ES348087A1 - Procedure for the preparation of morpholine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of morpholine derivatives, of general formula **(See formula)** wherein R1 and R2, which may be the same or different, represent hydrogen or alkyl radicals, preferably having no more than 3 carbon atoms, R3 represents hydrogen or an alkyl or alkenyl radical, each of which preferably does not it has more than 6 carbon atoms or a cycloalkyl radical, preferably it does not have more than 5 carbon atoms and X represents an aryl radical, preferably phenyl or naphthyl, which can be substituted at will by one or more substituents chosen from halogen atoms, alkyl, alkoxy, alkylthio radicals each having 10 or fewer carbon atoms, haloalkyl and haloalkoxy radicals each having 5 or fewer carbon atoms, alkenyl, alkyloyloxy, alkynyloxy and cycloalkoxy radicals each not having more than 6 carbon atoms, aryl, aryloxy, alkylaryloxy, aralkyl, and aralkoxy radicals with 10 or fewer carbon atoms each, alkyl radicals having no more than 5 rad-substituted carbon atoms alkoxy radicals with 5 or fewer carbon atoms and hydroxy and methylenedioxy radicals, or X represents an indanyl or tetrahydronaphthyl radical which may carry, as desired, one or more halogen or alkyl or alkoxy substituents each not having more than 3 atoms carbon, characterized in that a compound of the general formula is reduced, **(See formula)** in which R1, R2, R3 and X have the meanings indicated above, with a complex metal hydride, and if required when those morpholine derivatives in which R3 represents hydrogen are required, the α-aryl radical is removed. alkyl of a compound of the general formula, **(See formula)** wherein R1, R2 and X have the above meanings and R4 represents an α-aryl-alkyl radical. (Machine-translation by Google Translate, not legally binding)