ES2195571T3 - Nuevos benzonaftiridin-n-oxidos. - Google Patents
Nuevos benzonaftiridin-n-oxidos.Info
- Publication number
- ES2195571T3 ES2195571T3 ES99922133T ES99922133T ES2195571T3 ES 2195571 T3 ES2195571 T3 ES 2195571T3 ES 99922133 T ES99922133 T ES 99922133T ES 99922133 T ES99922133 T ES 99922133T ES 2195571 T3 ES2195571 T3 ES 2195571T3
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- hydroxy
- cycloalkylmethoxy
- cycloalkoxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- -1 1-piperidyl Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Glass Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
1. Compuestos de fórmula I en donde R1 significa alquilo (C1-C4), R2 significa hidroxi, alcoxi (C1-C4), cicloalcoxi (C3-C7), cicloalquilmetoxi (C3-C7) o alcoxi (C1-C4) completa o predominantemente sustituido por flúor, R3 significa hidroxi, alcoxi (C1-C4), cicloalcoxi (C3-C7), cicloalquilmetoxi (C3-C7) o alcoxi (C1-C4) completa o predominantemente sustituido por flúor, o en donde R2 y R3 significan juntos un grupo alquilendioxi (C1-C2), R4 representa un resto fenilo sustituido por R5 y R6, en donde R5 significa hidrógeno, hidroxi, halógeno, nitro, alquilo (C1-C4), trifluorometilo o alcoxi (C1-C4), R6 significa CO-R7 o CO-R8, en donde R7 significa hidroxi, alcoxi (C1-C8), cicloalcoxi (C3-C7) o cicloalquilmetoxi (C3-C7), y R8 significa N(R81)R82, significando R81 y R82, independientemente entre sí, hidrógeno, alquilo (C1C7), cicloalquilo (C3-C7) o cicloalquilmetilo (C3-C7), o en donde R81 y R82 juntos y con inclusión del átomo de nitrógeno al que ambos están unidos representan un resto 1-pirrolidinilo, 1-piperidilo, 1-hexahidroazepinilo o 4-morfolinilo, así como las sales de estos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98108124 | 1998-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2195571T3 true ES2195571T3 (es) | 2003-12-01 |
Family
ID=8231880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99922133T Expired - Lifetime ES2195571T3 (es) | 1998-05-05 | 1999-04-27 | Nuevos benzonaftiridin-n-oxidos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6306869B1 (es) |
| EP (1) | EP1075477B1 (es) |
| JP (1) | JP2002513793A (es) |
| AT (1) | ATE234301T1 (es) |
| AU (1) | AU3928999A (es) |
| CA (1) | CA2330738A1 (es) |
| DE (1) | DE59904535D1 (es) |
| DK (1) | DK1075477T3 (es) |
| ES (1) | ES2195571T3 (es) |
| PT (1) | PT1075477E (es) |
| SI (1) | SI1075477T1 (es) |
| WO (1) | WO1999057118A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002523505A (ja) | 1998-08-31 | 2002-07-30 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Ｐｄｅ３−及びｐｄｅ−４抑制作用を有するベンゾナフチリデン−ｎ−オキシド |
| EP2193808A1 (en) * | 1999-08-21 | 2010-06-09 | Nycomed GmbH | Synergistic combination |
| US6630483B2 (en) | 2000-01-11 | 2003-10-07 | Altana Pharma Ag | Phenanthridine-N-oxides |
| DK1377574T3 (da) | 2001-02-21 | 2005-04-25 | Altana Pharma Ag | 6-phenylbenzonaphtyridiner |
| PL373598A1 (en) * | 2002-08-17 | 2005-09-05 | Altana Pharma Ag | Novel benzonaphthyridines |
| DE60310576T2 (de) | 2002-08-29 | 2007-10-31 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer |
| AU2003273805B8 (en) * | 2002-08-29 | 2010-06-17 | Takeda Gmbh | 3-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| ATE360021T1 (de) * | 2002-09-04 | 2007-05-15 | Altana Pharma Ag | Neue benzonaphthyridine |
| US7470704B2 (en) * | 2002-09-04 | 2008-12-30 | Nycomed Gmbh | Benzonaphthyridines |
| IS7839A (is) * | 2002-11-22 | 2004-05-23 | Merck Frosst Canada Ltd. | 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar |
| CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| ES2505473T3 (es) | 2004-03-03 | 2014-10-10 | Takeda Gmbh | Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la PDE4 |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| KR20060124784A (ko) * | 2004-03-09 | 2006-12-05 | 알타나 파마 아게 | 신규한 이소아미도 치환된 히드록시-6-페닐페난트리딘 및ｐｄｅ４ 억제제로서의 이의 용도 |
| WO2005085203A1 (en) * | 2004-03-10 | 2005-09-15 | Altana Pharma Ag | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| CA2558390A1 (en) * | 2004-03-10 | 2005-09-22 | Altana Pharma Ag | Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| KR20060130697A (ko) * | 2004-03-10 | 2006-12-19 | 알타나 파마 아게 | 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도 |
| JP2007529471A (ja) | 2004-03-17 | 2007-10-25 | アルタナ ファルマ アクチエンゲゼルシャフト | 新規のｎ−（アルコキシアルキル）カルバモイル置換された６−フェニル−ベンゾナフチリジン誘導体及びｐｄｅ３／４インヒビターとしてのそれらの使用 |
| WO2006027344A2 (en) | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | 3-oxa-10-aza-phenanthrenes as pde4 or pde3/4 inhibitors |
| CA2579000C (en) | 2004-09-08 | 2013-02-05 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
| US7718668B2 (en) | 2005-03-02 | 2010-05-18 | Nycomed Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0247971A3 (en) * | 1986-05-29 | 1990-01-17 | Sandoz Ag | Novel pharmaceutical compositions comprising and use of cis-6-(4-acetanilido)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin |
| EA001551B1 (ru) | 1996-11-11 | 2001-04-23 | Бык Гюльден Ломберг Хемише Фабрик Гмбх | Бензонафтиридины в качестве бронхиальных терапевтических средств |
-
1999
- 1999-04-27 PT PT99922133T patent/PT1075477E/pt unknown
- 1999-04-27 ES ES99922133T patent/ES2195571T3/es not_active Expired - Lifetime
- 1999-04-27 EP EP99922133A patent/EP1075477B1/de not_active Expired - Lifetime
- 1999-04-27 SI SI9930279T patent/SI1075477T1/xx unknown
- 1999-04-27 JP JP2000547088A patent/JP2002513793A/ja not_active Withdrawn
- 1999-04-27 CA CA002330738A patent/CA2330738A1/en not_active Abandoned
- 1999-04-27 US US09/673,649 patent/US6306869B1/en not_active Expired - Fee Related
- 1999-04-27 DK DK99922133T patent/DK1075477T3/da active
- 1999-04-27 DE DE59904535T patent/DE59904535D1/de not_active Expired - Fee Related
- 1999-04-27 AU AU39289/99A patent/AU3928999A/en not_active Abandoned
- 1999-04-27 WO PCT/EP1999/002827 patent/WO1999057118A1/de active IP Right Grant
- 1999-04-27 AT AT99922133T patent/ATE234301T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1075477B1 (de) | 2003-03-12 |
| ATE234301T1 (de) | 2003-03-15 |
| WO1999057118A1 (de) | 1999-11-11 |
| DE59904535D1 (de) | 2003-04-17 |
| EP1075477A1 (de) | 2001-02-14 |
| US6306869B1 (en) | 2001-10-23 |
| SI1075477T1 (en) | 2003-08-31 |
| PT1075477E (pt) | 2003-07-31 |
| AU3928999A (en) | 1999-11-23 |
| DK1075477T3 (da) | 2003-06-30 |
| JP2002513793A (ja) | 2002-05-14 |
| CA2330738A1 (en) | 1999-11-11 |
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