ES2052619T3 - Un procedimiento para la preparacion de los nuevos derivados de tiazolidina. - Google Patents

Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.

Info

Publication number
ES2052619T3
ES2052619T3 ES88102243T ES88102243T ES2052619T3 ES 2052619 T3 ES2052619 T3 ES 2052619T3 ES 88102243 T ES88102243 T ES 88102243T ES 88102243 T ES88102243 T ES 88102243T ES 2052619 T3 ES2052619 T3 ES 2052619T3
Authority
ES
Spain
Prior art keywords
group
carbon atom
general formula
atom
single bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88102243T
Other languages
English (en)
Inventor
Masaaki Toda
Shuichi Shinbayashida Ohuchida
Hiroyuki Ohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2052619T3 publication Critical patent/ES2052619T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

NUEVO DERIVADO DE TIAZOLIDINA DE FORMULA GENERAL (I) EN LA QUE R, A, Y, B, D, R1, E Y G TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA DESCRIPCION. EL NUEVO DERIVADO TIENEN ACTIVIDAD INHIBIDORA DE PROLIL-ENDOPEPTIDASA Y PUEDE SER UTIL PARA TRATAR O PREVENIR LA AMNESIA.
ES88102243T 1987-02-23 1988-02-16 Un procedimiento para la preparacion de los nuevos derivados de tiazolidina. Expired - Lifetime ES2052619T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3784487 1987-02-23

Publications (1)

Publication Number Publication Date
ES2052619T3 true ES2052619T3 (es) 1994-07-16

Family

ID=12508841

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91111866T Expired - Lifetime ES2103287T3 (es) 1987-02-23 1988-02-16 Nuevos derivados de tiazolidina.
ES88102243T Expired - Lifetime ES2052619T3 (es) 1987-02-23 1988-02-16 Un procedimiento para la preparacion de los nuevos derivados de tiazolidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES91111866T Expired - Lifetime ES2103287T3 (es) 1987-02-23 1988-02-16 Nuevos derivados de tiazolidina.

Country Status (7)

Country Link
US (1) US4857537A (es)
EP (2) EP0280956B1 (es)
KR (1) KR960001205B1 (es)
AT (1) ATE151760T1 (es)
DE (2) DE3875361T2 (es)
ES (2) ES2103287T3 (es)
GR (1) GR3006406T3 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01250370A (ja) * 1987-12-23 1989-10-05 Zeria Pharmaceut Co Ltd 新規アミノ酸イミド誘導体、製法ならびに用途
JP2515568B2 (ja) * 1987-12-25 1996-07-10 株式会社ヤクルト本社 新規なチアゾリジン誘導体
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
CA2004028C (en) * 1988-12-08 1998-09-22 Motoki Torizuka Condensed benzene derivative
EP0419683A4 (en) * 1989-04-13 1992-03-11 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
US5073549A (en) * 1990-03-22 1991-12-17 Bristol-Myers Squibb Company BU-4164E - A and B, prolyl endopeptidase inhibitors and their methods of use
US4999349A (en) * 1990-03-22 1991-03-12 Bristol-Myers Squibb Co. BU-4164E - A and B, prolyl endopeptidase inhibitors
WO1991018891A1 (en) * 1990-06-04 1991-12-12 Pfizer Inc. Aromatic pyrrolidine and thiazolidine amides
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
IT1283782B1 (it) * 1996-08-09 1998-04-30 Ct Lab Farm Srl Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
US6419857B1 (en) * 1999-12-06 2002-07-16 Baker Hughes Incorporated Thiazolidines and use thereof for corrosion inhibition
ZA200508439B (en) 2003-05-05 2007-03-28 Probiodrug Ag Medical use of inhibitors of glutaminyl and glutamate cyclases
NZ546887A (en) 2003-11-03 2009-04-30 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
CA2554809C (en) 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
EP1760076A1 (en) 2005-09-02 2007-03-07 Ferring B.V. FAP Inhibitors
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
NZ579310A (en) 2007-03-01 2012-03-30 Probiodrug Ag Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
MX2012002993A (es) 2009-09-11 2012-04-19 Probiodrug Ag Derivados heterociclicos como inhibidores de ciclasa glutaminilo.
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
SG183229A1 (en) 2010-03-10 2012-09-27 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60188317A (ja) * 1984-03-09 1985-09-25 Yakult Honsha Co Ltd 抗健忘症剤
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
CA1298033C (en) * 1985-04-16 1992-03-24 Takaharu Tanaka Dipeptide derivative of fatty acid
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP0201741B1 (en) * 1985-04-16 1991-07-31 Suntory Limited Dipeptide derivatives, processes for preparing them, pharmaceutical composition and use

Also Published As

Publication number Publication date
GR3006406T3 (es) 1993-06-21
ATE151760T1 (de) 1997-05-15
KR880009949A (ko) 1988-10-06
EP0280956B1 (en) 1992-10-21
EP0280956A1 (en) 1988-09-07
DE3875361T2 (de) 1993-03-25
DE3855875T2 (de) 1997-08-28
ES2103287T3 (es) 1997-09-16
DE3855875D1 (de) 1997-05-22
KR960001205B1 (ko) 1996-01-24
US4857537A (en) 1989-08-15
EP0461677B1 (en) 1997-04-16
DE3875361D1 (de) 1992-11-26
EP0461677A1 (en) 1991-12-18

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