ES2215893T3 - Derivados de beta-aminoacidos como inhibidores de metaloproteasas de matriz y tnf-alfa. - Google Patents

Derivados de beta-aminoacidos como inhibidores de metaloproteasas de matriz y tnf-alfa.

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Publication number
ES2215893T3
ES2215893T3 ES01924171T ES01924171T ES2215893T3 ES 2215893 T3 ES2215893 T3 ES 2215893T3 ES 01924171 T ES01924171 T ES 01924171T ES 01924171 T ES01924171 T ES 01924171T ES 2215893 T3 ES2215893 T3 ES 2215893T3
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crara1
nra1
absent
substituted
group
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ES01924171T
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English (en)
Inventor
Jingwu Duan
Bryan W. King
Carl Decicco
Thomas P. Maduskuie, Jr.
Matthew E. Voss
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Bristol Myers Squibb Pharma Co
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Bristol Myers Squibb Pharma Co
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Abstract

Un nuevo compuesto de fórmula I: **(fórmula)** o un estereoisómero o forma de sal farmacéuticamente aceptable del mismo, donde: A se selecciona entre -COR5, -CO2H, -CO2R6, -C(O)NHOH, -C(O)NHOR5, -C(O)NHOR6, -NHRa, -N(OH)COR5, -N(OH)CHO, -SH, -CH2SH, -S(O)(=NH)Ra, -S(=NH)2Ra, -SC(O)Ra, -PO(OH)2 y -PO(OH)NHRa; X está ausente o se selecciona entre alquileno C1-3, alquenileno C2-3 y alquinileno C2-3; Z está ausente o se selecciona entre un carbociclo C3-13 sustituido con 0-5 Rb y un heterociclo de 5-14 miembrosque comprende átomos de carbono y 1-4 heteroátomos seleccionados entre el grupo constituido por N, O y S(O)p y sustituido con 0-5 Rb; Ua está ausente o se selecciona entre: O, NRa1, C(O), C(O)O, OC(O), C(O)NRa1, NRa1C(O), OC(O)O, OC(O)NRa1, NRa1C(O)O, NRa1C(O)NRa1, S(O)p, S(O)pNRa1, NRa1S(O)p y NRa1SO2NRa1; Xa está ausente o se selecciona entre alquileno C1-10, alquenileno C2-10 y alquinileno C2-10; Ya está ausente o se selecciona entre O, NRa1, S(O)p y C(O); Za se selecciona entre H, uncarbociclo C3-13 sustituido con 0-5 Rc y un heterociclo de 5-14 miembros que com -prende átomos de carbono y 1-4 heteroátomos seleccionados entre el grupo constituido por N, O y S(O)p y sustituido con 0-5 R Rc; con la condición de que Z, Ua, Ya y Za no se combinen para formar un grupo N-N, N-O, O-N, O-O, S(O)p-O, O-S(O)p o S(O)p-S(O)p; R1 se selecciona entre H, alquilo C1-4, fenilo y bencilo R2 se selecciona entre Q, alquilen C1-6Q, alquenilen C2~6-Q, alquinilen C2-6-Q, (CRaRa1)r1O(CRaRa1)r-Q, (CRa Ra1)r1NRa(CRaRa1)r-Q, (CRaRa1)r1C(O)(CRaRa1)r-Q, (CRaRa1)r1C(O)O(CRaRa1)r-Q, (CRaRa1)r1OC(O)(CRaRa1)rQ, (CRaRa1)r1C(O)NRaRa1, (CRaRa1)r1C(O)NRa(CRaRa1)r-Q, ((CRaRa1)r1NRaC(O)(CRaRa1)r-Q, ((CRaRa1)r1OC(O)O (CRaRa1)r-Q, (CRaRa1)r1OC(O)NRa(CRaRa1)r-Q, (CRaRa1)r1NRaC(O)O(CRaRa1)r-Q, (CRaRa1)r1NRaC(O)NRa(CRa Ra1)r-Q, (CRaRa1)r1S(O)p(CRaRa1)r-Q, (CRaRa1)r1SO2NRa(CRaRa1)r-Q, (CRaRa1)r1NRaSO2(CRaRa1)r-Q y (CRa Ra1)r1NRaSO2NRa(CRaRa1)r-Q; Q se selecciona entre H, un carbociclo C3-13 sustituido con 0-5 R Rd y un heterociclo de 5-14 miembros que com -prende átomos de carbono y 1-4 heteroátomos seleccionados entre el grupo compuesto por N, O y S(O)p y sustituido con 0-5 Rd.
ES01924171T 2000-03-17 2001-03-15 Derivados de beta-aminoacidos como inhibidores de metaloproteasas de matriz y tnf-alfa. Expired - Lifetime ES2215893T3 (es)

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ATE260272T1 (de) 2004-03-15
DE60102137D1 (de) 2004-04-01
DE60102137T2 (de) 2004-10-21
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US6495565B2 (en) 2002-12-17
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HK1049334A1 (en) 2003-05-09
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AU2001250850A1 (en) 2001-10-03
CA2400168A1 (en) 2001-09-27
AR035174A1 (es) 2004-05-05
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