ES2059285T1 - Un metodo mejorado para la preparacion de ciertos antibioticos beta-lactamicos. - Google Patents

Un metodo mejorado para la preparacion de ciertos antibioticos beta-lactamicos.

Info

Publication number
ES2059285T1
ES2059285T1 ES93902095T ES93902095T ES2059285T1 ES 2059285 T1 ES2059285 T1 ES 2059285T1 ES 93902095 T ES93902095 T ES 93902095T ES 93902095 T ES93902095 T ES 93902095T ES 2059285 T1 ES2059285 T1 ES 2059285T1
Authority
ES
Spain
Prior art keywords
preparation
improved method
certain beta
lactamic antibiotics
lactamic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES93902095T
Other languages
English (en)
Inventor
Kim Clausen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK64292A external-priority patent/DK64292D0/da
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of ES2059285T1 publication Critical patent/ES2059285T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

EL PRESENTE INVENTO RELATA A UN METODO MEJORADO PARA LA PREPARACION DE CIERTOS ANTIBIOTICOS B-LACTAM POR LA ACILACION ENZIMATICA O POR LA DESPROTECCION DE UN INTERMEDIO PROTEGIDO.
ES93902095T 1991-12-19 1992-12-18 Un metodo mejorado para la preparacion de ciertos antibioticos beta-lactamicos. Pending ES2059285T1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91610096 1991-12-19
DK64292A DK64292D0 (da) 1992-05-14 1992-05-14 Syntesemetode

Publications (1)

Publication Number Publication Date
ES2059285T1 true ES2059285T1 (es) 1994-11-16

Family

ID=26064375

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902095T Pending ES2059285T1 (es) 1991-12-19 1992-12-18 Un metodo mejorado para la preparacion de ciertos antibioticos beta-lactamicos.

Country Status (10)

Country Link
US (1) US5470717A (es)
EP (1) EP0618979A1 (es)
JP (1) JPH07502168A (es)
AU (1) AU3345193A (es)
DE (1) DE618979T1 (es)
ES (1) ES2059285T1 (es)
GR (1) GR940300079T1 (es)
PL (1) PL170842B1 (es)
SK (1) SK63894A3 (es)
WO (1) WO1993012250A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ247464A (en) * 1992-04-24 1994-12-22 Lilly Co Eli Preparation of 2-amino-acetamidocephalosporin derivatives, the 2-acetamido group substituted in the 2-position by a c5-6 cyclic hydrocarbon or a c5-heterocycle
US5753458A (en) * 1994-06-10 1998-05-19 Gist-Brocades B.V. Acylation method for penicillins and cephalosporins
BE1009194A3 (nl) * 1995-03-09 1996-12-03 Dsm Nv Werkwijze voor de winning van cefalexine.
WO1996023796A1 (en) * 1995-02-02 1996-08-08 Chemferm V.O.F. Process for the recovery of cephalexin
BE1009263A3 (nl) * 1995-03-31 1997-01-07 Dsm Nv Werkwijze voor de winning van cefalexine.
ATE191932T1 (de) * 1995-02-28 2000-05-15 Acs Dobfar Spa Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
US6060268A (en) * 1995-07-18 2000-05-09 Gist-Brocades B.V. Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer
AU6659296A (en) * 1995-07-18 1997-02-18 Gist-Brocades B.V. An improved immobilized penicillin g acylase
US6503727B1 (en) * 1995-12-08 2003-01-07 Gist-Brocades, B.V. Process for the preparation of an antibiotic
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
BE1010651A3 (nl) * 1996-09-27 1998-11-03 Dsm Nv Werkwijze voor het zuiveren van cefalexine.
AU9254498A (en) * 1997-07-03 1999-01-25 Gist-Brocades B.V. Preparation of enzyme with reduced beta-lactamase activity
NL1007828C2 (nl) * 1997-12-18 1999-06-21 Dsm Nv Complexen van beta-lactam antibiotica en 1-naftol.
NL1007827C2 (nl) * 1997-12-18 1999-06-21 Dsm Nv Complexen van beta-lactam antibiotica.
DE19823332C2 (de) * 1998-05-26 2000-09-07 Unifar Kimya Sanayii Ve Ticare Verfahren zur enzymatischen Herstellung von Betalactam-Antibiotika
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams
DE10256656A1 (de) * 2002-12-03 2004-06-17 Röhm GmbH & Co. KG Verfahren zur Herstellung von Cephalexin
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
PL2723882T3 (pl) 2011-06-23 2020-01-31 Centrient Pharmaceuticals Netherlands B.V. Sposób wytwarzania 3’-tiopodstawionych cefalosporyn z zastosowaniem acylazy penicyliny
CN107058447A (zh) * 2016-12-23 2017-08-18 苏州中联化学制药有限公司 一种酶法合成头孢羟氨苄的方法
CN108084211B (zh) * 2017-12-21 2020-06-05 中国科学院过程工程研究所 一种头孢氨苄的回收方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003896A (en) * 1974-12-17 1977-01-18 Novo Industri A/S Method of preparing a sparingly soluble complex of cephalexin
US4256733A (en) * 1979-09-26 1981-03-17 Pfizer Inc. Acetoxymethyl penam compounds as β-lactamase inhibitors
EP0186187B1 (en) * 1984-12-27 1992-02-26 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives
ES2090031T3 (es) * 1988-04-26 1996-10-16 Gist Brocades Nv Proceso para la preparacion enzimatica de beta-lactamas.
CZ381392A3 (en) * 1990-07-04 1993-12-15 Novo Nordisk As Process for preparing beta-lactams

Also Published As

Publication number Publication date
WO1993012250A1 (en) 1993-06-24
US5470717A (en) 1995-11-28
GR940300079T1 (en) 1994-11-30
SK63894A3 (en) 1995-03-08
JPH07502168A (ja) 1995-03-09
PL170842B1 (pl) 1997-01-31
EP0618979A1 (en) 1994-10-12
DE618979T1 (de) 1995-05-18
AU3345193A (en) 1993-07-19

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