ES2092539T3 - Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares. - Google Patents
Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares.Info
- Publication number
- ES2092539T3 ES2092539T3 ES91121524T ES91121524T ES2092539T3 ES 2092539 T3 ES2092539 T3 ES 2092539T3 ES 91121524 T ES91121524 T ES 91121524T ES 91121524 T ES91121524 T ES 91121524T ES 2092539 T3 ES2092539 T3 ES 2092539T3
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- thiazolidine
- pulmonary diseases
- carboxylate derivatives
- carboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION ACTUAL PROPORCIONA LA PREPARACION DE UN COMPUESTO UTILIZADO PARA EL TRATAMIENTO DE LAS ENFERMEDADES PULMONARES. MAS ESPECIFICAMENTE, LA INVENCION ACTUAL PROPORCIONA LA PREPARACION DE UN COMPUESTO PARA TRATAR AQUELLAS ENFERMEDADES, TALES COMO EL SINDROME DE RESPIRACION DOLOROSA DE LOS ADULTOS QUE DA COMO RESULTADO AL TENSION DE OXIDACION QUE DAÑA LAS CELULAS DE LOS PULMONES. DE CONFORMIDAD CON LA INVENCION ACTUAL, SE UTILIZA UN SUSTRATO NO CISTEINICO QUE ES UN PRECURSOR PARA LA SINTESIS INTRACELULAR DEL GLUTATIONE, PARA CREAR UN COMPUESTO QUE SE VA A ADMINISTRAR A UN PACIENTE Y QUE AUMENTA LOS NIVELES DE GLUTATIONE INTRACELULAR DE POR LO MENOS AQUELLAS CELULAS DEL PACIENTE CON ENFERMEDADES PULMONARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63927591A | 1991-01-10 | 1991-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2092539T3 true ES2092539T3 (es) | 1996-12-01 |
Family
ID=24563439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91121524T Expired - Lifetime ES2092539T3 (es) | 1991-01-10 | 1992-01-01 | Uso de derivados de la tiazolidina-4-carboxilato para el tratamiento de enfermedades pulmonares. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5824693A (es) |
EP (2) | EP0715853A1 (es) |
JP (2) | JP2969236B2 (es) |
AT (1) | ATE144142T1 (es) |
AU (2) | AU1006492A (es) |
CA (1) | CA2058793A1 (es) |
DE (1) | DE69214467T3 (es) |
DK (1) | DK0494405T3 (es) |
ES (1) | ES2092539T3 (es) |
GR (1) | GR3021890T3 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5631234A (en) * | 1991-04-15 | 1997-05-20 | Teijin Limited | Method for treating ischemia-reperfusion tissue injury |
FR2763845B1 (fr) | 1997-05-30 | 2003-04-18 | Centre Nat Rech Scient | Produits anti-cancereux pour le traitement de la mucoviscidose |
US6197749B1 (en) | 1997-10-29 | 2001-03-06 | Ajinomoto Co., Inc. | Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes |
EP1004302A3 (en) * | 1998-10-29 | 2003-06-04 | Ajinomoto Co., Inc. | Immunomodulator |
WO2001012166A2 (en) | 1999-08-17 | 2001-02-22 | University Of Saskatchewan Technologies Inc. | Improved treatment for acute physical insult to the central nervous system |
US7179791B2 (en) * | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
KR100478536B1 (ko) * | 2002-10-14 | 2005-03-24 | 주식회사 에이.비.아이 | L-2-옥소씨아졸리딘-4-카르복실산 또는 그 염을유효성분으로 함유하는 천식 치료용 약제학적 조성물 |
US20040229815A1 (en) | 2003-01-03 | 2004-11-18 | Nagasawa Herbert T. | Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug |
US7781539B2 (en) | 2003-02-21 | 2010-08-24 | Metabolix Inc. | PHA blends |
PT1603987E (pt) | 2003-02-21 | 2011-11-10 | Metabolix Inc | Composições adesivas pha |
JP2007517126A (ja) | 2003-12-30 | 2007-06-28 | メタボリックス インコーポレイティッド | 増核剤 |
US20090192227A1 (en) * | 2005-08-24 | 2009-07-30 | Rabindra Tirouvanziam | N-Acetylcysteine Compositions and Methods for Treating Acute Exacerbations of Inflammatory Lung Disease |
CA2620123C (en) * | 2005-08-24 | 2011-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating and monitoring inflammation and redox imbalance in cystic fibrosis |
US7526715B2 (en) | 2005-10-17 | 2009-04-28 | Ramot At Tel Aviv University Ltd. | Probabilistic error correction in multi-bit-per-cell flash memory |
US20070255406A1 (en) * | 2006-04-27 | 2007-11-01 | Sdgi Holdings, Inc. | Devices, apparatus, and methods for bilateral approach to disc augmentation |
CN109054254B (zh) | 2012-08-17 | 2021-02-02 | Cj第一制糖株式会社 | 用于聚合物共混物的生物基橡胶改性剂 |
WO2014070769A1 (en) | 2012-10-29 | 2014-05-08 | The University Of North Carolina At Chapel Hill | Methods and compositions for treating mucosal tissue disorders |
US20140234397A1 (en) * | 2013-02-15 | 2014-08-21 | Lou Ann Brown | Treatment of klebsiella pneumoniae with liposomally formulated glutathione |
WO2014194220A1 (en) | 2013-05-30 | 2014-12-04 | Metabolix, Inc. | Recyclate blends |
US11602555B2 (en) | 2016-11-17 | 2023-03-14 | Renovion, Inc. | Treatment of respiratory tract diseases and infections with ascorbic acid compositions |
CN111615395B (zh) | 2017-11-17 | 2024-08-06 | 莱诺翁股份有限公司 | 稳定的抗坏血酸组合物及其使用方法 |
CN113797230A (zh) * | 2020-06-12 | 2021-12-17 | 上海萨美细胞技术有限公司 | 无细胞脂肪提取液对肺部疾病的治疗用途 |
KR20240131358A (ko) | 2022-01-04 | 2024-08-30 | 레노비온, 아이엔씨. | 글루타치온 염을 포함하는 수용액 |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2712202A (en) * | 1954-06-08 | 1955-07-05 | Univ Alabama | Method of treating tree diseases |
DE1767335A1 (de) * | 1968-04-27 | 1971-09-02 | Bayer Ag | Anaesthetikum fuer Tiere |
US3755578A (en) * | 1969-06-06 | 1973-08-28 | Pfizer | Thiazoline and 5,6-dihydro-4h-1,3-thiazine anti-plant-viral agents |
DE2141765A1 (de) * | 1971-08-20 | 1973-03-01 | Henkel & Cie Gmbh | 4-chlor-4-thiazolin-2-one und verfahren zu deren herstellung |
FR2296428A1 (fr) * | 1975-01-03 | 1976-07-30 | Baignes Ste Radegonde Laiterie | Composition de proteines a usage dietetique et therapeutique chez le nourrisson, l'enfant et l'adulte |
JPS53119866A (en) * | 1977-03-25 | 1978-10-19 | Yoshitomi Pharmaceut Ind Ltd | 5-aryloxy-oxazoleakanoic acid derivatives and their preparation |
EP0002978B1 (fr) * | 1977-12-29 | 1982-10-06 | Synthelabo | Dérivés de thiazolidinedione-2,4, leur préparation et leur application en thérapeutique |
US4384001A (en) * | 1978-12-21 | 1983-05-17 | Gosalvez Mario | Treatment of tumors with thiazolidine-4-carboxylic acid |
US4338315A (en) * | 1979-11-14 | 1982-07-06 | Eli Lilly And Company | Antiviral method employing thiazinyl benzimidazole derivatives |
US4434158A (en) * | 1981-02-11 | 1984-02-28 | Cornell Research Foundation | Cysteine delivery system |
US4647571A (en) * | 1981-02-11 | 1987-03-03 | Cornell Research Foundation | Cysteine delivery composition |
US4665082A (en) * | 1981-02-11 | 1987-05-12 | Cornell Research Foundation | Cysteine delivery system |
US4335210A (en) * | 1981-02-11 | 1982-06-15 | Cornell Research Foundation | Method of producing L-cysteine |
US4438124A (en) * | 1981-02-11 | 1984-03-20 | Cornell Research Foundation, Inc. | Cysteine delivery system |
JPS57200373A (en) * | 1981-06-04 | 1982-12-08 | Taisho Pharmaceut Co Ltd | Thiazolidine derivative |
US4420479A (en) * | 1982-04-08 | 1983-12-13 | Eli Lilly And Company | Olefinic benzimidazoles, formulations, and antiviral methods |
DE3317000C2 (de) * | 1983-05-10 | 1986-09-25 | Gödecke AG, 1000 Berlin | 4-Oxo-thiazolidin-2-yliden-acetamid-derivate, Verfahren zu deren Herstellung und deren Verwendung bei der Bekämpfung von durch das Zentralnervensystem bedingten Konvulsionen |
US4879370A (en) * | 1983-12-02 | 1989-11-07 | Cornell Research Foundation, Inc. | Glutathione delivery system |
US4752618A (en) * | 1984-07-12 | 1988-06-21 | New England Deaconess Hospital | Method of minimizing efects of infection through diet |
US4647453A (en) * | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
US4710489A (en) * | 1985-04-22 | 1987-12-01 | Cornell Research Foundation, Inc. | Glutathione delivery system |
HU200177B (en) * | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
EP0218900B1 (en) * | 1985-09-10 | 1992-01-22 | Research Corporation Technologies, Inc. | Osmotic agents for peritoneal dialysis |
US4780475A (en) * | 1986-02-03 | 1988-10-25 | Cerra Frank B | Preparation for the prevention of catabolism |
JPS63152325A (ja) * | 1986-08-20 | 1988-06-24 | Yamanouchi Pharmaceut Co Ltd | 脳虚血症予防治療剤 |
IT1202426B (it) * | 1987-01-26 | 1989-02-09 | Poli Ind Chimica Spa | Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono |
US5053387A (en) * | 1987-02-20 | 1991-10-01 | Shriners Hospitals For Crippled Children | Omega-3 fatty acids in traumatic injury treatment |
US4868114A (en) * | 1987-08-05 | 1989-09-19 | Regents Of The University Of Minnesota | Method for elevating glutathione levels |
DE3856378T2 (de) * | 1987-09-04 | 2000-05-11 | Beecham Group P.L.C., Brentford | Substituierte Thiazolidindionderivate |
US4968671A (en) * | 1987-11-26 | 1990-11-06 | Yamanouchi Pharmaceutical Co., Ltd. | Therapeutic agents for ischemic heart diseases |
US4798835A (en) * | 1987-12-02 | 1989-01-17 | Pfizer Inc. | dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent |
US4791125A (en) * | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
ATE110954T1 (de) * | 1988-01-29 | 1994-09-15 | Peter H Proctor | Haarwachstumanregung mit nitroxyd und anderen radikalen. |
IE891173L (en) * | 1988-04-18 | 1989-10-18 | Univ Utrecht | Composition for promoting hair growth in androgenetic¹alopecia and method thereof |
DE3816603A1 (de) * | 1988-05-16 | 1989-11-30 | Behringwerke Ag | Verwendung des thiazol-derivates tiprotimod zur herstellung eines mittels zur therapie von virusinfektionen |
US5055446A (en) * | 1988-10-21 | 1991-10-08 | University Of Cincinnati | Method to improve survival of patients during sepsis by diet composition |
ES2068253T3 (es) * | 1988-12-09 | 1995-04-16 | Allergan Inc | Uso de acidos tiazolidin-4-carboxilicos sustituidos en la posicion 2 para tratamiento de cataratas. |
CA1338682C (en) * | 1988-12-23 | 1996-10-29 | Gustavo Bounous | Biologically active undenatured whey protein concentrate as food supplement |
GB8918709D0 (en) * | 1989-08-16 | 1989-09-27 | Unilever Plc | Cosmetic composition |
US5158883A (en) * | 1989-09-13 | 1992-10-27 | Cornell Research Foundation, Inc. | Method of using aminoarginine to block nitric oxide formation in vitro |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
AU7675891A (en) * | 1990-03-28 | 1991-10-21 | Atif M Hussein | Methods for protecting against chemotherapy-induced hair loss |
US5089268A (en) * | 1990-05-02 | 1992-02-18 | Katz David P | Egg phosphatide lipid emulsions altered for a specific therapeutic fatty acid composition |
US5095027A (en) * | 1991-02-28 | 1992-03-10 | Clintec Nutrition Co. | Method for treating reperfusion injury employing L-2-oxothiazolidine-4-carboxylic acid |
SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
US5214062A (en) * | 1992-04-08 | 1993-05-25 | Clintec Nutrition Co. | Method and composition for treating immune disorders, inflammation and chronic infections |
US5208249A (en) * | 1992-08-20 | 1993-05-04 | Clintec Nutrition Co. | Method for stimulating intracellular synthesis of glutathione using esters of L-2-oxothiazolidine-4-carboxylate |
-
1992
- 1992-01-01 ES ES91121524T patent/ES2092539T3/es not_active Expired - Lifetime
- 1992-01-01 EP EP96200042A patent/EP0715853A1/en not_active Withdrawn
- 1992-01-01 EP EP91121524A patent/EP0494405B2/en not_active Expired - Lifetime
- 1992-01-01 DK DK91121524.2T patent/DK0494405T3/da active
- 1992-01-01 DE DE69214467T patent/DE69214467T3/de not_active Expired - Fee Related
- 1992-01-01 AT AT91121524T patent/ATE144142T1/de not_active IP Right Cessation
- 1992-01-06 CA CA002058793A patent/CA2058793A1/en not_active Abandoned
- 1992-01-06 AU AU10064/92A patent/AU1006492A/en not_active Abandoned
- 1992-01-07 JP JP4019504A patent/JP2969236B2/ja not_active Expired - Lifetime
-
1994
- 1994-11-30 AU AU79121/94A patent/AU688803B2/en not_active Ceased
-
1995
- 1995-06-06 US US08/470,094 patent/US5824693A/en not_active Expired - Fee Related
-
1996
- 1996-12-04 GR GR960403311T patent/GR3021890T3/el unknown
-
1997
- 1997-05-13 JP JP9137722A patent/JPH1053523A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0494405A3 (en) | 1992-10-28 |
EP0494405A2 (en) | 1992-07-15 |
DK0494405T3 (da) | 1996-11-18 |
GR3021890T3 (en) | 1997-03-31 |
AU7912194A (en) | 1995-02-16 |
JP2969236B2 (ja) | 1999-11-02 |
US5824693A (en) | 1998-10-20 |
JPH1053523A (ja) | 1998-02-24 |
AU688803B2 (en) | 1998-03-19 |
DE69214467T2 (de) | 1997-04-30 |
EP0494405B1 (en) | 1996-10-16 |
EP0494405B2 (en) | 2000-04-19 |
CA2058793A1 (en) | 1992-07-11 |
DE69214467T3 (de) | 2000-09-28 |
AU1006492A (en) | 1992-07-16 |
JPH08319242A (ja) | 1996-12-03 |
ATE144142T1 (de) | 1996-11-15 |
EP0715853A1 (en) | 1996-06-12 |
DE69214467D1 (de) | 1996-11-21 |
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