ES2166278A1 - Method for the preparation of nasal powders by atomization using insoluble and absorbing excipients as nasal absorption promoters - Google Patents

Method for the preparation of nasal powders by atomization using insoluble and absorbing excipients as nasal absorption promoters

Info

Publication number
ES2166278A1
ES2166278A1 ES009902043A ES9902043A ES2166278A1 ES 2166278 A1 ES2166278 A1 ES 2166278A1 ES 009902043 A ES009902043 A ES 009902043A ES 9902043 A ES9902043 A ES 9902043A ES 2166278 A1 ES2166278 A1 ES 2166278A1
Authority
ES
Spain
Prior art keywords
drug
nasal
insoluble
atomization
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009902043A
Other languages
Spanish (es)
Other versions
ES2166278B2 (en
Inventor
Duran Santiago Torrado
Duran Juan Jose Torrado
Arieta Alfredo Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad Complutense de Madrid
Original Assignee
Universidad Complutense de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Complutense de Madrid filed Critical Universidad Complutense de Madrid
Priority to ES9902043A priority Critical patent/ES2166278B2/en
Priority to PCT/ES2000/000346 priority patent/WO2001019344A1/en
Priority to AU74229/00A priority patent/AU7422900A/en
Publication of ES2166278A1 publication Critical patent/ES2166278A1/en
Application granted granted Critical
Publication of ES2166278B2 publication Critical patent/ES2166278B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to an atomization method which involves adding the drug solution to the excipient which should be insoluble in the dispersing medium and in the solvent of the drug solution and capable of absorbing the added drug solution solvent. Said excipient that is hydrated and charged with the drug is dispersed in one of the two following media: 1) a medium in which the drug is insoluble and immiscible with the drug solution solvent to prevent the drug from escaping into the dispersing medium 2) a medium not matching the above-mentioned characteristics but to which the hydrated excipient charged with the drug is added just before nebulization so that the drug has no time to escape.
ES9902043A 1999-09-14 1999-09-14 PROCEDURE FOR PREPARING NASAL POWDER BY ATOMIZATION USING INSOLUBLE AND ABSORBENT EXCIPIENTS AS NASAL ABSORPTION PROMOTERS. Expired - Fee Related ES2166278B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9902043A ES2166278B2 (en) 1999-09-14 1999-09-14 PROCEDURE FOR PREPARING NASAL POWDER BY ATOMIZATION USING INSOLUBLE AND ABSORBENT EXCIPIENTS AS NASAL ABSORPTION PROMOTERS.
PCT/ES2000/000346 WO2001019344A1 (en) 1999-09-14 2000-09-14 Method for the preparation of nasal powders by atomization using insoluble and absorbing excipients as nasal absorption promoters
AU74229/00A AU7422900A (en) 1999-09-14 2000-09-14 Method for the preparation of nasal powders by atomization using insoluble and absorbing excipients as nasal absorption promoters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9902043A ES2166278B2 (en) 1999-09-14 1999-09-14 PROCEDURE FOR PREPARING NASAL POWDER BY ATOMIZATION USING INSOLUBLE AND ABSORBENT EXCIPIENTS AS NASAL ABSORPTION PROMOTERS.

Publications (2)

Publication Number Publication Date
ES2166278A1 true ES2166278A1 (en) 2002-04-01
ES2166278B2 ES2166278B2 (en) 2003-06-16

Family

ID=8309931

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9902043A Expired - Fee Related ES2166278B2 (en) 1999-09-14 1999-09-14 PROCEDURE FOR PREPARING NASAL POWDER BY ATOMIZATION USING INSOLUBLE AND ABSORBENT EXCIPIENTS AS NASAL ABSORPTION PROMOTERS.

Country Status (3)

Country Link
AU (1) AU7422900A (en)
ES (1) ES2166278B2 (en)
WO (1) WO2001019344A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576224B1 (en) 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20060024241A1 (en) * 2004-08-02 2006-02-02 Bebaas, Inc. Vitamin B12 compositions
US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0490806A2 (en) * 1990-09-20 1992-06-17 Sandoz Ltd. Nasal pharmaceutical compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0490806A2 (en) * 1990-09-20 1992-06-17 Sandoz Ltd. Nasal pharmaceutical compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CONTE, U. et al. Spray-dried albumin microspheres containing nicardipine. Eur. J. Pharm. Biopharm., (1994), 40 (4), 203-8. *
VIDGREN, P. et al. In vitro and in vivo evaluation of nasal mucoadhesion of disodium cromoglycate microspheres. Proc. Program. Int. Symp. Controlled Release Bioact. Mater., 18th, (1991), 638-9. Editor(s): Kellaway, Ian W. Publisher: Controlled Release Soc., Deerfield, IL. *

Also Published As

Publication number Publication date
WO2001019344A1 (en) 2001-03-22
AU7422900A (en) 2001-04-17
ES2166278B2 (en) 2003-06-16

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