
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
EP0095813A3 (en) * 1982-06-01 1985-05-08 THE PROCTER & GAMBLE COMPANY Penetrating topical pharmaceutical compositions containing 9-(2-hydroxyethoxymethyl) guanine
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
HUT36464A (en) * 1983-05-24 1985-09-30 Newport Pharmaceuticals Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide
EP0141927B1 (en) * 1983-08-18 1991-10-30 Beecham Group Plc Antiviral guanine derivatives
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
DE3571810D1 (en) * 1984-01-26 1989-08-31 Merck & Co Inc Substituted butyl guanines and their utilization in antiviral compositions
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0190123A1 (en) * 1984-07-20 1986-08-13 GAUNTT, Charles, O. Immunoregulatory and anti-viral compound
DE3667058D1 (en) 1985-05-02 1989-12-28 Wellcome Found Antiviral compounds
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
DE10299039I1 (de) * 1988-12-19 2003-02-20 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Praeparte
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
DE4020481A1 (de) * 1990-06-27 1992-01-02 Hoechst Ag Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
CA2152863A1 (en) * 1994-07-26 1996-01-27 Yeun-Kwei Han Preparation of acyclovir
US5567816A (en) * 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US6083953A (en) * 1994-07-28 2000-07-04 Syntex (U.S.A.) Inc. 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5559114A (en) * 1994-12-16 1996-09-24 Exley; Ray W. Treatment of autoimmune disease using 2-amino purine derivatives
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent

Also Published As

Publication number Publication date
PL247393A1 (en) 1984-10-22
GR76891B (es) 1984-09-04
PL141198B1 (en) 1987-07-31
JPH04989B2 (es) 1992-01-09
DD202717A5 (de) 1983-09-28
ZM6082A1 (en) 1984-04-23
ES521550A0 (es) 1985-04-16
ES8403128A1 (es) 1983-10-01
AU8702082A (en) 1983-05-05
FI76086C (fi) 1988-09-09
DK154561B (da) 1988-11-28
ZW16882A1 (en) 1984-03-14
DK154561C (da) 1989-04-24
PT75406B (en) 1985-11-15
PT75406A (en) 1982-09-01
CS594082A2 (en) 1989-08-14
PL247394A1 (en) 1984-10-22
GB2104070B (en) 1985-08-14
NO158539C (no) 1988-09-28
ATE34393T1 (de) 1988-06-15
ATA306082A (de) 1985-09-15
HU189609B (en) 1986-07-28
MC1475A1 (fr) 1983-06-17
NO158539B (no) 1988-06-20
JPS5841879A (ja) 1983-03-11
KR880002276B1 (ko) 1988-10-21
NZ201547A (en) 1986-01-24
EP0072027A1 (en) 1983-02-16
FI822783A0 (fi) 1982-08-10
IE54148B1 (en) 1989-07-05
DK359082A (da) 1983-02-12
GB2104070A (en) 1983-03-02
PL141281B1 (en) 1987-07-31
PH18814A (en) 1985-09-27
PL237847A1 (en) 1984-09-10
PH20148A (en) 1986-10-08
ES8504802A1 (es) 1985-04-16
IE821921L (en) 1983-02-11
CA1305138C (en) 1992-07-14
KR840001169A (ko) 1984-03-28
AT380252B (de) 1986-05-12
AU569462B2 (en) 1988-02-04
ZA825792B (en) 1984-03-28
NO822725L (no) 1983-02-14
ES8502117A1 (es) 1984-12-16
PH19940A (en) 1986-08-14
ES521551A0 (es) 1984-12-16
FI76086B (fi) 1988-05-31
EP0072027B1 (en) 1988-05-18
FI822783L (fi) 1983-02-12
DE3278501D1 (en) 1988-06-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519