ES2097703B1 - Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. - Google Patents
Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion.Info
- Publication number
- ES2097703B1 ES2097703B1 ES09500739A ES9500739A ES2097703B1 ES 2097703 B1 ES2097703 B1 ES 2097703B1 ES 09500739 A ES09500739 A ES 09500739A ES 9500739 A ES9500739 A ES 9500739A ES 2097703 B1 ES2097703 B1 ES 2097703B1
- Authority
- ES
- Spain
- Prior art keywords
- eburnamenine
- alkaloids
- nucleus
- alcaloids
- brain activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- VKTOXAGUZWAECL-RBUKOAKNSA-N eburnamenine Chemical class C1=CC=C2C(CCN3CCC4)=C5[C@H]3[C@@]4(CC)C=CN5C2=C1 VKTOXAGUZWAECL-RBUKOAKNSA-N 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 229930013930 alkaloid Natural products 0.000 title abstract 3
- 230000007177 brain activity Effects 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000004936 stimulating effect Effects 0.000 title abstract 2
- 244000299461 Theobroma cacao Species 0.000 abstract 2
- 235000009470 Theobroma cacao Nutrition 0.000 abstract 2
- VKTOXAGUZWAECL-OALUTQOASA-N eburnamenine Natural products C1=CC=C2C(CCN3CCC4)=C5[C@H]3[C@]4(CC)C=CN5C2=C1 VKTOXAGUZWAECL-OALUTQOASA-N 0.000 abstract 2
- VKTOXAGUZWAECL-UHFFFAOYSA-N trans-eburnamenine Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)C=CN5C2=C1 VKTOXAGUZWAECL-UHFFFAOYSA-N 0.000 abstract 2
- 241000208340 Araliaceae Species 0.000 abstract 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 abstract 1
- 235000003140 Panax quinquefolius Nutrition 0.000 abstract 1
- 241001255907 Tonica Species 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000008434 ginseng Nutrition 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 235000015961 tonic Nutrition 0.000 abstract 1
- 230000001256 tonic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/56—Cocoa products, e.g. chocolate; Substitutes therefor making liquid products, e.g. for making chocolate milk drinks and the products for their preparation, pastes for spreading, milk crumb
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/30—Further treatment of dried tea extract; Preparations produced thereby, e.g. instant tea
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F5/00—Coffee; Coffee substitutes; Preparations thereof
- A23F5/24—Extraction of coffee; Coffee extracts; Making instant coffee
- A23F5/36—Further treatment of dried coffee extract; Preparations produced thereby, e.g. instant coffee
- A23F5/40—Further treatment of dried coffee extract; Preparations produced thereby, e.g. instant coffee using organic additives, e.g. milk, sugar
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/14—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing fruits, nuts, e.g. almonds, seeds, plants, plant extracts or essential oils
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UNA NUEVA COMPOSICION ESTIMULANTE DE LA ACTIVIDAD CEREBRAL BASADA EN ALCALOIDES DE NUCLEO DE EBURNAMENINA, Y SUS METODOS DE PREPARACION. LA PRESENTE INVENCION SE BASA EN EL DESCUBRIMIENTO DE LA POTENTE ACCION QUE PRESENTAN CIERTOS ALCALOIDES DE NUCLEO DE EBURNAMENINA CUANDO SE ADMINISTRAN CONJUNTAMENTE CON COMPUESTOS DE ESTRUCTURA DE XANTINA. SE OBTIENE UNA POTENTE ACCION SINERGICA EN LA CAPACIDAD COGNOSCITIVA Y POR TANTO, LA ACTIVIDAD CEREBRAL SE VE REFORZADA EN GENERAL A CORTO Y LARGO PLAZO TRAS LA ADMINISTRACION ORAL DE LA COMPOSICION QUE SE PATENTA. LA COMPOSICION QUE SE PATENTA CONTIENE CANTIDADES COMPRENDIDAS ENTRE 0,5 Y 10YMG DE ALCALOIDES O EXTRACTO DE ALCALOIDES DEL TIPO EBURNAMENINA POR CADA 100YML DE BEBIDA DE COLA, LIMON, CACAO, GINSENG, AGUA TONICA, CAFE, O CUALQUIER OTRA BEBIDA A PARTIR DE EXTRACTOS, Y CANTIDADES COMPRENDIDAS ENTRE 0,5 Y 30YMG DE ALCALOIDES O EXTRACTO DE ALCALOIDES DEL TIPO EBURNAMENINA POR CADA 5-20YG DE EXTRACTO SECO, SEMISECO O HUMEDO DE CAFE, COLA, CACAO,TE, GINSENG DE TONICA O CUALQUIER OTRO EXTRACTO PARA BEBIDA.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09500739A ES2097703B1 (es) | 1995-04-12 | 1995-04-12 | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. |
CNB961905913A CN1161122C (zh) | 1995-04-12 | 1996-04-10 | 基于具有象牙烯宁核的生物碱的刺激大脑活动的新组合物及其制备方法 |
DE69635257T DE69635257D1 (de) | 1995-04-12 | 1996-04-10 | Zusammensetzung enthaltend Vinpocetin-Citrat und einen Xanthin-enthaltenden Pflanzenextrakt zur Stimulierung der Gerhirnaktivität |
MX9606217A MX9606217A (es) | 1995-04-12 | 1996-04-10 | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. |
EP96909178A EP0760240B1 (en) | 1995-04-12 | 1996-04-10 | Composition for stimulating the cerebral activity comprising vinpocetine citrate and a plant extract comprising xanthines |
NZ304889A NZ304889A (en) | 1995-04-12 | 1996-04-10 | Oral composition, which stimulates cerebral activity, containing alkaloids of the eburnamenine type and xanthine bases containing plant extracts |
PCT/ES1996/000082 WO1996032113A1 (es) | 1995-04-12 | 1996-04-10 | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preraracion |
JP8530733A JPH10501558A (ja) | 1995-04-12 | 1996-04-10 | エブルナメニン核のアルカロイドを主原料とする大脳活動を刺激する新しい組成物及びその調製法 |
AU52769/96A AU719877B2 (en) | 1995-04-12 | 1996-04-10 | A new composition which stimulates cerebral activity, based upon alkaloids with an eburnamenine nucleus, and methods for their preparation |
CA002192438A CA2192438C (en) | 1995-04-12 | 1996-04-10 | Novel composition stimulating the cerebral activity and based on alkaloids having an eburnamenine nucleus, and preparation methods |
HU9603272A HU225463B1 (en) | 1995-04-12 | 1996-04-10 | An oral composition enhancing brain's activity |
EA199600105A EA000189B1 (ru) | 1995-04-12 | 1996-04-10 | Композиция на основе алкалоидов эбурнаменинового типа, стимулирующая церебральную активность |
AT96909178T ATE306268T1 (de) | 1995-04-12 | 1996-04-10 | Zusammensetzung enthaltend vinpocetin-citrat und einen xanthin-enthaltenden pflanzenextrakt zur stimulierung der gerhirnaktivität |
BR9606302A BR9606302A (pt) | 1995-04-12 | 1996-04-10 | Composição estimulante da atividade cerebral para uso oral |
PL96317647A PL185056B1 (pl) | 1995-04-12 | 1996-04-10 | Kompozycja do podawania doustnego |
NO19965303A NO313536B1 (no) | 1995-04-12 | 1996-12-11 | Nytt preparat som stimulerer den cerebrale aktivitet og basert pa alkaloider som har en eburnameninkjerne |
US09/654,332 US6290994B1 (en) | 1995-04-12 | 2000-09-01 | Beverage containing caffeine or theobromine and vinpocetine citrate for stimulating cerebral activity |
JP2007247938A JP2008056681A (ja) | 1995-04-12 | 2007-09-25 | エブルナメニン核のアルカロイドを主原料とする大脳活動を刺激する新しい組成物及びその調製法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09500739A ES2097703B1 (es) | 1995-04-12 | 1995-04-12 | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2097703A1 ES2097703A1 (es) | 1997-04-01 |
ES2097703B1 true ES2097703B1 (es) | 1997-12-01 |
Family
ID=8290094
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09500739A Expired - Fee Related ES2097703B1 (es) | 1995-04-12 | 1995-04-12 | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. |
Country Status (17)
Country | Link |
---|---|
US (1) | US6290994B1 (es) |
EP (1) | EP0760240B1 (es) |
JP (2) | JPH10501558A (es) |
CN (1) | CN1161122C (es) |
AT (1) | ATE306268T1 (es) |
AU (1) | AU719877B2 (es) |
BR (1) | BR9606302A (es) |
CA (1) | CA2192438C (es) |
DE (1) | DE69635257D1 (es) |
EA (1) | EA000189B1 (es) |
ES (1) | ES2097703B1 (es) |
HU (1) | HU225463B1 (es) |
MX (1) | MX9606217A (es) |
NO (1) | NO313536B1 (es) |
NZ (1) | NZ304889A (es) |
PL (1) | PL185056B1 (es) |
WO (1) | WO1996032113A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2115561B1 (es) * | 1996-12-10 | 1999-02-16 | L B N Lab S L | Composicion energetica para uso alimentario. |
US6228418B1 (en) * | 1999-04-07 | 2001-05-08 | Cyvex Nutrition | Vegetarian pet treat |
US8153646B2 (en) * | 2000-08-10 | 2012-04-10 | Dart Neuroscience (Cayman) Ltd. | Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation |
DK1355669T3 (da) * | 2000-08-10 | 2011-11-21 | Cold Spring Harbor Lab | Forbedret kognitiv træning |
US20040067986A1 (en) * | 2002-10-04 | 2004-04-08 | Nathan Sassover | Neuro-degenerative inhibitor, neuro-endocrine modulator, and neuro-cerebral metabolism enhancer |
US7207263B2 (en) * | 2003-01-21 | 2007-04-24 | Frito-Lay North America, Inc. | Single mold form fryer with product centering elements |
US7429565B2 (en) | 2003-04-25 | 2008-09-30 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
EP1744732A4 (en) * | 2004-05-07 | 2009-08-26 | Thermo Formulations Ltd | NUTRITIONAL COMPOSITION FOR INCREASING CREATINE IN A SKELETON MUSCLE |
SI2258376T1 (sl) | 2004-07-27 | 2019-04-30 | Gilead Sciences, Inc. | Analogi fosfonata spojin inhibitorjev HIV |
US20060051461A1 (en) * | 2004-09-03 | 2006-03-09 | Jose Antonio | Nutrified coffee compositions |
US20080044522A1 (en) * | 2004-09-03 | 2008-02-21 | Jose Antonio | Nutrified coffee compositions |
US20080003278A1 (en) * | 2006-06-28 | 2008-01-03 | Fernando Calvo Mondelo | Food products and dietary supplements for improving mental performance |
JP2008017734A (ja) * | 2006-07-11 | 2008-01-31 | Memory Secret Inc | 精神的機能を改善するための栄養補助及び栄養摂取食品用の口経投与組成物 |
US8046976B2 (en) * | 2006-07-25 | 2011-11-01 | The Coca-Cola Company | Devices and methods for packaging beverages |
EP2307435B1 (en) | 2008-07-08 | 2012-06-13 | Gilead Sciences, Inc. | Salts of hiv inhibitor compounds |
NZ611965A (en) * | 2008-12-01 | 2015-01-30 | Targacept Inc | Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine |
US9145396B2 (en) | 2008-12-01 | 2015-09-29 | Targacept, Inc. | Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine |
EP2206438B1 (en) * | 2008-12-29 | 2012-02-08 | Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House | Frozen confectionery and beverage products comprising theobromine and caffeine |
CA2798911C (en) | 2010-05-19 | 2018-07-03 | Unilever Plc | Theobromine for increasing hdl-cholesterol |
CN104382846A (zh) * | 2014-10-27 | 2015-03-04 | 威海爱威制药有限公司 | 长春西汀葡萄糖注射液及其制备方法 |
EP3777861A1 (en) * | 2015-08-01 | 2021-02-17 | Sun Pharmaceutical Industries Ltd | Dosage form of vinca alkaloid drug |
CN105153147A (zh) * | 2015-08-04 | 2015-12-16 | 江苏正大清江制药有限公司 | 一种长春西汀与磷酸形成的盐的晶型及制备方法 |
US11124506B2 (en) * | 2016-08-04 | 2021-09-21 | Harbin Pharmaceutical Group Co., Ltd. General Pharmaceutical Factory | Salts and crystal forms of diaza-benzofluoranthrene compounds |
IT201700025286A1 (it) * | 2017-03-07 | 2018-09-07 | Linnea Sa | Forme cristalline di vinpocetina cloridrato |
SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2193587A1 (en) * | 1972-07-31 | 1974-02-22 | Centre Etd Ind Pharma | Vincamine lauryl sulphate compsns - for humans and animals, as a cerebral and coronary vasodilator, without bitter taste |
FR2193586A1 (en) * | 1972-07-31 | 1974-02-22 | Centre Etd Ind Pharma | Vincamine dioctyl sulphosuccinate for medical use - for humans and animals as a cerebral and coronary vasodilator, with no bitter taste |
FR2255890B1 (es) | 1973-12-28 | 1978-01-13 | Centre Etd Ind Pharma | |
ES430063A1 (es) * | 1974-09-14 | 1976-10-01 | Corbera Gubern | Procedimiento para la obtencion de una sal del acido alfa- cetoglutarico. |
FR2319362A1 (fr) * | 1975-07-31 | 1977-02-25 | Parcor | Medicament a base de substances possedant le squelette de l'eburnane |
DE2559384A1 (de) | 1975-12-31 | 1977-07-14 | Josef Dipl Chem Dr Rer N Klosa | Coffein-kombination |
DE2962239D1 (en) | 1978-10-18 | 1982-04-01 | Tate & Lyle Patent Holdings | A method for the preparation of 2-chloro-2-deoxy saccharides and some 2-chloro-2-deoxy saccharides |
US4362730A (en) * | 1980-08-25 | 1982-12-07 | Heinrich Mack Nachf. Chem-Pharm. Fabrik | Vincamine saccharinate and a pharmaceutical composition containing it dissolved therein |
DE3479423D1 (en) | 1984-02-29 | 1989-09-21 | Covex Sa | Citrate of vinpocetine, and process for its preparation |
ES8505677A1 (es) * | 1984-05-10 | 1985-06-16 | Covex Sa | Procedimiento para la preparacion del citrato de la (+) vinpocetina |
US4966893A (en) | 1989-01-13 | 1990-10-30 | Pang Peter K T | Method for treatment of senile dementia |
IT1236649B (it) | 1989-11-03 | 1993-03-25 | Nuovo Pignone Spa | Sistema perfezionato di azionamento a nastro della pinza portatrama per un telaio tessile senza navetta. |
US5571441A (en) | 1994-11-01 | 1996-11-05 | The Procter & Gamble Company | Nutrient supplement compositions providing physiologic feedback |
-
1995
- 1995-04-12 ES ES09500739A patent/ES2097703B1/es not_active Expired - Fee Related
-
1996
- 1996-04-10 AT AT96909178T patent/ATE306268T1/de not_active IP Right Cessation
- 1996-04-10 EP EP96909178A patent/EP0760240B1/en not_active Expired - Lifetime
- 1996-04-10 BR BR9606302A patent/BR9606302A/pt not_active Application Discontinuation
- 1996-04-10 AU AU52769/96A patent/AU719877B2/en not_active Ceased
- 1996-04-10 DE DE69635257T patent/DE69635257D1/de not_active Expired - Lifetime
- 1996-04-10 CA CA002192438A patent/CA2192438C/en not_active Expired - Fee Related
- 1996-04-10 NZ NZ304889A patent/NZ304889A/xx not_active IP Right Cessation
- 1996-04-10 WO PCT/ES1996/000082 patent/WO1996032113A1/es active IP Right Grant
- 1996-04-10 EA EA199600105A patent/EA000189B1/ru not_active IP Right Cessation
- 1996-04-10 PL PL96317647A patent/PL185056B1/pl unknown
- 1996-04-10 JP JP8530733A patent/JPH10501558A/ja not_active Withdrawn
- 1996-04-10 HU HU9603272A patent/HU225463B1/hu not_active IP Right Cessation
- 1996-04-10 CN CNB961905913A patent/CN1161122C/zh not_active Expired - Fee Related
- 1996-04-10 MX MX9606217A patent/MX9606217A/es active IP Right Grant
- 1996-12-11 NO NO19965303A patent/NO313536B1/no not_active IP Right Cessation
-
2000
- 2000-09-01 US US09/654,332 patent/US6290994B1/en not_active Expired - Lifetime
-
2007
- 2007-09-25 JP JP2007247938A patent/JP2008056681A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU719877B2 (en) | 2000-05-18 |
BR9606302A (pt) | 1997-11-18 |
CA2192438A1 (en) | 1996-10-17 |
NO965303L (no) | 1997-01-28 |
NZ304889A (en) | 1999-02-25 |
PL317647A1 (en) | 1997-04-14 |
WO1996032113A1 (es) | 1996-10-17 |
HU225463B1 (en) | 2006-12-28 |
MX9606217A (es) | 1998-03-31 |
DE69635257D1 (de) | 2006-02-23 |
HUP9603272A3 (en) | 2000-07-28 |
JP2008056681A (ja) | 2008-03-13 |
NO965303D0 (no) | 1996-12-11 |
EA199600105A1 (ru) | 1997-09-30 |
HUP9603272A2 (hu) | 2000-04-28 |
JPH10501558A (ja) | 1998-02-10 |
ES2097703A1 (es) | 1997-04-01 |
EP0760240A1 (en) | 1997-03-05 |
PL185056B1 (pl) | 2003-02-28 |
US6290994B1 (en) | 2001-09-18 |
CN1161122C (zh) | 2004-08-11 |
CA2192438C (en) | 2009-03-17 |
NO313536B1 (no) | 2002-10-21 |
AU5276996A (en) | 1996-10-30 |
EP0760240B1 (en) | 2005-10-12 |
EA000189B1 (ru) | 1998-12-24 |
ATE306268T1 (de) | 2005-10-15 |
CN1155842A (zh) | 1997-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2097703B1 (es) | Una nueva composicion estimulante de la actividad cerebral basada en alcaloides de nucleo de eburnamenina, y sus metodos de preparacion. | |
Feder | Bradycardia and syncope induced by fluoxetine. | |
Ross et al. | Dissociative experiences in adolescents and college students. | |
ES2173420T3 (es) | Comprimidos que contienen un antibiotico de beta-lactamico y procedimiento para su produccion. | |
AR003989A1 (es) | Composicion cosmetica o farmaceutica y procedimiento de tratamiento cosmetico, excluido tdo tratamiento terapeutico que utiliza la composicion cosmetica. | |
ES2037086T3 (es) | Procedimiento para preparar formulaciones farmaceuticas. | |
BR9916887A (pt) | Uso de derivados de pirimidina | |
Fawcett et al. | Fluoxetine versus amitriptyline in adult outpatients with major depression. | |
Bracco et al. | Lateralization of choline acetyltransferase (ChAT) activity in fetus and adult human brain | |
Whelpton et al. | Bioavailability of oral physostigmine. | |
Harbison | Clinical considerations in selecting antiplatelet therapy in cerebrovascular disease | |
Meco et al. | Risperidone in Huntington's disease. | |
KR960040370A (ko) | 알콜 장해 예방 및 치료제 조성물 | |
Garner | Sodium nitroprusside treatment in patients with acute strokes | |
Summers et al. | " Use of THA in treatment of Alzheimer-like dementia: Pilot study in twelve patients": Reply. | |
USD230970S (en) | Passenger vehicle | |
USD221340S (en) | Book support for holding a book in open position | |
de Wilde et al. | The antidepressive effect of zimelidine and doxepin in endogenous depression: A double blind study. | |
USD123226S (en) | Front car of a railway train | |
USD224657S (en) | Combined golf ball marker and holder | |
RU96108458A (ru) | Способ лечения заболеваний центральной нервной системы | |
Shimizu et al. | Effects of ozone administration on cerebral and hepatic tissue metabolism in hemorrhagic shock | |
Landes | STUDIES ON THE EFFECTS OF SEVERAL VASOACTIVE AGENTS ON THE BLOOD-CSF BARRIER TO POTASSIUM ION | |
Ledo et al. | Doxepin in the treatment of chronic urticaria | |
Hanna et al. | Erratum to “Impaired mitochondrial translation in human myoblasts harbouring the mitochondrial DNA tRNA lysine 8344 A→ G (MERRF) mutation: relationship to proportion of mutant mitochondrial DNA”: J. Neurol. Sci. 130 (1995) 154–160 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent |
Owner name: DECOX, S.A. |
|
EC2A | Search report published |
Date of ref document: 19970401 Kind code of ref document: A1 Effective date: 19970401 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20150826 |