EP3615921A4 - Orthogonal polybiosensing and imaging systems - Google Patents

Orthogonal polybiosensing and imaging systems Download PDF

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Publication number
EP3615921A4
EP3615921A4 EP18790804.1A EP18790804A EP3615921A4 EP 3615921 A4 EP3615921 A4 EP 3615921A4 EP 18790804 A EP18790804 A EP 18790804A EP 3615921 A4 EP3615921 A4 EP 3615921A4
Authority
EP
European Patent Office
Prior art keywords
polybiosensing
orthogonal
imaging systems
imaging
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18790804.1A
Other languages
German (de)
French (fr)
Other versions
EP3615921A2 (en
Inventor
Mandana Veiseh
Pirooz Parvarandeh
S. Bahram Bahrami
Oliver Peter King-Smith
Todd S. Rutherford
Aaron Peter SCHELLENBERG
Timothy Scott Edward HILLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polybiomics Inc
Original Assignee
Polybiomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polybiomics Inc filed Critical Polybiomics Inc
Publication of EP3615921A2 publication Critical patent/EP3615921A2/en
Publication of EP3615921A4 publication Critical patent/EP3615921A4/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B01L3/5055—Hinged, e.g. opposable surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G01N29/024—Analysing fluids by measuring propagation velocity or propagation time of acoustic waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/00—Additional constructional details
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    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/01—Indexing codes associated with the measuring variable
    • G01N2291/011—Velocity or travel time
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02809—Concentration of a compound, e.g. measured by a surface mass change
    • G—PHYSICS
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acoustics & Sound (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
EP18790804.1A 2017-04-27 2018-04-27 Orthogonal polybiosensing and imaging systems Pending EP3615921A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762491090P 2017-04-27 2017-04-27
PCT/US2018/029864 WO2018200995A2 (en) 2017-04-27 2018-04-27 Orthogonal polybiosensing and imaging systems

Publications (2)

Publication Number Publication Date
EP3615921A2 EP3615921A2 (en) 2020-03-04
EP3615921A4 true EP3615921A4 (en) 2021-04-14

Family

ID=63918676

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18790804.1A Pending EP3615921A4 (en) 2017-04-27 2018-04-27 Orthogonal polybiosensing and imaging systems

Country Status (3)

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EP (1) EP3615921A4 (en)
CN (1) CN110799830B (en)
WO (1) WO2018200995A2 (en)

Families Citing this family (11)

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DE102019135557A1 (en) * 2019-12-20 2021-06-24 Biophotonics Diagnostics GmbH SAMPLE CARRIERS FOR THE ELECTRICAL MANIPULATION OF LIQUID SAMPLES AND FOR VIBRATION SPECTROSCOPY ON THE SAMPLES
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
JPWO2021166597A1 (en) * 2020-02-19 2021-08-26
US20210301245A1 (en) * 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
KR102369697B1 (en) * 2020-05-18 2022-03-03 국민대학교산학협력단 Bio sensing module, and system including the same
EP3943924A1 (en) * 2020-07-22 2022-01-26 Technische Universität München Microwell plate for impedance measurements on cell clusters
US20240019404A1 (en) * 2020-10-15 2024-01-18 University Of Southern California System and method for high-frequency imaging array
CN112415002B (en) * 2020-11-10 2023-03-14 之江实验室 Multimode sensing device based on image sensor
CN114217208B (en) * 2021-12-10 2024-04-19 余姚舜宇智能光学技术有限公司 Module testing device and testing method of module testing device
CN114799495B (en) * 2021-12-28 2023-06-13 华中科技大学 Laser cutting control method and related device
CN114821576A (en) * 2022-06-30 2022-07-29 之江实验室 Target identification method and device based on visual sense and olfactory sense device

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US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
US20130341734A1 (en) * 2012-06-21 2013-12-26 Nxp B.V. Integrated circuit with sensors and manufacturing method
US20160077045A1 (en) * 2013-03-15 2016-03-17 Life Technologies Corporation Chemical Sensor with Consistent Sensor Surface Areas
EP3128309A1 (en) * 2015-08-03 2017-02-08 Palo Alto Research Center, Incorporated Polysensing bioelectronic test plate

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US6132683A (en) * 1998-12-23 2000-10-17 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
CA2229528A1 (en) * 1998-02-13 1999-08-13 Shailesh Mehta Apparatus and method for analyzing particles
DE10142393C1 (en) * 2001-08-30 2003-01-23 Fraunhofer Ges Forschung Apparatus measuring bioelectrical signals from spheroids, includes commensurately-sized chamber ringed internally with coplanar electrodes
DE102009043527B4 (en) * 2009-09-30 2021-06-10 Boehringer Ingelheim Vetmedica Gmbh Arrangement and method using microsensors for measuring cell vitalities
JP2013516999A (en) * 2010-01-20 2013-05-16 イー・エム・デイー・ミリポア・コーポレイシヨン Cell image acquisition and remote monitoring system
CH706326A2 (en) * 2012-03-14 2013-09-30 Tecan Trading Ag Procedures and microplate readers for study of biological cells or cell cultures.
KR101363791B1 (en) * 2012-03-30 2014-02-20 고려대학교 산학협력단 Apparatus for measuring cell viability and method for analyzing cell viability
US9274071B2 (en) * 2013-12-30 2016-03-01 General Electric Company Methods for assessing cell culture fluid by impedance spectra
WO2016167580A1 (en) * 2015-04-16 2016-10-20 연세대학교 산학협력단 Biosensor for monitoring three-dimensional cell culture in real time

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
JPH09281066A (en) * 1996-04-15 1997-10-31 Horiba Ltd Measuring system using impedance ct
US20080207465A1 (en) * 2002-10-28 2008-08-28 Millipore Corporation Assay systems with adjustable fluid communication
US20130341734A1 (en) * 2012-06-21 2013-12-26 Nxp B.V. Integrated circuit with sensors and manufacturing method
US20160077045A1 (en) * 2013-03-15 2016-03-17 Life Technologies Corporation Chemical Sensor with Consistent Sensor Surface Areas
EP3128309A1 (en) * 2015-08-03 2017-02-08 Palo Alto Research Center, Incorporated Polysensing bioelectronic test plate

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Title
See also references of WO2018200995A2 *

Also Published As

Publication number Publication date
EP3615921A2 (en) 2020-03-04
CN110799830B (en) 2023-04-14
WO2018200995A2 (en) 2018-11-01
CN110799830A (en) 2020-02-14
WO2018200995A3 (en) 2018-12-06

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Ipc: G01N 21/80 20060101ALI20201204BHEP

Ipc: G01N 21/64 20060101AFI20201204BHEP

Ipc: G01N 27/02 20060101ALI20201204BHEP

Ipc: G01N 21/25 20060101ALI20201204BHEP

Ipc: G01N 21/78 20060101ALI20201204BHEP

Ipc: G01N 33/487 20060101ALI20201204BHEP

Ipc: G01N 35/00 20060101ALI20201204BHEP

Ipc: C12M 3/06 20060101ALI20201204BHEP

Ipc: G01N 21/17 20060101ALI20201204BHEP

Ipc: C12M 1/00 20060101ALI20201204BHEP

Ipc: G01N 29/024 20060101ALI20201204BHEP

Ipc: B01L 3/00 20060101ALI20201204BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20210317

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 21/64 20060101AFI20210311BHEP

Ipc: G01N 33/483 20060101ALI20210311BHEP

Ipc: G01N 35/00 20060101ALI20210311BHEP

Ipc: G01N 21/17 20060101ALI20210311BHEP

Ipc: B01L 3/00 20060101ALI20210311BHEP

Ipc: C12M 3/06 20060101ALI20210311BHEP

Ipc: C12M 1/00 20060101ALI20210311BHEP

Ipc: C12M 1/34 20060101ALI20210311BHEP

Ipc: G01N 21/25 20060101ALI20210311BHEP

Ipc: G01N 21/80 20060101ALI20210311BHEP

Ipc: G01N 29/024 20060101ALI20210311BHEP

Ipc: G01N 33/487 20060101ALI20210311BHEP

Ipc: G01N 27/02 20060101ALI20210311BHEP

Ipc: G01N 21/78 20060101ALI20210311BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20240422