ES377858A1 - Isoxazolobenzoxazine derivatives - Google Patents

Isoxazolobenzoxazine derivatives

Info

Publication number
ES377858A1
ES377858A1 ES377858A ES377858A ES377858A1 ES 377858 A1 ES377858 A1 ES 377858A1 ES 377858 A ES377858 A ES 377858A ES 377858 A ES377858 A ES 377858A ES 377858 A1 ES377858 A1 ES 377858A1
Authority
ES
Spain
Prior art keywords
formula
hydrogen
see formula
substituted
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES377858A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meda Pharmaceuticals Inc
Original Assignee
Carter Wallace Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US4745A external-priority patent/US3598814A/en
Application filed by Carter Wallace Inc filed Critical Carter Wallace Inc
Publication of ES377858A1 publication Critical patent/ES377858A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of tensoxazinones, of general formula: **(See formula)** where n is 1 or 2 and each of the X is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, nitro, amino, acetamino, sulfonamido or trifluomethyl and each of the R1 and R2 are chosen from the group consisting of hydrogen and lower alkyl, characterized in that in a first step, substituted or unsubstituted salicylic hydroxamic acid of the formula: **(See formula)** where X and n are defined as above, with an acrolein substituted or not of the formula: **(See formula)** or an acetal thereof, wherein R1 and R2 are defined as above, in the presence of a hydrogen halide to obtain a 2- (2'-haloalkyl) -2,3-dihydro-3-hydroxyl-4H-1, 3-benzoxazin-4-one of formula: **(See formula)** Where X, n, R1 and R2 are defined as above, and in a second step this compound is cyclized. (Machine-translation by Google Translate, not legally binding)
ES377858A 1969-03-24 1970-03-24 Isoxazolobenzoxazine derivatives Expired ES377858A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82673869A 1969-03-24 1969-03-24
US4745A US3598814A (en) 1970-01-21 1970-01-21 3,3a-dihydro-2h,9h-isoxazolo(3,2-b)(1,3) benzoxazin-9-ones

Publications (1)

Publication Number Publication Date
ES377858A1 true ES377858A1 (en) 1972-11-01

Family

ID=26673406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES377858A Expired ES377858A1 (en) 1969-03-24 1970-03-24 Isoxazolobenzoxazine derivatives

Country Status (11)

Country Link
JP (1) JPS4940240B1 (en)
AT (1) AT303051B (en)
CH (1) CH514619A (en)
DE (1) DE2010418A1 (en)
DK (1) DK125859B (en)
ES (1) ES377858A1 (en)
FI (1) FI50531C (en)
GB (2) GB1298596A (en)
NL (1) NL170631C (en)
NO (1) NO130480C (en)
SE (1) SE343869B (en)

Also Published As

Publication number Publication date
DK125859B (en) 1973-05-14
DE2010418A1 (en) 1970-10-01
NL7003942A (en) 1970-09-28
SE343869B (en) 1972-03-20
NO130480C (en) 1974-12-18
GB1298595A (en) 1972-12-06
JPS4940240B1 (en) 1974-10-31
CH514619A (en) 1971-10-31
AT303051B (en) 1972-11-10
NL170631C (en) 1982-12-01
FI50531B (en) 1975-12-31
GB1298596A (en) 1972-12-06
NO130480B (en) 1974-09-09
FI50531C (en) 1976-04-12

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