ES405982A1 - Aza-benzimidazoles - Google Patents

Aza-benzimidazoles

Info

Publication number
ES405982A1
ES405982A1 ES405982A ES405982A ES405982A1 ES 405982 A1 ES405982 A1 ES 405982A1 ES 405982 A ES405982 A ES 405982A ES 405982 A ES405982 A ES 405982A ES 405982 A1 ES405982 A1 ES 405982A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
alcohol
compound
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES405982A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of ES405982A1 publication Critical patent/ES405982A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of 4-aza-benzimidazoles of the general formula **(See formula)** where R1 signifies fluorine, chlorine or bromine, R2 signifies hydrogen or an alcohol group with 1 to 6 carbon atoms, signifies hydrogen, an alcohol group with 1 to 6 carbon atoms, optionally substituted by a phenyl radical, or the group CH2- COX, where X is an amino group, an alcoholic group with 1 to 6 carbon atoms, a hydroxy group or alkoxy with 1 to 6 carbon atoms and Y means a halogen atom, a hydroxy group, a mercapto group, a amino group, an alkoxy group with 1 to 6 carbon atoms, a phenylalkyl amino group, where the alcohol radical consists of 1 to 6 carbon atoms, an alcohol mercapto group with 1 to 6 carbon atoms, an alcohol group with 1 to 6 carbon atoms, a beta-oxy-ethylamino group, a phenylamino group, a pyridylamino group, an alcohol group with 1 to 6 carbon atoms, a hydroxyalkyl group with 1 to 6 carbon atoms, the trifluoromethyl group, a phenylalkyl group, where the alcoholic bridge may consist r in 1 to 6 carbon atoms, or the group -SCH2COX, where X can have the two above indicated, and its salts, characterized in that, in a manner known per se, a compound of the general formula is condensed **(See formula)** where V means an amino group, a hydroxy group, an etherified hydroxy group or a halogen atom, with a compound Y-CN or with a compound Y1Y2C = Z, where Y has the meanings indicated above, Z is oxygen, sulfur or NH, and Y1 as well as Y2 are the same or different and can have the meanings indicated for Y, or together signify sulfur, to form the imidazole ring, and eventually the obtained compounds are transformed into their salts. (Machine-translation by Google Translate, not legally binding)
ES405982A 1971-08-26 1972-08-19 Aza-benzimidazoles Expired ES405982A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT748871A AT315831B (en) 1971-08-26 1971-08-26 Process for the preparation of new 4-aza-benzimidazole derivatives and their salts

Publications (1)

Publication Number Publication Date
ES405982A1 true ES405982A1 (en) 1975-09-16

Family

ID=3596529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES405982A Expired ES405982A1 (en) 1971-08-26 1972-08-19 Aza-benzimidazoles

Country Status (19)

Country Link
JP (1) JPS4832898A (en)
AR (1) AR199879A1 (en)
AT (1) AT315831B (en)
AU (1) AU461671B2 (en)
BE (1) BE788065A (en)
BR (1) BR7205845A (en)
CA (1) CA979907A (en)
CH (1) CH592660A5 (en)
DD (1) DD99580A5 (en)
DE (1) DE2241575A1 (en)
ES (1) ES405982A1 (en)
FR (1) FR2150820B1 (en)
GB (1) GB1397645A (en)
HU (1) HU166382B (en)
IL (1) IL40080A (en)
NL (1) NL7211407A (en)
SU (1) SU557758A3 (en)
YU (1) YU34897B (en)
ZA (1) ZA725868B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
US4772600A (en) * 1986-06-09 1988-09-20 A. H. Robins Company, Inc. Fused imidazoheterocyclic compounds and pharmaceutical compositions
JP2679745B2 (en) * 1989-06-29 1997-11-19 明治製菓株式会社 Azole derivatives and antiulcer agents containing them as active ingredients
US5200407A (en) * 1989-06-29 1993-04-06 Meiji Seika Kaburhiki Kaisha Azole derivatives and anti-ulcerative composition containing same
DK1017384T3 (en) 1997-09-26 2005-01-31 Zentaris Gmbh Azabenzimidazole-based compounds for modulating serine / threonine protein kinase function
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
RS54542B1 (en) 2006-08-02 2016-06-30 Cytokinetics, Inc. Certain chemical entities, compositions and methods comprising imidazopyrimidines
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
EP2707373A1 (en) 2011-05-10 2014-03-19 Bayer Intellectual Property GmbH Bicyclic (thio)carbonylamidines
CN104039148A (en) 2011-07-13 2014-09-10 赛特凯恩蒂克公司 Combination als therapy
KR20140040801A (en) * 2011-07-15 2014-04-03 시오노기세야쿠 가부시키가이샤 Azabenzimidazole derivative having ampk-activating activity

Also Published As

Publication number Publication date
IL40080A (en) 1975-12-31
BR7205845D0 (en) 1973-07-03
NL7211407A (en) 1973-02-28
JPS4832898A (en) 1973-05-02
BE788065A (en) 1973-02-26
CA979907A (en) 1975-12-16
AT315831B (en) 1974-06-10
CH592660A5 (en) 1977-10-31
SU557758A3 (en) 1977-05-05
DE2241575A1 (en) 1973-03-08
AR199879A1 (en) 1974-10-08
IL40080A0 (en) 1972-10-29
FR2150820B1 (en) 1975-10-17
FR2150820A1 (en) 1973-04-13
BR7205845A (en) 1976-05-04
GB1397645A (en) 1975-06-11
ZA725868B (en) 1973-05-30
YU34897B (en) 1980-04-30
AU4598172A (en) 1974-02-28
YU204172A (en) 1979-10-31
HU166382B (en) 1975-03-28
DD99580A5 (en) 1973-08-12
AU461671B2 (en) 1975-06-05

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