ES2107376B1 - NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY. - Google Patents

NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY.

Info

Publication number
ES2107376B1
ES2107376B1 ES9501564A ES9501564A ES2107376B1 ES 2107376 B1 ES2107376 B1 ES 2107376B1 ES 9501564 A ES9501564 A ES 9501564A ES 9501564 A ES9501564 A ES 9501564A ES 2107376 B1 ES2107376 B1 ES 2107376B1
Authority
ES
Spain
Prior art keywords
alquilo
optionally replaced
pirimidona
antifungal activity
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9501564A
Other languages
Spanish (es)
Other versions
ES2107376A1 (en
Inventor
Javier Bartroli
Manuel Anguita
Enric Turmo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES9501564A priority Critical patent/ES2107376B1/en
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to CA002201478A priority patent/CA2201478A1/en
Priority to MX9702382A priority patent/MX9702382A/en
Priority to KR1019970701515A priority patent/KR100423590B1/en
Priority to DK96929201T priority patent/DK0783501T3/en
Priority to EP96928404A priority patent/EP0783502A1/en
Priority to KR1019970701516A priority patent/KR970705560A/en
Priority to BR9606547A priority patent/BR9606547A/en
Priority to ES96929201T priority patent/ES2153975T3/en
Priority to JP9507253A priority patent/JPH10507205A/en
Priority to EP96929201A priority patent/EP0783501B9/en
Priority to US08/809,967 priority patent/US5807854A/en
Priority to PCT/EP1996/003420 priority patent/WO1997005130A1/en
Priority to CA002201477A priority patent/CA2201477C/en
Priority to BR9606546A priority patent/BR9606546A/en
Priority to AT96929201T priority patent/ATE198593T1/en
Priority to AU67889/96A priority patent/AU6788996A/en
Priority to MX9702380A priority patent/MX9702380A/en
Priority to AU68703/96A priority patent/AU6870396A/en
Priority to US08/809,815 priority patent/US5888941A/en
Priority to PT96929201T priority patent/PT783501E/en
Priority to JP50725497A priority patent/JP4049207B2/en
Priority to DE69611512T priority patent/DE69611512T2/en
Priority to PCT/EP1996/003419 priority patent/WO1997005131A1/en
Priority to ARP960103877A priority patent/AR004180A1/en
Priority to NO19971470A priority patent/NO312898B1/en
Priority to NO971471A priority patent/NO971471L/en
Publication of ES2107376A1 publication Critical patent/ES2107376A1/en
Publication of ES2107376B1 publication Critical patent/ES2107376B1/en
Application granted granted Critical
Priority to GR20010400466T priority patent/GR3035621T3/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA I, EN FORMA DE RACEMICOS O EN FORMA DE SU ENANTIOMEROS BIOLOGICAMENTE ACTIVOS PUROS, Y SUS SALES Y SOLVATOS, EN DONDE AR ES UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO POR UNO O MAS GRUPOS HALOGENO Y/O TRIFLUOROMETILO; R1 ES C1-C4 ALQUILO; R2 ES HIDROGENO O C1-C4 ALQUILO, O BIEN R1 JUNTO CON R2 FORMAN UNA CADENA DE C2-C4 POLIMETILENO; R3 ES HIDROGENO, C1-C6 ALQUILO, C3-C6 CICLOALQUILO, C3-C6 CICLOALQUIL-C1-C4 ALQUILO, C1-C4 HALOALQUILO, FENIL-C1-C4 ALQUILO, OH, SH, FENILO OPCIONALMENTE SUSTITUIDO, NAFTILO, UN GRUPO HETEROCICLICO DE 5 A 6 ATOMOS OPCIONALMENTE SUSTITUIDO; A REPRESENTA UN ANILLO BENCENICO O UN GRUPO HETEROCICLICO DE 5 A 6 ATOMOS QUE PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS. DICHOS COMPUESTOS SON UTILES COMO ANTIFUNGICOS. SE DESCRIBE TAMBIEN PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.COMPOUNDS OF FORMULA I, IN THE FORM OF RACEMICS OR IN THE FORM OF ITS BIOLOGICALLY ACTIVE PURE ENANTIOMERS, AND THEIR SALTS AND SOLVATES, WHERE AR IS A PHENYLUS GROUP OPTIONALLY REPLACED BY ONE OR MORE HALOGEN AND / OR TRIFLUOROME GROUPS; R1 IS C1-C4 ALKYL; R2 IS HYDROGEN OR C1-C4 ALKYL, OR R1 TOGETHER WITH R2 FORM A CHAIN OF C2-C4 POLYMETHYLENE; R3 ES HYDROGEN, C1-C6 ALQUILO, C3-C6 CICLOALQUILO, C3-C6 CICLOALQUIL-C1-C4 ALQUILO, C1-C4 HALOALQUILO, FENIL-C1-C4 ALQUILO, OH, SHENO, FUTYL, UNIQUE, NAFURO 5 TO 6 ATOMS OPTIONALLY REPLACED; A REPRESENTS A BENZENE RING OR A HETERO-CYCLIC GROUP OF 5 TO 6 ATOMS THAT MAY BE OPTIONALLY REPLACED. SUCH COMPOUNDS ARE USEFUL AS ANTIFUNGALS. IT IS ALSO DESCRIBED PROCEDURES FOR THEIR OBTAINING AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

ES9501564A 1995-08-02 1995-08-02 NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY. Expired - Fee Related ES2107376B1 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
ES9501564A ES2107376B1 (en) 1995-08-02 1995-08-02 NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY.
PCT/EP1996/003419 WO1997005131A1 (en) 1995-08-02 1996-08-02 New carboxamides with antifungal activity
KR1019970701515A KR100423590B1 (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with antifungal activity
DK96929201T DK0783501T3 (en) 1995-08-02 1996-08-02 Pyrimidone derivatives with anti-fungal activity
EP96928404A EP0783502A1 (en) 1995-08-02 1996-08-02 New carboxamides with antifungal activity
KR1019970701516A KR970705560A (en) 1995-08-02 1996-08-02 NEW CARBOXAMIDES WITH ANTIFUNGAL ACTIVITY WITH ANTIFUNGAL ACTIVITY
MX9702380A MX9702380A (en) 1995-08-02 1996-08-02 New carboxamides with antifungal activity.
ES96929201T ES2153975T3 (en) 1995-08-02 1996-08-02 DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGIC ACTIVITY.
JP9507253A JPH10507205A (en) 1995-08-02 1996-08-02 Novel carbonamide with antifungal activity
EP96929201A EP0783501B9 (en) 1995-08-02 1996-08-02 pyrimidone derivatives with antifungal activity
US08/809,967 US5807854A (en) 1995-08-02 1996-08-02 Pyrimidone derivatives with antifungal activity
PCT/EP1996/003420 WO1997005130A1 (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with antifungal activity
CA002201477A CA2201477C (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with antifungal activity
BR9606546A BR9606546A (en) 1995-08-02 1996-08-02 New carboxamides with fungicidal activity
CA002201478A CA2201478A1 (en) 1995-08-02 1996-08-02 New carboxamides with antifungal activity
AT96929201T ATE198593T1 (en) 1995-08-02 1996-08-02 PYRIMIDONE DERIVATIVES WITH ANTI-FUNGAL EFFECT
BR9606547A BR9606547A (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with fungicidal activity
AU68703/96A AU6870396A (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with antifungal activity
US08/809,815 US5888941A (en) 1995-08-02 1996-08-02 Carbozamides with antifungal activity
PT96929201T PT783501E (en) 1995-08-02 1996-08-02 PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY
JP50725497A JP4049207B2 (en) 1995-08-02 1996-08-02 Novel pyrimidone derivatives with antifungal activity
DE69611512T DE69611512T2 (en) 1995-08-02 1996-08-02 PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL EFFECT
MX9702382A MX9702382A (en) 1995-08-02 1996-08-02 New pyrimidone derivatives with antifungal activity.
AU67889/96A AU6788996A (en) 1995-08-02 1996-08-02 New carboxamides with antifungal activity
ARP960103877A AR004180A1 (en) 1995-08-02 1996-08-05 NEW PIRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY AND PROCEDURE TO PREPARE THEM.
NO19971470A NO312898B1 (en) 1995-08-02 1997-04-01 New pyrimidone derivatives with fungicidal activity
NO971471A NO971471L (en) 1995-08-02 1997-04-01 New carboxamides with fungicidal activity
GR20010400466T GR3035621T3 (en) 1995-08-02 2001-03-23 New pyrimidone derivatives with antifungal activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501564A ES2107376B1 (en) 1995-08-02 1995-08-02 NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY.

Publications (2)

Publication Number Publication Date
ES2107376A1 ES2107376A1 (en) 1997-11-16
ES2107376B1 true ES2107376B1 (en) 1998-07-01

Family

ID=8291256

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501564A Expired - Fee Related ES2107376B1 (en) 1995-08-02 1995-08-02 NEW DERIVATIVES OF PIRIMIDONA WITH ANTIFUNGAL ACTIVITY.

Country Status (1)

Country Link
ES (1) ES2107376B1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1204494B (en) * 1986-03-28 1989-03-01 Roussel Maestretti Spa DERIVATIVES OF 1-STYRENE SULPHONYL 2-BONE 5-ALCOSS PYROLIDINE, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION AS DRUGS
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (en) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
ES2107376A1 (en) 1997-11-16

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