EP2095833A3 - Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices - Google Patents

Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices Download PDF

Info

Publication number
EP2095833A3
EP2095833A3 EP09152298.7A EP09152298A EP2095833A3 EP 2095833 A3 EP2095833 A3 EP 2095833A3 EP 09152298 A EP09152298 A EP 09152298A EP 2095833 A3 EP2095833 A3 EP 2095833A3
Authority
EP
European Patent Office
Prior art keywords
agents
compounds
layer
medical devices
medical device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP09152298.7A
Other languages
German (de)
French (fr)
Other versions
EP2095833A2 (en
EP2095833B1 (en
Inventor
Jonathan Z. Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardinal Health Switzerland 515 GmbH
Original Assignee
Cordis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cordis Corp filed Critical Cordis Corp
Publication of EP2095833A2 publication Critical patent/EP2095833A2/en
Publication of EP2095833A3 publication Critical patent/EP2095833A3/en
Application granted granted Critical
Publication of EP2095833B1 publication Critical patent/EP2095833B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)

Abstract

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque, and atherosclerosis in type 2 diabetic patients. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned.
EP09152298.7A 2008-02-26 2009-02-06 Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices Active EP2095833B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/037,307 US9603980B2 (en) 2008-02-26 2008-02-26 Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices

Publications (3)

Publication Number Publication Date
EP2095833A2 EP2095833A2 (en) 2009-09-02
EP2095833A3 true EP2095833A3 (en) 2013-09-18
EP2095833B1 EP2095833B1 (en) 2019-08-28

Family

ID=40785308

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09152298.7A Active EP2095833B1 (en) 2008-02-26 2009-02-06 Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices

Country Status (5)

Country Link
US (1) US9603980B2 (en)
EP (1) EP2095833B1 (en)
JP (1) JP5774268B2 (en)
CA (1) CA2654479C (en)
ES (1) ES2758733T3 (en)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794490B2 (en) * 2004-06-22 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices with antimicrobial and biodegradable matrices
US11975161B2 (en) 2006-11-20 2024-05-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080311177A1 (en) 2007-06-14 2008-12-18 Massachusetts Institute Of Technology Self Assembled Films for Protein and Drug Delivery Applications
US9375327B2 (en) 2007-12-12 2016-06-28 Intact Vascular, Inc. Endovascular implant
US10022250B2 (en) 2007-12-12 2018-07-17 Intact Vascular, Inc. Deployment device for placement of multiple intraluminal surgical staples
US10166127B2 (en) 2007-12-12 2019-01-01 Intact Vascular, Inc. Endoluminal device and method
US9603730B2 (en) 2007-12-12 2017-03-28 Intact Vascular, Inc. Endoluminal device and method
US8128677B2 (en) 2007-12-12 2012-03-06 Intact Vascular LLC Device and method for tacking plaque to a blood vessel wall
US7896911B2 (en) 2007-12-12 2011-03-01 Innovasc Llc Device and method for tacking plaque to blood vessel wall
US9480826B2 (en) * 2008-03-21 2016-11-01 Cagent Vascular, Llc Intravascular device
US11229777B2 (en) 2008-03-21 2022-01-25 Cagent Vascular, Inc. System and method for plaque serration
CA2718067C (en) 2008-03-21 2014-07-08 Innovasc Llc Device and method for opening blood vessels by pre-angioplasty serration and dilatation of atherosclerotic plaque
US9198875B2 (en) * 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
JP2010218270A (en) * 2009-03-17 2010-09-30 Renesas Electronics Corp Structural analysis device, method and program for composite material layer
US20100280600A1 (en) * 2009-04-30 2010-11-04 Vipul Bhupendra Dave Dual drug stent
US9089331B2 (en) 2009-07-31 2015-07-28 Case Western Reserve University Characterizing ablation lesions using optical coherence tomography (OCT)
EP2550030B1 (en) * 2010-03-25 2018-04-25 Lutonix, Inc. Drug releasing coatings for medical devices
US20220175370A1 (en) * 2010-09-30 2022-06-09 Cilag Gmbh International Tissue thickness compensator comprising at least one medicament
WO2012149494A2 (en) * 2011-04-27 2012-11-01 Massachusetts Institute Of Technology Coating compositions, methods and coated devices
US10285831B2 (en) 2011-06-03 2019-05-14 Intact Vascular, Inc. Endovascular implant
US8487017B2 (en) 2011-06-27 2013-07-16 Covidien Lp Biodegradable materials for orthopedic devices based on polymer stereocomplexes
CA2862856C (en) 2012-01-25 2018-03-13 Intact Vascular, Inc. Endoluminal device and method
WO2013163234A1 (en) 2012-04-23 2013-10-31 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
WO2014150074A1 (en) 2013-03-15 2014-09-25 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
WO2015187872A1 (en) 2014-06-04 2015-12-10 Cagent Vascular, Llc Cage for medical balloon
CA2969535A1 (en) 2014-11-03 2016-05-12 Cagent Vascular, Llc Serration balloon
US9433520B2 (en) 2015-01-29 2016-09-06 Intact Vascular, Inc. Delivery device and method of delivery
US9375336B1 (en) 2015-01-29 2016-06-28 Intact Vascular, Inc. Delivery device and method of delivery
CN113384390B (en) 2015-09-15 2023-08-22 萨维奇医疗股份有限公司 Devices and methods for anchoring a sheath in a tissue cavity
CN113907834A (en) 2015-09-17 2022-01-11 开金血管公司 Wedge-shaped cutter of medical air bag
US10993824B2 (en) 2016-01-01 2021-05-04 Intact Vascular, Inc. Delivery device and method of delivery
US20190090906A1 (en) 2016-03-17 2019-03-28 Eric S. Rugart Organ Enclosures For Inhibiting Tumor Invasion And Detecting Organ Pathology
JP7441043B2 (en) 2016-11-16 2024-02-29 ケイジェント ヴァスキュラー， インコーポレイテッド System and method for inserting a drug into tissue through serrations
JP6730956B2 (en) * 2017-04-11 2020-07-29 テルモ株式会社 Medical equipment
US11660218B2 (en) 2017-07-26 2023-05-30 Intact Vascular, Inc. Delivery device and method of delivery
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
AU2019310102A1 (en) 2018-07-25 2021-01-28 Cagent Vascular, Inc. Medical balloon catheters with enhanced pushability
EP3975841A1 (en) 2019-05-30 2022-04-06 Massachusetts Institute of Technology Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids
KR102711856B1 (en) * 2019-06-17 2024-10-02 보스톤 싸이엔티픽 싸이메드 인코포레이티드 Covered intraluminal prosthesis with improved branch access
JP6880136B2 (en) * 2019-09-27 2021-06-02 ルトニックス，インコーポレーテッド Drug release coating for medical devices
KR102222588B1 (en) * 2020-06-18 2021-03-05 한국광기술원 Led patch combination fusion stent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008008495A2 (en) * 2006-07-13 2008-01-17 Abbott Cardiovascular Systems Inc. Stereocomplex-forming composition and implantable medical device comprising same

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862332A (en) 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
US3576883A (en) 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US3959078A (en) 1973-05-18 1976-05-25 Midwest Research Institute Enzyme immobilization with a thermochemical-photochemical bifunctional agent
SU1088712A1 (en) 1979-11-14 1984-04-30 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Apparatus for circular suture of blood vessels
US4368736A (en) 1980-11-17 1983-01-18 Kaster Robert L Anastomotic fitting
US4366819A (en) 1980-11-17 1983-01-04 Kaster Robert L Anastomotic fitting
US4917091A (en) 1982-06-24 1990-04-17 Unilink Ab Annular fastening means
SE431609B (en) 1982-06-24 1984-02-20 Unilink Ab SURGICAL INSTRUMENT FOR THE ASTAD COMMAND OF ANASTOMOS AND ITS PARTS
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4902515A (en) * 1988-04-28 1990-02-20 E. I. Dupont De Nemours And Company Polylactide compositions
JPH0833718B2 (en) 1989-12-04 1996-03-29 三菱電機株式会社 Television screen display
US5234447A (en) 1990-08-28 1993-08-10 Robert L. Kaster Side-to-end vascular anastomotic staple apparatus
US5308641A (en) 1993-01-19 1994-05-03 Medtronic, Inc. Biocompatibility of solid surfaces
US5229172A (en) 1993-01-19 1993-07-20 Medtronic, Inc. Modification of polymeric surface by graft polymerization
US5350800A (en) 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US5924997A (en) 1996-07-29 1999-07-20 Campbell; Thomas Henderson Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body
US6755846B1 (en) 1997-02-03 2004-06-29 Angioguard, Inc. Vascular filter
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208011B2 (en) * 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
EP1132058A1 (en) * 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
US20040073294A1 (en) 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US6939376B2 (en) * 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
CN1911460A (en) * 2002-02-15 2007-02-14 Cv医药有限公司 Polymer coating for medical devices
WO2003080147A1 (en) * 2002-03-20 2003-10-02 Advanced Cardiovascular Systems, Inc. Biodegradable hydrophobic polymer for stents
DE60229671D1 (en) 2002-06-21 2008-12-11 Nokia Corp SIGNALWAY DETECTION FOR WIRELESS NETWORKS WITH INTERMEDIATE AMPLIFIERS
AU2003285195A1 (en) 2002-11-08 2004-06-03 Innovational Holdings, Llc Method and apparatus for treating vulnerable artherosclerotic plaque
AU2004247027A1 (en) 2003-05-28 2004-12-23 Innovational Holdings, Llc Methods of delivering anti-restenotic agents from a stent
US8778375B2 (en) * 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
US20070043434A1 (en) 2005-08-18 2007-02-22 David Meerkin Biodegradable endovascular stent using stereocomplexation of polymers
JPWO2007116646A1 (en) 2006-04-04 2009-08-20 テルモ株式会社 In vivo indwelling

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008008495A2 (en) * 2006-07-13 2008-01-17 Abbott Cardiovascular Systems Inc. Stereocomplex-forming composition and implantable medical device comprising same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TAKESHI SERIZAWA ET AL: "Stepwise Assembly of Enantiomeric Poly(lactide)s on Surfaces", MACROMOLECULES, vol. 34, no. 6, 1 March 2001 (2001-03-01), pages 1996 - 2001, XP055074888, ISSN: 0024-9297, DOI: 10.1021/ma001705o *

Also Published As

Publication number Publication date
CA2654479C (en) 2017-01-03
US20090214615A1 (en) 2009-08-27
EP2095833A2 (en) 2009-09-02
ES2758733T3 (en) 2020-05-06
JP5774268B2 (en) 2015-09-09
US9603980B2 (en) 2017-03-28
CA2654479A1 (en) 2009-08-26
EP2095833B1 (en) 2019-08-28
JP2009201992A (en) 2009-09-10

Similar Documents

Publication Publication Date Title
EP2095833A3 (en) Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices
EP2042202A3 (en) Local vascular delivery of mTor inhibitors in combination with peroxisome proliferators-activated receptor stimulators
EP2108390A3 (en) Device for local and/or regional delivery employing liquid formulations of therapeutic agents
EP2392363A3 (en) Drug coated expandable devices
EP1723976A3 (en) Intraluminal medical devices in combination with therapeutic agents
EP1586337A3 (en) The local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
EP2392364A3 (en) Rapamycin coated expandable devices
EP1591108A3 (en) Solution formulations of sirolimus and its analogs for CAD treatment
EP1586338A3 (en) The use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices
MXPA03003354A (en) Coated medical devices for the treatment of vascular disease.
EP1974758A3 (en) Local vascular delivery of probucol alone or in combination with sirolimus to treat restenosis, vulnerable plaque, AAA and stroke
EP1749545A3 (en) System for treating aneurysmal disease
EP2272550A3 (en) Rapamycin reservoir eluting stent
ATE358505T1 (en) COATED ENDOVASCULAR DEVICE
EP1582225A3 (en) Drug delivery device
WO2009129509A3 (en) Methods and compositions for treating post-operative pain comprising a local anesthetic
MXPA03003869A (en) Coated medical devices.
EP2196226A3 (en) Coated medical devices
MX2013013809A (en) Expandable devices coated with a paclitaxel composition.
ATE432096T1 (en) COATED VESSEL DEVICES
WO2010039641A3 (en) Long term drug delivery devices with polyurethane-based polymers and their manufacture
EP2286848A3 (en) Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis
AU9486901A (en) Coated medical devices
DE602005016479D1 (en) Local, vascular administration of cladribine in combination with rapamycin for the prevention of restenosis after vascular injury
EP1568387A3 (en) Radioprotective compound coating for medical devices

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA RS

RIC1 Information provided on ipc code assigned before grant

Ipc: A61L 31/10 20060101AFI20130814BHEP

Ipc: A61L 31/16 20060101ALI20130814BHEP

17P Request for examination filed

Effective date: 20140318

RBV Designated contracting states (corrected)

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

17Q First examination report despatched

Effective date: 20140612

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZHAO, JONATHAN Z.

INTG Intention to grant announced

Effective date: 20190102

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CORDIS CORPORATION

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CARDINAL HEALTH SWITZERLAND 515 GMBH

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAJ Information related to disapproval of communication of intention to grant by the applicant or resumption of examination proceedings by the epo deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR1

GRAL Information related to payment of fee for publishing/printing deleted

Free format text: ORIGINAL CODE: EPIDOSDIGR3

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

GRAR Information related to intention to grant a patent recorded

Free format text: ORIGINAL CODE: EPIDOSNIGR71

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTC Intention to grant announced (deleted)
INTG Intention to grant announced

Effective date: 20190618

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602009059595

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1171560

Country of ref document: AT

Kind code of ref document: T

Effective date: 20190915

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: SERVOPATENT GMBH, CH

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191230

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191128

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191128

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191228

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20191129

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1171560

Country of ref document: AT

Kind code of ref document: T

Effective date: 20190828

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2758733

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20200506

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20200224

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602009059595

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: NEW ADDRESS: WANNERSTRASSE 9/1, 8045 ZUERICH (CH)

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG2D Information on lapse in contracting state deleted

Ref country code: IS

26N No opposition filed

Effective date: 20200603

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20200206

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20220225

Year of fee payment: 14

Ref country code: GB

Payment date: 20220225

Year of fee payment: 14

Ref country code: DE

Payment date: 20220225

Year of fee payment: 14

Ref country code: CH

Payment date: 20220302

Year of fee payment: 14

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20220224

Year of fee payment: 14

Ref country code: IT

Payment date: 20220222

Year of fee payment: 14

Ref country code: FR

Payment date: 20220223

Year of fee payment: 14

Ref country code: ES

Payment date: 20220301

Year of fee payment: 14

Ref country code: BE

Payment date: 20220225

Year of fee payment: 14

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190828

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602009059595

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20230301

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20230228

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20230206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230228

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230301

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230206

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230206

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230206

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230228

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230228

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20240405

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230207

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20230207