ES2000714A6 - Un procedimiento para preparar derivados de tetrahidroisoquinoleina - Google Patents

Un procedimiento para preparar derivados de tetrahidroisoquinoleina

Info

Publication number
ES2000714A6
ES2000714A6 ES8600468A ES8600468A ES2000714A6 ES 2000714 A6 ES2000714 A6 ES 2000714A6 ES 8600468 A ES8600468 A ES 8600468A ES 8600468 A ES8600468 A ES 8600468A ES 2000714 A6 ES2000714 A6 ES 2000714A6
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
intermediates
preparation
compositions containing
tetrahydroisoquinoline derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600468A
Other languages
English (en)
Inventor
Carl Kaiser
Lawrence Ivan Kruse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES2000714A6 publication Critical patent/ES2000714A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA PREPARACION DE ESTOS COMPUESTOS, QUE TIENEN LA FORMULA EN LA QUE Y ES HALOGENO, X1 ES ALCOXI, C1-4, X2 ES ALCOXI C1-4, HLOGENO O ALQUILO C1-4 Y M ES 0 A 4, SE EFECTUA REDUCIENDO UN COMPUESTO DE FORMULA EN LA QUE Y, X1, X 2 Y M SON COMO ANTES, Y CONVIRTIENDO OPCIONALMENTE EL COMPUESTO OBTENIDO EN UNA DE SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. LOS DERIVADOS OBTENIDOS TIENEN ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES B-ADRENERGICOS EN ANIMALES, INCLUIDO EL HOMBRE, Y SON APLICABLES AL TRATAMIENTO DE ENFERMEDADES VASCULARES Y OTROS TRASTORNOS TALES COMO LA MIGRANYA Y EL GLAUCOMA.
ES8600468A 1985-07-23 1986-07-22 Un procedimiento para preparar derivados de tetrahidroisoquinoleina Expired ES2000714A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858518634A GB8518634D0 (en) 1985-07-23 1985-07-23 Chemical compounds

Publications (1)

Publication Number Publication Date
ES2000714A6 true ES2000714A6 (es) 1988-03-16

Family

ID=10582746

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600468A Expired ES2000714A6 (es) 1985-07-23 1986-07-22 Un procedimiento para preparar derivados de tetrahidroisoquinoleina

Country Status (10)

Country Link
US (2) US4707485A (es)
EP (1) EP0210827A3 (es)
JP (1) JPS6222768A (es)
AU (1) AU585039B2 (es)
DK (1) DK346186A (es)
ES (1) ES2000714A6 (es)
GB (1) GB8518634D0 (es)
GR (1) GR861899B (es)
PT (1) PT83025B (es)
ZA (1) ZA865462B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332821A (en) * 1987-03-20 1994-07-26 Hoffmann-La Roche Inc. Process for preparing isoquinolines
BE1002413A3 (nl) * 1988-05-11 1991-01-29 Spoelders Ludy Inrichting voor het in zaagtandvorm tussen twee paren van boven- en ondermessen uitsnijden en verlijmen van de einden van fineerbanden.
AU9512298A (en) * 1997-09-30 1999-04-23 Molecular Design International, Inc. Beta3-adrenoreceptor agonists, agonist compositions and methods of using
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
CN101588803B (zh) * 2006-12-06 2013-03-20 康乃尔研究基金会有限公司 中等持续时间神经肌肉阻断剂及其拮抗剂
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1250828B (de) * 1962-10-10 1967-09-28 Chinoin Gyogyszer es Vegyeszeti Termekek Gyära R.T., Budapest Verfahren zur Herstellung des spasmolytisch wirksamen 6,7,3',4' - Tetraäthoxy -l-benzyliden-1,2,3,4tetrahydroisochinolins und seiner Salze
SE352889B (es) * 1968-01-31 1973-01-15 Tanabe Seiyaku Co
US3905982A (en) * 1973-07-23 1975-09-16 Searle & Co 1-Aryl-n-dialkylaminoalkyl-3,4-dihydro-2(1H)-isoquinolinecarboxamides and related compounds
US3910915A (en) * 1973-07-23 1975-10-07 Searle & Co 1-Aryl-2-{8 (substituted amino)alkanoyl{9 -1,2,3,4-tetrahydroisoquinolines
US4514569A (en) * 1982-01-28 1985-04-30 Hendrickson James B Synthesis of 1-substituted isoquinolines

Also Published As

Publication number Publication date
DK346186D0 (da) 1986-07-21
GR861899B (en) 1986-11-24
PT83025A (en) 1986-08-01
PT83025B (en) 1988-07-08
AU6024786A (en) 1987-01-29
AU585039B2 (en) 1989-06-08
DK346186A (da) 1987-01-24
US4767862A (en) 1988-08-30
EP0210827A2 (en) 1987-02-04
GB8518634D0 (en) 1985-08-29
JPS6222768A (ja) 1987-01-30
ZA865462B (en) 1987-04-29
US4707485A (en) 1987-11-17
EP0210827A3 (en) 1988-03-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201