ES2007607A6 - Un procedimiento para la obtencion de un preparado de insulina para la administracion no parenteral. - Google Patents
Un procedimiento para la obtencion de un preparado de insulina para la administracion no parenteral.Info
- Publication number
- ES2007607A6 ES2007607A6 ES8701124A ES8701124A ES2007607A6 ES 2007607 A6 ES2007607 A6 ES 2007607A6 ES 8701124 A ES8701124 A ES 8701124A ES 8701124 A ES8701124 A ES 8701124A ES 2007607 A6 ES2007607 A6 ES 2007607A6
- Authority
- ES
- Spain
- Prior art keywords
- insulin
- parenteral administration
- insulin preparation
- possibly
- absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE UN PREPARADO DE INSULINA PARA LA ADMINISTRACION NO PARENTERAL. COMPRENDE MEZCLAR UNA O MAS INSULINAS O DERIVADOS DE LAS MISMAS CON UNO O VARIOS VEHICULOS O PORTADORES APROPIADOS A LA FORMA DE ADMINISTRACION QUE SE DESEE OBTENER. CUANDO EL PREPARADO SE ENCUENTRA EN SOLUCION EN LA REGION DEL PH FISIOLOGICO LA INSULINA SE ENCUENTRA PREDOMINANTEMENTE EN FORMA MONOMERICA. EL PREPARADO PERMITE UNA RAPIDA ABSORCION DE LA ACTIVIDAD INSULINICA ADMINISTRADA. APLICACION EN EL TRATAMIENTO DE LA DIABETES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK179286A DK179286D0 (da) | 1986-04-18 | 1986-04-18 | Insulinpraeparat |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2007607A6 true ES2007607A6 (es) | 1989-07-01 |
Family
ID=8108089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8701124A Expired ES2007607A6 (es) | 1986-04-18 | 1987-04-15 | Un procedimiento para la obtencion de un preparado de insulina para la administracion no parenteral. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5053389A (es) |
EP (1) | EP0267208B1 (es) |
JP (1) | JPH01500116A (es) |
AT (1) | ATE66614T1 (es) |
AU (1) | AU598543B2 (es) |
CA (1) | CA1283358C (es) |
DE (1) | DE3772521D1 (es) |
DK (2) | DK179286D0 (es) |
ES (1) | ES2007607A6 (es) |
FI (1) | FI87529C (es) |
IL (1) | IL82209A0 (es) |
NO (1) | NO875299L (es) |
WO (1) | WO1987006137A1 (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69006662T2 (de) * | 1989-08-21 | 1994-05-26 | Hoffmann La Roche | Insulinzubereitung für nicht-parenterale Verabreichung. |
IL99699A (en) * | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US6131567A (en) * | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
EP1607086A1 (en) * | 1993-01-29 | 2005-12-21 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
TW404844B (en) | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
US6893664B1 (en) * | 1996-06-17 | 2005-05-17 | Powderject Research Limited | Particle delivery techniques |
US5948751A (en) * | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
DK1283051T3 (da) * | 1997-06-13 | 2006-10-16 | Lilly Co Eli | Stabile insulinformuleringer |
CO4750643A1 (es) | 1997-06-13 | 1999-03-31 | Lilly Co Eli | Formulacion estable de la insulina que contiene l-arginina y protamina |
US20010007853A1 (en) * | 1998-01-08 | 2001-07-12 | Dimarchi Richard Dennis | Method for administering monomeric insulin analogs |
US6350458B1 (en) | 1998-02-10 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Mixed micellar drug deliver system and method of preparation |
US7070799B1 (en) * | 1998-02-10 | 2006-07-04 | Generex Pharmaceuticals, Inc. | Method for administering insulin to the buccal region |
US6221378B1 (en) | 1998-02-10 | 2001-04-24 | Generex Pharmaceuticals Incorporated | Mixed micellar delivery system and method of preparation |
US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
US6294153B1 (en) | 1998-12-21 | 2001-09-25 | Generex Pharmaceuticals, Inc. | Aerosol pharmaceutical formulation for pulmonary and nasal delivery |
US6849263B2 (en) * | 1998-12-21 | 2005-02-01 | Generex Pharmaceutical Incorporated | Pharmaceutical compositions for buccal delivery of pain relief medications |
US7087215B2 (en) * | 1998-12-21 | 2006-08-08 | Generex Pharmaceuticals Incorporated | Methods of administering and enhancing absorption of pharmaceutical agents |
US6451286B1 (en) | 1998-12-21 | 2002-09-17 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds |
WO2001077137A1 (en) | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US6350432B1 (en) | 1999-03-19 | 2002-02-26 | Generex Pharmaceuticals Incorporated | Pressurized container having an aerosolized pharmaceutical composition |
EP1187639A1 (en) | 1999-06-04 | 2002-03-20 | Delrx Pharmaceutical Corporation | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
GB2355009A (en) * | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
EP2277910A1 (en) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
WO2007140619A1 (en) * | 2006-06-08 | 2007-12-13 | Diabecore Medical Inc. | Derivatized insulin oligomers |
EP3050568B1 (en) | 2007-03-13 | 2020-12-02 | JDS Therapeutics, LLC | Methods and compositions for the sustained release of chromium |
WO2008132224A2 (en) * | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
WO2010133294A2 (de) | 2009-05-18 | 2010-11-25 | Boehringer Ingelheim International Gmbh | Adapter, inhalationseinrichtung und zerstäuber |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
AP3141A (en) | 2009-11-25 | 2015-02-28 | Boehringer Ingelheim Int | Nebulizer |
WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
AU2012223282B2 (en) | 2011-03-01 | 2017-02-02 | Nutrition 21, Llc | Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders |
WO2012130757A1 (de) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medizinisches gerät mit behälter |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
EP2835146B1 (en) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
HUE055604T2 (hu) | 2014-05-07 | 2021-12-28 | Boehringer Ingelheim Int | Porlasztó |
EP3139979B1 (en) | 2014-05-07 | 2023-07-05 | Boehringer Ingelheim International GmbH | Unit, nebulizer and method |
EP3139983B1 (en) | 2014-05-07 | 2023-07-19 | Boehringer Ingelheim International GmbH | Container and indicator device, and nebulizer |
US11865121B2 (en) | 2016-02-11 | 2024-01-09 | Nutrition21, LLC | Chromium containing compositions for improving health and fitness |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1381273A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
IE36225B1 (en) * | 1971-01-28 | 1976-09-15 | Nat Res Dev | Improvements relating to insulin derivatives |
GB1381274A (en) * | 1971-01-28 | 1975-01-22 | Nat Res Dev | Insulin derivatives |
DK135268A (es) * | 1973-02-09 | |||
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
US4164573A (en) * | 1975-06-13 | 1979-08-14 | Galinsky Alvin M | Composition and method for making a suppository for introducing a hypoglycemic agent into a mammal |
GB1554157A (en) * | 1975-06-13 | 1979-10-17 | Takeda Chemical Industries Ltd | Stable insulin preparation for intra nasal administration |
GB1527605A (en) * | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
US4442090A (en) * | 1980-11-09 | 1984-04-10 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use |
JPS58189118A (ja) * | 1982-04-30 | 1983-11-04 | Takeda Chem Ind Ltd | 経鼻投与製剤 |
DE3382112D1 (de) * | 1982-04-30 | 1991-02-21 | Ajinomoto Kk | Pharmazeutische zusammensetzung. |
US4534894A (en) * | 1982-11-17 | 1985-08-13 | The Rockefeller University | Process for sulphation and phosphorylation of proteins and peptides |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
US4746508A (en) * | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
JPS60224616A (ja) * | 1984-04-24 | 1985-11-09 | Teijin Ltd | 経鼻投与用組成物 |
-
1986
- 1986-04-18 DK DK179286A patent/DK179286D0/da not_active Application Discontinuation
-
1987
- 1987-04-10 CA CA000534467A patent/CA1283358C/en not_active Expired - Fee Related
- 1987-04-13 IL IL82209A patent/IL82209A0/xx not_active IP Right Cessation
- 1987-04-14 EP EP87902450A patent/EP0267208B1/en not_active Expired - Lifetime
- 1987-04-14 WO PCT/DK1987/000038 patent/WO1987006137A1/en active IP Right Grant
- 1987-04-14 AU AU73561/87A patent/AU598543B2/en not_active Ceased
- 1987-04-14 JP JP62502696A patent/JPH01500116A/ja active Pending
- 1987-04-14 DE DE8787902450T patent/DE3772521D1/de not_active Expired - Fee Related
- 1987-04-14 AT AT87902450T patent/ATE66614T1/de active
- 1987-04-14 US US07/132,969 patent/US5053389A/en not_active Expired - Fee Related
- 1987-04-15 ES ES8701124A patent/ES2007607A6/es not_active Expired
- 1987-12-08 DK DK642587A patent/DK160460C/da not_active IP Right Cessation
- 1987-12-16 FI FI875533A patent/FI87529C/fi not_active IP Right Cessation
- 1987-12-17 NO NO875299A patent/NO875299L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO875299D0 (no) | 1987-12-17 |
EP0267208A1 (en) | 1988-05-18 |
FI875533A (fi) | 1987-12-16 |
DK160460B (da) | 1991-03-18 |
IL82209A0 (en) | 1987-10-30 |
DK160460C (da) | 1991-08-26 |
FI87529B (fi) | 1992-10-15 |
FI875533A0 (fi) | 1987-12-16 |
CA1283358C (en) | 1991-04-23 |
NO875299L (no) | 1987-12-17 |
JPH01500116A (ja) | 1989-01-19 |
FI87529C (fi) | 1993-01-25 |
DK179286D0 (da) | 1986-04-18 |
EP0267208B1 (en) | 1991-08-28 |
DK642587D0 (da) | 1987-12-08 |
DK642587A (da) | 1987-12-08 |
ATE66614T1 (de) | 1991-09-15 |
AU7356187A (en) | 1987-11-09 |
US5053389A (en) | 1991-10-01 |
AU598543B2 (en) | 1990-06-28 |
WO1987006137A1 (en) | 1987-10-22 |
DE3772521D1 (de) | 1991-10-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960416 |