ES2080703B1 - STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS. - Google Patents

STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS.

Info

Publication number
ES2080703B1
ES2080703B1 ES9401862A ES9401862A ES2080703B1 ES 2080703 B1 ES2080703 B1 ES 2080703B1 ES 9401862 A ES9401862 A ES 9401862A ES 9401862 A ES9401862 A ES 9401862A ES 2080703 B1 ES2080703 B1 ES 2080703B1
Authority
ES
Spain
Prior art keywords
chewing
pills
isooctane
water
substances incorporated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9401862A
Other languages
Spanish (es)
Other versions
ES2080703A1 (en
Inventor
Redondo Ana Maria Jimenez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmalider SA
Original Assignee
Farmalider SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmalider SA filed Critical Farmalider SA
Priority to ES9401862A priority Critical patent/ES2080703B1/en
Publication of ES2080703A1 publication Critical patent/ES2080703A1/en
Application granted granted Critical
Publication of ES2080703B1 publication Critical patent/ES2080703B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Confectionery (AREA)

Abstract

METODO DE ESTABILIZACION DE SUSTANCIAS MEDICAMENTOSAS INCORPORADAS A PASTILLAS DE CHICLE. CONSISTE EN LA MICROENCAPSULACION DEL O LOS PRINCIPIOS ACTIVOS, MEDICAMENTOSOS, MEDIANTE UN PRODUCTO DE MICROENCAPSULADO CUYO COMPONENTE FUNDAMENTAL ES ALBUMINA DE HUEVO Y EN EL QUE PARTICIPAN TAMBIEN GLICIRRICINATO AMONICO, ASPARTAMO, ISOOCTANO, AGUA DESIONIZADA Y SPAN. LOS PRINCIPIOS ACTIVOS SE DISUELVEN POR SEPARADO, CONJUNTAMENTE CON LA ALBUMINA, EL GLICIRRICINATO AMONICO Y EL ASPARTAMO EN AGUA DESIONIZADA, AÑADIENDOSE SEGUIDAMENTE EL ISOOCTANO Y EL SPAN Y AGITANDOSE PARA FORMAR UNA EMULSION QUE SE CALIENTA A 60 C DURANTE UNA HORA. SEGUIDAMENTE SE DECANTA EL ISOOCTANO Y SE LAVA EL PRODUCTO SOLIDO OBTENIDO, LAS MICROCAPSULAS, CON ETANOL. FINALMENTE SE SECA A 60 C Y SE PASA POR UN TAMIZ DE ABERTURA CUADRADA, QUEDANDO EN CONDICIONES DE SER APORTADO, POR METODOS CONVENCIONALES, A LA MASA DE CHICLE.STABILIZATION METHOD OF MEDICATION SUBSTANCES INCORPORATED IN CHEWING PILLS. IT CONSISTS OF THE MICROENCAPSULATION OF THE ACTIVE PRINCIPLE (S), MEDICINES, BY MEANS OF A MICROENCAPSULATED PRODUCT WHICH IS A FUNDAMENTAL COMPONENT OF EGG ALBUMINE AND IN WHICH ALSO AMYCHRICHINATE, ASPARTAMO, WATER, ISOOCTANE, WATER. THE ACTIVE SUBSTANCES ARE DISSOLVED SEPARATELY, TOGETHER WITH ALBUMINE, GLYCUMRICINATE AMMONIA AND ASPARTAMO IN DEIONIZED WATER, FURTHER ADDING THE ISOOCTANE AND SPAN AND WAVING TO FORM AN EMULSION THAT IS WARMING TO 60 DUR. THEN THE ISOOCTANE IS DECANTS AND THE SOLID PRODUCT OBTAINED, THE MICROCAPSULES, IS WASHED WITH ETHANOL. FINALLY DRY AT 60 C AND GO THROUGH A SQUARE OPENING SIEVE, REMAINING IN CONDITION OF BEING CONTRIBUTED, BY CONVENTIONAL METHODS, TO THE CHEWING MASS.

ES9401862A 1994-08-25 1994-08-25 STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS. Expired - Fee Related ES2080703B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9401862A ES2080703B1 (en) 1994-08-25 1994-08-25 STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9401862A ES2080703B1 (en) 1994-08-25 1994-08-25 STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS.

Publications (2)

Publication Number Publication Date
ES2080703A1 ES2080703A1 (en) 1996-02-01
ES2080703B1 true ES2080703B1 (en) 1996-10-16

Family

ID=8287340

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9401862A Expired - Fee Related ES2080703B1 (en) 1994-08-25 1994-08-25 STABILIZATION METHODS OF DRUG SUBSTANCES INCORPORATED IN CHEWING PILLS.

Country Status (1)

Country Link
ES (1) ES2080703B1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727565B2 (en) 2004-08-25 2010-06-01 Cadbury Adams Usa Llc Liquid-filled chewing gum composition
US7851000B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and edible confectionery and chewing gum products containing same
US7851005B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
US7851006B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
US7955630B2 (en) 2004-09-30 2011-06-07 Kraft Foods Global Brands Llc Thermally stable, high tensile strength encapsulated actives
US9198448B2 (en) 2005-02-07 2015-12-01 Intercontinental Great Brands Llc Stable tooth whitening gum with reactive ingredients

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2014008314A (en) * 2014-07-07 2016-01-06 Andres Abelino Choza Romero Nebulisation-based method for mixing substances.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1189727B (en) * 1985-08-30 1988-02-04 Roberto Cappellari CHEWING RUBBER WITH DIFFERENT EFFECT IN THE TASTE AND TIME
US4822621A (en) * 1987-07-30 1989-04-18 Warner-Lambert Company Method and product for increased aspartame stability in chewing gum

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727565B2 (en) 2004-08-25 2010-06-01 Cadbury Adams Usa Llc Liquid-filled chewing gum composition
US7955630B2 (en) 2004-09-30 2011-06-07 Kraft Foods Global Brands Llc Thermally stable, high tensile strength encapsulated actives
US8524295B2 (en) 2004-09-30 2013-09-03 Intercontinental Great Brands Llc Thermally stable, high tensile strength encapsulated actives
US9198448B2 (en) 2005-02-07 2015-12-01 Intercontinental Great Brands Llc Stable tooth whitening gum with reactive ingredients
US7851000B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and edible confectionery and chewing gum products containing same
US7851005B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
US7851006B2 (en) 2005-05-23 2010-12-14 Cadbury Adams Usa Llc Taste potentiator compositions and beverages containing same
US7879376B2 (en) 2005-05-23 2011-02-01 Cadbury Adams Usa Llc Taste potentiator compositions and edible confectionery and chewing gum products containing same
US8455033B2 (en) 2005-05-23 2013-06-04 Kraft Foods Global Brands Llc Taste potentiator compositions and edible confectionery and chewing gum products containing same

Also Published As

Publication number Publication date
ES2080703A1 (en) 1996-02-01

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