ES355003A2 - Procedure for the preparation of new amino-cetonas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new amino-cetonas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES355003A2
ES355003A2 ES355003A ES355003A ES355003A2 ES 355003 A2 ES355003 A2 ES 355003A2 ES 355003 A ES355003 A ES 355003A ES 355003 A ES355003 A ES 355003A ES 355003 A2 ES355003 A2 ES 355003A2
Authority
ES
Spain
Prior art keywords
radicals
phenyl
amino
translation
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES355003A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES355003A2 publication Critical patent/ES355003A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Improvements introduced in the object of the main patent No. 354,961, applied for on June 12, 1968 by: a process for the preparation of new amino ketones of the general formula I: **(See formula)** wherein the Hal radicals signify a chlorine or bromine atom; R1 signifies a hydrogen, chlorine or bromine atom; R2 and R3, may be the same or different, signify hydrogen atoms, straight or branched chain alcohol radicals, alkenyl, alkynyl, hydroxy alcohol, alkoxyalkoyl, dialkoxylaminoalcohyl, cycloalkoxy, phenyl, benzyl, or adamantyl or, together with the nitrogen atom, a pyrrolidino, piperidino, hexamethyleneimino, piperazino, morpholino or canfidino ring optionally substituted by lower alcohol radicals or by phenyl radicals; R4 and R5 which may be the same or different, signify hydrogen atoms, alcohol radicals with 1 to 3 carbon atoms or phenyl groups; and n means the numbers 0 or 1 or 2, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that an amino-halogen-phenyl-amino alkanol of the general formula II is oxidized by means of oxidizing agents. **(See formula)** in which the radicals hal, R1 to R5 and n have the meanings indicated initially and, provided that the compounds obtained are in the form of their salts by addition of acid, they are transformed into their bases if desired, and/or converted to the free bases according to the usual methods in acid addition salts physiologically compatible with an inorganic organic acid. (Machine-translation by Google Translate, not legally binding)
ES355003A 1967-06-15 1968-06-14 Procedure for the preparation of new amino-cetonas. (Machine-translation by Google Translate, not legally binding) Expired ES355003A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DET0034103 1967-06-15
DET0036083 1968-03-15

Publications (1)

Publication Number Publication Date
ES355003A2 true ES355003A2 (en) 1970-12-01

Family

ID=26000342

Family Applications (4)

Application Number Title Priority Date Filing Date
ES355001A Expired ES355001A2 (en) 1967-06-15 1968-06-14 A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)
ES355003A Expired ES355003A2 (en) 1967-06-15 1968-06-14 Procedure for the preparation of new amino-cetonas. (Machine-translation by Google Translate, not legally binding)
ES355002A Expired ES355002A2 (en) 1967-06-15 1968-06-14 A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)
ES354961A Expired ES354961A1 (en) 1967-06-15 1969-06-12 A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES355001A Expired ES355001A2 (en) 1967-06-15 1968-06-14 A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES355002A Expired ES355002A2 (en) 1967-06-15 1968-06-14 A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)
ES354961A Expired ES354961A1 (en) 1967-06-15 1969-06-12 A procedure for the preparation of new aminocetons. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
AT (2) AT283321B (en)
DE (2) DE1618010A1 (en)
ES (4) ES355001A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503705A1 (en) * 1981-04-14 1982-10-15 Synthelabo PHENETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DE3706585A1 (en) * 1987-02-25 1988-09-08 Schering Ag ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL USE

Also Published As

Publication number Publication date
AT283324B (en) 1970-08-10
ES355002A2 (en) 1970-04-16
DE1618010A1 (en) 1970-11-05
ES355001A2 (en) 1970-04-16
ES354961A1 (en) 1969-11-16
DE1668981A1 (en) 1971-07-08
AT283321B (en) 1970-08-10

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Legal Events

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FD2A Announcement of lapse in spain

Effective date: 20170630