ES2007177A6 - 1-(6-amino-9-purinyl)- beta -D-ribofuranuronic acid amides and thioamides - Google Patents

1-(6-amino-9-purinyl)- beta -D-ribofuranuronic acid amides and thioamides

Info

Publication number
ES2007177A6
ES2007177A6 ES8801031A ES8801031A ES2007177A6 ES 2007177 A6 ES2007177 A6 ES 2007177A6 ES 8801031 A ES8801031 A ES 8801031A ES 8801031 A ES8801031 A ES 8801031A ES 2007177 A6 ES2007177 A6 ES 2007177A6
Authority
ES
Spain
Prior art keywords
thioamides
purinyl
amino
beta
acid amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801031A
Other languages
Spanish (es)
Inventor
Fulvio Gadient
Arnold Vogel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2007177A6 publication Critical patent/ES2007177A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for preparing amidas and thioamides of the acid 1 '' - desoxy-1 "- (6-amino-9-purinyl) -ribofuranuronic substituted in position 2, of formula (I) where r1, r2, r3, r6 yx they have the definitions indicated in the claims (Machine-translation by Google Translate, not legally binding)
ES8801031A 1987-04-06 1988-04-05 1-(6-amino-9-purinyl)- beta -D-ribofuranuronic acid amides and thioamides Expired ES2007177A6 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3711562 1987-04-06
DE3711561 1987-04-06
DE3711563 1987-04-06
DE3711564 1987-04-06

Publications (1)

Publication Number Publication Date
ES2007177A6 true ES2007177A6 (en) 1989-06-01

Family

ID=27433888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801031A Expired ES2007177A6 (en) 1987-04-06 1988-04-05 1-(6-amino-9-purinyl)- beta -D-ribofuranuronic acid amides and thioamides

Country Status (22)

Country Link
JP (1) JPS63258892A (en)
KR (1) KR880012629A (en)
AT (1) AT393507B (en)
AU (1) AU609109B2 (en)
BE (1) BE1002151A5 (en)
CA (1) CA1326017C (en)
CH (1) CH676121A5 (en)
DK (1) DK183488A (en)
ES (1) ES2007177A6 (en)
FI (1) FI87463C (en)
FR (1) FR2613367A1 (en)
GB (1) GB2203149B (en)
HU (1) HU201955B (en)
IL (1) IL85969A (en)
IT (1) IT1219892B (en)
LU (1) LU87181A1 (en)
MY (1) MY102323A (en)
NL (1) NL8800862A (en)
NZ (1) NZ224131A (en)
PH (1) PH25424A (en)
PT (1) PT87153B (en)
SE (1) SE8801236L (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
HU198950B (en) * 1986-12-15 1989-12-28 Sandoz Ag Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
PT86660B (en) * 1987-02-04 1992-02-28 Ciba Geigy Ag PROCESS FOR THE PREPARATION OF ADENOSIN-5'-CARBOXAMIDE DERIVATIVES
USRE36494E (en) * 1990-02-20 2000-01-11 Discovery Therapeutics, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5140015A (en) * 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
IT1254915B (en) * 1992-04-24 1995-10-11 Gloria Cristalli ADENOSINE DERIVATIVES FOR ACTIVITY A2 AGONIST
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (en) 1998-01-31 2003-01-31 Glaxo Group Limited 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
PL345062A1 (en) 1998-06-23 2001-11-19 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
WO2000063703A1 (en) 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
AR049384A1 (en) 2004-05-24 2006-07-26 Glaxo Group Ltd PURINA DERIVATIVES
ATE531377T1 (en) * 2004-09-20 2011-11-15 Inotek Pharmaceuticals Corp PURINE DERIVATIVES AND METHODS OF APPLICATION
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH606084A5 (en) * 1975-02-18 1978-10-13 Hoffmann La Roche (Di) nitrates of adenosine -5'-carboxylic acid derivs
US4167565A (en) * 1976-11-08 1979-09-11 Abbott Laboratories Adenosine-5'-carboxamides and method of use
DE3406533A1 (en) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim USE OF ADENOSINE DERIVATIVES AS ANTIALLERGICA AND MEDICINAL PRODUCTS CONTAINING THEM
HU198950B (en) * 1986-12-15 1989-12-28 Sandoz Ag Process for producing new furanuronic acid derivatives and pharmaceutical compositions comprising such compounds
PT86660B (en) * 1987-02-04 1992-02-28 Ciba Geigy Ag PROCESS FOR THE PREPARATION OF ADENOSIN-5'-CARBOXAMIDE DERIVATIVES

Also Published As

Publication number Publication date
GB8807750D0 (en) 1988-05-05
FR2613367A1 (en) 1988-10-07
FI87463C (en) 1993-01-11
NZ224131A (en) 1991-12-23
CA1326017C (en) 1994-01-11
FI87463B (en) 1992-09-30
PT87153A (en) 1988-05-01
CH676121A5 (en) 1990-12-14
PH25424A (en) 1991-07-01
NL8800862A (en) 1988-11-01
FI881571A (en) 1988-10-07
SE8801236D0 (en) 1988-04-05
SE8801236A0 (en) 1988-10-17
HUT48902A (en) 1989-07-28
DK183488D0 (en) 1988-04-05
KR880012629A (en) 1988-11-28
FI881571A0 (en) 1988-04-05
AU1415188A (en) 1988-10-06
IL85969A (en) 1992-03-29
AU609109B2 (en) 1991-04-26
SE8801236L (en) 1988-10-17
AT393507B (en) 1991-11-11
ATA87388A (en) 1991-04-15
JPS63258892A (en) 1988-10-26
IT1219892B (en) 1990-05-24
IL85969A0 (en) 1988-09-30
PT87153B (en) 1992-07-31
LU87181A1 (en) 1988-11-17
HU201955B (en) 1991-01-28
GB2203149B (en) 1991-02-13
MY102323A (en) 1992-05-28
DK183488A (en) 1988-10-07
BE1002151A5 (en) 1990-08-07
GB2203149A (en) 1988-10-12
IT8847794A0 (en) 1988-03-30

Similar Documents

Publication Publication Date Title
ES2007177A6 (en) 1-(6-amino-9-purinyl)- beta -D-ribofuranuronic acid amides and thioamides
BG41820A3 (en) Method for preparing n- (3- hydroxy- 4- piperidinyl) benzamide derivatives
MY108885A (en) Heterocyclic-cyclic amine derivatives.
MX9203338A (en) NEW DERIVATIVES OF OXICO A_NOR-ESTEROIDE-3-CARBOXILICO.
BG101112A (en) The use of heterocyclic compounds
HU9500836D0 (en) Fluoroalkoxybenzyl derivatives of nitrogen containing heterocycles
CA2111461A1 (en) 3-Aminopiperidine Derivatives and Related Nitrogen Containing Heterocycles
FI96204C (en) Process for the preparation of therapeutically useful heterocyclic compounds
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
ES8800272A1 (en) Polypeptide, a process for preparing the same, a pharmaceutical composition containing said polypeptide as well as the use thereof.
MY107819A (en) Preparation of substituted piperidines.
AU1413788A (en) Dihydropyridinamides process for their preparation, and their use in medicaments
ES2001389A6 (en) Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors.
BG40962A3 (en) Method for preparing n- substituted n- (dichloracetyl)- glycinamides
ES454501A1 (en) Pyrrolidonecarboxylic acid derivatives as anti-ulcer agents
ES8305717A1 (en) Substituted 2-amino-3,4-dihydro-pyridine derivatives, process for their preparation and their use in medicines.
DK0432841T3 (en) Spiro-indoline-oxazine compounds with photochromatic and photosensitizing properties and process for their preparation
ES8704897A1 (en) 1,4-Dihydropyridines, process for their preparation and their use.
GR3015132T3 (en) Novel ureas and thioureas, preparation thereof and application in therapy.
FI960588A0 (en) Thiocarbamoyl compounds for use as microbicides
ES8800666A1 (en) 1,4-Dihydropyridine derivatives, process for their preparation and their use in medicaments.
CA1262906C (en) 3-(2-furoyl)-5-alkoxycarbonyl-2,6-dimethyl-4- (2-nitrophenyl)-1,4-dihydropyridine calcium antagonists
ATE53839T1 (en) 2,3-DIHYDRO-3-PHENYL-BENZOFURAN-2-ONACETAMIDE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THEM.
ES8606298A1 (en) 1,4-Dihydropyrazines, process for their preparation and their use in medicines.
NO912420L (en) ANTIATHEROSCLEROTIC AND ANTITROMOBOTIC 1-BENZOPYRANE-4-ONER AND 2-AMINO-1,3-BENZOKSAZIN-4-ONER.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301