ES476168A1 - Procedimiento para la preparacion de nuevas imidazo-isoquinoleindionas. - Google Patents
Procedimiento para la preparacion de nuevas imidazo-isoquinoleindionas.Info
- Publication number
- ES476168A1 ES476168A1 ES476168A ES476168A ES476168A1 ES 476168 A1 ES476168 A1 ES 476168A1 ES 476168 A ES476168 A ES 476168A ES 476168 A ES476168 A ES 476168A ES 476168 A1 ES476168 A1 ES 476168A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- salts
- hydrogen
- compounds
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento para la preparación de nuevas imidazo-isoquinoleín-dionas de la fórmula general **fórmula** en la que R1 significa un grupo alcohilo inferior eventualmente sustituido con un grupo fenilo, un grupo cicloalcohilo con 3 hasta 6 átomos de carbono o un grupo fenilo, eventualmente monosustituido o disustituido con átomos de halógeno , grupos hidroxi, metoxi, metilmercapto, metilsulfinilo, metilsulfonilo y/o benciloxi, pudiendo ser los sustituyentes iguales o diferentes, así como de sus sales por adición de ácido fisiológicamente compatibles, con ácidos inorgánicos u orgánicos, que se caracteriza porque se reduce una 8- nitro-isoquinolein-diona de la fórmula general **fórmula** y la 8-amino-isoquinolein-diona , formada in situ, de la formula general**fórmula** en la que R1 está definido como al principio, se condensa en presencia de un agente de condensación ácido y, si se desea, un compuesto, obtenido según la invención, de la fórmula general I, en la que R1 representa un grupo fenilo, que está sustituido con un grupo metilmercapto y/o metilsulfinilo, se trannsforma por medio de oxidación en un correspondiente compuesto de metilsulfinilo o de metilsulfonilo de la formula general I y/o un compuesto obtenido de la fórmula general I, en la que R1 representa un grupo fenilo, que está sustituido con un grupo benciloxi, por medio de desbencilación se transforma en un correspondiente compuesto hidroxílico de la fórmula general I y/o un compuesto obtenido de la fórmula general I se transforma en una sal por adición de ácido fisiológicamente compatible con un ácido inorgánico u orgánico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772732951 DE2732951A1 (de) | 1977-07-21 | 1977-07-21 | Neue imidazo-isochinolin-dione |
| DE2732906A DE2732906C2 (de) | 1977-07-21 | 1977-07-21 | In 5-Stellung durch einen Aminoalkylrest substituierte Imidazo-isochinolin-dione, Verfahren zu ihrer Herstellung und Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES476168A1 true ES476168A1 (es) | 1979-05-16 |
Family
ID=25772367
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471254A Expired ES471254A1 (es) | 1977-07-21 | 1978-06-29 | Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas |
| ES476166A Expired ES476166A1 (es) | 1977-07-21 | 1978-12-20 | Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas |
| ES476168A Expired ES476168A1 (es) | 1977-07-21 | 1978-12-20 | Procedimiento para la preparacion de nuevas imidazo-isoquinoleindionas. |
| ES476167A Expired ES476167A1 (es) | 1977-07-21 | 1978-12-20 | Procedimiento para la preparacion de nuevas imidazo-isoquinolein-dionas. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471254A Expired ES471254A1 (es) | 1977-07-21 | 1978-06-29 | Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas |
| ES476166A Expired ES476166A1 (es) | 1977-07-21 | 1978-12-20 | Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476167A Expired ES476167A1 (es) | 1977-07-21 | 1978-12-20 | Procedimiento para la preparacion de nuevas imidazo-isoquinolein-dionas. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4176184A (es) |
| JP (1) | JPS5422400A (es) |
| AT (1) | AT366383B (es) |
| AU (1) | AU519769B2 (es) |
| BG (1) | BG30021A3 (es) |
| CA (1) | CA1091232A (es) |
| CH (1) | CH642367A5 (es) |
| CS (1) | CS204032B2 (es) |
| DD (1) | DD137933A5 (es) |
| DK (1) | DK323378A (es) |
| ES (4) | ES471254A1 (es) |
| FI (1) | FI64371C (es) |
| FR (1) | FR2398069A1 (es) |
| GB (1) | GB2002751B (es) |
| GR (1) | GR65025B (es) |
| HK (1) | HK20685A (es) |
| HU (1) | HU181000B (es) |
| IL (1) | IL55168A (es) |
| IT (1) | IT1107653B (es) |
| LU (1) | LU80001A1 (es) |
| NL (1) | NL7807760A (es) |
| NO (1) | NO149314C (es) |
| NZ (1) | NZ187916A (es) |
| PL (1) | PL110398B1 (es) |
| PT (1) | PT68329A (es) |
| SE (1) | SE441746B (es) |
| SG (1) | SG185G (es) |
| SU (1) | SU688129A3 (es) |
| YU (1) | YU40340B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3531678A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JP2558707Y2 (ja) * | 1986-06-25 | 1998-01-14 | 松下電工 株式会社 | 蓄積式防排煙受信機 |
| DE4027592A1 (de) * | 1990-08-31 | 1992-03-05 | Beiersdorf Ag | Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| DE19918211A1 (de) | 1999-04-22 | 2000-10-26 | Basf Ag | Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung |
| US6506769B2 (en) * | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| DE60014130T2 (de) * | 1999-10-06 | 2006-03-09 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Heterocyclische verbindungen verwendbar als tyrosinkinase inhibitoren |
| WO2002014319A2 (en) * | 2000-08-11 | 2002-02-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
| CA2541618C (en) * | 2003-10-30 | 2011-12-13 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE368009B (es) * | 1971-09-16 | 1974-06-17 | Kabi Ab | |
| US3919238A (en) * | 1973-06-06 | 1975-11-11 | Morton Norwich Products Inc | 9-(Substituted amino)imidazo(4,5-f) quinolines |
| US3878206A (en) * | 1973-06-06 | 1975-04-15 | Morton Norwich Products Inc | 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines |
-
1978
- 1978-06-07 GR GR56730A patent/GR65025B/el unknown
- 1978-06-22 FI FI782011A patent/FI64371C/fi not_active IP Right Cessation
- 1978-06-29 ES ES471254A patent/ES471254A1/es not_active Expired
- 1978-07-11 AT AT0498878A patent/AT366383B/de active
- 1978-07-12 BG BG040381A patent/BG30021A3/xx unknown
- 1978-07-17 US US05/925,461 patent/US4176184A/en not_active Expired - Lifetime
- 1978-07-17 IT IT50337/78A patent/IT1107653B/it active
- 1978-07-18 CH CH772778A patent/CH642367A5/de not_active IP Right Cessation
- 1978-07-19 LU LU80001A patent/LU80001A1/de unknown
- 1978-07-19 DK DK323378A patent/DK323378A/da not_active Application Discontinuation
- 1978-07-19 CS CS784822A patent/CS204032B2/cs unknown
- 1978-07-19 DD DD78206810A patent/DD137933A5/xx unknown
- 1978-07-19 CA CA307,712A patent/CA1091232A/en not_active Expired
- 1978-07-19 SU SU782636902A patent/SU688129A3/ru active
- 1978-07-19 IL IL55168A patent/IL55168A/xx unknown
- 1978-07-20 PL PL1978208543A patent/PL110398B1/pl unknown
- 1978-07-20 PT PT68329A patent/PT68329A/pt unknown
- 1978-07-20 NZ NZ187916A patent/NZ187916A/xx unknown
- 1978-07-20 HU HU78TO1085A patent/HU181000B/hu unknown
- 1978-07-20 YU YU1747/78A patent/YU40340B/xx unknown
- 1978-07-20 AU AU38210/78A patent/AU519769B2/en not_active Expired
- 1978-07-20 SE SE7808018A patent/SE441746B/sv not_active IP Right Cessation
- 1978-07-20 GB GB7830585A patent/GB2002751B/en not_active Expired
- 1978-07-20 JP JP8889578A patent/JPS5422400A/ja active Granted
- 1978-07-20 NO NO782498A patent/NO149314C/no unknown
- 1978-07-20 NL NL7807760A patent/NL7807760A/xx not_active Application Discontinuation
- 1978-07-21 FR FR7821745A patent/FR2398069A1/fr active Granted
- 1978-12-20 ES ES476166A patent/ES476166A1/es not_active Expired
- 1978-12-20 ES ES476168A patent/ES476168A1/es not_active Expired
- 1978-12-20 ES ES476167A patent/ES476167A1/es not_active Expired
-
1985
- 1985-01-03 SG SG1/85A patent/SG185G/en unknown
- 1985-03-21 HK HK206/85A patent/HK20685A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971201 |