ES387016A1 - Un procedimiento para la preparacion de derivado de isoqui-nolina. - Google Patents

Un procedimiento para la preparacion de derivado de isoqui-nolina.

Info

Publication number
ES387016A1
ES387016A1 ES387016A ES387016A ES387016A1 ES 387016 A1 ES387016 A1 ES 387016A1 ES 387016 A ES387016 A ES 387016A ES 387016 A ES387016 A ES 387016A ES 387016 A1 ES387016 A1 ES 387016A1
Authority
ES
Spain
Prior art keywords
group
lower alkyl
hydroxy
general formula
isoquinoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES387016A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES387016A1 publication Critical patent/ES387016A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES387016A 1970-01-06 1971-01-05 Un procedimiento para la preparacion de derivado de isoqui-nolina. Expired ES387016A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH10370A CH527194A (de) 1970-01-06 1970-01-06 Verfahren zur Herstellung von Isochinolin-Derivaten

Publications (1)

Publication Number Publication Date
ES387016A1 true ES387016A1 (es) 1976-05-01

Family

ID=4179328

Family Applications (1)

Application Number Title Priority Date Filing Date
ES387016A Expired ES387016A1 (es) 1970-01-06 1971-01-05 Un procedimiento para la preparacion de derivado de isoqui-nolina.

Country Status (19)

Country Link
JP (1) JPS5515476B1 (es)
AT (1) AT303041B (es)
BE (1) BE761219A (es)
CA (1) CA999866A (es)
CH (2) CH527194A (es)
DE (1) DE2062001C2 (es)
DK (1) DK125021B (es)
ES (1) ES387016A1 (es)
FI (1) FI49503C (es)
FR (1) FR2081412B1 (es)
GB (1) GB1335261A (es)
IE (1) IE34859B1 (es)
IL (1) IL35916A (es)
NL (1) NL171444C (es)
NO (1) NO135315C (es)
PH (1) PH9682A (es)
SE (3) SE368401B (es)
YU (1) YU33660B (es)
ZA (1) ZA708590B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844402B (en) * 1983-06-23 1986-01-29 Mcneil Pharmaceutical Hexahydropyrrolo(2,1-a)isoquinoline derivatives
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors
EP1246806B1 (en) 1999-11-03 2008-02-27 AMR Technology, Inc. Arly- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en) * 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100436420C (zh) * 1999-11-03 2008-11-26 Amr科技公司 4-苯基取代的四氢异喹啉及其用于制备药物的用途
EP1113007A1 (en) 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
EP1299393A2 (en) 2000-07-11 2003-04-09 Bristol-Myers Squibb Pharma Company 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
MX2007000428A (es) 2004-07-15 2008-03-05 Amr Technology Inc Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina.
DK1899334T3 (da) * 2005-06-17 2008-11-24 Janssen Pharmaceutica Nv Naphthyridinforbindelser
CN101495184A (zh) 2005-07-15 2009-07-29 Amr科技公司 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
PE20120373A1 (es) 2009-05-12 2012-05-17 Albany Molecular Res Inc 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina
WO2010132487A1 (en) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
AU2010247849B2 (en) 2009-05-12 2015-11-19 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670694B2 (de) * 1966-05-05 1976-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von tetrahydroisochinolinen

Also Published As

Publication number Publication date
PH9682A (en) 1976-02-10
IE34859L (en) 1971-07-06
NL171444B (nl) 1982-11-01
AT303041B (de) 1972-11-10
IE34859B1 (en) 1975-09-03
DK125021B (da) 1972-12-18
IL35916A0 (en) 1971-02-25
YU33660B (en) 1977-12-31
IL35916A (en) 1973-11-28
FI49503C (fi) 1975-07-10
SE368401B (es) 1974-07-01
NO135315B (es) 1976-12-13
JPS5515476B1 (es) 1980-04-23
CA999866A (en) 1976-11-16
FI49503B (es) 1975-04-01
FR2081412A1 (es) 1971-12-03
NL7018956A (es) 1971-07-08
SE386672B (sv) 1976-08-16
GB1335261A (en) 1973-10-24
CH527194A (de) 1972-08-31
SE399879B (sv) 1978-03-06
BE761219A (fr) 1971-07-05
NO135315C (es) 1977-03-23
DE2062001A1 (de) 1971-07-15
CH538477A (de) 1973-06-30
ZA708590B (en) 1971-09-29
NL171444C (nl) 1983-04-05
YU1971A (en) 1977-06-30
DE2062001C2 (de) 1986-10-16
FR2081412B1 (es) 1974-04-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19880205