ES2092962B1 - Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. - Google Patents

Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.

Info

Publication number
ES2092962B1
ES2092962B1 ES09500756A ES9500756A ES2092962B1 ES 2092962 B1 ES2092962 B1 ES 2092962B1 ES 09500756 A ES09500756 A ES 09500756A ES 9500756 A ES9500756 A ES 9500756A ES 2092962 B1 ES2092962 B1 ES 2092962B1
Authority
ES
Spain
Prior art keywords
acid derivatives
fenilacetoxiacetico
dihalofenilamino
igu
preparation procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09500756A
Other languages
English (en)
Other versions
ES2092962A1 (es
Inventor
Masia Xavier Serra
Sallent Joan Pi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prodesfarma SA
Original Assignee
Prodes SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodes SA filed Critical Prodes SA
Priority to ES09500756A priority Critical patent/ES2092962B1/es
Priority to CO96013810A priority patent/CO4700445A1/es
Priority to AU50428/96A priority patent/AU683790B2/en
Priority to ZA962981A priority patent/ZA962981B/xx
Priority to KR1019960011470A priority patent/KR960037641A/ko
Priority to CA002174287A priority patent/CA2174287A1/en
Priority to EP96106009A priority patent/EP0738706B1/en
Priority to AT96106009T priority patent/ATE171936T1/de
Priority to CN96105067A priority patent/CN1138027A/zh
Priority to NZ286388A priority patent/NZ286388A/en
Priority to DE69600739T priority patent/DE69600739D1/de
Priority to HU9600996A priority patent/HUP9600996A3/hu
Priority to NO961537A priority patent/NO961537L/no
Priority to US08/634,763 priority patent/US5844696A/en
Priority to JP8098815A priority patent/JPH0920738A/ja
Publication of ES2092962A1 publication Critical patent/ES2092962A1/es
Application granted granted Critical
Publication of ES2092962B1 publication Critical patent/ES2092962B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTERES NITRICOS DE DERIVADOS DEL ACIDO 2-(2,6 DIHALOFENILAMINO)FENILACETOXIACETICO DE FORMULA (I) DONDE: [A IGU F, CL O BR; X IGU O, NH O NR (R IGU ALQUILO C1-C6); R1 Y R2 INDEPENDIENTEMENTE IGU ALQUILO C1-C6 Y N ES UN ENTERO DE 1 A 10. EL PROCEDIMIENTO COMPRENDE LA CONDENSACION DEL ACIDO 2-(2,6-DIHALOFENILAMINO)FENILACETOXIACETICO CON UN COMPUESTO DE FORMULA *FIG* DONDE Y IGU OH, NH2 O NHR Y Z ES CL, BR O ONO2.
ES09500756A 1995-04-19 1995-04-19 Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion. Expired - Fee Related ES2092962B1 (es)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ES09500756A ES2092962B1 (es) 1995-04-19 1995-04-19 Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.
CO96013810A CO4700445A1 (es) 1995-04-19 1996-03-20 Esteres nitricos de derivados del acido 2-(2,6-dihalofenil- amino)fenilacetoxiacetico y sus procedimientos de prepara- cion
AU50428/96A AU683790B2 (en) 1995-04-19 1996-04-01 Nitric esters from derivatives of 2-(2-6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process
ZA962981A ZA962981B (en) 1995-04-19 1996-04-15 Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process
CA002174287A CA2174287A1 (en) 1995-04-19 1996-04-16 Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid and their preparation procedures
KR1019960011470A KR960037641A (ko) 1995-04-19 1996-04-16 2-(2,6-디할로페닐아미노)페닐아세톡시아세트산 유도체의 질산 에스테르 및 그의 제조방법
NZ286388A NZ286388A (en) 1995-04-19 1996-04-17 Esters of 2-(2,6-dihalophenylamino)phenylacetoxyacetic acid with a diolmononitrate and amides with a nitrate ester of an alkanolamine
CN96105067A CN1138027A (zh) 1995-04-19 1996-04-17 2-(2，6-二卤代苯氨基)苯乙酰氧乙酸衍生物的硝酸酯及其制备方法
EP96106009A EP0738706B1 (en) 1995-04-19 1996-04-17 Nitric esters of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid derivatives and their preparation process
DE69600739T DE69600739D1 (de) 1995-04-19 1996-04-17 Salpetersäureester von 2-(2,6-Dihalophenylamino) Phenylacetoessigsäurederivaten und Verfahren zu ihrer Herstellung
HU9600996A HUP9600996A3 (en) 1995-04-19 1996-04-17 Nitric esters from derivatives of 2-(2,6-dihalophenylamino)-phenylacetoxyacetic acid and their preparation procedures
AT96106009T ATE171936T1 (de) 1995-04-19 1996-04-17 Salpetersäureester von 2-(2,6-dihalophenylamino) phenylacetoessigsäurederivaten und verfahren zu ihrer herstellung
NO961537A NO961537L (no) 1995-04-19 1996-04-18 Salpetersyreestere fra derivater av 2-(2,6-dihalofenylamino)-fenylacetoksyeddiksyre, og deres fremstillingsprosedyrer
US08/634,763 US5844696A (en) 1995-04-19 1996-04-19 Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process
JP8098815A JPH0920738A (ja) 1995-04-19 1996-04-19 ２−（２，６−ジハロフェニルアミノ）フェニルアセトキシ酢酸の誘導体から得られる硝酸エステルおよびその製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09500756A ES2092962B1 (es) 1995-04-19 1995-04-19 Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.

Publications (2)

Publication Number Publication Date
ES2092962A1 ES2092962A1 (es) 1996-12-01
ES2092962B1 true ES2092962B1 (es) 1997-07-16

Family

ID=8290121

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09500756A Expired - Fee Related ES2092962B1 (es) 1995-04-19 1995-04-19 Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.

Country Status (15)

Country Link
US (1) US5844696A (es)
EP (1) EP0738706B1 (es)
JP (1) JPH0920738A (es)
KR (1) KR960037641A (es)
CN (1) CN1138027A (es)
AT (1) ATE171936T1 (es)
AU (1) AU683790B2 (es)
CA (1) CA2174287A1 (es)
CO (1) CO4700445A1 (es)
DE (1) DE69600739D1 (es)
ES (1) ES2092962B1 (es)
HU (1) HUP9600996A3 (es)
NO (1) NO961537L (es)
NZ (1) NZ286388A (es)
ZA (1) ZA962981B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
WO1999062865A1 (en) * 1998-06-03 1999-12-09 Jae Chul Kim Haloethyl-2-[ (2,6-dichlorophenyl) amino] phenylacetoxyacetate derivatives and their use as an intermediate to synthesize aceclofenac
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
JP2005539089A (ja) * 2002-07-03 2005-12-22 ニトロメッド インコーポレーティッド ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES520813A0 (es) * 1983-03-21 1984-05-16 Prodes Sa Procedimiento para la obtencion del ester del acido 2-(2,6-diclorofenil)amino bencenoacetico con acido glicolico.
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione

Also Published As

Publication number Publication date
CN1138027A (zh) 1996-12-18
AU5042896A (en) 1996-10-31
DE69600739D1 (de) 1998-11-12
US5844696A (en) 1998-12-01
ATE171936T1 (de) 1998-10-15
JPH0920738A (ja) 1997-01-21
AU683790B2 (en) 1997-11-20
HUP9600996A3 (en) 1997-11-28
NO961537D0 (no) 1996-04-18
ES2092962A1 (es) 1996-12-01
NZ286388A (en) 1997-03-24
KR960037641A (ko) 1996-11-19
CA2174287A1 (en) 1996-10-20
HUP9600996A2 (en) 1996-11-28
EP0738706B1 (en) 1998-10-07
ZA962981B (en) 1996-10-22
NO961537L (no) 1996-10-21
CO4700445A1 (es) 1998-12-29
HU9600996D0 (en) 1996-06-28
EP0738706A1 (en) 1996-10-23

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