ES2195040T3 - Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento. - Google Patents

Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento.

Info

Publication number
ES2195040T3
ES2195040T3 ES96946222T ES96946222T ES2195040T3 ES 2195040 T3 ES2195040 T3 ES 2195040T3 ES 96946222 T ES96946222 T ES 96946222T ES 96946222 T ES96946222 T ES 96946222T ES 2195040 T3 ES2195040 T3 ES 2195040T3
Authority
ES
Spain
Prior art keywords
polypeptide
polieteres
conjugado
various
active principle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96946222T
Other languages
English (en)
Inventor
Hannsjorg Sinn
Wolfgang Maier-Borst
Hans-Hermann Schrenk
Gerd Stehle
Heinz-H Fiebig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Application granted granted Critical
Publication of ES2195040T3 publication Critical patent/ES2195040T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Cosmetics (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE CONJUGADOS, QUE COMPRENDEN UN PRINCIPIO ACTIVO, UN POLIPEPTIDO Y UN POLIETER, PROCEDIMIENTO PARA LA PREPARACION DE TALES CONJUGADOS ASI COMO SU UTILIZACION.
ES96946222T 1995-12-21 1996-12-20 Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento. Expired - Lifetime ES2195040T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19548114A DE19548114C2 (de) 1995-12-21 1995-12-21 Konjugat, umfassend einen Wirkstoff, ein Polypeptid und einen Polyether

Publications (1)

Publication Number Publication Date
ES2195040T3 true ES2195040T3 (es) 2003-12-01

Family

ID=7780997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96946222T Expired - Lifetime ES2195040T3 (es) 1995-12-21 1996-12-20 Conjugado que incluye un principio activo, un polipeptido y varios polieteres y su uso como medicamento.

Country Status (8)

Country Link
US (1) US6395254B1 (es)
EP (1) EP0952853B1 (es)
JP (1) JP2000502109A (es)
AT (1) ATE234636T1 (es)
DE (2) DE19548114C2 (es)
DK (1) DK0952853T3 (es)
ES (1) ES2195040T3 (es)
WO (1) WO1997023240A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818626B1 (en) * 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US6852334B1 (en) * 1999-04-20 2005-02-08 The University Of British Columbia Cationic peg-lipids and methods of use
US7189705B2 (en) * 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
CN1969190A (zh) * 2004-04-20 2007-05-23 爱默蕾大学 多峰性纳米结构，其制造方法以及其使用方法
EP2325232A1 (en) 2005-12-05 2011-05-25 Nitto Denko Corporation Polyglutamate-amino acid conjugates and methods
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
JP2010526159A (ja) * 2007-04-10 2010-07-29 日東電工株式会社 多機能性ポリグルタミン酸塩薬物担体
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
CN101707869A (zh) * 2007-05-09 2010-05-12 日东电工株式会社 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物
EP2155255B1 (en) * 2007-05-09 2013-08-14 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
JP2011513412A (ja) * 2008-03-06 2011-04-28 日東電工株式会社 ポリマーパクリタキセル結合体を含む癌を治療するための薬学組成物
GB201401453D0 (en) * 2014-01-28 2014-03-12 Univ Birmingham Transmucosal and transepithelial drug delivery system
EP3400945A4 (en) * 2016-01-08 2019-09-11 Nippon Kayaku Kabushiki Kaisha POLYMER DERIVATIVE OF MACROLIDE IMMUNOSUP PRESSIVA
US10905770B2 (en) 2017-07-17 2021-02-02 Macregen, Inc. Topical delivery of therapeutic agents using cell-penetrating peptides for the treatment of age-related macular degeneration and other eye diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US5308604A (en) * 1989-04-19 1994-05-03 Deutsches Krebsforschungsinstitut Conjugates for tumor localization and/or tumor therapy
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
DE4017439C2 (de) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyethersubstituierte Tumormittel
WO1994005203A1 (en) 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
US5605672A (en) 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5567410A (en) 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
WO1996000079A1 (en) 1994-06-27 1996-01-04 The General Hospital Corporation Graft co-polymer adducts of platinum (ii) compounds
US5958372A (en) 1994-06-28 1999-09-28 Nycomed Imaging As Low viscosity chelating polymers for diagnostic imaging

Also Published As

Publication number Publication date
US6395254B1 (en) 2002-05-28
EP0952853B1 (de) 2003-03-19
DE19548114A1 (de) 1997-06-26
EP0952853A2 (de) 1999-11-03
DE19548114C2 (de) 2000-04-27
WO1997023240A2 (de) 1997-07-03
WO1997023240A3 (de) 1997-10-09
DK0952853T3 (da) 2003-07-14
DE59610251D1 (de) 2003-04-24
ATE234636T1 (de) 2003-04-15
JP2000502109A (ja) 2000-02-22

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