EP3498376B1 - Syringe, syringe family and dispensing device - Google Patents

Description

The invention relates to a syringe and a syringe family for use with a dosing device and to a dosing device for use with a syringe or a syringe family.

Pipettes are dosing devices for measuring and transferring liquids. They are often designed as repeater or multipettes, which are used together with a syringe in order to absorb liquid into the syringe and dispense it gradually from it. A repeater pipette is from the DE 29 26 691 C2 and the U.S. 4,406,170 known, which describes in particular the repeating mechanism of the repeating pipette. It also describes how to fix the syringe to the repeater pipette. For this purpose, the syringe has a syringe flange which can be inserted from the side into a laterally open, essentially U-shaped groove in the pipette. An axial pressure spring fixes the inserted syringe flange in the groove. To connect the syringe plunger to a plunger adjusting device of the pipette, there is an insert element which receives an end section of the syringe plunger between two jaws. The jaws can be pressed against the syringe plunger by means of a flap-shaped clamping member, the actuating lever of which protrudes from the housing through an opening. This syringe fixation has the disadvantage that the syringe has to be touched for insertion and coupling with the plunger adjusting device or for decoupling and removal.

the DE 43 41 229 C2 and the U.S. 5,620,660 propose a pipette system that is better suited for manual operation with a syringe that can be easily pushed axially into the pipette or removed from it. This pipette system has a syringe, which has a fastening section and a syringe plunger, and a pipette that has a receptacle for the fastening section in a pipette housing and a receptacle body with a plunger receptacle for the syringe plunger or a plunger rod connected thereto. There are also fastening devices for reversibly or detachably fixing the fastening section and syringe plunger in the receptacles and plunger adjusting devices for moving the receptacle body in the pipette housing. The fastening section and the syringe plunger can be pushed axially into their fastening positions through axial openings in their receptacles.

The fastening devices have radially adjustable gripping devices for fixing the fastening section and the syringe plunger in the fastening positions. The gripping devices have syringe gripping levers pivotably mounted in the pipette housing and piston gripping levers pivotably mounted in the receiving body. The syringe gripping levers and the plunger gripping levers are two-armed with a gripping arm and an actuating arm, the syringe gripping levers having contact points on the inside of their actuating arms which can be pivoted against the actuating arms of the piston gripping levers by actuating their actuating arms on the outside and actuating the piston gripping levers.

This ensures that the syringe and the pipette can be connected to one another by a purely axial relative movement and can be separated from one another by actuating the actuating arms. According to one embodiment, the fastening section is a syringe flange and according to a further embodiment the syringe piston has a piston collar for the gripping devices to grip from behind.

From the DE 10 2005 023 203 A1 , the EP 1 724 020 A1 and the US 2006263261 A1 is an embodiment of the pipette according to DE 43 41 229 C2 known in which the syringe can be released from the pipette by actuating only a single trigger.

the EP 20 33 712 A1 describes a pipette with fastening devices for a syringe that corresponds to the fastening devices of DE 10 2005 023 203 A1 correspond. By actuating the actuator, liquid can be dispensed from the syringe in a single step or in several steps. After the liquid has been dispensed, an ejector slide is moved into a release position and the syringe is ejected by actuating the actuating element again, without the user having to actuate a special trigger.

the WO 2009/046482 A1 describes a syringe system comprising syringes that have a glass cylinder with a piston barrel area in a tubular glass cylinder, a needle held at the bottom of the glass cylinder, a connector held at the top of the glass cylinder for connection to a laboratory machine, a piston inserted into the glass cylinder and sealingly guided therein, and an end piece on the having upper end of the piston for connection to a piston connector of the laboratory automat. On the upper edge, the connecting piece has a circumferential projection which protrudes radially inward and which closely surrounds the piston.

the EP 1 524 035 A1 describes a method for attaching a syringe to a pipetting device and the associated device.

The commercial versions Multipette® (plus / stream / Xstream) of this dosing system from Eppendorf AG include syringes Combitips® (plus), which have a cylinder with a piston barrel area on the inside and a syringe flange at the upper end of the cylinder. The syringes are offered with different filling volumes (0.1 ml, 0.2 ml, 0.5 ml, 1 ml, 2.5 ml, 5 ml and 10 ml). The inner diameter of the piston barrel area is dimensioned so that the filling volume is taken up or dispensed from the syringe with a maximum piston travel of the Multipette® from Eppendorf AG of 50 mm plus an overstroke of a few millimeters. In the case of the syringe with a nominal volume of 10 ml, the inner diameter of the piston barrel area is accordingly 15.96 mm. In the case of the smaller syringes, the inner diameter of the piston barrel area is correspondingly smaller. The cylinders of the smaller syringes have a cylindrical extension at the upper end of the piston barrel area, the inner diameter of which is significantly smaller than 15.96 mm and which is smaller the lower the filling volume of the syringe. One reason for the cylindrical widening is that it enables the piston to reach its depth in the cylinder, which prevents the piston sealing lip from being damaged by placing the sealing lip on the lower end face of the cylinder. Another reason is that in the small syringes the piston area below the coupling piece introduced into the dosing system is made thicker, in particular designed as a wing piece, in order to thereby achieve an increase in the flexural rigidity of the piston rod in the storage state.

Starting from the flange, the cylinders have four outwardly projecting, axially extending ribs on the circumference, which are evenly distributed over the circumference. The ribs each have a shoulder at the bottom for support on the edge of holes in a carrier ("tray") or a box. So that syringes with different filling volumes can be used in uniform holes of a carrier or box, the shoulders of syringes of different filling volumes have the same distances from the axis of the cylinder.

The well-known dosing system enables precise dosing with small measurement errors.

Proceeding from this, the invention is based on the object of providing a syringe and a syringe family for use with a dosing device and a dosing device for use with a syringe or a syringe family, which allow even more precise dosing.

The object is achieved by a syringe with the features of claim 1.

A syringe according to the invention for use with a dosing device comprises the following features:
a syringe cylinder and a syringe plunger, the syringe cylinder having an outlet at the bottom, a centering collar at the top on the outer circumference, a piston barrel area connected to the outlet, in which the syringe plunger is guided in a sealing manner, and further up a centering area into which a centering element with an axial passage of the dosing device can be used and rests radially on the inside of the centering area, the syringe plunger
Has coupling piece at the upper end and can be inserted with the coupling piece through the axial passage of the centering element so that the syringe plunger can be pulled out of the syringe cylinder, the syringe cylinder is in several parts, the syringe cylinder having the piston barrel area and the outlet at a lower part and the centering collar and has the centering area on an upper part and the upper part is connectable to the lower part.

Furthermore, the object is achieved by a syringe family with the features of claim 13.

The syringe family according to the invention for use with a dosing device with a centering element with an axial passage in a receptacle for a syringe cylinder and an axially displaceable plunger receptacle for a syringe plunger comprises several syringes with different filling volumes, each with a syringe cylinder and a syringe plunger, the syringe cylinder having an outlet at the bottom, a centering collar at the top on the outer circumference, a piston barrel area connected to the outlet in which the syringe plunger is sealingly guided, and further up a centering area in which a centering element with an axial passage of the metering device can be used and rests radially on the inside of the centering area, the syringe plunger has a coupling piece at the upper end, and the coupling piece can be pushed through the axial passage of the centering element so that the syringe plunger can be pulled out of the syringe cylinder can, the syringe cylinder is in several parts, wherein the syringe cylinder has the piston barrel area and the outlet on a lower part and the centering collar and the centering area on an upper part and the upper part is connectable to the lower part t, the centering areas of syringes with different filling volumes having a matching contour on the inside.

The multiple syringes are preferably selected from the group of syringes with filling volumes of 10 ml, 5 ml, 2.5 ml, 1 ml, 0.5 ml, 0.2 ml and 0.1 ml.

The centering areas of the syringes with different filling volumes have a matching contour. A matching contour in the centering area is understood to mean identical and / or different geometries which are matched to the same predetermined centering contour. The syringes with a matching contour are therefore suitable for interacting with one and the same centering element of the dosing system that has the centering contour.

The object is also achieved by a metering device with the features of claim 17.

• ein Gehäuse umfassend
• eine Aufnahme für den Zentrierbund des Spritzenzylinders mit einer Axialöffnung zum axialen Einsetzen des Zentrierbundes in eine Befestigungsposition,
• ein in der Aufnahme angeordnetes, auf die Axialöffnung ausgerichtetes, Zentrierelement mit axialem Durchgang zum axialen Einsetzen in den Zentrierbereich und radialen Anlegen an die Innenseite des Zentrierbereiches des Spritzenzylinders,
• einen Aufnahmekörper mit einer Kolbenaufnahme zum axialen Einsetzen des Kupplungsstückes in eine Befestigungsposition,
• Befestigungseinrichtungen zum lösbaren Halten von Zentrierbund und Kupplungsstück in ihren Befestigungspositionen in der Aufnahme und in der Kolbenaufnahme,
• wobei die Befestigungseinrichtungen radial zustellbare Greifeinrichtungen zum Greifen des Zentrierbundes und des Kupplungsstückes in den Befestigungspositionen aufweisen,
• und Kolbenstelleinrichtungen zum Verschieben des Aufnahmekörpers im Gehäuse.

The dosing device according to the invention for use with a syringe with a syringe cylinder and a syringe plunger, the syringe cylinder having an outlet at the bottom, a centering collar at the top on the outer circumference, a cylindrical piston barrel area connected to the outlet, in which the syringe plunger is sealingly guided, and further up a centering area and has a coupling at the top of the syringe plunger or for use with a family of syringes comprising a plurality of such syringes

• comprising a housing
• a receptacle for the centering collar of the syringe cylinder with an axial opening for axial insertion of the centering collar into a fastening position,
• a centering element arranged in the receptacle and aligned with the axial opening with an axial passage for axial insertion into the centering area and radial application to the inside of the centering area of the syringe cylinder,
• a receptacle body with a piston receptacle for axial insertion of the coupling piece in a fastening position,
• Fastening devices for releasably holding the centering collar and coupling piece in their fastening positions in the receptacle and in the piston receptacle,
• wherein the fastening devices have radially adjustable gripping devices for gripping the centering collar and the coupling piece in the fastening positions,
• and piston adjusting devices for moving the receiving body in the housing.

Advantageous configurations of the syringe, the syringe family and the metering device are specified in the subclaims.

The information "above" and "below" relate to the preferred alignment of the syringe during dosing, in which the syringe is held vertically with the outlet at the bottom and the centering collar at the top.

The metering device can in particular be a manually and / or motor-driven, manageable and / or stationary metering device. In particular, it can be a pipette, repeater pipette, dispenser, metering station or automatic metering device. It is preferably a dispenser.

The syringe according to the invention can be reversibly fixed to a metering device according to the invention in a simple manner. For this purpose, the syringe is inserted into the dosing device in the axial direction, the centering collar being gripped by means of radially adjustable gripping devices for gripping the centering collar in the receptacle of the dosing device and the syringe plunger on its coupling piece in the plunger receptacle by means of radially adjustable gripping devices for gripping the Piston rod is gripped. The gripping of the centering collar and the coupling piece by the gripping devices can be controlled by inserting the syringe axially into the receptacle of the dosing device. For this purpose, the metering device can be designed as in FIG DE 43 41 229 C2 and the U.S. 5,620,660 described.

When the syringe is inserted into the dosing device, the centering element penetrates axially into the centering area and rests radially against the inside of the centering area. The dimensions and geometries of the centering element and the centering area are matched to one another, so that the syringe cylinder is centered by the centering element used. As a result, the syringe cylinder with the centering area is guided precisely into the receptacle so that it can be easily and safely gripped by the gripping devices.

Because the centering area rests on the centering element, a deformation in the centering area of the syringe cylinder can be corrected. In particular, the centering element can correct a non-circular shape of the syringe cylinder to an ideal circular shape. Since the centering area is either in the immediate vicinity of the piston running area, which is decisive for precise dosing, or in the immediate vicinity of the transition area which counteracts damage to the sealing lip of the piston, the correction in the centering area has a positive effect on the dosing accuracy. A non-circular cylinder has a different cross-sectional area than a circular cylinder, which leads to metering errors. In particular, the circular shape improves the tightness of the seal of the syringe plunger in the cylinder and thus improves the precision of the dosage. Due to the changed cross-sectional area, an out-of-round syringe cylinder still has the consequence that air flows past the syringe plunger and closes in, particularly at the end of the intake stroke and during the initial dispensing strokes a small volume of liquid is absorbed or dispensed. This disadvantage is overcome by the invention.

Furthermore, the guidance of the centering area on the centering element prevents misalignment of the syringe to the dosing device and a tilting of the syringe with respect to the dosing device under load. Misalignment can occur in a conventional dispensing system when the syringe is gripped in a tilted orientation by the dispensing system's gripping devices. A tipping under load can occur in a conventional dosing system if, during dosing, the syringe is placed on a wall near its outlet with a pressing force. This form of delivery is known as wall delivery. In particular, it is used for small dispensing volumes in order to avoid errors due to uneven tear-offs from the syringe. As a result, the syringe cylinder is pivoted with respect to the syringe plunger, whereby liquid can be displaced and a dosing error can be caused. In addition, a reduced tightness of the sealing of the plunger in the tilted syringe cylinder can impair the accuracy of the dosing. These disadvantageous properties of the previously known syringe and metering devices are also overcome by the present invention.

The syringe plunger can be inserted with its coupling piece through the axial passage of the centering element, so that the syringe plunger can be pulled out of the syringe cylinder. If necessary, the piston receptacle engages in the axial passage of the centering element for coupling the coupling piece. An inner diameter in the centering area of at least 16.2 mm ensures that syringes with a filling volume of up to 10 ml with an inner diameter of the piston barrel area of up to 15.96 mm can be fed into a dosing device with a maximum piston travel of 50 mm plus an overstroke of a few millimeters can be used. Syringes with all common filling volumes are thus covered by the invention. Larger filling volumes (e.g. 25-50 ml) are possible if an adapter is used that reduces the larger diameter of the syringe cylinder to the smaller diameter of the holder for the dosing device. In the case of small-volume syringes, the adapter can make small syringes easier to grip and handle. The adapter has the centering area. As a result, the adapter is also centered in the dosing device and thus aligns the syringe, supports it and prevents the syringe from tipping over, in particular when dispensing from the wall.

The invention relates to syringes in which the syringe barrel is in several parts. In particular, it includes syringes in which the syringe barrel is the Piston running area and the outlet on a lower part and the centering collar and centering area on an upper part, which can be connected to the lower part, for example by means of a bayonet, screw or snap connection. The upper part can in particular be an adapter.

A jump in the inside diameter between the piston barrel area and the centering area enables the syringe plunger pushed completely into the syringe cylinder to be guided at the top in the piston barrel area when the syringe is not connected to the dosing device. For this purpose, the outside diameter of a guide area of the syringe plunger arranged below the coupling piece can correspond almost to the inside diameter of the plunger running area. The outside diameter of the guide area should be less than the inside diameter of the plunger running area by at least the sum of the tolerances of the syringe plunger (eg 0.1 mm) and syringe cylinder (eg 0.1 mm). Due to the larger inside diameter in the centering area, a gap remains between the syringe plunger and the centering area, into which the centering element can be inserted. Thus, by widening the inside diameter in the centering area compared to the inside diameter in the piston barrel area, a centering of the

Syringe plunger in the syringe ensured when the syringe is connected to the dosing device and the centering element engages in the expanded centering area and fills it. The centering and guidance of the syringe plunger in the syringe separated from the dosing device is given despite the extended centering area, since the guiding area of the fully inserted plunger rests and is guided on the piston barrel area or, in the case of syringes with small volumes (e.g. 1 ml and smaller), on the transition area .

The centering of the syringe plunger by the guide area in the syringe separated from the dosing device avoids tilting of the syringe plunger in the syringe cylinder and thus deformations in the sealing area of the syringe plunger and / or the syringe cylinder due to partial irreversible expansion, thereby avoiding dosing errors.

The guidance of the syringe plunger at the top in the plunger running area can be effected by axially extending wings of the syringe plunger projecting outward and / or by a disk below the coupling piece of the syringe plunger. The disk can also cover the piston barrel area, which prevents contamination from penetrating into the syringe cylinder, which can impair the sealing of the piston and / or contaminate the liquid to be metered.

Furthermore, a jump in the inside diameter between the centering area and the piston running area enables a simple tolerance check by means of force measurement when joining the syringe plunger and syringe cylinder during production. If the diameter of the syringe plunger is too large, two increases in force are measured when joining, namely when the syringe plunger with its sealing area penetrates into the centering area and then when the sealing area penetrates into the piston running area. If the diameter of the piston does not exceed the
Upper tolerance limit, an increase in force is only measured when the sealing area penetrates the piston running area. A simple and unambiguous measurement can thus determine whether the diameter of the syringe plunger exceeds the upper tolerance limit and whether the syringe plunger has to be discarded. Checking compliance with the upper tolerance limit is particularly important because out-of-roundness in the syringe plunger can be detected as an increase in diameter. The use of syringe plungers, which cause dosing errors due to a non-circular sealing area, can thus be avoided. Since the tolerances of the syringe plunger and the syringe cylinder are included in the test, the entire syringe is preferably rejected if the upper tolerance limit is exceeded. The present invention thus also comprises a method for tolerance checking.

According to the method according to the invention for tolerance testing of syringes with a cylindrical piston barrel area with a first inner diameter and a centering area with a second inner diameter which exceeds the first inner diameter, when a syringe piston is pushed into the syringe cylinder, the force for pushing the syringe piston into the syringe cylinder is measured and in the event that the force for pushing the syringe plunger into the centering area exceeds an upper tolerance limit, the syringe plunger and / or the syringe cylinder are rejected.

After use, the syringe can easily be released from the dosing system by operating the gripping devices. The separation can also take place in an axial movement. The centering prevents the syringe cylinder from tilting in the receptacle, so that separation can take place more easily. In particular, after releasing the gripping devices, the syringe can fall out of the dosing system due to its own weight. This can optionally be supported by a spring-loaded stop on which the centering collar of the syringe cylinder can be fixed.

According to one embodiment, the inner diameter in the centering area of the syringe according to the invention is at most 17.7 mm. Limiting the inner diameter in the centering area to a maximum of 17.7 mm means that the syringes can be gripped using a conventional Multipette® dispenser from Eppendorf AG when they are held in a carrier. In these dosing systems, the gripping devices for releasably fixing the syringe flange have hook-shaped gripping ends, the inner edges of which are spaced 20.8 mm apart when they are pivoted together. The syringes can be provided in a carrier with carrier sleeves protruding from a plate. The syringes can be inserted into holes in the carrier sleeves, the syringe cylinder being guided in the carrier sleeves on the outer circumference of the centering area. So that the syringe gripping levers do not get stuck on the carrier sleeves, the outer diameter of the carrier sleeves can be selected so that it falls below the distance between the pivoted gripper ends. Taking into account a minimum wall thickness of the carrier sleeves, a clearance for inserting the syringe cylinder into the carrier sleeve and a minimum wall thickness for the syringe cylinder in the centering area, the inner diameter in the centering area is at most 17.7 mm.

The syringe is preferably made of plastic, in particular a thermoplastic. The thermoplastic is preferably selected from the group of polyolefins. Preferred polyolefins are polyethylene (PE), polypropylene (PP) and cyclic olefin (co) polymers, COC or COP for short. The syringe and plunger can be made from the same plastic or from different ones. In particular, due to the better friction pairing, the piston is made of PE and the cylinder is made of PP or vice versa.

The syringe according to the invention can be designed in such a way that it can also be used in conventional dispensers of the Multipette® type from Eppendorf AG that do not have a centering element.

The advantageous effects of the syringes according to the invention are in principle also given in the syringes of the syringe family according to the invention. In the syringes with different filling volumes of the syringe family, the centering areas have contours that are matched to the same predetermined centering contour so that they can be used with the same metering device whose centering element has the centering contour. The user can use a syringe with a suitable filling volume in every application and the dosing accuracy is always improved by centering the respective syringe in the dosing device.

For this purpose, the syringes with different filling volumes of the syringe family preferably have the same contours in the centering areas. But they can also have at least partially different contours, provided that these are matched to one and the same centering contour. For example, cylindrical and polygonal contours can be matched to the same cylindrical centering element, so that the centering areas provided with these different contours are centered by the same centering element. The centering areas of the syringes with different filling volumes of a syringe family thus have a functionally matching contour that is matched to the same predetermined centering contour. A matching contour in the centering area is understood to mean the same and / or different contours or geometries which interact with the same centering element of a metering device that has the predetermined centering contour, ie are complementary thereto. In particular, in the case of a syringe family with several syringes with different syringes Filling volumes, that between the individual members with different filling volumes (eg 10 ml, 5 ml, 2.5 ml, 1 ml, 0.5 ml, 0.2 ml and 0.1 ml) there can be different contours or geometries in the centering area However, they are all characterized by the fact that the same centering element of a dosing system engages in them, is applied and thus corrects any roundness of the syringe cylinder, as well as aligning and supporting the syringe.

According to one embodiment of the invention, within a syringe family for an individual member of the family, the matching contour or geometry in the centering area is selected from the group of conical hollow bodies, convex hollow bodies, pyramidal hollow bodies, columnar hollow bodies with an ellipsoidal outer base or cross-sectional area, the polygonal columnar, in particular octagonal columnar hollow body, the hollow body with circumferential or partially circumferential ribs or webs, the hollow body with at least two flattened inner sides, or the hollow body, which are cut by at least two secants, the hollow body with projections, warts, webs and the elliptical hollow body, and a combination thereof. Preferred combinations are conical with a circumferential bead, e.g. as a torus, a combination of conical and cylindrical as well as conical with webs or round elevations.

According to one embodiment of the invention, the predetermined centering contour of the centering element is also selected from the aforementioned groups.

According to a preferred embodiment, the syringes of the syringe family have an inner diameter of at least 16.2 mm and at most 17.7 mm in the centering area.

In principle, the syringe family can have a syringe with a filling volume of 10 ml, which has the same inner diameter of 15.96 mm in the piston barrel area and in a centering area. A second inner diameter of at least 16.2 mm is an advantageous embodiment of the syringes of the syringe family according to the invention, which ensures that a syringe with a filling volume of 10 ml also has the advantages of a centering area with a larger inner diameter than in the piston barrel area.

According to one embodiment, the syringe cylinder has a greater wall thickness in the cylindrical piston barrel area than in the centering area. In this way, a particularly effective flow brake is achieved, since to increase the flow resistance due to the deflection of the flow of the hot plastic mass in the area of the jump in diameter, there is an increase in the interference resistance due to the reduced flow cross-section.

According to a further embodiment, the syringe cylinder has a conical insertion area at the upper end of the centering area and / or a conical transition area between the centering area and the cylindrical piston barrel area. The conical insertion area and / or the conical transition area guide the syringe plunger when it is inserted into the plunger barrel area, so that the sealing area of the plunger is correctly inserted and not damaged. The insertion area and / or the transition area preferably have an angle of 15 to 30 ° to the axis of the syringe cylinder. An angle of the insertion area of approximately 15 ° and an angle of the transition area of approximately 25 ° are particularly preferred. In the case of smaller syringes (e.g. with a maximum filling volume of 5 ml), an insertion area can be dispensed with because the inner diameter in the centering area is large enough for contactless insertion of the syringe plunger and it can only be correctly inserted into the plunger barrel area through the transition area.

The centering area can be designed in different ways. It can be designed inside as a freeform surface or a ruled surface. A freeform surface is understood to mean a surface that cannot be precisely described mathematically, whereas a ruled surface can be described precisely mathematically. On the inside, it preferably has the contour or geometry of a surface of revolution (for example cylinder, cone, hyperbolic, parabolic surface). The centering area is preferably slightly conical with a cone angle of 0.5 to 5 °, in particular approximately 2 °, to the longitudinal axis of the syringe. The contour or geometry of the centering area can be smooth on the inside. According to an alternative embodiment of the invention, the centering area has a contour on the inside with projections and / or depressions, the largest inscribed circle imagined in the contour having the second inner diameter. The imaginary largest inscribed circle corresponds to the outer diameter of the centering element. The contour or geometry of the centering area, in cooperation with a complementary centering contour or geometry of the centering element, leads to a correction of a possibly non-circular shape of the syringe cylinder, to an alignment and support of the syringe plunger and thus prevents the plunger from tilting in the syringe cylinder. Furthermore, the interaction of the contour or geometry of the centering area with the complementary centering contour or geometry of the centering element enables the correct alignment of a syringe coding with a sensor for scanning the syringe coding and / or a rotation lock. The anti-twist device prevents the syringe from twisting in the dosing device, which can damage a sensor for scanning a syringe code. The contour can also serve to reduce the friction between the syringe cylinder and the centering element in order to facilitate the insertion of a smooth centering element into the centering area.

The contour or geometry can only touch the imaginary / projected largest inscribed circle at two diametrically opposite points, whereby a centering is already achieved. It preferably touches the circle in more than two places. The points are preferably evenly distributed over the circumference of the circle.

The centering element of a dosing system, which interacts with the syringes of the syringe family, has, according to one embodiment, an outer diameter of 16.2 to 17.7 mm and / or a wall thickness of 0.4 to 2.5 mm and / or stands for a stop for the top of the centering collar 2.2 to 6 mm in front.

According to one embodiment, the centering collar has an outer diameter of 21 to 24.2 mm and / or a height of 3.2 to 5.4 mm and / or the centering area is at least at a distance of at least 3 mm and at most 6 mm from the upper end of the syringe barrel. This enables the syringe to be inserted into the commercial Multipette® dispensers from Eppendorf AG.

According to one embodiment, the syringe has a filling volume selected from the following volumes: 10 ml, 5 ml, 2.5 ml, 1 ml, 0.5 ml, 0.2 ml, 0.1 ml. The centering area always ensures exact centering on one Centering element of a dosing system.

According to one embodiment, the syringe piston has a disk and / or axially extending wings below the coupling piece and an annular gap with a gap width of 0.5 to 2.5 mm is present between the disk and / or the wings and the centering area. The disk prevents contaminants from entering the syringe cylinder and the disk and / or the wings guide the syringe cylinder at the top of the piston path. The annular gap with a gap width of 0.5 to 2.5 mm ensures that the centering element is between the washer
and / or wing and syringe cylinder find space and the disc and / or wing can be inserted into the centering element.

The centering element can in particular be a torus or hollow cylinder of low height. Furthermore, it can be designed as a hollow cylinder of greater height, a hollow cone or some other continuous body of revolution, so that line contact or surface contact with the centering area is possible. Multi-point contact can also be useful. In particular, the centering element can be pyramid-shaped or polygonal column-shaped, wherein the pyramid or polygonal column can have any number of corners (e.g. 8). The centering element is preferably cylindrical, in particular circular cylindrical, or slightly conical, in particular with a cone angle of 0.1 to 2.5 °, in particular approximately 1 °. Furthermore, the centering element preferably has a conical insertion area at the lower end.

According to a further embodiment, the centering element has a contour with projections and / or depressions on the outside, the smallest circle that circumscribes the contour having the second inner diameter. This contour can interlock with a complementary contour of the syringe. In this way, a syringe coding can be aligned directly with a sensor of the dosing device. Furthermore, this can be used to prevent rotation, which prevents the syringe from rotating in the coding device. Furthermore, by interacting with a smooth centering area, the contour can reduce the friction when the centering element is inserted into the syringe.

According to one embodiment, the centering element is arranged rigidly with respect to the receptacle or is spring-loaded with respect to the receptacle in the axial direction. The rigid arrangement results in a more rigid guidance of the syringe with respect to the dosing device compared to the spring-loaded arrangement. The rigid The arrangement has the advantage that a spring-loaded stop, against which the centering collar rests with its upper side, supports the release of the syringe from the dosing device. The advantage of the rigid arrangement is that it can prevent tipping when the syringe is placed on a surface, for example a vessel rim, with a certain amount of force, as is common, for example, with the pipetting technique of wall dispensing, which has already been discussed. A spring-loaded centering element can compensate for alignment errors when the centering tube is inserted into the receptacle. According to a preferred embodiment, the centering element is spring-loaded with respect to the receptacle in that it is fixed to a spring-loaded stop for the centering collar.

According to one embodiment, the centering element in the contact area with the centering area has an outer diameter of 16.2 to 17.7 mm and / or a wall thickness of 0.4 to 2.5 mm and / or is 2 with respect to a stop for the top of the centering collar , 2 to 6 mm in front. These details relate to the state of the dosing device in which the syringe is not inserted, and include arrangements of centering element and stop that are spring-loaded relative to one another and also rigid relative to one another. If the stop is designed as a sensor plate, they relate to the base of the sensor plate from which contact elements may protrude.

Fig. 1a bis f

eine Spritze mit einem Füllvolumen von 10 ml in Seitenansicht (Fig. 1a), Ansicht von oben (Fig. 1b), Ansicht von unten (Fig. 1c), einem Vertikalschnitt entlang der Linie A-A von Fig. 1a (Fig. 1d), einer vergrößerten Detailansicht A von Fig. 1d (Fig. le), zerlegt in Spritzenkolben und Spritzenzylinder in Seitenansicht (Fig. 1f) und Spritzenzylinder derselben Spritze in einem Vertikalschnitt (Fig. 1g) und derselbe Spritzenzylinder im Vertikalschnitt mit Varianten des Zentrierbereiches in vertikalen Teilschnitten und in vergrößerten halben Querschnitten (Fig. 1h);

Fig. 2a bis f

eine Spritze mit einem Füllvolumen von 0,1 ml in Seitenansicht (Fig. 2a), Ansicht von oben (Fig. 2b), Ansicht von unten (Fig. 2c), einem Vertikalschnitt entlang der Linie A-A von Fig. 2a (Fig. 2d), vergrößerter Detailansicht A von Fig. 2d (Fig. 2e) und zerlegt in Spritzenkolben und Spritzenzylinder in Seitenansicht (Fig. 2f);

Fig. 3a und b

Spritzen einer Spritzenfamilie in Seitenansicht mit einem Ausbruch im Oberbereich (Fig. 3a) und vergrößerte Details A bis C von Fig. 3a (Fig. 3b);

Fig. 4a und b

Spritzgießwerkzeug zum Spritzgießen eines Spritzenzylinders einer Spritze mit einem Füllvolumen von 0,1 ml im geschlossenen Zustand beim Spritzgießen eines Spritzenzylinders (Fig. 4a) und im geöffneten Zustand beim Auswerfen des Spritzenzylinders (Fig. 4b);

Fig. 5

Spritze mit einem Füllvolumen von 10 ml mit Spritzenkolben in zwei verschiedenen Einschiebepositionen in einem vertikalen Vollschnitt;

Fig. 6

Kraft zum Einschieben zweier Spritzenkolben mit unterschiedlichen Abmessungen aufgrund Fertigungsschwankungen in den Spritzenzylinder einer Spritze von Fig. 5 in Abhängigkeit vom Weg des Einschiebens im Kraft/WegDiagramm;

Fig. 7

Spritze mit einem Zentrierbereich bestehend aus drei im Wesentlichen zylindrischen Zentrierabschnitten, die als Prüfdurchmessern genutzt werden und Spritzenkolben in vier verschiedenen Einschiebepositionen in einem vertikalen Vollschnitt;

Fig. 8

Kraft zum Einschieben von vier Spritzenkolben mit unterschiedlichen Abmessungen aufgrund Fertigungsschwankungen in den Spritzenzylinder einer Spritze von Fig. 7 in Abhängigkeit vom Weg des Einschiebens in einem Kraft/Weg-Diagramm;

Fig. 9

Dosiervorrichtung, insbesondere Dispenser für den Gebrauch von Spritzen gemäß Fig. 1 bis 8 in einer Perspektivansicht schräg von unten und von der Seite;

Fig. 10

verfederter oberer Anschlag mit Zentrierelement mit axialem Durchgang derselben Dosiervorrichtung in einem vergrößerten perspektivischen Sprengbild;

Fig. 11

derselbe verfederte obere Anschlag mit Zentrierelement mit axialem Durchgang zusammengesetzt mit anliegender Spritze in einer vergrößerten Perspektivansicht des Spritzenzylinders im vertikalen Vollschnitt;

Fig. 12

dieselbe Dosiervorrichtung mit eingesetzter Spritze in einer Perspektivansicht schräg von unten und von der Seite mit Spritzenzylinder im vertikalen Halbschnitt;

Fig. 13

verfederter oberer Anschlag einer alternativen Dosiervorrichtung mit starr bezüglich der Aufnahme angeordnetem Zentrierelement mit axialem Durchgang in einem perspektivischen Sprengbild;

Fig. 14a bis c

Spritze mit axial verlaufenden Vertiefungen im Zentrierbereich in Draufsicht (Fig. 14a) und im Vertikalschnitt (Fig. 14b) sowie Zentrierelement mit zu den Vertiefungen komplementären Erhebungen in einer Perspektivansicht schräg von unten und von der Seite;

Fig. 15

verschiedene Spritzen angeordnet auf einem Träger für Spritzen im Vertikalschnitt;

Fig. 16a bis c

eine Spritze umfassend einen Adapter in Seitenansicht (Fig. 16a), Seitenansicht von der gegenüberliegenden Seite (Fig. 16b), Draufsicht (Fig. 16c) und einem Vertikalschnitt (Fig. 16d);

Fig. 17a und b

Ausschnitt einer Dosiervorrichtung mit unverfedertem Zentrierring, der mit der Halteplatte verbunden ist (Fig. 17a) und einer Dosiervorrichtung mit verfedertem Zentrierring, der mit der Trägerplatte mitfedert (Fig. 17b);

Fig. 18a und b

eine Tabelle mit Messergebnissen aus Versuchen mit einem herkömmlichen Dispenser und solchen mit verfedertem bzw. nichtverfedertem Zentrierelement (Fig. 18a) und eine grafische Darstellung der Ergebnisse (Fig. 18b).

The invention is explained in more detail below in the drawings 16-18 with reference to the attached drawings of exemplary embodiments. The ones in the Fig. 1-15 Examples shown are not part of the invention and are only used for better understanding of the invention. In the drawings show:

Fig. 1a to f

a syringe with a filling volume of 10 ml in side view ( Fig. 1a ), View from above ( Figure 1b ), Bottom view ( Figure 1c ), a vertical section along the line AA of Fig. 1a (Fig. 1d ), an enlarged detail view A of Fig. 1d (Fig. Le), disassembled into syringe plunger and syringe cylinder in side view ( Fig. 1f ) and syringe barrel of the same syringe in a vertical section ( Fig. 1g ) and the same syringe cylinder in vertical section with variants of the centering area in vertical partial sections and in enlarged half cross-sections ( Fig. 1h );

Fig. 2a to f

a syringe with a filling volume of 0.1 ml in side view ( Fig. 2a ), View from above ( Figure 2b ), Bottom view ( Figure 2c ), a vertical section along the line AA of Fig. 2a (Fig. 2d ), enlarged detail view A of Fig. 2d (Fig. 2e ) and disassembled into syringe plunger and syringe barrel in side view ( Fig. 2f );

Figures 3a and b

Syringes of a syringe family in side view with an eruption in the upper area ( Fig. 3a ) and enlarged details A to C of Fig. 3a (Fig. 3b );

Figures 4a and b

Injection molding tool for injection molding a syringe barrel of a syringe with a filling volume of 0.1 ml when closed when injecting a syringe barrel ( Figure 4a ) and when open when ejecting the syringe barrel ( Figure 4b );

Fig. 5

Syringe with a filling volume of 10 ml with syringe plunger in two different insertion positions in a full vertical section;

Fig. 6

Force to insert two syringe plungers with different dimensions due to manufacturing fluctuations in the syringe barrel of a syringe from Fig. 5 depending on the path of insertion in the force / path diagram;

Fig. 7

Syringe with a centering area consisting of three essentially cylindrical centering sections that are used as test diameters and syringe plungers in four different insertion positions in a full vertical section;

Fig. 8

Force to insert four syringe plungers with different dimensions due to manufacturing fluctuations in the syringe barrel of a syringe from Fig. 7th as a function of the path of insertion in a force / path diagram;

Fig. 9

Dosing device, in particular dispenser for the use of syringes according to Figures 1 to 8 in a perspective view obliquely from below and from the side;

Fig. 10

spring-loaded upper stop with centering element with axial passage of the same metering device in an enlarged perspective exploded view;

Fig. 11

the same spring-loaded upper stop with a centering element with an axial passage, assembled with the syringe attached, in an enlarged perspective view of the syringe cylinder in full vertical section;

Fig. 12

the same dosing device with inserted syringe in a perspective view obliquely from below and from the side with syringe cylinder in vertical half section;

Fig. 13

Spring-loaded upper stop of an alternative metering device with a centering element arranged rigidly with respect to the receptacle with an axial passage in an exploded perspective view;

Figures 14a to c

Syringe with axially extending depressions in the centering area in plan view ( Figure 14a ) and in vertical section ( Figure 14b ) and centering element with complementary to the depressions Elevations in a perspective view obliquely from below and from the side;

Fig. 15

various syringes arranged on a support for syringes in vertical section;

Figures 16a to c

a syringe comprising an adapter in side view ( Figure 16a ), Side view from the opposite side ( Figure 16b ), Top view ( Figure 16c ) and a vertical section ( Figure 16d );

Figures 17a and b

Section of a dosing device with an unsprung centering ring that is connected to the retaining plate ( Figure 17a ) and a dosing device with a spring-loaded centering ring that springs along with the carrier plate ( Figure 17b );

Figures 18a and b

a table with measurement results from tests with a conventional dispenser and those with a spring-loaded or non-spring-loaded centering element ( Figure 18a ) and a graphic representation of the results ( Figure 18b ).

In the following explanation, parts of different exemplary embodiments that correspond to one another are provided with several reference numbers separated by a point, the numbers in front of the point being the same and the numbers after the point designating the respective embodiment. In summary, parts of different exemplary embodiments that correspond to one another are also designated solely by the corresponding numbers.

The ones in the Figures 1 to 15 Syringes shown are not the subject of the invention and are only used for a better understanding of the invention.

According to Fig. 1 a 10 ml syringe 1.1 has a syringe cylinder 2.1 in which a syringe plunger 3.1 is arranged. The syringe cylinder 2.1 is not strictly cylindrical everywhere from a geometric point of view. The syringe cylinder 2.1 has an outside cylindrical cylinder section 4.1, which has a cylindrical piston barrel area 5.1 on the inside.

The cylinder section 4.1 has a bottom 6.1 with a central hole 7.1. The edge of the hole 7.1 is connected to an internally and externally conical tip section 8.1 with a small cone angle, which at the bottom has an internally and externally more conical cone section 9.1. The syringe section 8.1 and the cone section 9.1 taper downwards.

The cylinder section 4.1 is connected at the top via a short internally and externally conical transition area 10.1 to an internally and externally cylindrical or slightly conical centering area 11.1.

The centering area 11.1 is connected at the top to a centering collar 12.1 which has an essentially circular disk-shaped contact section 13.1 and an essentially cylindrical jacket section 14.1. The contact section 13.1 has a contact surface 15.1. This can have codes in the form of axially directed scanning surfaces which are arranged at one or more defined positions. The codes can be designed as in EP 0 657 216 B1 and the U.S. 5,620,661 described.

Furthermore, the syringe cylinder 2.1 has a conical insertion area 16.1 above the centering area 11.1 which widens towards the top.

In the cylinder section 4.1, base 6.1, tip section 8.1 and transition area, the syringe cylinder 2.1 has an approximately constant wall thickness.

The syringe cylinder 2.1 is made in one piece from plastic. It is preferably produced by injection molding a thermoplastic. The thermoplastic is, for example, polypropylene; Polyethylene or a cyclic olefinic (CO) polymer, with polypropylene being preferred due to its stability properties.

The syringe piston 3.1 has a flat cylindrical or circular disk-shaped piston section 17.1 which has a circumferential sealing lip 18.1 on the circumference. At the bottom, the piston section 17.1 is connected to a piston tip section 19.1 which is conical with the same or a similar small cone angle as the tip section 8.1.

The syringe piston 3.1 is provided with a piston rod 20.1 at the top. The piston rod 20.1 has a coupling piece 21.1 at the top. The coupling piece 21.1 has a plurality of radially projecting, circumferential piston collars 22.1, between which circumferential grooves 23.1 are present.

Below the coupling piece 21.1, a disk 24.1 is arranged on the piston rod 20.1, which is designed in the shape of a circular disk.

Below the disk 24.1 on the piston rod 20.1 are four radially protruding wings 25.1, which are evenly distributed over the circumference of the piston rod 20.1. At the top, the wings 25.1 are connected to the disk 24.1 and at the bottom with the piston section 17.1. The wings 25.1 have, adjacent to the disk 24.1, outer edges 26.1 which are parallel to the piston rod 20.1. The wings 25.1 are widest there. This is followed by a first bevel 27.1, within which the width of the wings 25.1 decreases. This is in turn followed by an outer edge 28.1 which is parallel to the piston rod 20.1. At the bottom, the wings 25.1 have a further bevel 29.1, within which the width of the wings 25.1 decreases further.

The syringe piston 3.1 is preferably made in one piece from plastic. It is also preferably injection molded from a thermoplastic. For example, it is made of polyethylene or polypropylene, with polyethylene being preferred because the material pairing of polyethylene in the piston and polypropylene in the cylinder has a low frictional force. Polypropylene is preferred for the cylinder because of its high strength,

The cylindrical sections and areas of the syringe cylinder 2.1 and the syringe piston 3.1 are circular cylindrical.

When the piston 3.1 is completely pushed into the syringe cylinder 2.1, the piston section 17.1 sits on the base 6.1 and a small annular gap remains between the piston tip section 19.1 and the tip section 8.1. The outer edges 26.1 extend from the upper end of the piston running area 5.1 over the transition area 10.1 into the centering area 11.1. The disk 24.1 engages the centering area 11.1 at the bottom. A small annular gap remains between the outer edges 26.1 and the piston barrel area 5.1, so that the outer edges 26.1 prevent the syringe piston 3.1 from tilting in the syringe cylinder. A somewhat larger annular gap 290.1 is present between the disk 24.1 or the outer edges 26.1 and the centering area 11.1. The coupling piece 21.1 is partially arranged in the centering area 11.1 and projects upward beyond the centering collar 12.1.

The above information also applies to syringes 1.2 to 1.7 with other filling volumes. Special features of syringes 1.2 to 1.7 can be found in the following explanations:
According to Fig. 2 has a 0.1 ml syringe 1.2, a syringe cylinder 2.2 and a syringe plunger 3.2. The syringe barrel 2.2 is not geometrical strictly cylindrical everywhere. At the bottom it has an internally and externally cylindrical cylinder section 4.2, which has a cylindrical piston barrel area 5.2 on the inside.

The lower end of the cylinder section 4.2 is connected to an internally and externally conical tip section 8.2, which is designed as a more conical conical section 9.2.

The upper end of the cylinder section 4.2 is connected to an internally and externally conical transition area 10.2. The upper end of the transition area 10.2 is connected to an internally and externally cylindrical centering area 11.2.

The centering area 11.2 is in turn connected to a centering collar 12.2 at the upper end. The centering collar 12.2 has an essentially circular disk-shaped contact section 13.2, which is connected to the centering area 11.2 at the inner edge. Furthermore, the centering collar 12.2 has an essentially cylindrical jacket section 14.2, which is connected at the upper end to the outer edge of the contact section 13.2.

The contact section 13.2 has a contact surface 15.2 at the top, which can have codes corresponding to the contact surface 15.1.

The syringe piston 3.2 has a long cylindrical piston section 17.2, which has a circumferential sealing lip 18.2 at the bottom. The piston section 17.2 is connected at the bottom to a piston tip section 19.2 which has a cylindrical part at the top and a conical part at the bottom.

The piston section 17.2 is provided at the top with a piston rod 20.2 which has a coupling piece 21.2 at the top, which is designed in accordance with the coupling piece 21.1.

A disk 24.2 is arranged on the piston rod 20.2 below the coupling piece 21.2. Below the disk 24.2, four wings 25.2 protrude radially from the piston rod 20.2, which are evenly distributed over the circumference of the piston rod 20.2. The wings 22.1 are connected at the top to the underside of the disk 24.2 and end at the bottom just above the piston section 17.2. At the top, they each have outer edges 26.2 parallel to the piston rod section 20.2 and each have a bevel 27.2 at the bottom.

When the piston 3.2 is completely pushed into the syringe cylinder 2.2, the bevels 27.2 sit on the inside of the transition area 10.2. A small annular gap remains between the plunger tip section 19.2 and the cone section 9.2 of the syringe cylinder 2.2. The disk 24.2 is arranged at the bottom in the centering area 11.2. There is a small annular gap 290.2 between the centering area 11.2 and the disk 24.2. The coupling piece 21.2 is partially arranged in the centering area 11.2 and protrudes above the centering collar 12.2.

According to Fig. 1a and 2a have the syringes 1.1, 1.2 on the circumference of their centering collars 12.1, 12.2 radially outwardly projecting alignment noses 30.1, 30.2 which taper upwards. The alignment noses 30.1 and 30.2 have a parabolic contour at the top. In the example, seven alignment lugs 30.1, 30.2 are distributed evenly over the circumference of the centering collars 12.1, 12.2.

According to Fig. 1e and 2e the centering area 11.1, 11.2 has an inner diameter a of 16.2 to 17.7 mm at the top and extends to a depth d of 6 mm. Furthermore, the piston barrel area 5.1, 5.2 has an inner diameter b of 15.96 and 1.60 mm, respectively. The centering collar 12.1, 12.2 has a height e of 3.2 to 5.4 mm and an outer diameter b of 21 to 24.2 mm. The coupling piece 22.1, 22.2 projects approximately 13.5 mm from the centering collar 12.1, 12.2. In the field of Piston collars 22.1, 22.2, the coupling piece 21.1, 21.2 has a diameter g of 7 to 7.2 mm and in the area of the grooves 23.1, 23.2 a diameter h of preferably less than 5 mm. This area is preferably designed as a crossed bar construction to reduce the mass.

In Fig. 1g concrete dimensions of the centering area 11.1 of the 10 ml syringe 1.1 are given. Accordingly, the centering area 11.1 has a minimum diameter of 16.2 mm and a maximum diameter of 17.7 mm. The centering area 11.1 begins at a distance of 3 mm from the top of the centering collar 12.1 and extends over an axial length of 3 mm. In Fig. 1g the centering area 11.1 is shown free of hatching, although the syringe cylinder 2.1 is also cut vertically in the centering area 11.1.

Fig. 1h also shows the syringe cylinder 2.1 in a vertical section in which the centering area 11.1 is shown free of hatching, since it can basically assume different geometries. Preferred configurations of this free-form surface or regular-form surface are shown in partial sections to the right of the vertical section through the entire syringe cylinder 2.1. A total of six geometries are indicated, three of which are shown in a vertical partial section and a further three in a half cross section through the centering area 11.1.

The top vertical partial section shows a conical centering area 11.11. The second vertical partial section shows an indicated convex centering area 11.12. The third vertical partial section shows a circumferential or partially circumferential centering area 11.13 provided with (possibly rounded) ribs or webs. This last type of configuration can also serve as a demolding aid.

The lowermost, empty vertical partial section serves to illustrate the viewing direction from below through the syringe cylinder 2.1 onto the centering area 11.1 which can be designed with different geometries. Different configurations are then shown on the far right in the half cross-sections. Half cross-sections are shown because they are cross-sections through the vertical section through the syringe cylinder 2.1 shown on the left.

The top half cross section represents a flattened centering area 11.14 cut by several secants. The middle half cross section shows a centering area 11.15 provided with projections or protrusions or webs. The lowermost half cross section shows an elliptically cut centering area 11.16.

In all of these designs of the centering area 11.1, the smallest diameter, which is at a distance of at least 3 and preferably a maximum of 6 mm below the top of the centering collar 12.1, is a maximum of between 16.2 and 17.7 mm. The outer diameter of a centering ring - explained further below - for centering the centering area must also have these dimensions, since otherwise the centering ring will not fit into the centering area and cannot fulfill its function. This is indicated at the centering area 11.14 in that a radius is drawn in there.

These design options and dimensions also apply to all further syringes 1.3 to 1.7 of the syringe family explained below.

According to Fig. 3 the other syringes 1.3 to 1.7 of the syringe family with filling volumes of 5 ml, 2.5 ml, 1 ml, 0.5 ml and 0.2 ml are structured accordingly. The parts of the further syringes 1.3 to 1.7, which correspond to those of the syringes 1.1, 1.2 described above, are provided with corresponding reference numerals, with the before the number given corresponds to the point and the number given after the point denotes the respective syringe.

In Figure 3b the flow brakes are illustrated below the centering areas 11.1, 11.2, 11.3. Accordingly, there are corners between the centering areas 11.1, 11.2, 11.3 and the transition areas 10.1, 10.2, 10.3, in which the plastic compound is deflected during injection molding so that they form a flow brake. In addition, the centering areas 11.1, 11.2, 11.3 have a smaller wall thickness than the adjacent transition areas 10.1, 10.2, 10.3. In the 10 ml syringe, the centering area 11.1 has a larger inside diameter than the piston barrel area 5.1. This causes pressure losses during injection molding, which result in the cylinder sections 4.1, 4.2, 4.3 being evenly filled with hot plastic compound.

In Fig. 4 An injection molding tool 31 comprises a tool plate 32 with a hot runner nozzle 33, a tool cover plate 34 and a stripping plate 35. It also has a tool core 36. A cavity 37 is formed between the above-mentioned components, which represents the contour of a 0.1 ml syringe cylinder 2.2.

The hot plastic compound is injected into the cavity 37 through the hot runner nozzle 33. Due to the flow brake between the transition area 10.2 and the centering area 11.2, the transition area 10.2 and the cylinder section 4.2 of the syringe cylinder 2.2 are evenly filled so that the syringe cylinder 2.2 has very good dimensional accuracy there. This is also helped by the fact that the transition area 10.2 is injected into, in which the tool core 36 has a relatively large diameter, so that there is no disadvantageous lateral deflection of the tool core 36 that leads to uneven wall thicknesses.

According to Figure 4b the injection-molded syringe cylinder 2.2 is ejected from the injection molding tool 31 by pulling the stripping plate 35 off the tool plate 32 and pulling the tool core 36 out of the stripping plate 35. The molding 2.2 then falls out of the tool 31.

the Figures 5 and 6 show how the jump in the inside diameter between the centering area 11.1 and the piston barrel area 5.1 of the 10 ml syringe 1.1 can be used to identify syringe plungers 3.1 that are not dimensionally accurate, in which the outside diameter of the plunger section 17.1 in the area of the sealing lip 18.1 exceeds the upper tolerance limit. The inner diameter of the centering area 11.1 is designed so that it corresponds to the upper tolerance limit of the outer diameter of the sealing lip 18.1. The inside diameter of the piston barrel area 5.1 is 15.96 mm. Corresponding parts of different syringe plungers 3.1, the dimensions of which differ due to manufacturing tolerances, are distinguished below by reference numbers that have a different number in the second place after the point.

The diameter of the in Fig. 5 Sealing lip 18.11 shown in the left position is too big. According to Fig. 6 When this piston section 17.11 is pushed in, a force gauge (load cell) integrated into the push-in mechanism determines two levels of force increase. This clearly indicates that the syringe piston 3.1 is too large. The lack of dimensional accuracy can in particular be due to an out-of-roundness of the piston section 17.11, which results in an excessive outer diameter of the sealing lip 18.11, which can be determined using the test method described above. The in Fig. 5 Piston section 17.12 shown in the right position is within tolerance or too small with sealing lip 18.12. According to Fig. 6 only a single force increase stage is measured in this syringe plunger 3.1.

Figures 7 and 8 show a further embodiment with which it is also easy to determine whether the piston section 17.1 falls below the lower tolerance limit. This configuration has a centering area consisting of three centering sections 11.11, 11.12, 11.13, the inner diameter of the centering section 11.12 being smaller than the inner diameter of the centering section 11.11 and the inner diameter of the centering section 11.13 being smaller than the inner diameter of the centering section 11.12. A piston running area 5.1 adjoins the centering section 11.13, the inner diameter of the piston running area 5.1 in turn being smaller than the inner diameter of the centering section 11.13.

The inside diameters are designed so that the inside diameter of the centering section 11.11 corresponds to the upper tolerance limit of the outside diameter of the sealing lip 18.1 of the piston section 17.1. The inner diameter of the centering section 11.12 corresponds to the lower engagement limit of the outer diameter of the sealing lip 18.1 and the inner diameter of the centering section 11.13 corresponds to the lower tolerance limit for the sealing lip 18.1.

The in Fig. 7 The piston section 17.11 shown on the left has an outer diameter that is too large at the sealing lip 18.11. As a result, four levels of force increase can be determined in the force / displacement diagram when this piston section 17.11 is pushed in.

The in Fig. 7 Piston section 17.12 shown in the second position from the left has a sealing lip 18.12 with an outer diameter at the upper tolerance limit. When inserting this piston section 17.12 are in accordance with Fig. 8 three levels of force increase measurable. This syringe piston 3.1 is within the tolerance range.

The in Fig. 7 Piston section 17.13 shown at the third point from the left has an outer diameter at the lower tolerance limit on the sealing lip 18.13. According to Fig. 8 two levels of force increase are visible when this piston section 17.13 is pushed in. This syringe piston 3.1 is still within the tolerance range.

The in Fig. 7 The piston section 17.14 shown on the right has an outside diameter that is too small at the sealing lip 18.14, but which exceeds the inside diameter in the piston running area 5.1. When inserting this piston section 17.14 is according to Fig. 8 a single force increase step measurable. This syringe piston 3.1 is too small.

The centering sections 11.11 to 11.13 can also be referred to as test sections. This is particularly the case when only some of the centering sections 11.11 to 11.13 are used for centering. In principle, however, all centering sections 11.11 to 11.13 can also be used for centering. The centering is explained below.

According to Fig. 9 a metering device 370 has a housing 38 designed as an elongated handle. At the lower end of the housing 38 there is an essentially circular-cylindrical receptacle 39 for the centering collar 12 of the syringe cylinder 2. The receptacle 39 is accessible from the outside through a circular opening 40 at its lower end. A plurality of axially directed guide lugs 41 protrude radially inward on the circumference of the receptacle 39.

Furthermore, a receiving body 42 with an essentially cylindrical piston receptacle 43 for a coupling piece 21 of a syringe piston 3 is present in the housing 38. The piston receptacle 43 is accessible from the outside through a further circular opening 44 at its lower end.

The receiving body 42 can be displaced axially in the housing 38 by means of a repeating mechanism (not shown). The repeating mechanism can in particular be designed in this way be like in the DE 29 26 691 C2 and the U.S. 4,406,170 or the DE 43 41 229 C2 and the U.S. 5,620,660 described.

The repeating mechanism comprises a winding lever 440, which can be axially displaced on the outside of the housing 38, with FIG Fig. 9 the elevator lever 440 is shown in the lowermost position. Accordingly, the receiving body 42 is also in the lowermost position in which its lower end is arranged approximately at the level of the bottom of the receiving element 39.

Furthermore, the repeating mechanism comprises a metering lever 45 which protrudes from the top of the housing 38 and is pivotably mounted in the housing 38. The metering lever 45 is loaded by a spring device in such a way that it is pressed into its uppermost position. By pivoting the metering lever 45 downward, the receiving body 42 can be displaced downward by one metering step. The step size of the metering step can be adjusted by means of an adjusting wheel 46 which is located at the upper end of the housing 38.

Furthermore, two diametrically opposite syringe gripping levers 47 are arranged at the bottom of the housing 38. The syringe gripping levers 47 are pivotably mounted in the housing 38. The syringe gripping levers 47 have actuation buttons 48 protruding from the outside of the housing 38. They reach through openings in the housing 38 and have hook-like cylinder gripping ends 49 protruding into the receptacle 39.

Furthermore, two piston gripping levers 50 are mounted diametrically opposite one another in the receiving body 42. The piston gripping levers 50 reach through openings in the receiving body 42, so that they engage in the piston receptacle 43 with hook-like piston gripping ends 51.

The syringe gripping levers 47 and plunger gripping levers 50 are each designed with two arms with a gripping arm and an actuating arm and are pivotably mounted in the connecting area of the gripping arm and actuating arm. Furthermore, the syringe gripping levers 47 have unlocking cams on the inside of their actuating arms and the piston gripping levers 50 on the actuating arms have cam-like projections. Spring elements, not shown, load the syringe gripping levers 47 and the piston gripping levers 50 in such a way that they are pivoted towards one another with their cylinder gripping 49 or piston gripping arms 51. The construction corresponds to the embodiment according to DE 43 41 229 C2 and U.S. 5,620,660 .

At the bottom of the receptacle 39 there is a scanning device 52.1 for coding on a centering collar 12 of a syringe 1, which is shown in FIG Fig. 10 and 11 is shown. The scanning device 52.1 has a circular disk-shaped sensor plate 53 with a central hole 54 and seven axially protruding knobs 55, which are evenly distributed over the underside of the sensor plate 53. Each knob 55 is operatively connected to a microswitch arranged in the sensor plate 53. As a result of the actuation of a knob 55, the microswitch operatively connected to it is actuated.

Furthermore, the scanning device 52.1 comprises a carrier plate 56 for the sensor plate 53. The sensor plate 53 can be fixed on the carrier plate 56 by means of bolts 57, which pass through holes 58 in the sensor plate 53.

The carrier plate 56 has a central hole 59, the diameter of which corresponds to the diameter of the hole 54 in the sensor plate 53. A circular hollow cylindrical centering element 60.1 (also "Centering tube" called) fixed with an axial passage, which has a bevel 61 on the outside at the lower edge. The centering element 60.1 engages through the hole 54 of the sensor plate 53 when the sensor plate 53 is fixed to the carrier plate 56 by means of the bolts 57.

Pins 62 protrude from the top of the carrier plate 56, a pin 62 being arranged in each case at one corner. The pins 62 are firmly connected to the carrier plate 56.

Helical springs 63 are guided on the pins 62.

There is also a holding plate 64 which also has a central hole 65, the diameter of which corresponds approximately to the diameter of the holes 54, 59. The holding plate 64 has a bore 66 at each of the corners, into each of which a pin 62 of the carrier plate 56 can be inserted.

When the pins 62 are inserted into the bores 66, the helical springs 63 are arranged between the carrier plate 56 and the holding plate 64 with a slight bias. This state is in Fig. 11 shown.

Furthermore, the holding plate 64 has axially directed spring hooks 67 on opposite sides, each with a hook end 68, which slide through lateral grooves 69 of the carrier plate 56 when the carrier plate 56 and the holding plate 64 are joined together and finally overlap the underside of the carrier plate 56 with the hook ends 68. This is also in Fig. 11 shown. The spring hooks 67 hold the arrangement of carrier plate 56 and holding plate 64 together.

In the Fig. 11 The arrangement shown enables carrier plate 56 and retaining plate 64 to spring together.

Details of a sensor plate 53 are shown in the exemplary embodiment in FIG EP 0 657 216 B1 and the U.S. 5,620,661 described.

According to Fig. 11 a syringe 1 is attached to the scanning device 52.1. The top of the centering collar 12 of the syringe 1 rests against the sensor plate 53. A coding arranged on the contact surface can thus be scanned by means of the knobs 55.

The centering element 60.1 with an axial passage engages in the centering collar 12. The centering element 60.1 rests against the cylindrical centering area 11 with an axial passage.

The above-described arrangement of sensor plate 53, carrier plate 56, centering element 60.1 with an axial passage and holding plate 64 is in the housing 38 of the metering device 370 from Fig. 9 built-in. The holding plate 64 is fixed in the housing 38. The sensor plate 53 forms the bottom of the receptacle 39. The centering element 60.1 protrudes from this bottom into the receptacle 39. The receptacle body 42 is accessible from the outside through the opening 40 of the receptacle and the holes 59 and 65 of the scanning device 52.1.

Fig. 12 shows a dosing device 370 with an inserted syringe 1. The syringe 1 is inserted with the centering collar 12 through the opening 40 into the receptacle 39. Here, the syringe 1 is guided by the alignment lugs 30 on the guide lugs 41, so that the codes on the contact surface 15 are precisely assigned to the knobs 55. The syringe gripping levers 47 slide with their cylinder gripping ends 49 over the edge of the centering collar due to the spring action 12 until they snap under its bottom. When the contact surface 15 rests against the sensor plate 53, the centering collar 12 is gripped from behind on the underside by the cylinder gripping ends 49 of the syringe gripping levers 47.

When inserting the syringe 1, the receiving body 42 is arranged in its lowest position. In this position, the coupling piece 21 engages in the piston receptacle 43. The piston gripping levers 50 slide with their gripping ends 51 over the coupling piece 21 until they snap into a groove 23 behind a piston collar 22.

Furthermore, when the syringe 1 is inserted, the centering element penetrates the centering area 11 with an axial passage 60.1, so that the syringe 1 is fixed in the dosing device 370. Because the centering element 60.1 is resiliently mounted, it can easily penetrate into the centering area 11, even if the syringe 1 is attached to the centering element 60.1 at a slight angle.

As a result of this centering, the syringe 1 is positioned precisely in its seat in the receptacle 39 and the piston receptacle 43, so that it is gripped exactly by the gripping devices 47, 50. Furthermore, the centering element with axial passage 60.1 corrects any out-of-roundness of the syringe cylinder 2. Furthermore, the centering element 60.1 keeps the syringe 1 in the correct alignment, even if the tip end 8 of the syringe 1 is placed and a transverse force is introduced into the syringe 1.

Fig. 13 shows an alternative scanning device 52.2, in which the centering element 60.2 is fixed on a holding plate 64. The scanning device 52.2 can be mounted in the metering device 370 instead of the scanning device 52.1. The holding plate 64 is fixed in the housing 38. In this embodiment, the syringe 1 is subject to an even smaller deflection when subjected to a transverse force.

According to Fig. 14 a syringe 1 has axially extending grooves 70 in the centering region 11. Furthermore, the centering element with axial passage 60.3 has ribs 71 which extend axially on the outside of the circumference and which fit into the grooves 70. When the syringe 1 is pushed onto the centering element 60.3, the interlocking of grooves 70 and ribs 71 prevents the syringe 1 from rotating with respect to the receptacle 39. This prevents damage to the sensor plate 53.

According to Fig. 15 If a lid 72 of a box or tray (not shown) has a plate 73 which has a plurality of carrier sleeves 74 protruding upward. Syringes 1.1, 1.2, 1.4 of different sizes are placed with their centering collar 12.1, 12.2, 12.4 on top of the edge of the carrier sleeves 74. In doing so, they are guided in the carrier sleeves 74 on the outer circumference of the centering area 11.1, 11.2, 11.4. The externally conical transition areas 10.1, 10.2, 10.4 ensure that the syringes 1.1, 1.2, 1.4 are guided precisely into the correct holding position.

According to Fig. 16 a syringe 1.8 has a syringe cylinder 2.8 with a cylinder section 4.8 which has a cylindrical piston barrel area 5.8 on the inside. The cylinder section 4.8 has a bottom 6.8 with a central hole 7.8, the edge of which has a conical tip section 8.8 which has a more conical conical section 9.8 at the lower end.

The cylinder section 4.8 has on the upper edge two diametrically opposite, radially outwardly projecting projections 75 of a bayonet connection.

Furthermore, the syringe cylinder 2.8 comprises an adapter 76 which is essentially sleeve-shaped. The adapter 76 has on the inside of the lower edge extending axial grooves 77 of the bayonet connection, which on an axial End distance from the bottom edge. The axial grooves 77 are arranged on two diametrically opposite inner sides of the adapter 76. At the top, the axial grooves 77 open into circumferential grooves 78 of the bayonet connection.

The syringe barrel 2.8 is in Fig. 16 with the projections 75 pushed through the axial grooves 77 and screwed into the circumferential grooves 78, up to the end of the respective circumferential groove 78. The syringe cylinder 2.8 is connected to the adapter 76 by this bayonet connection 75, 77, 78.

The adapter 76 has a centering area 11.8 above an intermediate base 79 which delimits the circumferential grooves 78 at the top. The adapter 76 has a radially outwardly projecting centering collar 12.8 on the upper edge, which has a contact surface 15.8 with codings at the top.

The intermediate base 79 has a large through opening 80 through which a syringe plunger 3.8 is inserted into the syringe cylinder 2.8. The syringe piston 3.8 has a piston section 17.8 with a circumferential sealing lip 18.8 on the circumference. At the bottom the piston section 17.8 is connected to a piston tip section 19.8 and at the top it is provided with a piston rod 20.8. The piston rod 20.8 has a coupling piece 21.8 at the top. Below the coupling piece 21.8, the piston rod 20.8 is provided with a disk 24.8 and radially protruding vanes 25.8 sit underneath on the piston rod 3.8.

This syringe 1.8 can be inserted with the adapter 76 in the receptacle 39 and with the coupling piece 21.8 in the receptacle body 42 of a metering device 370, as is done for the syringe 1 with reference to FIG Fig. 12 is explained above. The adapter is guided by the centering element 60.1 in the centering area so that the syringe 1.8 is centered.

According to the following examination report, the deflections of the syringe 1 held in the dosing device 370 (cf. Fig. 12 ) extremely low under load compared to a dosing device that does not have a centering of the syringe.

In the investigation report, the syringes examined are also referred to as "Combitips®", the dosing devices examined as "Multipette®" and the centering element as "centering tube" or "centering sleeve" or "centering ring".

Task:

It should be investigated to what extent the tilting of the Combitip® to the Multipette® can be reduced by a centering ring on the Multipette®. Current status: If the vessel is pressed too hard when a volume is dispensed on a vessel wall, the Combitip® tilts compared to the Multipette®. Here, the Combitip cylinder with the spring-loaded switching mat compresses on one side. However, since the piston does not spring together, there may be movement between the Combitip cylinder and the Combitip piston. This in turn can lead to metering errors. If the cylinder tilts too much, a malfunction message is output in the Multipette®. This can only be eliminated by moving to the zero position.

Summary:

With a non-spring loaded centering sleeve (see Figure 17a ) in the Multipette®, the force required to tilt the cylinder has been increased. 78% higher than a standard Multipette®. With a Multipette® with a spring-loaded Centering sleeve (see Figure 17b ) the force required for tilting has been increased by 40%.

Examined objects / examined material:

The prototypes were compared with a standard Multipette® X-Stream. Two Multipettes® were converted for the tests. The safety mats with the mounting plates were changed as follows.

In Figure 17a the centering sleeve is shown not spring-loaded attached to the support plate. The arrangement of Figure 17a corresponds to the in Fig. 13 arrangement shown. In Figure 17b the centering sleeve is attached to the floor so that the centering sleeve is also spring-loaded. The arrangement of Figure 17b corresponds to that in the Figures 10 and 11 arrangement shown. The serial components used in a Multipette® dispenser have not been changed.

10 ml Combitip® plus were used for the measurements. The centering sleeves were matched to this diameter.

Procedure / investigation procedure:

The measurements were carried out on a pull / press machine (type Z005) from Zwick Roell.

The test speed was 50 mm / min. The measurements were started after a pre-load of 0.1N.

Individual results:

Fig. 18 (Table and graphic) shows the comparison of a conventional dispenser of the Mulitipette® type with a dosing device according to the invention with a spring-loaded centering sleeve and with a dosing device according to the invention with a non-spring-loaded centering sleeve. In measurements 1 and 2 (see Fig 18a : Table) a series Multipette® was used. For measurements 3 and 4, a prototype Mulipette® with a non-spring-loaded centering sleeve - as in Fig 17a shown - used. Measurements 5 and 6 were made with a prototype Mulipette® with a spring-loaded centering sleeve - as in Figure 17b shown- carried out. A graphic representation of the results is in Figure 18b shown, where a shows the results with the conventional dispenser, b the results with the dispenser with the spring-loaded centering sleeve and c the results with the dispenser with the non-spring-loaded centering sleeve.

According to the following investigation report, in a conventional dosing system which does not have the syringe centered in the dosing device, dosing errors are caused by deflection of the syringe as a result of a transverse force. Accordingly, with syringes 1 and dosing device 370 according to the invention, considerably more precise dosages are possible.

In the investigation report, the syringes examined are also referred to as "Combitips®", the dosing devices examined as "Multipette®" and the centering element as "centering tube" or "centering sleeve" or "centering ring".

Task:

In the above investigation, among other things, the force required to tilt the Combitip® was determined. Background: If the vessel is pressed too hard when a volume is dispensed on a vessel wall, the Combitip® tilts opposite the Multipette. Here, the Combitip cylinder with the spring-loaded switching mat compresses on one side. It should now be investigated how large the volumetric error is due to the tilting of the Combitip®.

Summary:

If the Combitip® is tilted by 1mm compared to the Multipette® - this requires less than IN force - an error results with a volume of 5ml that can be twice as large as the permissible inaccuracy (according to Eppendorf specification).

Examined objects / examined material:

The investigation was carried out with a standard Multipette® X-stream and a 50ml Combitip® plus. For technical reasons, the largest Combitip® was selected for this experiment.

Procedure / investigation procedure:

The experimental setup from the above investigation has been expanded to include a Mettler AE 163 balance, which was placed under the Combitip®. The Combitip® were filled with water. By delivering the reverse stroke overhead, the air bubble was forced out. Before the measurement, 90% of the water was released again. The piston was therefore 5mm above the remaining stroke position during the measurements. The Combitip® was refilled for each experiment. Since small volumes dispensed at a slow dispensing speed usually collect as drops at the outlet of the Combitip®, the liquid that was pushed out by the tilting was covered with a 10 cm ² Kimberly Clark cloth absorbed. The drip tray under the clamped Combitip® with the cloth was weighed before and after the experiment.

The Z005 type pulling / pushing machine from Zwick / Roell was used with the scales for the measurement setup.

The test speed was 50 mm / min. The measurements were started after a pre-load of 0.1N.

Individual results:

Deflection attempt pressed out vol. observation 1 mm 1 0.03g = 0.03ml The squeezed out curd will stick to the tip 0.03ml is roughly a sphere 3.9mm in diameter 1 mm 2 0.02g = 0.02ml 1 mm 3rd 0.02g = 0.02ml 2mm 4th 0.055g = 0.055ml One drop falls, the second gets stuck 0.065ml is roughly a 5mm diameter ball 2mm 5 0.06g = 0.06ml 2mm 6th 0.07g = 0.07ml

To tilt the 50ml Combitip® by 2mm compared to the Multipette® X-Stream, 1.2 to 1.3N were required.

The Eppendorf specification for the Multipette® Xstream in connection with a 50ml plus: volume Inaccuracy Imprecision 5,000 µl ± 0.3% ≤ 0.25% 50,000 µl ± 0.3% ≤ 0.15%

Percentage error at 1mm deflection:

With a volume of 50,000µl 0.03ml / 50ml * 100% = 0.06% With a volume of 5,000µl 0.03ml / 5ml * 100% = 0.6% larger than Eppendorf specification

Percentage error at 2mm deflection:

With a volume of 50,000µl 0.06ml / 50ml * 100% = 0.12% With a volume of 5,000µl 0.06ml / 5ml * 100% = 1.2% larger than Eppendorf specification

List of reference symbols

1

syringe

2

Syringe barrel

3rd

Syringe plunger

4th

Cylinder section

5

Piston running area

6th

floor

7th

hole

8th

Syringe section

9

Cone section

10

Transition area

11

Centering area

12th

Centering collar

13th

Plant section

14th

Jacket section

15th

Contact surface

16

Lead-in area

17th

Piston section

18th

Sealing lip

19th

Piston tip section

20th

Piston rod

21

Coupling piece

22nd

Piston collar

23

Groove

24

disc

25th

wing

26th

Outer edges

27

Bevel

28

Outer edge

29

Bevel

290

Annular gap

30th

Alignment tab

31

Injection mold

32

Tool plate

33

Hot runner nozzle

34

Tool cover plate

35

Stripping plate

36

Tool core

37

cavity

370

Dosing device

38

casing

39

recording

40

opening

41

Guide nose

42

Receiving body

43

Piston seat

44

opening

440

Elevator lever

45

Metering lever

46

Adjustment wheel

47

Syringe handle

48

Operating buttons

49

Cylinder gripping

50

Piston gripping lever

51

Piston gripping ends

52

Scanning device

53

Sensor plate

54

hole

55

Knobs

56

Carrier plate

57

bolt

58

Holes

59

hole

60

Centering element

61

chamfer

62

Pen

63

Coil spring

64

Retaining plate

65

hole

66

drilling

67

Spring hook

68

Hook end

69

Grooves

70

Grooves

71

Ribs

72

lid

73

plate

74

Carrier sleeves

75

head Start

76

adapter

77

Axial element

78

Circumferential groove

79

Intermediate floor

80

Through opening

Claims (23)

1. A syringe for use with a dispensing device, wherein the syringe comprises the following features: a syringe cylinder (2) and a syringe plunger (3), wherein the syringe cylinder (2) has an outlet at the bottom, a centering collar (12) at the top on the outer perimeter, a plunger running region (5) connected to the outlet, in which region the syringe plunger (3) is guided in a sealing manner, and a centering region (11) farther up, into which a centering element (60) can be axially inserted with an axial passage of the dispensing device and lies radially against the inner side of the centering region (11), the syringe plunger (3) has a coupling piece (21) at the upper end and can be placed through the axial passage of the centering element with the coupling piece (21) so that the syringe plunger (3) can be pulled out of the syringe cylinder, the syringe cylinder (2) is designed with multiple parts, wherein the syringe cylinder (2) has the plunger running region (5) and the outlet on a lower part and the centering collar (12) and the centering region (11) on an upper part, and the upper part can be connected to the lower part.
2. The syringe according to claim 1, in which the upper part (76) of the syringe cylinder (2) can be connected to the lower part of the syringe cylinder (2) by means of a bayonet, screw, or snap connection.
3. The syringe according to claim 1 or 2, in which the upper part (76) of the syringe cylinder (2) is connected to the lower part of the syringe cylinder (2).
4. The syringe according to one of claims 1 to 3, in which the syringe cylinder (2.8) has a cylinder section (4.8) that has a cylindrical plunger running region (5.8) on the inside.
5. The syringe according to claim 4, in which the cylinder section (4.8) has a base (6.8) with a hole (7.8), the edge of which is connected to a conical tip section (8.8) that has a more conical cone section (9.8) at the lower end.
6. The syringe according to claim 4 or 5, in which the cylinder section (4.8) has two diametrically opposite projections (75) of a bayonet connection projecting radially outward on the upper edge, the upper part (76) of the syringe cylinder (2) has axial grooves (77) of the bayonet connection on the inside starting from the lower edge, which grooves end at an axial distance from the lower edge, are arranged on two diametrically opposite inner sides of the upper part (76) of the syringe cylinder (2) and terminate at the top in peripheral grooves (78) of the bayonet connection, and the syringe cylinder (2.8) is slid with the projections (75) through the axial grooves (77) and rotated into the peripheral grooves (78) until the end of the respective peripheral groove (78).
7. The syringe according to one of claims 1 to 6, in which the upper part (76) of the syringe cylinder (2) is sleeve-shaped.
8. The syringe according to claim 6 and 7, in which the upper part (76) of the syringe cylinder (2) has the centering region (11.8) above an intermediate base (79) that delimits the peripheral grooves (78) at the top, wherein the intermediate base (79) has a large through-opening (80) through which a syringe plunger (3.8) is inserted into the syringe cylinder (2.8).
9. The syringe according to one of claims 1 to 8, in which the upper part (76) of the syringe cylinder (2) has a centering collar (12.8) projecting radially outward on the upper edge, which collar has a contact surface (15.8) at the top with codings.
10. The syringe according to one of claims 1 to 9, in which the syringe plunger (3.8) has a plunger section (17.8) with a circumferential sealing lip (18.8) on the perimeter, the plunger section (17.8) is connected at the bottom to a plunger tip section (19.8) and is provided at the top with a plunger rod (20.8) that has a coupling piece (21.8) at the top and is provided with a disk (24.8) below the coupling piece (21.8), below which radially projecting wings (25.8) sit on the plunger rod (3.8).
11. The syringe according to one of claims 1 to 10, in which the inner diameter of the centering region (11) exceeds the inner diameter of the plunger running region (5).
12. The syringe according to one of claims 1 to 11, which has a fill volume selected from the volumes 50 ml, 25 ml, 10 ml, 5 ml, 2.5 ml, 1 ml, 0.5 ml, 0.2 ml, 0.1 ml.
13. A syringe family for use with a dispensing device (370), wherein the syringe family comprises the following features: multiple syringes (1) with different fill volumes each having a syringe cylinder (2) and a syringe plunger (3), wherein the syringe cylinder (2) has an outlet at the bottom, a centering collar (12) at the top on the outer perimeter, a plunger running region (5) connected to the outlet, in which region the syringe plunger (3) is guided in a sealing manner, and a centering region (11) farther up, into which a centering element (60) can be axially inserted with an axial passage of the dispensing device and lies radially against the inner side of the centering region (11), the syringe plunger (3) has a coupling piece at the upper end and can be placed through the axial passage of the centering element with the coupling piece (21) so that the syringe plunger (3) can be pulled out of the syringe cylinder, the syringe cylinder (2) is designed with multiple parts, wherein the syringe cylinder (2) has the plunger running region (5) and the outlet on a lower part and the centering collar (12) and the centering region (11) on an upper part, and the upper part can be connected to the lower part, wherein the centering regions (11) of syringes (1) with different fill volumes have a matching contour on the inside.
14. The syringe family according to claim 13, in which the outer diameter of the centering collars (12) and/or the heights of the centering collars (12) and/or the heights of the centering regions (11) of syringes (1) with different fill volumes match.
15. The syringe family according to claim 13 or 14, comprising syringes (1) in which the inner diameter of the centering region (11) exceeds the inner diameter of the plunger running region (5).
16. The syringe family according to one of claims 13 to 15, in which the syringes are designed according to one of claims 1 to 12.
17. A dispensing device for use with a syringe (1) according to one of claims 1 to 12 with a syringe cylinder (2) and a syringe plunger (3), wherein the syringe cylinder (2) has an outlet at the bottom, a centering collar (12) at the top on the outer perimeter, a plunger running region (5) connected to the outlet, in which region the syringe plunger (3) is guided in a sealing manner, and farther up a centering region (11) and a coupling piece (21) at the upper end of the syringe plunger (3), or for use with a syringe family comprising multiple such syringes according to one of claims 13 to 16 with

    - a housing (38) comprising

    - a seat (39) for the centering collar (12) of the syringe cylinder (2) with an axial opening (40) for axially inserting the centering collar (12) into a fastening position,

    - a centering element (60), arranged in the seat (39) and aligned with the axial opening (40), with an axial passage for axial insertion into the centering region (11) and radial placement on the inner side of the centering region (11) of syringe cylinder (2),

    - a receiving body (42) with a plunger seat (43) for axially inserting a coupling piece (21) into a fastening position,

    - fastening apparatuses (47, 50) for releasably holding the centering collar (12) and coupling piece (21) in their fastening positions in the seat (39) and in the plunger seat (43),

    - wherein the fastening apparatuses (47, 50) have radially adjustable gripping apparatuses for gripping the centering collar (12) and the coupling piece (21) in the fastening positions, and

    - plunger adjusting apparatuses for shifting the receiving body (42) in the housing (38).
18. The dispensing device according to claim 17, in which the centering element (60), in the contact region with the centering face, has an outer diameter of 16.2 to 17.7 mm and/or a wall thickness of 0.4 to 2.5 mm and/or projects 2.2 to 6 mm in relation to a stop for the upper side of the centering collar (12).
19. The dispensing device according to claim 17 or 18, in which the centering element (60) has an outer contour with projections (70) and/or recesses, wherein the contour is externally tangential to an imaginary cylinder with the second outer diameter.
20. The dispensing device according to one of claims 17 to 19, in which the centering element (60) is arranged immovably in relation to the seat (39) or is springloaded in the axial direction in relation to the seat (39).
21. The dispensing device according to one of claims 17 to 20 comprising a syringe according to claim 1 to 12 or at least one syringe of the syringe family according to one of claims 13 to 16.
22. A use of a syringe according to one of claims 1 to 12 and/or of a syringe from a syringe family according to one of claims 13 to 16 in a dispensing device for drawing in and discharging liquids.
23. A use of a dispensing device according to one of claims 17 to 21 with a syringe according to one of claims 1 to 12 for drawing in and discharging liquids.

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