ES395208A1 - Procedure for the preparation of new substitute bis-arilalcohylamine acilderives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new acylarivates of substituted bis-arylalcohil-amines of the general formula **(See formula)** in which Ar is a phenyl or naphthyl radical, X signifies an oxygen atom or a hydroxy group a hydrogen atom, Y signifies an optionally substituted alcoholic group based on 1 to 4 carbon atoms; R1 signifies an acyloxy, acyloxyalkoxy, acylamino or acylalkyl amino [-N (alcoholic) (acyl)] group; R4 means hydrogen or a low molecular weight alcohol group, R5 means hydrogen, a low molecular weight alcohol group or an acyl group and R2, R3, R6 and R7, which are the same or different, mean hydrogen atoms, halogen atoms, hydroxy, low molecular weight alkoxy groups, acyloxy, amino, alkoxylamino, dialkoxylamino, acylamino, nitro, low molecular weight alcohol, low molecular weight halogenoalkoxy, such as for example trifluoromethyl and low molecular weight alcoholylthio groups and in which the groups acyl are derived from straight or branched chain saturated or unsaturated fatty acids with 2 to 10 carbon atoms, optionally substituted by halogen atoms, hydroxy groups, acylated hydroxy groups, oxo groups, low molecular weight alkoxy groups or phenyl radicals, phenyl radicals may also be substituted by alcohol groups with 1 to 6 carbon atoms, alkoxy groups with 1 to 6 carbon atoms, hydroxy groups as well as d atoms. and halogen, from benzoic acids optionally substituted one or more times by halogen atoms, hydroxy groups, acylated hydroxy groups, low molecular weight alcohol groups or low molecular weight alkoxy groups or low molecular weight aliphatic semi-esters of carbonic acid or phenylsemi-ester of carbonic acid, as well as its salts, its optically active isomers or diastereoisomers, characterized in that, in a manner known per se in a compound of the general formula **(See formula)** where the symbols Ar, X, Y as well as R1-R7 have the meanings indicated above, the double CC bond is reduced; and optionally in the obtained compounds one or more oxo groups are reduced to hydroxy groups and/or optionally other oxy or amino groups are acylated. (Machine-translation by Google Translate, not legally binding)