EP2069376A4 - Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions - Google Patents

Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Info

Publication number
EP2069376A4
EP2069376A4 EP07861332.0A EP07861332A EP2069376A4 EP 2069376 A4 EP2069376 A4 EP 2069376A4 EP 07861332 A EP07861332 A EP 07861332A EP 2069376 A4 EP2069376 A4 EP 2069376A4
Authority
EP
European Patent Office
Prior art keywords
peptide
nucleic acid
influenza virus
immune responses
cellular immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07861332.0A
Other languages
German (de)
French (fr)
Other versions
EP2069376A2 (en
Inventor
Jeffery L Alexander
Scott F Southwood
Pamuk A Bisel
Mark J Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmexa Inc
Original Assignee
Pharmexa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmexa Inc filed Critical Pharmexa Inc
Publication of EP2069376A2 publication Critical patent/EP2069376A2/en
Publication of EP2069376A4 publication Critical patent/EP2069376A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
EP07861332.0A 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions Withdrawn EP2069376A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83211206P 2006-07-21 2006-07-21
PCT/US2007/016529 WO2008039267A2 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Publications (2)

Publication Number Publication Date
EP2069376A2 EP2069376A2 (en) 2009-06-17
EP2069376A4 true EP2069376A4 (en) 2013-10-16

Family

ID=39230737

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07861332.0A Withdrawn EP2069376A4 (en) 2006-07-21 2007-07-23 Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions

Country Status (4)

Country Link
EP (1) EP2069376A4 (en)
AU (1) AU2007300663A1 (en)
CA (1) CA2658559A1 (en)
WO (1) WO2008039267A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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EP2170365B1 (en) 2007-06-25 2016-05-25 The Administrators of The Tulane Educational Fund Influenza inhibiting compositions and methods
MX2010001284A (en) 2007-08-02 2010-08-31 Biondvax Pharmaceuticals Ltd Multimeric multiepitope influenza vaccines.
EP2296688A2 (en) * 2007-10-26 2011-03-23 Glykos Finland Oy Peptide vaccine for influenza virus
FI20080333A0 (en) * 2008-05-02 2008-05-02 Glykos Finland Oy Influenza virus nucleic acids and peptides
MX2011005231A (en) * 2008-11-19 2011-07-29 Avi Mex S A De C V Lab Recombinant inactivated viral vector vaccine.
US8282938B2 (en) * 2008-11-28 2012-10-09 National Institute Of Infectious Diseases Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
US9249187B2 (en) 2009-01-28 2016-02-02 Epimmune Inc. Pan-DR binding polypeptides and uses thereof
CA2750922A1 (en) * 2009-01-28 2010-08-05 Antigen Express, Inc. Li-key hybrid peptides that modulate the immune response to influenza
CN101792745B (en) * 2009-02-04 2014-09-17 中国科学院生物物理研究所 Expression and purification of influenza virus polymerase PA N-terminal polypeptide and crystal structure thereof
CN101565455B (en) * 2009-05-25 2012-03-14 中国科学院微生物研究所 CTL epitope polypeptides of bird flu H5N1 virus and applications thereof
CA2761733C (en) * 2009-06-01 2019-01-08 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Reagents and methods for detecting influenza virus proteins
ES2603779T3 (en) 2009-07-31 2017-03-01 Paxvax, Inc. Adenoviral base vectors
JP2013506682A (en) * 2009-09-30 2013-02-28 セント ルイス ユニバーシティ Peptides for inducing a heterologous subtype influenza T cell response
CN102153621B (en) * 2010-02-12 2014-07-02 广东省疾病预防控制中心 B-cell epitope of NA-protein for new influenza A (H1N1) and application thereof
AU2010346373A1 (en) 2010-02-19 2012-08-02 Universite De Liege A polynucleotide for use in treatment of influenza A virus induced diseases, encoding modified Mx protein, said modified Mx protein, and a transgenic animal expressing gene encoding modified Mx protein
WO2011138032A2 (en) * 2010-05-05 2011-11-10 Artemev, Timur Universal influenza vaccines and methods for their generation
EP2619216A4 (en) 2010-09-22 2014-04-02 Alios Biopharma Inc Substituted nucleotide analogs
CA2828068C (en) 2011-02-22 2019-03-19 Biondvax Pharmaceuticals Ltd. Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines
WO2013059403A1 (en) * 2011-10-19 2013-04-25 Immunotope, Inc. Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of influenza virus infection
US8980865B2 (en) 2011-12-22 2015-03-17 Alios Biopharma, Inc. Substituted nucleotide analogs
WO2013093514A2 (en) * 2011-12-23 2013-06-27 Retroscreen Virology Ltd Vaccines - peptides
EP2828277A1 (en) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013142157A1 (en) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
MX2015008847A (en) * 2013-01-10 2015-10-30 Novartis Ag Influenza virus immunogenic compositions and uses thereof.
CN103333224B (en) * 2013-05-10 2015-03-25 中国农业科学院哈尔滨兽医研究所 Avian influenza virus NS1 protein B cell epitope polypeptide and applications thereof
JP6525214B2 (en) * 2014-06-03 2019-06-05 国立研究開発法人農業・食品産業技術総合研究機構 Antibody or antibody fragment containing the variable region thereof, antigenic polypeptide, and use thereof
KR20190129032A (en) 2016-12-28 2019-11-19 인벡스, 인크. Influenza vaccine
CN106589105B (en) * 2017-01-23 2020-09-15 中国医科大学 HLA-A2-restricted ECM 1-specific CTL epitope peptide and application thereof
EP3679056A1 (en) 2017-09-08 2020-07-15 The University of Melbourne Methods and compositions for preventing influenza infection
US20220118077A1 (en) * 2018-09-11 2022-04-21 Shanghai Public Health Clinical Center Immunogen for broad-spectrum influenza vaccine and application thereof
WO2021255221A1 (en) * 2020-06-19 2021-12-23 Intervet International B.V. Swine influenza a virus vaccine comprising a nucleic acid construct encoding antigens of specific virus lineages
JP2023530134A (en) * 2020-06-19 2023-07-13 インターベット インターナショナル ベー． フェー． A swine influenza A virus vaccine comprising a nucleic acid construct comprising first, second and third nucleic acid sequences encoding separate neuraminidase antigens of the virus
WO2022032274A1 (en) * 2020-08-02 2022-02-10 Richard Ascione Vaccine compositions for influenza viruses and methods of use
EP4204445A2 (en) * 2020-08-25 2023-07-05 Genentech, Inc. Assays and reagents for characterization of mhci peptide binding
CN116410271B (en) * 2023-03-13 2024-07-19 华南农业大学 H5N1 subtype AIV MHC B1 restricted T cell epitope peptide and application thereof

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Non-Patent Citations (11)

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Also Published As

Publication number Publication date
CA2658559A1 (en) 2008-04-03
WO2008039267A2 (en) 2008-04-03
AU2007300663A1 (en) 2008-04-03
WO2008039267A3 (en) 2008-12-31
EP2069376A2 (en) 2009-06-17

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