ES336531A1 - Lysergic Acid Derivatives - Google Patents

Lysergic Acid Derivatives

Info

Publication number
ES336531A1
ES336531A1 ES336531A ES336531A ES336531A1 ES 336531 A1 ES336531 A1 ES 336531A1 ES 336531 A ES336531 A ES 336531A ES 336531 A ES336531 A ES 336531A ES 336531 A1 ES336531 A1 ES 336531A1
Authority
ES
Spain
Prior art keywords
acid
lysergic
lysergic acid
carbons
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES336531A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES336531A1 publication Critical patent/ES336531A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C07D457/08—Lysergic acid amides in which the amide nitrogen is a member of a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel lysergic acid derivatives (and acid addition salts thereof) of the general formula wherein R1 is H or Me, R2 is aralkyl of from 7 to 9 carbons on an aryl radical which may be substituted by one or more Me, alkoxy, having 1 to 4 carbons, chlorine or bromine substituents and x#y is are prepared by the interaction of a functional acid derivative of the appropriate d-lysergic acid or 9,10-dihydro-d-lysergic acid (e.g. acid chloride hydrochloride, acid azide or a mixed anhydride with sulphuric acid) and the appropriate piperazine compound. Compounds of the invention wherein R1 is H may be methylated to the corresponding N-methyl derivative and those wherein x#y is may be hydrogenated in the presence of a catalyst to afford a 9,10-dihydro-compound. Pharmaceutical compositions exhibiting sedative-neuroleptic properties and also having a sympathomimetio and serotonin antagonistic effect contain as the active ingredient the above novel compounds and may be provided in the form of tablets, dragÚes, syrups, injection solutions and suppositories.
ES336531A 1966-02-08 1967-02-07 Lysergic Acid Derivatives Expired ES336531A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH175666A CH475252A (en) 1966-02-08 1966-02-08 Process for the production of new lysergic acid derivatives
CH1753066A CH493521A (en) 1966-02-08 1966-12-09 (A) Compds. (I):- where R1 = H or Me; R2 = 7-9 C aralkyl or aryl (opt. substd. by one or more methyl or 1-4 C alkoxy groups, Br or Cl); X Y = CH

Publications (1)

Publication Number Publication Date
ES336531A1 true ES336531A1 (en) 1968-04-01

Family

ID=25688570

Family Applications (1)

Application Number Title Priority Date Filing Date
ES336531A Expired ES336531A1 (en) 1966-02-08 1967-02-07 Lysergic Acid Derivatives

Country Status (8)

Country Link
CH (2) CH475252A (en)
DE (1) DE1695682A1 (en)
DK (1) DK125175B (en)
ES (1) ES336531A1 (en)
FI (1) FI47189C (en)
FR (2) FR1510553A (en)
GB (1) GB1154682A (en)
SE (1) SE324785B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE564825A (en) * 1957-02-15
IL41409A (en) * 1972-02-04 1977-04-29 Richter Gedeon Vegyeszet Lysergic acid amides and process for their preparation
HU169073B (en) * 1974-05-28 1976-09-28
GB9711043D0 (en) * 1997-05-29 1997-07-23 Ciba Geigy Ag Organic compounds

Also Published As

Publication number Publication date
SE324785B (en) 1970-06-15
CH475252A (en) 1969-07-15
DK125175B (en) 1973-01-08
FR6554M (en) 1968-12-23
CH493521A (en) 1970-07-15
DE1695682A1 (en) 1971-04-08
FI47189C (en) 1973-10-10
GB1154682A (en) 1969-06-11
FI47189B (en) 1973-07-02
FR1510553A (en) 1968-01-19

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