ES469573A1 - D-homosteroids - Google Patents
D-homosteroidsInfo
- Publication number
- ES469573A1 ES469573A1 ES469573A ES469573A ES469573A1 ES 469573 A1 ES469573 A1 ES 469573A1 ES 469573 A ES469573 A ES 469573A ES 469573 A ES469573 A ES 469573A ES 469573 A1 ES469573 A1 ES 469573A1
- Authority
- ES
- Spain
- Prior art keywords
- homosteroid
- formula
- fluorine
- denotes
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Anti-inflammatory D-homosteroids of the formula < IMAGE > in which the dotted 1,2 bond denotes an optional C-C bond R<6> denotes hydrogen, fluorine, chlorine or methyl R<9> denotes hydrogen, fluorine or chlorine and R<17a> denotes hydroxyl or acyloxy, where R<9> is to be fluorine or chlorine if R<6> is hydrogen in a 17 alpha -hydroxy compound or R<6> is fluorine in a singly unsaturated 17a-hydroxy compound, are prepared by treating a corresponding 21-iodo-D-homosteroid with a reducing agent. A singly unsaturated D-homosteroid of the formula I can then be dehydrogenated to the doubly unsaturated D-homosteroid of the formula I, a 6-unsubstituted D-homosteroid of the formula I can be fluorinated or chlorinated in position 6, and a 17a alpha -hydroxy-D-homosteroid of the formula I can be acylated in position 17a alpha .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT656076A AT356301B (en) | 1976-09-03 | 1976-09-03 | METHOD FOR THE PRODUCTION OF NEW D-HOMOSTEROIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469573A1 true ES469573A1 (en) | 1978-12-01 |
Family
ID=3587531
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES462076A Expired ES462076A1 (en) | 1976-09-03 | 1977-09-02 | D-homosteroids |
| ES469574A Expired ES469574A1 (en) | 1976-09-03 | 1978-05-08 | D-homosteroids |
| ES469573A Expired ES469573A1 (en) | 1976-09-03 | 1978-05-08 | D-homosteroids |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES462076A Expired ES462076A1 (en) | 1976-09-03 | 1977-09-02 | D-homosteroids |
| ES469574A Expired ES469574A1 (en) | 1976-09-03 | 1978-05-08 | D-homosteroids |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS5910680B2 (en) |
| AR (1) | AR220320A1 (en) |
| AT (1) | AT356301B (en) |
| AU (1) | AU516174B2 (en) |
| BE (1) | BE858354A (en) |
| CA (1) | CA1098897A (en) |
| CH (4) | CH629827A5 (en) |
| DE (1) | DE2738363A1 (en) |
| DK (1) | DK140947B (en) |
| ES (3) | ES462076A1 (en) |
| FI (1) | FI57600C (en) |
| FR (1) | FR2363580A1 (en) |
| GB (1) | GB1586504A (en) |
| GR (1) | GR73039B (en) |
| HK (1) | HK26484A (en) |
| HU (2) | HU184769B (en) |
| IE (1) | IE45671B1 (en) |
| IL (1) | IL52831A (en) |
| IT (1) | IT1085032B (en) |
| LU (1) | LU78064A1 (en) |
| MC (1) | MC1166A1 (en) |
| MY (1) | MY8500293A (en) |
| NL (1) | NL182314C (en) |
| NO (1) | NO145621C (en) |
| NZ (1) | NZ185046A (en) |
| PH (1) | PH14434A (en) |
| PT (1) | PT66983B (en) |
| SE (1) | SE440783B (en) |
| YU (2) | YU40009B (en) |
| ZA (1) | ZA775192B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1188616A (en) * | 1981-06-11 | 1985-06-11 | Hoffmann-La Roche Limited | Pharmaceutical preparations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH571018A5 (en) * | 1972-03-29 | 1975-12-31 | Hoffmann La Roche | |
| NO140672C (en) * | 1973-03-28 | 1979-10-17 | Hoffmann La Roche | ANALOGICAL PROCEDURES FOR THE MANUFACTURE OF NEW ANTI-INFLAMMATORY EFFECTIVE STEROIDS |
| DE2349023A1 (en) * | 1973-09-26 | 1975-04-10 | Schering Ag | NEW D-HOMO-STEROIDS |
| DE2349022A1 (en) * | 1973-09-26 | 1975-04-10 | Schering Ag | NEW D-HOMO-STEROIDS |
| CH601351A5 (en) * | 1973-09-26 | 1978-07-14 | Hoffmann La Roche | |
| DE2442615A1 (en) * | 1974-09-04 | 1976-03-18 | Schering Ag | NEW D-HOMO-STEROIDS |
-
1976
- 1976-09-03 AT AT656076A patent/AT356301B/en not_active IP Right Cessation
-
1977
- 1977-08-09 CH CH973377A patent/CH629827A5/en not_active IP Right Cessation
- 1977-08-22 YU YU2009/77A patent/YU40009B/en unknown
- 1977-08-25 DE DE19772738363 patent/DE2738363A1/en active Granted
- 1977-08-26 IL IL52831A patent/IL52831A/en unknown
- 1977-08-26 ZA ZA00775192A patent/ZA775192B/en unknown
- 1977-08-29 AU AU28304/77A patent/AU516174B2/en not_active Expired
- 1977-08-29 IE IE1800/77A patent/IE45671B1/en unknown
- 1977-08-29 NZ NZ185046A patent/NZ185046A/en unknown
- 1977-08-30 CA CA285,723A patent/CA1098897A/en not_active Expired
- 1977-08-31 HU HU80306A patent/HU184769B/en unknown
- 1977-08-31 NL NLAANVRAGE7709585,A patent/NL182314C/en not_active IP Right Cessation
- 1977-08-31 PH PH20179A patent/PH14434A/en unknown
- 1977-08-31 HU HU77HO2011A patent/HU176255B/en unknown
- 1977-08-31 IT IT27147/77A patent/IT1085032B/en active
- 1977-09-01 FR FR7726562A patent/FR2363580A1/en active Granted
- 1977-09-01 MC MC771258A patent/MC1166A1/en unknown
- 1977-09-01 AR AR269060A patent/AR220320A1/en active
- 1977-09-01 FI FI772599A patent/FI57600C/en not_active IP Right Cessation
- 1977-09-01 PT PT66983A patent/PT66983B/en unknown
- 1977-09-01 LU LU78064A patent/LU78064A1/xx unknown
- 1977-09-02 SE SE7709916A patent/SE440783B/en not_active IP Right Cessation
- 1977-09-02 JP JP52105054A patent/JPS5910680B2/en not_active Expired
- 1977-09-02 DK DK393277AA patent/DK140947B/en not_active IP Right Cessation
- 1977-09-02 NO NO773057A patent/NO145621C/en unknown
- 1977-09-02 BE BE180635A patent/BE858354A/en not_active IP Right Cessation
- 1977-09-02 GB GB36737/77A patent/GB1586504A/en not_active Expired
- 1977-09-02 ES ES462076A patent/ES462076A1/en not_active Expired
-
1978
- 1978-05-08 ES ES469574A patent/ES469574A1/en not_active Expired
- 1978-05-08 ES ES469573A patent/ES469573A1/en not_active Expired
-
1979
- 1979-09-01 GR GR54275A patent/GR73039B/el unknown
-
1981
- 1981-09-16 CH CH598381A patent/CH629829A5/en not_active IP Right Cessation
- 1981-09-16 CH CH598281A patent/CH629828A5/en not_active IP Right Cessation
- 1981-09-16 CH CH598481A patent/CH629830A5/en not_active IP Right Cessation
-
1982
- 1982-10-08 YU YU2277/82A patent/YU40089B/en unknown
-
1984
- 1984-03-22 HK HK264/84A patent/HK26484A/en unknown
-
1985
- 1985-12-30 MY MY293/85A patent/MY8500293A/en unknown
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