EP1731174A3 - Polypeptides having a covalently bound N-terminal polyethylene glycol via hydrazone or oxime bond - Google Patents

Polypeptides having a covalently bound N-terminal polyethylene glycol via hydrazone or oxime bond Download PDF

Info

Publication number
EP1731174A3
EP1731174A3 EP06020565A EP06020565A EP1731174A3 EP 1731174 A3 EP1731174 A3 EP 1731174A3 EP 06020565 A EP06020565 A EP 06020565A EP 06020565 A EP06020565 A EP 06020565A EP 1731174 A3 EP1731174 A3 EP 1731174A3
Authority
EP
European Patent Office
Prior art keywords
covalently bound
polypeptides
polyethylene glycol
oxime bond
hydrazone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06020565A
Other languages
German (de)
French (fr)
Other versions
EP1731174A2 (en
Inventor
Ziping Wei
Sunitha Menon-Rudolf
Dastidar Pradip Ghosh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of EP1731174A2 publication Critical patent/EP1731174A2/en
Publication of EP1731174A3 publication Critical patent/EP1731174A3/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal ±-carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.
EP06020565A 1996-08-02 1997-08-01 Polypeptides having a covalently bound N-terminal polyethylene glycol via hydrazone or oxime bond Withdrawn EP1731174A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2305096P 1996-08-02 1996-08-02
EP97936407A EP0964702B1 (en) 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP97936407A Division EP0964702B1 (en) 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer
EP97936407.2 Division 1998-02-12

Publications (2)

Publication Number Publication Date
EP1731174A2 EP1731174A2 (en) 2006-12-13
EP1731174A3 true EP1731174A3 (en) 2007-01-17

Family

ID=21812842

Family Applications (2)

Application Number Title Priority Date Filing Date
EP97936407A Expired - Lifetime EP0964702B1 (en) 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer
EP06020565A Withdrawn EP1731174A3 (en) 1996-08-02 1997-08-01 Polypeptides having a covalently bound N-terminal polyethylene glycol via hydrazone or oxime bond

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP97936407A Expired - Lifetime EP0964702B1 (en) 1996-08-02 1997-08-01 Polypeptides having a single covalently bound n-terminal water-soluble polymer

Country Status (19)

Country Link
US (1) US6077939A (en)
EP (2) EP0964702B1 (en)
JP (1) JP4410852B2 (en)
KR (1) KR20000029673A (en)
CN (1) CN100471521C (en)
AT (1) ATE341344T1 (en)
AU (1) AU3908597A (en)
BR (1) BR9711009A (en)
CA (1) CA2262994A1 (en)
DE (1) DE69736780T2 (en)
DK (1) DK0964702T3 (en)
ES (1) ES2273373T3 (en)
IL (2) IL128229A0 (en)
NO (1) NO990465L (en)
NZ (1) NZ333993A (en)
PT (1) PT964702E (en)
RU (1) RU2199347C2 (en)
SI (1) SI0964702T1 (en)
WO (1) WO1998005363A2 (en)

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