ES368949A1 - Procedure for the obtaining of 3,4-dihydroquinazolinones (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of 3,4-dihydroquinazolinones (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES368949A1
ES368949A1 ES368949A ES368949A ES368949A1 ES 368949 A1 ES368949 A1 ES 368949A1 ES 368949 A ES368949 A ES 368949A ES 368949 A ES368949 A ES 368949A ES 368949 A1 ES368949 A1 ES 368949A1
Authority
ES
Spain
Prior art keywords
alkyl
amino
alkylamino
alkoxy
isopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES368949A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES368949A1 publication Critical patent/ES368949A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/02—Viewing or reading apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of formula wherein n is 1 or 2, R when n = 1 is H, F, Cl, Br, C 1-5 alkyl, C 1-4 alkoxy, alkythio or alkylamino, di(C 1-4 alkyl)amino, NO 2, CN, NH 2, OH, SH, AcNH or CF 3, R when n = 2 is H, F, Cl, Br, C 1-5 alkyl or C 1-4 alkoxy, R 1 is C 1-5 alkyl, R 2 is H, C 1-5 alkyl or omega-di(C 1-4 alkyl)- amino-C 1-4 -alkyl, and R 3 is Ph possibly containing up to 2 substituents which are F, Cl, Br, C 1-4 alkyl or C 1-4 alkoxy and/or a CF 3 group. These compounds may be prepared by (1) hydrogenating the 3,4 - dehydro analogues (2) alkylating the 3-position (3) reacting the 3,4- dehydro analogues with an alkyl-lithium or Grignard compound (4) cyclizing a corresponding 1 - alkyl - 1 - (2 - benzoyl)phenylurea or a 1 -alkyl- 1 -phenylurea/benzaldehyde mixture (5) alkylating in the compound where R is amino or alkylamino, to give an alkylamino or dialkylamino group (6) reductively alkylating the compound where R is nitro. Starting materials.-Details are given for the preparation of 2-isopropylamino-4-methylbenzophenone, N-isopropyl-m-toluidene and its N- carbamyl derivative, p-chloro-N-methylaniline and its N-formyl derivative, 2-amino-5-chloro- 4-methylbenzhydrol and its N-isopropyl derivative, and 2-(N-ethyl or -isopropyl)amino-5- nitrobenzophenone. Therapeutic compositions having antiinflammatory, and in some cases antipyretic or analgesic activity, comprise compounds of the above formula in association with a physiologically acceptable diluent or carrier for oral or parenteral administration.
ES368949A 1968-07-01 1969-06-30 Procedure for the obtaining of 3,4-dihydroquinazolinones (Machine-translation by Google Translate, not legally binding) Expired ES368949A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74180768A 1968-07-01 1968-07-01
US78725468A 1968-12-26 1968-12-26
US81943569A 1969-04-25 1969-04-25

Publications (1)

Publication Number Publication Date
ES368949A1 true ES368949A1 (en) 1971-07-16

Family

ID=27419280

Family Applications (6)

Application Number Title Priority Date Filing Date
ES368949A Expired ES368949A1 (en) 1968-07-01 1969-06-30 Procedure for the obtaining of 3,4-dihydroquinazolinones (Machine-translation by Google Translate, not legally binding)
ES388759A Expired ES388759A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388760A Expired ES388760A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388758A Expired ES388758A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388761A Expired ES388761A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388762A Expired ES388762A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES388759A Expired ES388759A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388760A Expired ES388760A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388758A Expired ES388758A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388761A Expired ES388761A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)
ES388762A Expired ES388762A1 (en) 1968-07-01 1971-03-01 Procedure for the obtaining of 3,4-dihydro-quinazolinones. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
BE (1) BE735439A (en)
CH (1) CH515911A (en)
DE (1) DE1932396A1 (en)
ES (6) ES368949A1 (en)
FR (1) FR2012062A1 (en)
GB (1) GB1256593A (en)
NL (1) NL6909864A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759671A (en) * 1969-12-01 1971-06-01 Sandoz Sa QUINAZOLINONE DERIVATIVES, THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES
DK129348B (en) * 1970-07-13 1974-09-30 Sumitomo Chemical Co Analogous process for the preparation of 1-substituted 3,4-dihydro-2 (1H) -quinazolinone derivatives.
DE2162327C3 (en) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Process for the preparation of 3,4-Oihydro-2 (1 H) -quinazolinones
IL102764A0 (en) * 1991-08-16 1993-01-31 Merck & Co Inc Quinazoline derivatives,and pharmaceutical compositions containing them
AU2436792A (en) * 1991-08-16 1993-03-16 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
CA2124306C (en) * 1993-05-26 2004-04-06 Masami Muraoka Quinazolinone derivatives
US9834525B2 (en) * 2014-02-04 2017-12-05 University Of Tennessee Research Foundation Inhibitors of paxillin function and related compositions and methods

Also Published As

Publication number Publication date
NL6909864A (en) 1970-01-05
DE1932396A1 (en) 1970-01-08
ES388762A1 (en) 1974-03-01
ES388758A1 (en) 1974-03-01
BE735439A (en) 1969-12-30
CH515911A (en) 1971-11-30
FR2012062A1 (en) 1970-03-13
ES388760A1 (en) 1974-03-01
ES388761A1 (en) 1974-03-01
ES388759A1 (en) 1974-03-01
GB1256593A (en) 1971-12-08

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