ES2396745T3 - Devices for medication administration - Google Patents

Abstract

An apparatus, comprising: a housing (1100); a medicine container (5100) disposed within the housing (1100), the medicine container (5100) is configured to contain a medicine; an activation mechanism (2000) configured to produce a force to administer the medication from the container (5100) of medication; and a base (1300) configured to activate the activation mechanism (2000); characterized in that: a locking member (1200) is configured to engage a part of the base to prevent actuation of the activation mechanism; and an electronic circuit system configured to be coupled to the housing (1100), the electronic circuit system includes a switch arranged where a part of the base slides to activate the deactivation mechanism (2000) such that the switch is operated when activates the activation mechanism (2000), the electronic circuit system is further configured to produce a recorded output of the address when the switch is operated, the activation mechanism (2000) is configured to produce the force independently of the electronic circuit system.

Description

Devices for administration of medicaments In the prior art, WO 02/24257 teaches a medication administration device that

It comprises a system that is capable of feeling if the administration device is in real physical contact with a human being or if the administration device has been abandoned. WO 99/07425 describes an administration device that includes an electronic circuit that

Directly control an engine. According to the present invention, an apparatus is provided comprising: accommodation; a medicine container disposed within the housing, the medicine container is configured to

contain a medicine;

an activation mechanism configured to produce a force to administer the medication from the medication container; Y a base configured to activate the activation mechanism; characterized by: a locking member configured to engage a part of the base to prevent actuation of the

activation mechanism; Y an electronic circuit system configured to be coupled to the housing, the electronic circuit system includes a switch arranged where a part of the base slides to activate the activation mechanism of such that the switch is activated when the activation mechanism is actuated, the circuit system

electronic is also configured to produce a recorded speech output when the switch, the activation mechanism is configured to produce the force independently of the circuit system

electronic.

A wide variety of possible embodiments will be understood more easily by the following detailed description of certain examples of systems, with reference to the examples of accompanying drawings in which: FIG. 1 is a perspective view of an embodiment of a system; FIG. 2 is a front view of an exemplary embodiment of a system 1000; FIG. 3 is a side view of an exemplary embodiment of a system; FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an example of

realization of a system 1000 in a first operative position;

FIG. 5 is a cross-sectional view taken along line A-A of FIG. 3 of an example of realization of a system 1000 in a second operative position; FIG. 6 is a cross-sectional view taken along line A-A of FIG. 3 of an example of

realization of a system 1000 in a third operative position;

FIG. 7 is a cross-sectional view taken along line A-A of FIG. 3 of an example of realization of a system 1000 in a fourth operative position; FIG. 8 is a cross-sectional view taken along line A-A of FIG. 3 of an example of

realization of a system 1000 in a fifth operational position;

FIG. 9 is a cross-sectional view taken along line A-A of FIG. 3 of an example of realization of a 1000 system in a sixth operational position; FIG. 10 is a flow chart of an exemplary embodiment of a 10,000 method; FIG. 11 is a perspective view of an embodiment of a system 1000; FIG. 12 is a perspective cross-sectional view taken along lines B-B of Fig. 11; FIG. 13 is a perspective view of an exemplary embodiment of the drive stick 2200;

FIG. 14 is a cross-sectional view of an exemplary embodiment of the discharge mechanism 8000 of

gases taken along line A-A of FIG. 3; FIG. 15 is a cross-sectional view taken along line A-A of FIG. 3 of an example of 15000 system;

FIG. 16 is a perspective view of an example of a 16000 auto-injector;

FIG. 17 is a cross-sectional view taken along line A-A of FIG. 3 of an example of 17000 system; FIG. 18A is an end view of an example of system 18000; FIG. 18B is a cross-sectional view taken along line A-A of FIG. 18A of an example of

18000 system;

FIG. 19 is a cross-sectional view taken along line A-A of FIG. 18A of an example of 19000 system; FIG. 20 is a cross-sectional view taken along line A-A of FIG. 18A of an example of

20000 system;

FIG. 21A is a cross-sectional view taken along line A-A of FIG. 18A of an example of 21000 system; FIG. 21B is a front view of an example of system 21000; FIG. 22A is a cross-sectional view taken along line A-A of FIG. 18A of an example of

22000 system; FIG. 22B is a front view of an example 22500 system; FIG. 23 is a perspective view of an example of auto-injector 23000; FIG. 23 is a cross-sectional view taken along line A-A of FIG. 18A of an example of

23000 system; FIG. 24 is a perspective view of an example of auto-injector 24000; FIG. 25 is a perspective view of an example of 25000 auto-injector; Y FIG. 26 is a block diagram of an example of an information device 26000.

Definitions

When the following terms are used substantially herein, the definitions apply companions: one - at least one. activate - actuate and / or set in motion and / or action. activity - an action, act, stage and / or process or part thereof.

drive part - the part that puts something into action. drive lock - a device adapted to prevent drive, such as, for example, a lock Pivoting, translatable, guided by key, which can be squeezed and / or removable.

drive device - a mechanism that puts something into action. adapted to - suitable or appropriate for a particular purpose. and / or - either jointly or as an alternative. apparatus - a mechanism and / or device. arm - an elongated structural member, which does not have to be only linear. auto-injector - device that allows a user to administer a medication without having to prepare

Manually the injection. Examples of devices include pen injectors, syringes,

needleless injectors, gas-powered auto-injectors and / or any other auto-injector and / or medical device

used to inject a medication into a user / patient, etc. automatically - act or operate essentially independently of external influence or control. For example, an automatic lighting switch can be turned on by "seeing" a person in your vision, without have the person manually operate the lighting switch.

axis - a straight line around which a body or geometric object rotates or can be conceived to rotate. can - be able to something, at least in some embodiments. channel - a conduit for one or more fluids. compressed gas - a substantially pressurized substance, such as helium, nitrogen and / or carbon dioxide,

etc., in gaseous form. that includes - that includes, but not limited to them. contains - keep inside. content - a compressed gas content. credit card - a card (usually plastic) that assures a seller that the person who

used has a satisfactory credit rating and that the issuer agrees that the seller receives payment for the merchandise and / or for services rendered. It typically has a size of about 76.2 to about 101.6 millimeters (3 to 4 inches) in length, such as about 86.36 millimeters (3.40 inches), 85.7 millimeters (3,375 inches), 85 millimeters , etc., and about 44.4 to about 69.8 millimeters (1.75 to 2.75 inches) wide, such as about 53.3 millimeters (2.10 inches), 56.2 millimeters (2 , 2125 inches), 63.5 millimeters (2.5 inches), 55 millimeters, etc.

data - different parts of information, usually with a special or predetermined format and / or organized to Express concepts define - establish the general lines, form or structure of something. device - a machine, manufacture and / or collection of them.

download - free from confinement; to emit. driving force - a force sufficient to cause, directly or indirectly, the expulsion of a medicine injectable from one or more vials and / or from a self-injector.

dry substance - a material that is substantially free of liquids or moisture. eject - expeler. integrated system - a programmed hardware device that includes a microprocessor controlled by a

operating system and / or control logic that has been specifically designed for a particular type of application. The operating system and / or the control logic of an integrated system comprise a limited set of predefined functions that cannot be modified or added by additional software installed by the user, although some integrated systems allow the user to modify variable values and / o parameters of the predefined functions. Examples of devices that may include integrated systems are: medical devices, calculators, cars, airplanes, vending machines, toys, programmable logic controllers, appliances, refrigerators, microwave ovens, clothes washers, thermostats, alarm systems, sprinkler systems, lighting controllers, electronic equipment, laser printers, CD players, DVD players, watches and / or digital cameras, etc.

Exhaust hole - an opening for the exit of a gas. expulsion - is the act of forcefully expelling a fluid through a designated outlet of a container. expulsion pressure - a force applied to an area of a liquid, enough force to expel the liquid

in a predetermined way. extend - move out and / or get away from something. extensible - able to move out and / or away from something. fluid - a gas and / or a liquid.

it can be coupled by fluid - capable of being related by a fluid.

force initiator - a source, such as a container of compressed gas, spring and / or chemical reaction, etc., capable of delivering a driving force.

frangible - a device that can break and / or be penetrated to allow a fluid to pass through it.

haptic - implies the human sense of kinetic movement and / or the human sense of touch. Among the many possible haptic experiences there are numerous sensations, positional differences of the body in the sensations, and time-based changes in the sensations that are perceived at least partially in a non-visual, non-audible and non-olfactory way, including touch experiences touch (be touched), active touch, grip, pressure, friction, traction, sliding, stretching, force, torque, impact, puncture, vibration, movement, acceleration, pull, pulsation, orientation, limb position, gravity, texture, separation, recess, viscosity, pain, itching, humidity, temperature, thermal conductivity and thermal capacity.

Critical real time - relative to computer systems that provide an absolute deterministic response to an event. That response is not based on an average time of the event. On the other hand, in these computer systems, the deadlines are fixed and the system must guarantee a response within a fixed and well defined time. Real-time systems typically interact at a low level with physical hardware through integrated systems, and can suffer a critical failure if time constraints are violated. A classic example of a critical real-time computer system is the anti-lock braking system in a car. The critical real time constraint, or term, in this system is the time it is necessary to release the brakes to prevent the wheel from locking. Another example is a car engine control system, in which a delayed control signal could cause engine failure or damage. Other examples of integrated real-time critical systems include medical systems such as pacemakers and industrial process controllers.

dangerous condition - a situation marked by risk, danger and / or threat.

accommodation - something that covers, encloses, protects, maintains and / or supports.

as a reaction to - respond indirectly and / or directly.

indicate - show, mark, mean, denote, evidence, express, manifest, declare, enunciate, specify, explain, exhibit, present, reveal, describe and / or expose.

indicator - a device and / or substance that indicates.

information device - any device capable of processing information, such as any general-purpose and / or special-purpose computer, such as a personal computer, workstation, server, minicomputer and macrocomputer, supercomputer, computer terminal, laptop and / or a personal digital assistant (PDA), mobile terminal, Bluetooth device, communicator, "smart phone" (for example, a device such as Treo), messaging service receiver (eg, Blackberry), pager, fax, telephone mobile, traditional telephone, telephone device, a programmed microprocessor or microcontroller and / or integrated peripheral circuit elements, an ASIC or other integrated circuit, an electronic hardware logic circuit such as a discrete element circuit, and / or a programmable logic device such as a PLD, PLA, FPGA or PAL, or something similar, etc. In general, any device in which a finite state machine resides capable of implementing at least a part of a method, structure and / or graphical user interface described herein can be used as an information device. An information device may comprise components such as one or more network interfaces, one or more processors, one or more memories containing instructions and / or one or more input / output (I / O) devices, one or more interface interfaces. user coupled to an I / O device, etc.

injectable medication - a medicine, medication, drug, pharmaceutical product, prescriptive agent, antidote, anti-poison, hormones, stimulants, vasodilators, anesthesia and / or nutritional supplement that is substantially prepared for injection.

input / output device (I / O) - sense-oriented input and / or output device, such as an audio, visual, haptic, olfactory and / or taste-oriented device, including, for example, a monitor, display, projector, raised screen, keyboard, numeric keypad, mouse, scroll ball, control lever, game controller, steering wheel, touch panel, touch screen, pointing device, microphone, speaker, camcorder, camera, scanner, printer, device haptic, vibrator, touch simulator and / or touch pad, potentially including a port to which an I / O device can be attached or connected.

liquid - a body of matter that shows a characteristic disposition to flow, little or no tendency to disperse and relatively high incompressibility.

longitudinal - of or relative to the length.

machine instructions - addresses adapted to make a machine, such as an information device, perform a certain operation or function.

machine-readable support - a physical structure from which a machine can obtain data and / or information. Examples include a memory, punch cards, etc.

can - be allowed, at least in some embodiments.

memory device - a device capable of storing analog or digital information, such as instructions and / or data. Examples include nonvolatile memory, volatile memory, random access memory, RAM, read-only memory, ROM, flash memory, magnetic media, a hard disk, a floppy disk, a magnetic tape, an optical media, optical disk, a disk compact, a CD, a digital versatile disc, a DVD and / or a raid array, etc. The memory device can be coupled to a processor and / or can store instructions adapted to be executed by processor, such as according to an embodiment described herein.

method - a process, procedure and / or collection of related activities to achieve something.

microprocessor - an integrated circuit that comprises a central processing unit.

mixable - dissolvable, which can be dispersed and / or able to be placed in such a way that the dry substance is diffused and / or combined in the liquid.

needle - a hollow, thin, pointed instrument that is used for injection. It includes the cannulas.

network - a plurality of nodes coupled in communication.

network interface - any device, system or subsystem capable of attaching an information device to the network. For example, a network interface can be a telephone, mobile phone, mobile modem, telephone data modem, fax modem, wireless transceiver, ethernet card, cable modem, digital subscriber line interface, bridge, hub, router or other similar device.

non-coaxial - not having common linear axes.

output device - an apparatus configured to represent information for a human being in a visual, auditory and / or haptic manner. Examples include an audible output subsystem (e.g., speaker, horn, buzzer and / or piezoelectric transducer, etc.), a visual output subsystem (e.g., flag, marker, light, liquid crystal display ( LCD), light emitting diode (LED), fiber optic, organic polymer screen, electronic paper, screen, display, monitor and / or tube, etc.), and a touch output subsystem (for example, buzzer, vibrator, bulky part, touch stimulator, cooler and / or heater, etc.), etc.

patient - a recipient of an injectable medication, such as a human, mammal, animal, etc.

piston - a sliding piece that is either moved by fluid pressure, or moves against it.

pivoting - able to pivot.

plurality - the state of being plural and / or more than one.

Default - set in advance.

processor - a device and / or a set of machine-readable instructions to perform one or more predetermined tasks. A processor may comprise any or a combination of hardware, firmware and / or software. A processor can use principles, signals and / or mechanical, pneumatic, hydraulic, electrical, magnetic, optical, informative, chemical and / or biological inputs to perform the task (s). In certain embodiments, a processor may act on the information by manipulation, analysis, modification, conversion, transmission of the information for use by an executable procedure and / or an information device and / or direct the information to an output device. A processor can function as a central processing unit, local controller, remote controller, parallel controller and / or distributed controller, etc. Unless otherwise indicated, the processor may be a general purpose device, such as a microcontroller and / or a microprocessor, such as the Pentium IV series of microprocessors manufactured by Intel Corporation of Santa Clara, California. In certain embodiments, the processor may be a device for specific use, such as an integrated circuit for specific applications (ASIC) or an FPGA (Field Programmable Gate Array) programmable gate distribution that has been designed to implement at least one part of an embodiment described herein in its hardware and / or firmware.

Programmable logic controller (PLC) - a critical real-time computer system in solid state, based on a microprocessor, which is used, over the network, to automatically monitor the status of inputs from sensors connected in the field, and automatically control devices of control coupled in communication of a controlled system (for example, drive devices, solenoids, relays, switches, starters, speed units (for example, variable frequency units, silicon controlled rectifiers, etc.), pilot lights , lighters, speakers, tape drives, printers, monitors, screens, etc.) according to the set of values created by the user and the logic created by the user and / or instructions stored in memory. Sensor inputs reflect measurements and / or status information related to the control system. A PLC provides some type of: automated input / output control; commutation; counting, arithmetic operations, manipulation of complex data; logic; synchronization; sequencing; communication; data file manipulation; report generation, control; relay control; Movement control; process control; distributed control; and / or supervision of processes, equipment and / or other control system automation. Due to its precise and real-time critical synchronization and sequencing capabilities, a PLC is programmed using ladder logic or some form of structured programming language specified in IEC 61131-3, that is, FDB (Functional Block Diagram) , LD (ladder diagram), ST (Structured Text, Pascal type language), IL (Instruction List) and / or SFC (Sequential Function Chart). Due to its precise and real-time synchronization and sequencing capabilities, a PLC can replace up to thousands of relays and cam timers. Physical PLC equipment often has good redundancy and fault recovery capabilities. A PLC can use a Human Machine Interface (HMI) to interact with users for configuration, alarm reports and / or control.

perforator - a device adapted to penetrate using a tip, tip, edge or something similar substantially sharp and / or narrow.

pusher - a device adapted to convert fluid pressure into mechanical movement.

represent - make a human perceivable, for example as data, orders, text, graphics, audio, video, animation and / or hyperlinks, etc., such as through any visual, audio and / or haptic means, such as through a screen, monitor, electronic paper, eye implant, cochlear implant, speaker, etc.

repeatedly - again and again; repeatedly.

reservoir - a container or chamber to store and / or direct the movement of a fluid.

resist - avoid and / or stand firm against the actions, effects and / or strength of something.

retract - pull in.

safety tab - a removable device configured to prevent the actuation of a self-injector when the safety tongue is in one orientation and allow the drive when it is in another orientation.

felt variable - a measured parameter.

set - a related plurality.

cover - a protective cover.

shield - a protective device or structure.

Uncritical real time - relative to computer systems that adopt a better effort approach and minimize latency from the event to the response as much as possible while maintaining performance even with external events in general. These systems do not suffer a critical failure if time constraints are violated. For example, live sound and video systems are usually real-time uncritical; Violation of time constraints may cause quality degradation, but the system may continue to function. Another example is a network server, which is a system for which a quick response is desired but for which there is no deadline. If the network server is heavily loaded, its response time can be slowed down without any service failure. This contrasts with the anti-lock brake system where a slowdown in the response would likely cause system failures, possibly even catastrophic failures.

spring - an elastic device, such as a wire spiral, that recovers its original shape after being compressed or extended.

state - a situation or condition.

store - place, maintain and / or retain data, typically in a memory.

substantially - to a large extent or degree.

system - a collection of mechanisms, devices, data and / or instructions, the collection is designed to perform one or more specific functions.

limb - a terminal end.

transfer - transmit from one place to another.

transferable - capable of being transferred from one place to another and / or being moved with respect to something else.

that can be fired - capable of being triggered.

indication of use - information relating to the use of an auto-injector, such as information regarding any selection of auto-injector; auto-injector maintenance; expiration of auto-injector; auto-injector replacement; expiration of medication; medication selection; medication mixture; injection delay; removal of security guard; auto-injector placement; auto-injector orientation; location of the drive device; injection risk prevention; auto-injector drive; injection duration; injection status; injection error; auto-injector withdrawal; auto-injector reuse; auto-injector recycling; and removal of auto-injector, etc.

User input - information provided by humans.

user interface - any device to represent information to a user and / or request information from the user. A user interface includes at least one of text, graphics, audio, video, animation and / or haptic elements. A textual element may be provided, for example by a printer, monitor, screen, projector, etc. A graphic element can be provided, for example through a monitor, screen, projector, and / or visual indication device, such as a light, flag, beacon, etc. An audio element may be provided, for example through a loudspeaker, microphone and / or other generating device and / or sound receiver. A video element or animation element may be provided, for example, through a monitor, screen, projector and / or other visual device. A haptic element can be provided, for example, through a very low frequency speaker, vibrator, touch stimulator, touch pad, simulator, keyboard, numeric keypad, mouse, trackball, control lever, game controller, steering wheel, touch panel, touch screen, signaling device and / or other haptic devices, etc. A user interface may include one or more textual elements, such as, for example, one or more letters, numbers, symbols, etc. A user interface can include one or more graphic elements such as, for example, an image, photograph, drawing, icon, window, title bar, panel, sheet, tab, drawer, matrix, table, form, calendar, schematic view , frame, dialog box, static text, text box, list, selection list, pop-up list, drop-down list, menu, toolbar, station, check box, option button, hyperlink, browser, button, control, palette, preview panel, color wheel, dial, slide, scroll bar, cursor, status bar, dancer, and / or progress indicator, etc. A textual and / or graphic element can be used to select, program, adjust, change, specify, etc. an appearance, background color, background style, border style, border thickness, foreground color, typeface, font style, font size, alignment, line spacing, script, maximum data size, validation, query , cursor type, pointer type, auto-adjustment of size, position, and / or dimension, etc. A user interface may include one or more audio elements, such as, for example, a volume control, tone control, speed control, voice selector, and / or one or more elements for controlling audio reproduction, speed, pause, fast forward, fast reverse, etc. A user interface may include one or more video elements such as, for example, elements that control video playback, speed, pause, fast forward, fast reverse, inversion, zoom in and out, rotation, and / or tilt, etc. . A user interface can include one or more animation elements such as, for example, elements that control animation playback, pause, fast forward, fast reverse, inversion, zoom, zoom out, rotation, tilt, color, intensity, speed , frequency, appearance, etc. A user interface may include one or more haptic elements, such as, for example, elements that use tactile stimulation, force, pressure, vibration, movement, displacement, temperature, etc.

valve - a device that regulates the flow through a tube and / or through an opening by opening, closing and / or blocking a hole and / or passage.

download - free from confinement.

via - by and / or using.

vial - a container that can be closed.

Detailed description

Exposure, such as through ingestion, inhalation and / or injection, to certain allergens, toxins and / or other substances can cause profound reactions for some and / or all people and / or animals. For example, certain people are highly allergic to certain substances, such as peanuts, shellfish, certain drugs, certain proteins, bee venom, insect bites, etc. The allergic response to exposure can lead to anaphylactic shock, which can cause a sharp drop in blood pressure, hives, and / or significant respiratory difficulties caused by severe airway constriction. As another example, the inhalation of certain nerve agents can cause severe physiological trauma. Responding quickly to such exposures can prevent injuries and / or death. For example, in response to an exposure that leads to anaphylactic shock, an injection of epinephrine (i.e. adrenaline) may provide an important and / or complete relief from the reaction. As another example, the injection of an antidote against a nerve agent can greatly reduce and / or eliminate the potential damage from exposure. As another example, rapid injection of certain drugs, such as a beta blocker, anticoagulant, nitroglycerin, antihistamines, insulin and opioids, etc., can provide substantial relief to various dangerous medical conditions.

Thus, some examples of embodiments provide systems, devices and / or methods for rapid injection of a medication.

Some examples of embodiments comprise an apparatus, comprising: a container of compressed gas; a plurality of vials adapted to store a liquid medicament, each vial defines a longitudinal axis, the longitudinal axis of the plurality of vials is parallel and not coaxial, the plurality of vials can be coupled by fluid to an actuating part of a content of the gas container; and a plurality of pistons, each of the pistons is adapted to move within a corresponding vial of the plurality of vials, the plurality of pistons are adapted, in response to the discharge of the actuating part of the contents of the compressed gas container , to transfer at least a portion of the liquid medication from the plurality of vials and through a needle that is extensible inside a patient. Some examples of embodiments comprise a method comprising a plurality of activities, comprising: unloading an actuating part of a contents of a compressed gas container, the compressed gas container is contained within an apparatus; in reaction to said discharge activity, move the piston into a vial, the vial one of a plurality of vials contained within the apparatus, each vial is adapted to store a liquid medicament, each vial defines a longitudinal axis, the longitudinal axis of the plurality of vials is parallel and not coaxial, the plurality of vials can be coupled by fluid to a gas container contents; and transfer a liquid medication from the vial and through a needle that is extensible inside a patient.

FIG. 1 is a perspective view, FIG. 2 is a front view, and FIG. 3 is a side view of an exemplary embodiment of a system 1000, which may comprise a housing 1100, which, in certain operational embodiments, may comprise a manual part 1800 separated by a drive protector 1200 from the drive bar 1300. The drive protector 1200 can prevent accidental activation of the system 1000. The housing 1100 can be constructed of a durable material, such as stainless steel, aluminum, polycarbonate, etc., to protect a container of compressed gas, medicament, apparatus of injection and / or user of the system 1000. The injection apparatus can be operated by pressure of a fluid, such as the pressure provided by the compressed gas, which once its actuation functions are finished can escape from the housing 1100 through an opening of gas exhaust, such as through status indicator 1400.

A state of a system 1000 can be determined by the status indicator 1400, which can provide a vision, such as through a translucent, photo-sensitive and / or UV blocking window, into the housing 1100. Through the window may be visible a state of the medicine transported by the housing 1100, a location of a needle and / or injection device for the medicine and / or an activation state of the system 1000. For example, if the medicine has aged until the discoloration point, such aging may or may not make the medication useless, harmful, etc., the status indicator 1400 may allow this situation to be determined. In some examples of embodiments, the gas can escape from the housing 1100 through the status indicator 1400 and / or from any other opening in the housing 1100.

Some examples of embodiments of the system 1000 may provide a compact medication delivery mechanism that can efficiently and / or rapidly deliver a prescribed dose. The length (L) and width (W) of the system 1000 may be similar to that of a credit card, and the thickness (T) may be less than 2.54 cm (one inch). Thus, some examples of embodiments of system 1000 may provide a convenient, easy-to-use and easy-to-activate drug delivery apparatus that may require little or no training to be transported, used and / or disposed of.

To help a user place a system 1000 with a correct orientation for injection, the system 1000 and / or the housing 1100 can provide various tactile tracks. For example, an upper part 1110 of the housing 1100 may be rounded, and a lower part 1120 of the drive bar 1300 of the housing 1100 may be flat. Other tactile tracks are also possible, such as bumps, ribs, grooves, gaps, rough surfaces, depressions, etc.

FIG. 4 is a cross-sectional view taken along lines A-A of FIG. 3 of an exemplary embodiment of a system 1000 in a first operating position. FIGs. 5, 6, 7, 8 and 9 show the system 1000 of FIG. 4 in the second, third, fourth, fifth and sixth operational positions, respectively.

The system 1000 may comprise a housing 1100, manual part 1800, drive protector 1200 and / or drive bar 1300. The system 1000 may comprise a system drive device 2000, gas tanks 3000, drug drive device 4000, 5000 medication storage set, 9000 medication carrier, 6000 needle assembly, 7000 usage indicator and / or 8000 gas discharge mechanism, etc.

After removal, release, rotation and / or transfer of the drive protector 1200, the system drive device 2000 can be adapted to quickly discharge a drive portion of a contents of a compressed gas container. For example, the system drive device 2000 may comprise a compressed gas container 2400, which may initially contain a compressed gas 2500, an actuation part from which it can be released from a container 2400 by penetration of a gas orifice 2600 through a tip of a perforator 2700. With the removal and / or transfer of the drive protector 1200, the drive bar 1300 can be approached and / or contacted with manual part 1800. With the removal and / or transfer of the drive protector 1200, the gas container 2400 can be contacted with the perforator 2700 through an extension of a pre-compressed spring 2300 and / or the movement of a drive stick 2200. Thus, the drive protector 1200 can prevent accidental activation of system 1000 and / or unintentional discharge of a drive part of the content 2500 of the gas container 2400.

Once the gas orifice 2600 has been drilled, a compressed gas drive portion 2500 can escape from the container 2400 and flow through the gas reservoirs 3000, such as the gas channel 3100. The flowing gas can be found and / or apply gas pressure to the medicament drive device 4000, which can comprise a pusher 4100, which can move within a sleeve 1500 defined by the walls 1520. The sleeve 1500 can be constructed of metal, steel stainless, aluminum, plastic, polycarbonate, etc. Seals 4200, such as O-rings, can withstand gas leaks, such as by passing pusher 4100 and / or leaving housing 1100. In this way, pusher 4100 can function as a piston that travels within a cylinder, although it is not necessarily required that the cross-sectional shape of the sleeve 1500 be round.

The medication drive device 4000 may have an interface with the medication storage assembly 5000. For example, the medication drive device 4000 may comprise a plurality of pistons 4300, each of which can be plugged with a piston 4400 that can slide and / or move in a sealed manner within a corresponding vial 5100 containing a medicament liquid 5200. For example, in response to the pressure applied by a drive part of the content 2500 of the compressed gas container 2400, the pusher 4100 can cause the pistons 4300 and / or the pistons 4400 to move simultaneously. The number of corresponding sets of pistons 4300, pistons 4400 and / or vials 5100 may be 2, 3, 4, 5, 6 or more. The pistons 4400 can be constructed of an elastic, durable and / or sealing material, such as a rubber. Each piston 4300 of the plurality of pistons can define a longitudinal axis, the longitudinal axes (for example, axes 4310, 4320, 4330, 4340) of the plurality of pistons are parallel, non-coaxial and / or coplanar.

Each vial 5100 of the plurality of vials may be substantially cylindrical, with a substantially round and / or substantially elliptical cross-sectional shape. Thus, each vial 5100 can define a longitudinal axis, the longitudinal axis of the plurality of parallel, non-coaxial, and / or coplanar vials. The longitudinal axis of each vial can be coaxial with the longitudinal axis of its corresponding piston.

Each vial can be capped at one end with a frangible element 5300, which can burst when the piston 4400 generates sufficient pressure on the medication 5200, thereby allowing at least a portion of the medication 5200 to flow out of the vial 5100 and inside the carrier 9000 of medication. In this way, the plurality of vials could be fluidly coupled to the actuating part of the content 2500 of the gas container 2400.

The medicament carrier 9000 can hold each of the vials 5100 and can be displaced within the sleeve 1500. The medicament carrier 9000 can comprise a plurality of channels 9200 adapted to receive the medication 5200 as it exits its respective vial 5100, and direct the medicine 5200 to a common conduit 9300. The medicine holder 9000 may have an interface with the needle assembly 6000 and / or the use indicator 7000.

From the common conduit 9300, the medicine 5200 can enter the needle assembly 6000, such as a single needle 6100 through which the medicine can approach the needle end 6200. When the medication drive device 4000 and / or the drug holder 9000 are driven towards the drive bar 1300, the needle tip 6200 can penetrate an end 6400 of the needle sleeve 6300 and exit the drive bar 1300 in needle hole 1340.

Referring to FIG. 5, with the movement of the drive bar 1300 closer to the manual part 1800, a seat seat 1330 can come into contact with the sleeve end 6400, thereby causing the cover 6300 to buckle and / or crumble . When the drive bar 1300 comes into contact with the manual part 1800, the bar stop 1320 can approach the drug carrier stop 9400, while the carrier spring 1600 is compressed.

Referring to FIG. 6, since at least part of the content 2500 of the gas container 2400 escapes, it can flow through the channel 3100. The gas, which may still be relatively pressurized, can begin to accumulate behind the pusher 4100 to form a chamber 3200 of expanding gas and causing the drug drive device 4000, the drug storage assembly 5000 and the drug carrier 9000 to slide together into the sleeve 1500. When the drug drive device 4000, the storage assembly 5000 of medication and the medication carrier 9000 slide closer to the drive bar 1300, the spring 1600 is increasingly compressed between the bar stop 1320 and the drug carrier stop 9400. When the drug drive device 4000, drug storage assembly 5000 and drug carrier 9000 slide closer to the drive bar 1300, the needle end 6200 may extend beyond the drive bar 1300 and the sleeve 6300 It can be compressed and / or deformed further. At its last extension point, the needle tip 6200 can extend from the housing 1100 from about 0.25 millimeters to about 20 millimeters, including all values and intervals in between, such as up to about 2 millimeters, more than about 5 millimeters, from about 5.13 millimeters to about 9.98 millimeters, etc.

Referring to FIG. 7, when the gas chamber 3200 continues to expand, the medication carrier 9000 can be driven until the medication carrier stop 9400 contacts the actuator bar stop 1300 thereby resisting further displacement of the medication carrier 9000 . At that point, the further expansion of the gas chamber 3200 can cause the drug drive device 4000, push bar 4100, pistons 4300 and / or pistons 4400 to initiate a displacement relative to the drug storage assembly 5000, generating thereby an expulsion pressure in the vials 5100 and / or thereby breaking the frangible elements 5300 and allowing the medication 5200 to enter the medication carrier 9000 and begin to flow through the medication channels 9200, conduit 9300 medication, 6100 needle and / or 6200 needle tip and inside a patient. Alternatively, frangible elements 5300 can be replaced and / or augmented by a frangible element located at or near where the medicament conduit 9300 is coupled to needle 6100. Frangible elements 5300 can be constructed of a thin, resilient, elastic material. , durable and / or sealant that potentially has a predetermined creep limit, such as a rubber, such as chrome-butyl rubber, and / or of a relatively fragile material that potentially has a predetermined creep limit, such as ceramic, certain plastics, such as polystyrene, etc.

When the drug carrier stop 9400 contacts the drive bar stop 1300, the medicine carrier hooks 9600 can be coupled with the coupling receivers 7100 in the use indicator 7000.

Referring to FIG. 8, when the gas chamber 3200 continues to expand, the drug drive device 4000, the push rod 4100, the pistons 4300 and / or the pistons 4400 can continue to move until they complete their movement within the drug storage assembly 5000, thereby expelling a predetermined dose of medication 5200 from vials 5100, out of needle assembly 6000, out of housing 1100 and / or inside the patient. When the gas chamber 3200 reaches its maximum size, the medication drive device 4000, the push rod 4100, the pistons 4300 and / or the pistons 4400 can continue to move until they complete their displacement with respect to the drug carrier 9000, causing in this way that the gas release drive device 9700 is coupled with the gas release valve 8200. The coupling of the gas release drive device 9700 with the gas release valve 8200 can cause the gas inside the gas chamber 3200 to exit the gas chamber 3200, discharge away from the pistons 4400, and / or exhaust of system 1000 and / or housing 1100, such as through status indicator 1400 through and / or a gas exhaust port located in housing 1100).

Referring to FIG. 8 and FIG. 9, when sufficient gas is discharged from the gas chamber 3200, the pressure applied by the gas in the gas chamber 3200 may decrease until the force applied by the gas on the drug drive device 4000 is less than the force of the compressed spring 1600. In this way, the spring (s) 1600 can begin to expand, thereby moving the drug holder 9000, the vial assembly 5000 and medication drive device 4000 away from the drive bar 1300 and aiding to expel gases from the gas chamber 3200. When the medication carrier 9000 moves, the usage indicator 7000 may move with it, due to the coupling ratio of the medication carrier hooks 9600 and the coupling receivers 7100 and / or the coupling hooks 7200 on the indicator of use 7000. When the use indicator 7000 moves away from the drive bar 1300, the sheath 6300 can move with it, thereby creating a gap between the end 6400 of the sheath and the needle hole 1340, and exposing that way a colored part 1350, previously not visible, of the drive bar 1300 and / or providing an indication that the system 1000 has been used (and probably has substantially depleted its medication), thereby deterring any other attempt to use the 1000 system.

When the drug holder 9000 moves away from the drive bar 1300, the needle 6100 can be retracted into a sleeve 6300 that is unfastened and / or is no longer deformed into its original shape. Finally, the needle 6100 can be fully retracted within the limits of the housing 1100, thereby tending to avoid accidental needle punctures after the initial injection and / or potentially reducing and / or eliminating a risk of sharp elements.

In certain examples of embodiments, the system drive device 2000 may comprise a mechanism that can be triggered, twisted, pivoted and / or leveraged with the fingers. For example, the system drive device 2000 may comprise a rotating handle that can be screwed into the gas hole 2600. In some examples of embodiments, the system drive device 2000 may be a finger trigger located on one side of the housing.

FIG. 10 is a flow chart of an exemplary embodiment of a method 10000 for the operation of a medication delivery apparatus. In activity 10100, a drive lock for the device is released. In activity 10200, an actuating part is released from the contents of a container of compressed gas. In activity 10300, by means of the pressure provided by the released gas, a needle extends from the apparatus. In activity 10400, by means of the pressure provided by the released gas, a piston applies pressure to a medicament stored in one of the plurality of vials. In activity 10500, a frangible element containing the medicine in the vial is bursting. In activity 10600, the medication flows from the vial, through the needle, and into a patient. In activity 10700, once a predetermined dose is expelled and / or injected, the patient's needle is removed and / or retracted to the limits prior to the use of the apparatus. In activity 10800, the apparatus is disabled for additional injections and / or indicated to have been previously used.

FIG. 11 is a perspective view of an embodiment of the system 1000, which shows the drive protector 1200 removed from the housing 1100, so that the drive protector 1200 no longer separates the drive bar 1300 from the manual part 1800. The drive shield 1200 may comprise a part that can be grasped 1220 that can be grasped by a user to pull the drive shield 1200 away from the housing 1100, thereby allowing system 1000 to be activated, such as by tapping the bar 1300 drive against a user's thigh. The drive shield 1200 may comprise a drive stick spacer 1240, which can be kept separate from the drive stick tips 2240 when the drive shield 1200 is installed in the housing 1100. The drive shield 1200 can comprise a portion 1260 of guard that can separate the drive bar 1300 from the manual part 1800 when the system 1000 is not in use and / or when the system 1000 has not been used.

FIG. 12 is a perspective cross-sectional view taken along line B-B of FIG. 11, and FIG. 13 is a perspective view of an exemplary embodiment of the drive stick 2200. Referring to FIGs. 12 and 13, the system 1000 may comprise the housing 1100, the drive bar 1300, and the system drive device 2000, which may comprise a tip clamp 1390, drive stick 2200, tip retainer 2100, spring 2300, upper spring retainer 2260, gas container 2400, gas hole 2600 and / or perforator 2700. When the drive bar 1300 is pressed firmly against the body of a user, such as tapping with the drive bar of the housing Against the thigh, buttocks and / or on the user's arm, the tip presser 1390 can push the tip ends 2220 of the tips 2240 of the drive stick 2200 together. It should be noted that the tip ends 2200 can have a triangular, wedge, angular and / or conical shape. When the tip ends 2220 slide along the angled V groove of the tip fastener 1390, the tip hooks 2230 can substantially loosen the contact with the tip retainer 2100. This may allow the compressed spring 2300 to quickly push the drive stick 2200 and the gas container 2400 towards the perforator 2700, which can penetrate the gas hole 2600, thereby allowing the gas to escape from the gas container 2400. Although any of many different types of gas containers can be used, an example of a gas container can be obtained from Leland limitada, Inc. of South Plainfield, NJ.

FIG. 14 is a cross-sectional view of an exemplary embodiment of the gas discharge mechanism 8000 of system 1000 taken along lines A-A of FIG. 3. The system 1000 may comprise a manual part 1800, drive bar 1300, sleeve 1500. As the pistons 4440 approach the limit of their displacements, the medicine 5200 can be ejected along the medication path 5900, which The frangible elements 5300 can be extended past the medication channels 9200, medication conduit 9300 and the needle 6100, and into a user's body, such as subcutaneously, intramuscularly and / or at a depth of around 0.25 millimeters to approximately 20 millimeters, including all values and intervals between, such as up to 2 millimeters, more than 5 millimeters, etc.

When the pistons 4440 approach the limit of their displacement, the coupling of the gas release drive device 9700 with the compressed gas release valve 8200 can cause the compressed spring 8300 to move the valve arm such that the gasket O-ring 8400 is pushed away from its seat 8500. This movement can reveal a passage 8600, through which gas can escape from the gas chamber 3200 along the gas escape path 8900 and which can extend between the interior walls 1520 of the sleeve and outer walls 9100 of the drug holder 9000. Finally, the gas exhaust path 8900 can extend between the manual part 1800 and a drive bar 1300. Similarly, a

Alternative embodiment of valve 8200, made of rubber or any other elastic material, can be placed through the seat 8500 to provide a seal that, once the gas release actuator 9700 interacts with the valve 8200, allows Valve 8200 bends or hangs up away from seat 8500, causing gas to escape through passage 8600.

The following paragraphs extend in the foregoing and describe various examples of embodiments related to compact auto-injectors that may comprise and / or use a vial or a plurality of vials for storing and / or containing an injectable medicament. These auto-injectors can have a compact form factor, such as about the size of a credit card. There are many methods to administer these medications in such compact devices. The following descriptions cover multiple methods and / or mechanisms that can effectively administer a medication using a compact auto-injector.

Example one: Methods for using a self-injector

This example describes a method for implementing a self-injector using a spring and / or gas driven system to administer a medication and / or comprises a needle protection system.

An example of a system for administering a medicine from a chamber can comprise a vial or plurality of vials; said camera is in communication with a needle, which can be initially hidden by a shield and / or sheath; extending said needle from the sheath at least 1 mm and / or inserting the needle by passing a needle insertion point to an injection site at a depth of at least 5 mm; the application of a force that may originate from the contents of a gas cylinder and / or by means of a spring or multiple springs sufficient to expel the medicine contained within said chamber to the needle and / or through the insertion point of the needle at a depth of at least 5 mm to administer up to 5 ml of medication at the injection site in less than 5 seconds; wherein the medicament can be injected and / or contained during the use of a vial system comprising a plunger, vial (s), reservoir and / or needle that can be found within said chamber; wherein the force can be applied on the plunger at the proximal end to allow the plunger, vial (s), reservoir and / or needle to move towards the distal end of the housing, where the plunger can slide sliding through from the vial to the distal end to allow the appropriate dose of medication to be administered; where the needle insertion point may be located more superficial than the injection site; wherein the needle can have a length of at least 6 mm and / or the medication can be ejected at a pressure of at least 172 kPa (25 p.s.i.) at a rate of at least 0.20 ml / s; and / or where the needle can retract into the shield and / or the housing and / or a needle guard part slides over the needle after the administration of the medication.

FIG. 15 shows an example of a 15000 auto-injector. Although the figure shows the force mechanism used as being compressed gas, the force method can be created by a spring force (see the description of FIG. 18 below). The upper part of the housing can be laser welded to ensure stability due to high pressure. Similarly, the entire housing should be made smaller by removing screws and / or pins that hold the base and / or the top in the housing. In FIG. 15, this can be completed by adding hooks to the base. The hooks can allow the base to slide into the housing, thereby pushing the fasteners inward and allowing the gas cylinder to puncture through the compressed spring. These hooks can also click on the housing, making the base cannot move after injection; This eliminates repeated use of the device and acts as an indicator to determine if the device has been used or if the device has not been activated. The gas release mechanism is also a novel addition in the device. A rubber and / or other elastic material fin can be located inside the piston rod. A solid piece or member can be lifted from the tank near the top of the vials. Once the plunger rod dispenses the medication, this piece can push the rubber flap up, thereby releasing the excess gas in the system. The drilling device for the gas cylinder could be a rolling pin that is cut at an angle of 45 degrees to ensure sharpening for puncture.

FIG. 16 shows the safety tab used to protect the user from accidental activation. FIG. 16 also shows an enlarged part of the safety tab with grooves added to it. This can help the user to remove the safety tab by creating a larger grip surface and / or a tactile sensation on the tongue.

Example Two: Chemical reaction

This example involves a self-injection system that uses a chemical reaction as an activation mechanism to administer the medication to a patient. It also includes a needle protection system.

This example is related to an administration system that may surround a housing, vial or plurality of vials, plunger for each vial, a single needle or needle cannula, and medicament or medications within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger (s) at the proximal end and in communication with a reservoir containing a single needle or needle cannula at the distal end; the needle may be protected by some sheath / shield; A chemical reaction can occur when a chemical is allowed to interact with another chemical and / or a substance that can create such a reaction through the use of some activation mechanism; and said chemical reaction that can generate a force that is strong enough to drive said plunger, vial, reservoir and needle toward the distal end of the housing; the needle leaves said sheath / shield and enters an injection site; the plunger (s) is sliding in the vial (s) that contains the medication; and said medication leaves the vials through the reservoir and the needle cannula at the injection site; After the desired content of the vial is removed, the entire needle, reservoir, vial and plunger assembly can be retracted to the proximal end of the housing by some means such as a wire, spring, O-ring and / or rubber membrane and / or a needle protection part slides over the needle after administration of the medication.

FIG. 17 is a view of the compact injector with various modifications to allow a chemical reaction to occur as a primary method of force in order to administer the medication. In the particular drawing, the puncture pin may include a rough surface. Likewise, the container used in the device may have a similar rough material and / or surface and may contain mainly sodium azide (NaN3). Once the spring is activated (connected to the container), the two rough surfaces can simultaneously come into contact with each other to create a spark and pierce the azide container. This can create an immediate chemical reaction due to the spark. The reaction (2 NaN3 -> 2 Na + 3 N2) can form hot nitrogen and sodium gas to create enough force to inject the medication. A modification of this figure can be made to include another container at the top in the place that the puncture pin can open by breaking by the force of the spring and the second container, thereby mixing the two chemicals and can cause it to occur. a chemical reaction in order to produce the necessary force.

Example three: The spring driven injector

Some examples of the auto-injector may cause a spring or multiple springs to inject the medication into a patient. The novelty of this system can be based on the orientation of the activation springs of the vial system (comprising the plunger, vial (s), reservoir and the needle / cannula) system. Because the activation springs can be located parallel to the road system, the device may be smaller than the devices existing in the market (which are linear in nature), potentially having a shape factor that is approximately the size of a credit card.

Certain examples refer to an administration system that may surround a housing, vial or plurality of vials, plunger for each vial, a single needle or needle cannula, and medication and / or medications within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger (s) at the proximal end and in communication with a reservoir containing a single needle or needle cannula at the distal end; the needle is protected by some sheath / shield; The housing further comprises at least one spring (this may comprise a gas spring, spiral spring, flat spring, etc.) where the spring (s) is parallel to the plunger, vial (s) and reservoir system and is in communication with a solid member (which can be made of rubber, plastic, metal and / or some other elastic material) that is also in communication with the proximal end of the plunger such that when the spring (s) is activated, it apply a force on the plunger at the proximal end to allow the plunger (s), vial (s), reservoir and needle to move towards the distal end of the housing; wherein the plunger can slide slidably through the vial to the distal end to allow the appropriate dose of medication to be administered; The solid member is displaced loosely from the plunger, which may allow retraction of the entire needle, reservoir, vial (s) and plunger assembly towards the proximal end of the housing by some means such as a wire, spring, o-ring and / or rubber membrane and / or a needle protection part to slide over the needle after administration of the medication.

FIG. 18 shows several views of the spring driven injector. The primary force used to push down the push bar, vial system, reservoir and needle can be provided by compressed springs. In the cross-sectional drawing, two springs can be located on the outside of the central chamber (which contains the push bar, vials, reservoir and needle). The springs can be held in place by a rod coupled with hooks. Each spring can have a solid rolling member connected to it that is also connected to a bar that is held in a slit / dent in the reservoir near the bottom of the vials. On the other hand, a solid beam can wrap around the top of the pusher bar and can be connected to the said bar. The bar can slide in and out of the tank and the solid beam, but only if the rolling solid member rolls away from the beam and tank. The device can be activated by the user by removing the safety mechanism and pushing down the outer sleeve. This can cause the hooks from the rods, which hold the springs in place, to pinch inward, thereby releasing the springs with force downward. When the springs are driven down, the solid rolling member and the rod can roll down through the passage of the solid member. When the solid rolling member moves, the solid beam wrapped around the pusher bar can also be lowered, pushing the needle into the user. The medication can be administered in the user and / or the patient once the rolling solid member drops further, which can be continuously driven by the force of the springs. The solid member passageway can finally move away from the vial system and the reservoir (also shown in the side view drawing as a hidden line). This can slide the bar out of the reservoir and out of the beam, allowing the retraction of the springs to push the pusher bar, vials, reservoir and needle back into the housing.

Example Four: Pulley System

This exemplary embodiment can use a pulley system as an activation mechanism to inject medication into the patient and which can also comprise a needle protection system.

Certain examples refer to an administration system that may surround a housing, vial or plurality of vials, plunger for each vial, a single needle or needle cannula, and medicament or medications within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger (s) at the proximal end and in communication with a reservoir that may contain a single needle or needle cannula at the distal end; the needle that may be protected by some sheath / shield; The housing further comprises one or more pulley spring system (s) that may constitute a spring connected to some sliding elastic material such as wire chains, wire coil, flat metal band, etc. at the proximal end of the housing, and said material that can be moved through a channel in the housing from the proximal end of the housing towards the distal end of the housing and then returning through a parallel channel towards the proximal end where this material it is connected to a solid member (made of rubber, plastic, metal and / or some other elastic material); the solid member in communication with the proximal end of the plunger, such that when the spring is activated the spring can produce enough force to allow the pulley system to function by having the elastic material, such as a cord, which can move with force towards the proximal end of the housing and can cause the cord to move the solid member in communication with the plunger, vial (s), the reservoir and / or needle towards the distal end; wherein the needle can exit said sheath / shield and can enter an injection site; the plunger (s) is sliding in the vial (s) that the medicine may contain; and said medication can leave the vials through the reservoir and / or the needle cannula to the injection site; With the release of the desired contents of the vial, the solid member can be moved away from the plunger allowing the entire needle, reservoir, vial and / or plunger assembly to retract toward the proximal end of the housing by some means such as a wire, Spring, O-ring and / or rubber membrane and / or a needle guard part slide over the needle after medication administration.

In FIG. 19 A pulley system is shown as the primary method for forcing the push bar, vials, reservoir and needle down for medication injection. Similar to the previous spring-driven injector, the activation springs can be placed parallel to the vial system and the device can be activated by the user pressing down on the outer sleeve of the device. The use of a pulley system can create a mechanical advantage, producing the appropriate force necessary to effectively push down the road system and administer the appropriate dose of medication. FIG. 19 shows a bar that can be connected to one end of the rod / spring member. This bar can be connected to the pulley system (which can comprise some elastic and / or movable material). The other end of the pulley system can be connected on the top of the pusher bar to a beam that may be able to slide when moving to a certain position. When the springs are driven down, the pulley system can also pull the push bar, vials, reservoir and needle down. Similar to the spring-driven injector, the solid beam member at the top of the pusher bar can slide down the solid member passageway and finally be dislodged from the pusher rod. Once this occurs, the entire system can retract back into the housing due to the force of the retraction springs.

Example five: The needleless injector

This example is related to a needleless injector that can be activated by gas and / or spring and that can allow a user to inject a medication into a patient without the use of a needle. The use of a plurality of vials can be considered as the novel component and can allow the device of a compact nature, such as having the approximate length and width similar to that of a credit card.

A certain example of a system for administering a medicine from a chamber can comprise a plurality of vials; said chamber in communication with a passageway in a small injection opening; the application of a force that can originate from the contents of a gas cylinder and / or by means of at least one spring that can expel medicament contained within said chamber to the passageway to the small injection opening, which can be defined and / or created by the housing and / or a small sterile rod that can be a needle or cannula that allows slight puncture of the injection site in order to allow the medication to be administered, and through the tip of this small opening injection at a depth of at least 1 mm, which can administer up to 5 ml of medication at the injection site; wherein the medicament can be injected and contained during the use of a vial system comprising a plunger, vial (s) and / or reservoir, all located within said chamber; wherein the force can be applied on the plunger at the proximal end to allow the plunger, vial (s) and / or reservoir to move towards the distal end of the housing; wherein the plunger can slide slidably through the vial to the distal end to allow the appropriate dose of medication to be administered through the reservoir into the small injection opening; wherein the injection opening point may be located more superficial than the injection site; wherein the medicament can be expelled at a pressure of at least 172 kPa (25 psi) (For example, in those embodiments, the pressure to administer a dose of 0.5 cc may be approximately 45 kg (100 pounds) of the force).

FIG. 20 represents the components of the needleless injector. The injector can be activated by removing a safety tab and pushing down on the housing. The rod with hooks that hold the spring in place can be initiated by the base moving upwards and pushing the hooks inwards. The spring can propel the high pressure gas cylinder to a puncture pin, releasing the contents of the gas cylinder. The contents of the gas cylinder can push down the push bar, vials and the reservoir to the small opening at the base of the device near the injection site. A small cannula and / or needle can be located at the bottom of the reservoir and / or can be used to slightly puncture the injection site. This slight puncture may allow the medication stored in the vial to flow through the reservoir and into the injection site. Once the pressure is released, the entire system (including the push bar, vials and reservoir) can be pushed up into the housing by the retraction springs.

Example six: The multi-pharmaceutical injector

This example is related to a compact auto-injector that can incorporate a plurality of vials, allowing multiple medications to be injected at one time or at different times. The use of a plurality of vials can be considered as the novel component and can also have the advantage of creating a device that is of a compact nature, such as one that has the length and width of a credit card. The device may also comprise a needle protection system.

A certain example of a system for administering a medicine from a chamber can comprise a plurality of vials; said camera or cameras in communication with a needle or needles that can be initially hidden by shields and / or covers; that said needle can extend from said sheath at least 1 mm and / or can insert the needle by passing a needle insertion point to an injection site at a depth of at least 5 mm; the application of a force and / or forces that can be originated from the contents of a gas cylinder and / or multiple gas cylinders, and / or by means of a spring and / or springs sufficient to expel medication contained in said chamber inside from the needle and through the needle insertion point; wherein the medicament can be injected and contained during the use of a vial system and / or vial systems that may comprise a plunger, vial, reservoir and / or needle, all located within said chamber (s); wherein the force can be applied on the plunger at the proximal end to allow the plunger, vial, reservoir and / or needle to move towards the distal end of the housing, where the plunger can slide slidably through the vial to the distal end to allow the appropriate dose of medication to be administered; where the needle insertion point may be located more superficial than the injection site. The device that potentially has a multitude of such components (including, but not limited to, vials, plungers, gas cylinders, springs, needles, tanks, sleeves, shields, chambers and / or retraction springs) in order to administer multiple medications in a patient at a time and / or at different times, as a single and / or in multiple doses, depending on when each system is activated. The device may have selectors and / or other mechanisms to allow the user to choose which medication to administer. Each system may comprise an activation mechanism (such as a spring and / or gas cylinder), a chamber within said housing, and a plunger, vial, reservoir, needle and / or retraction spring; where with the exit of the desired contents of the vial, the entire needle, reservoir, vial and / or plunger assembly retracts towards the proximal end of the housing by some means such as a wire, spring, o-ring and / or rubber membrane and / or a needle protection part slides over the needle after medication administration.

In FIG. 21 represents a method for administering multiple pharmaceutical products. The injector may include medication selectors in order to allow the user to select which medication to inject. The user can select the medications by sliding one or more selectors up to their final position. It can produce an audible click or some other indicator to alert the user of this final position. By moving the selector or multiple selectors upwards, a pin can be allowed to jump elastically on the piston rod and / or on the push bar, which can create a complete piece that can push the vial system down and inject the medication through the vial, the reservoir and / or needle. (This method can also be used with the needleless injector method as described hereinbefore) methods such as this embodiment could be very useful in applications of anti-nerve agents or pain therapies. The device can also include an elastic material, such as rubber, to seal the openings of the selector and which can also slide inside the housing once the selector is pushed up. Once the aforementioned pins are in place, the device can operate and activate in a manner similar to that described above. A safety mechanism can be modified to prevent sliding selectors from being prematurely pushed up.

Example seven: The wet / dry injector

This example is related to a compact auto-injector that may have the ability to mix two or more medications in a liquid or powder form to create an injectable medication. The novel component of this device can be considered to be the use of a plurality of vials to administer the medication. The device may also comprise a needle protection system.

An example of a delivery system may comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, a single needle or needle cannula and / or a medication or medications stored within of each vial. Prior to injection, two or more medications may be stored separately in a vial and / or storage compartment and may communicate with each other once the mixing activation mechanism is initiated. The mixing activation mechanism could comprise a button, trigger, threaded rod and / or some other member that removes a piece or part and / or punctures a piece or part that prevents each medication from communicating with the other. The mixing activation mechanism may comprise a membrane, piece and / or part that can be removed before injection by the user in order to allow independent vials and / or storage containers to communicate with each other. The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to make the contents of each compartment mix with the other. This communication can occur by shaking the device and / or can occur automatically with the mixing activation mechanism. For example, the mixing activation mechanism can cause each medication to be released into an activation chamber, which can itself be an independent vial. This mixed medication may be the medication that will be injected into the patient. The delivery system that further surrounds the mixed medication vial or plurality of mixed medication vials in communication with the plunger (s) at the proximal end of the housing and in communication with a reservoir that may contain a single needle or needle cannula in the distal end; the needle may be protected by some sheath / shield; The housing can further comprise a passageway that is also in communication with the proximal end of the plunger such that when the spring (s) is activated from the proximal or distal end, a force can be applied through the passageway on the plunger in the proximal end to allow the plunger (s), vial (s), reservoir and / or needle to move towards the distal end of the housing; wherein the force provided may be produced by a spring, bar, the contents of a gas cylinder and / or other force mechanism; wherein the plunger can slide slidably through the vial to the distal end to allow the appropriate dose of medication to be administered; With the exit of the desired contents of the vial, any needle, reservoir, vial and / or plunger assembly can be retracted towards the proximal end of the housing by some means such as, for example, a wire, spring, O-ring and / or membrane of rubber and / or a needle protection part slides over the needle after administration of the medication.

FIG. 22 represents a novel method for injecting lyophilized drugs, and / or powdered biological products that may need to be reconstituted before injection. FIG. 22 shows a mechanism for mixing and / or creating an injectable medicament of two or more independent substances mentioned above. The figure shows multiple vials that could have two substances in each vial separated by a perforable membrane and / or other frangible piece. The vials in this embodiment may have a wet substance (such as sterilized water) and a dry substance (such as glucagon powder). The user can remove the safety tab that can prevent the user from accidentally injecting and / or premature activation of the device. Once the safety device is removed, the user can rotate and / or rotate the rotating part at the top of the housing. By rotating this upper part, the rods connected to this part (which can be threaded rods) can move down. These rods can be located in the vials and / or through the push bar. The rods can have a sharp part of perforation on the distal end that can help puncture the said perforable membrane that can separate the substances in the vial. Once the piercing rod punctures the frangible elements and / or the pierceable membrane, the substances can be mixed together to form a medicament. The user can also shake the entire housing in order to help in this mixing process.

Example eight: Needle end safety system

Some examples are related to a security system that can allow a user to remove a cap, bar, lock at the same end of a self-injector housing where the needle is located. This may allow the device to be ready for activation and while still protecting the needle at the same time. Many auto-injectors, such as most pen-type injectors, have a safety activation mechanism at the opposite end of the needle. In an emergency situation, the user can confuse this safety cap as the protection of the needle, when in fact this is not the case. There have been many documented cases of digital injection in a user's thumb or other finger due to this reason. If you have the safety mechanism at the same end as the needle, this risk can be eliminated.

Example nine: Auto-injector with reaction

The use of auto-injectors and drug delivery systems is common in the medical industry. Autoinjectors can administer a wide range of medications in a patient, ranging from chronic therapies to injectables for critical care. As more therapies develop, the need for a vehicle to administer these therapies grows continuously. Some auto-injectors currently on the market may lack attributes that allow the user to understand the functionality and / or operation of the device. Thus, it is considered that there is a need for a self-injector that can provide an audible, haptic and / or visual reaction for the user in order to train and / or guide the user about how to properly operate the car. injector and / or mitigate user-related risks that could occur if the device is not used correctly.

The incidence of hazards related to the use associated with auto-injectors is increasing. Common problems associated with certain injectors in the market include poor design, exposure to sharp elements and poor instructions. Many auto-injectors on the market are in the form of a device that resembles a pen or marker. The safety mechanism for most of these devices can cause confusion to the patient as it often protects the activation mechanism and not the place where the needle protrudes from the device. There have been numerous cases of users accidentally injecting the needle into their own thumb or other finger due to this risk. Examples of devices incorporating this design may include certain pen-type autoinjectors for allergic emergencies, and / or certain auto-injectors of anti-nerve agents currently supplied to domestic and foreign armies. These devices, and most auto-injectors on the market, can also allow the needle to continue protruding after use, thereby presenting a danger of sharp elements after injection. In addition, many of these injectors have poor instructions and / or labeling. Due to the cylindrical design of certain auto-injectors, the surface area for labeling can be small, rounded and, therefore, can prevent a user from easily reading important information about the use of the device. For many injectors used in emergency situations, it may be important for users to be able to use the device correctly and efficiently. The user may not use or have time to read the instructions on the device in a critical situation.

For one or more of these reasons, a self-injector or interactive medical device is described that can provide a user with a visual, haptic and / or audible reaction in order to mitigate the aforementioned risks and / or to allow easy injection of medicines.

Some examples of systems may provide an interactive auto-injector and / or method to provide an audible, haptic and / or visual reaction to a user while driving the auto-injector. A self-injector can be defined as a device that allows a user to administer a medication without having to manually prepare the injection. This may include injectors delivered with a pen, syringes, needleless injectors, gas-powered auto-injectors and / or any other auto-injector and / or medical device used to inject a pharmaceutical product into a user / patient, etc.

Some examples of systems may provide a self-injector that may comprise an information device and / or system comprising at least one sensor (e.g., a pressure sensor, proximity sensor, touch sensor and / or device). biometric inputs, etc.), switch (e.g., gate switch, micro switch and / or push-button, etc.) integrated system (e.g., microprocessor, memory, integrated operating system, system bus, input interface / output and / or network interface, etc.), audible output subsystem (e.g., speaker, horn, buzzer and / or piezoelectric transducer, etc.), visual output subsystem (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electronic paper, screen, display, monitor and / or tube, etc.), touch output subsystem ( e.g., buzzer, vibrator, bulky part, touch stimulator, cooler and / or heater, etc.), and / or any or a component and / or subsystem that helps provide an audible, visual and / or haptic reaction to a user of the injector, together with circuits, control system (s), housing (s), shielding, electrical conductors and / or the power supply (s), etc. appropriate.

Certain self-injectors may comprise a housing, safety mechanism, activation mechanism (such as spring means or compressed gas cylinder), a vial or container for storing the medication, and a needle for administering the medication. Some examples of embodiments may provide one or more audible, visual and / or haptic outputs to guide and / or instruct the user how to properly use the auto-injector. Sensors and / or switches can be placed on the safety tab, on the bottom of the device where the needle comes out, and / or where the inner sleeve slides up to activate the device. Visual exits can be placed in each of the above locations additionally and / or in place. An audible output subsystem can be placed anywhere in the device for an audible reaction. A haptic output subsystem can be placed anywhere on the device. These active and / or electronically triggered components and / or subsystems can be incorporated into the device labeling and / or as a separate component to provide this visual, haptic and / or audible reaction.

For example, the user can press a button or switch on the device to initiate an audible, haptic and / or visual output subsystem. An audible voice recorded in advance can instruct the user to pull the safety tab, while a visual and / or haptic output may occur on the security tab to provide a visual and / or tactile clue to the user as to where it is Find the security tab. Once the safety tab has been removed correctly, a sensor or switch could trigger the next stage for the voice to announce, for example, asking the user to place the base of the device on the outside of his thigh while also firing a visual output to illuminate the base of the device. As a further example, the user can be provided with a visual track in which at least a part of the base of the device is illuminated and / or red, and / or the user can be provided with a haptic track in which the base on the device moves and / or the base is sufficiently heated (such as between approximately 40.5 ° C (105 degrees F), and approximately 48.9 ° C (120 degrees F), including all values and intervals in between) to substantially heat, but not burn, the user's skin. The integrated operating system, which can be executed in critical real time to avoid delays that could be important and / or endanger life, can also recognize a failure to complete a stage in a specific period of time and make the stage repeat if necessary and / or provide a negative reaction if the user cannot perform a stage properly (eg through the input from a sensor or switch, the operating system can warn in time that the device is not placed on the skin of the thigh correctly and may cause the audible output subsystem to tell the user to repeat the placement stage). Once the user places the device on the thigh correctly, the sensor or commutator could fire the next track and / or audible, visual and / or haptic output, such as asking the user to push down the outer sleeve of the device with force. By giving the user step-by-step instructions on each task, user errors and / or the risks of some hazards can be reduced and / or eliminated.

Some examples of systems may provide a compact auto-injector, size of a credit card, used to administer a wide variety of medications, such as pharmaceuticals and / or agents. Although this auto-injector can eliminate many of the problems associated with certain pen-style auto-injectors, such as the danger of sharp elements and / or a bad design of the safety tab, there may be a need for an interactive auto-injector in order to help instruct the user of the device and / or to help ensure that the device is used properly at any time and / or whenever necessary. The following, and the attached figures, further describe a self-injector.

FIG. 23 represents a self-injector having a housing similar to the length and width of a credit card, an activation mechanism on one side and a non-coaxial vial system with the activation mechanism. The activation mechanism may comprise a compressed spring and a compressed gas cylinder used as a force mechanism, and a puncture mechanism to dissipate the contents of the compressed gas cylinder. A vial system may comprise a push bar, plungers, medication storage vial (s), a reservoir, a needle and a needle sheath. Retraction springs located at the base of the reservoir can push the needle into the housing after injection. A sliding base can be used to activate the activation mechanism, which can be transparent to show the location of the said needle. A safety tab can be placed between the base and the housing and / or it can maintain the activation mechanism so that it is not activated while protecting the user from the needle. Sensors and / or switches can be placed on the base and / or on the safety tab, which can help trigger an audible, haptic and / or visual reaction. A button and / or a switch can be placed in the housing, which can help trigger an audible, haptic and / or visual reaction subsystem (s). The reaction subsystem (s) can be activated based on the contributions received and / or interpreted by the integrated operating system.

For example, an audible output subsystem located in the housing can provide an audible reaction to the user of the device. The audible output subsystem may comprise one or more piezoelectric transducers, small and / or large cones and / or speakers, sensors, capacitors, memories, power supplies (e.g., battery, fuel cells, spring-powered generator, etc.) housing, wires and other electronic components necessary to provide a recorded audible reaction to a user. The audible output subsystem can be activated by the above button or switch on the housing. The speaker can provide instructions on how the device is used and / or certain medication requirements.

As another example, the visual outputs may be located throughout the device, and / or at the base, safety tab, labeling and / or the housing to provide visual clues to the user. These visual outputs can be activated by the operating system once a sensor or switch is triggered. An LCD screen, optical polymer, LED, electronic paper and / or other form of display, monitor and / or screen and / or other visual output can provide data to the user such as the amount of dose, expiration date, instructions, Federal Drug Administration (FDA) requirements, and / or other labeling requirements, etc.

Referring to FIGS. 24 and 25, the user can press the button on the housing to, through the integrated processor, activate the audible, haptic and / or visual reaction subsystem of the auto-injector. For example, a voice from the audible output subsystem (now activated) can provide an audible message to the user, such as "Please, remove the safety tab". The safety tab can also be illuminated from visual exits located on the safety tab. Once the safety tab has been removed, a sensor can be triggered that can also trigger the next audible task from the audible output subsystem. If the safety tab is not removed within a certain period of time, the first voice response can be repeated. The button or switch can be pressed several times or held in order to stop the process (in case the injector should not be used or the button has been accidentally pressed). After the safety tab has been removed, the next audible track can be announced, such as "Please place the base of the device on the outside of the thigh." The base can be illuminated simultaneously during this audible track, providing a visual clue that shows where the base is located and / or what part of the database should be placed on the thigh. A sensor or switch, located at the base, can be used to help determine if the auto-injector is properly placed at the injection site. The same switch and / or sensor, and / or another switch and / or sensor located in the base can help trigger the next audible message, such as "Push down on the top of the device to activate the injector". That switch and / or sensor can also fire one or more visual outputs to illuminate the labels and / or an arrow pointing down towards the injection site (as shown in FIG. 24).

Certain examples of systems may comprise a compact auto-injector that may have the ability to mix two or more medications, agents, solutes, solvents, etc., either in a liquid or powder form and / or create an injectable medication. Some examples of embodiments may include an interactive system that can provide a haptic, audible and / or visual reaction to provide the user with instructions, suggestions and / or clues in order to use the device properly. The auto-injector may also comprise a needle protection system.

An example of a delivery system may comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, a single needle or needle cannula, and / or a medication or stored medications inside each vial, etc. Prior to injection, two or more medications may be stored separately in a vial and / or storage compartment and may communicate with each other by fluids once the mixing activation mechanism is initiated. The mixing activation mechanism may comprise a button, trigger, threaded rod, and or any other member that removes a part or part and / or punctures a part or part that prevents each medication from communicating with the other. The mixing activation mechanism may comprise a membrane, piece and / or part that can be removed before injection by the user in order to allow independent vials and / or storage containers to communicate fluidly with each other. . The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to make the contents of each compartment mix with the other. This communication can occur by shaking the device and / or can occur automatically with the mixing activation mechanism. For example, the mixing activation mechanism can cause each medication to be released into an activation chamber, which can itself be an independent vial. This mixed medication may be the medication that will be injected into the patient.

The delivery system may comprise the mixed medication vial or plurality of mixed medication vials in mechanical and / or fluid communication with the plunger (s) at the proximal end of the housing and in mechanical and / or fluid communication with a reservoir It may contain a single needle or needle cannula at the distal end. The needle may be protected by a sheath and / or shield. The housing may comprise a passage that is also in mechanical and / or fluid communication with the proximal end of the plunger such that when the spring (s) is activated from the proximal or distal end, a force can be applied through the passage over the plunger at the proximal end to allow the plunger (s), vial (s), reservoir and / or needle to move towards the distal end of the housing. The applied force can be produced by a spring, bar, the contents of a gas cylinder and / or other force mechanism; The plunger can slide slidably through the vial to the distal end to allow the appropriate dose of medication to be administered; With the release of the desired contents of the vial, any needle, reservoir, vial and / or plunger assembly can be retracted to the proximal end of the housing by some means such as, for example, a wire, spring, o-ring and / or Rubber membrane and / or a needle protection part slides over the needle after administration of the medication.

The interactive system may comprise a speaker subsystem that can comprise piezoelectric elements and / or other components to produce audible sounds and / or the human voice; a haptic subsystem that can provide haptic reaction to the user; a visual subsystem that can comprise light emitting diodes, LCDs, optical fibers and / or other components that can produce visual outputs such as light and / or color; a processor that can be used to control the activation of said components, a power source, such as a battery that can power the aforementioned interactive system; and / or switches, buttons and / or sensors that can activate certain visual, haptic and / or audible tracks at a given time.

FIG. 25 represents a novel method for injecting lyophilized drugs, and / or powdered biological products that may need to be reconstituted before injection. FIG. 25 shows a mechanism for mixing and / or creating an injectable medicament of two or more independent substances mentioned above. FIG. 25 represents multiple vials that may have, for example, at least two substances in each vial separated by one or more perforable membranes and / or other frangible parts. The vials may have at least one wet substance (such as sterilized water) and at least one dry substance (such as glucagon powder). The user can remove the safety tab, which can prevent the user from accidentally injecting and / or premature activation of the device. Once the device and / or safety tab is removed, the user can twist and / or rotate the rotating part at the top of the housing. By rotating this upper part, the rods connected to this part (which can be threaded rods) can move down. These rods can be located in the vials and / or through the push bar. The rods can have a sharp part of perforation on the distal end that can help puncture the said perforable membrane (s) that can separate the substances in the vial. Once the piercing rod pierces the frangible elements and / or the pierceable membrane (s), the previously separated substances can thereby be mixed together to form a medicament. The user can also shake the entire housing in order to help in this mixing process.

The device may include an electronic / interactive system to provide visual, haptic and / or audible reaction to the user. This interactive system may include a microprocessor to control specific reaction components, a speaker subsystem, a haptic subsystem, a switch and / or sensor subsystem, an LED or optical subsystem, a battery power source, and any other necessary element to produce visual or audible outputs. Figure 4 represents these components located throughout the device; However, the actual placement of these components is flexible. The user can activate the interactive system by pressing a button or switch located in the device housing. This button or switch can activate the processor that can then send signals to the audible output subsystem, haptic output subsystem and / or visual output subsystem. The audible output subsystem can provide an audible clue to the initial task, which may be in the form of a human, humanoid and / or understandable voice indicating: "Please remove the safety tab." A signal can also be sent simultaneously to the visual safety tongue output (possibly one or more LEDs) to provide a visual clue of light and / or color to the user about where the safety tongue is located. Once the safety tab has been removed, a switch or sensor can send a signal to the processor and activate the next audible, haptic and / or visual track. This may be a human voice that says "Please rotate the top of the injector to activate the mixing mechanism." As with the safety tab, an LED or some other visual track can then be activated, illuminating the mixing activation mechanism, and / or a haptic track can be activated, such as vibrating, heating, cooling, bulking, move, change a texture, etc., of the mixing activation mechanism. A switch or sensor located near or in the mixing trigger mechanism can be used to ensure the mixing is complete and to trigger the next visual and / or audible track through the processor. A voice below may indicate, "Please shake gently to mix the solution." After a certain period of time, the processor can then send a signal to the audible output subsystem for the next task. This may be a voice that says: "Please place the injector on the outside of the thigh." A visual indicator of where the base / injector should be placed can also be activated simultaneously. A switch, sensor or button can then recognize the correct placement of the device and trigger the next audible and visual track. This may be a voice that says "Push down on the top of the injector to activate the injection." Similarly, an arrow or some other visual and / or haptic clue can illuminate and / or cause movement of how the injector should be pushed. The last track may be an audible track that indicates, "Hold in place for a few seconds, remove and dispose of properly," indicating that the injection is complete. Additional audible, haptic and / or visual reaction subsystems can be used to provide the user with important information such as expiration of the drug, misuse and / or error. For example, the LEDs or optics of the device may flash, a display may represent a message, a vibrator may vibrate and / or an audible beep and / or the voice may be activated after a certain time stamp corresponding to the expiration of the drug and / or the device. As another example, once an auto-injector has been used, a message describing appropriate disposal and / or recycling techniques can be displayed.

FIG. 26 is a block diagram of an example information system and / or device 26000, which in certain operational embodiments may comprise, for example, the interactive, integral, integrated, audible, haptic and / or visual reaction system, such as It is described herein. The information system and / or device 26000 may comprise any of many components, such as, for example, one or more network interfaces 26100, one or more processors 26200 running an integrated operating system in real time, critical real time and / or in real-time uncritical, one or more 26300 memories containing 26400 instructions, one

or more 26500 input / output (I / O) devices, and / or one or more 26600 user interfaces coupled to the 26500 I / O device, etc.

In certain examples of systems through one or more user interfaces 26600, such as a graphical user interface, the user may see a representation of the information related to the selection, purchase, procurement, operation, maintenance, repeated use and / or elimination of a self-injection. In some examples of embodiments, instructions 26400 can be modified and / or updated by replacing a removable memory 26300 and / or replacing instructions 26400 (such as, for example, by rapid programming (flashing) of the EEPROM, etc. ). In certain examples of systems, the instructions 26400 can be modified and / or updated by downloading the replacement instructions through the network interface 26100. The 26000 system may comprise a programmable logic controller.

However, other practical and useful embodiments will be apparent to those skilled in this art after reading the aforementioned detailed description and drawings of certain examples of embodiments. It should be understood that numerous variants, modifications and additional embodiments are possible, and therefore all these variations, modifications and embodiments must be considered within the spirit and scope of this application.

Thus, regardless of the content of any part (for example, title, field, background, compendium, summary, figures of drawings, etc.) of this application, unless clearly stated otherwise, such as by definition, Explicit statement or argument, with respect to any claim, either of this application and / or any claim of any application that claims the right of priority of this report, and whether it is originally filed or otherwise:

there is no requirement for the inclusion of any particular characteristic, function, activity or element described or illustrated, particular sequence of activities or of particular interrelation of elements;

any element can be integrated, segregated and / or duplicated;

any activity can be repeated, carried out by multiple entities and / or carried out in multiple jurisdictions; 5 and

Any activity or element may be specifically excluded, the sequence of activities may vary and / or the interrelation of the elements may vary.

Therefore, descriptions and drawings should be considered illustrative in nature and not as restrictive. On the other hand, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate. When any interval is described herein, unless otherwise indicated, that interval includes all the values in it and all sub-intervals in it. Any information on any material (for example, a United States patent, United States patent application, book, article, etc.) that has been incorporated by reference herein, is incorporated by reference only to the extent that there is any conflict between that information and others

15 statements and drawings described in this report.

In the case of such conflicts, including a conflict that could invalidate any claim in this report or seek priority over it, then any conflicting information incorporated therein as reference material is not incorporated into this report especially by reference.

Claims (15)

1. An apparatus, comprising: an accommodation (1100); a medicine container (5100) disposed within the housing (1100), the medicine container (5100) is configured to contain a medicine; an activation mechanism (2000) configured to produce a force to administer the medication from the medication container (5100); Y a base (1300) configured to activate the activation mechanism (2000); characterized in that: a locking member (1200) is configured to engage a part of the base to prevent actuation of the activation mechanism; Y an electronic circuit system configured to be coupled to the housing (1100), the electronic circuit system includes a switch arranged where a part of the base slides to activate the activation mechanism (2000) such that the switch is actuated when the activation mechanism (2000) is operated, the electronic circuit system is further configured to produce a recorded output of the address when the switch is operated, The activation mechanism (2000) is configured to produce the force independently of the electronic circuit system.

2.

The apparatus of claim 1, wherein the recorded speech output is a first recorded speech output of a plurality of recorded output outputs, the electronic circuit system is configured to produce each of the plurality of recorded output outputs in a default sequence

3.

The apparatus of any preceding claim, wherein the recorded address output includes any of an instruction to use the apparatus, an indication of a condition of the apparatus, an indication of the expiration date associated with the medicament or an indication of a position of the device

Four.

The apparatus of any preceding claim, wherein the recorded address output includes an instruction associated with placing the apparatus next to a body.

5.

The apparatus of any preceding claim, wherein: the electronic circuit system includes a sensor; and the electronic circuit system is configured to produce an electronic output in response to a signal

received from the sensor.

6.

The apparatus of any preceding claim, wherein the electronic circuit system includes at least one of a loudspeaker, a light emitting diode, a liquid crystal display, an organic polymer screen, a fiber optic screen, a vibrator , a heater, a cooler or a piezoelectric transducer.

7.

The apparatus of any one of claims 1 to 7, further comprising:

A needle (6100) configured to be in fluid communication with the medication container (5100), the activation mechanism (2000) is configured to produce the force to move the needle (6100) between a first position, where the needle (6100) is contained within the housing (1100), and a second position, where a part of the needle (6100) extends from the housing (1100).

8.

The apparatus of any preceding claim, wherein:

the recorded speech output is a first recorded speech output; and the electronic circuit system is configured to produce a second recorded speech output when the locking member (1200) is moved relative to the housing (1100).

9.

The apparatus of any preceding claim, wherein: the switch is a first switch; the recorded speech output is a first recorded speech output; Y

the electronic circuit system, including a second switch functionally coupled to the locking member (1200) such that the locking member (1200) operates the second switch when the locking member (1200) moves, the electronic circuit system It is configured to produce a second recorded address output when the second switch is operated.

10.

The apparatus of any preceding claim, wherein:

the recorded speech output is a first recorded speech output; Y The electronic circuit system further includes a light output device next to the base, the electronic circuit system is configured to produce a light output through the light output device and a second recorded speech output when the member of locked (1200) moves relative to the housing (1100).

eleven.

The apparatus of any preceding claim, wherein the base defines an opening through which a needle (6100) is disposed when the medication is administered from the medication container (5100).

12.

The apparatus of any preceding claim, wherein the activation mechanism (2000) includes at least one of a compressed gas container or a spring configured to produce force.

13.

The apparatus of any preceding claim, wherein the medicament container (5100) contains epinephrine.

14.

The apparatus of any preceding claim, wherein:

the activation mechanism (2000) includes an actuation member (2200) configured to move inside the housing (1100) when the activation mechanism (2000) is operated; Y A part of the base (1300) is configured to engage the drive member (2200) when the base (1300) is moved relative to the housing (1100) to allow movement of the drive member (2200). 15. The apparatus of any preceding claim, wherein: The activation mechanism (2000) includes a spring (2300) and a drive member (2200), the drive member (2200) is configured to be moved into the housing (1100) by the spring, when the release member is released. drive (2200), the drive member (2200) includes two tips (2240); Y The locking member (1200) includes a separation part (1240) configured to be disposed between the tips (2240) of the actuating member (2200) when the locking member is coupled to the housing to prevent activation of the activation mechanism ( 2000), the electronic circuit system is configured to produce a second recorded address output when the locking member moves relative to the housing.