EP1712272A2 - Method of producing suspensions of powdery materials, apparatus therefor and pharmaceutical compositions containing said powdery materials - Google Patents

Method of producing suspensions of powdery materials, apparatus therefor and pharmaceutical compositions containing said powdery materials Download PDF

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Publication number
EP1712272A2
EP1712272A2 EP06290628A EP06290628A EP1712272A2 EP 1712272 A2 EP1712272 A2 EP 1712272A2 EP 06290628 A EP06290628 A EP 06290628A EP 06290628 A EP06290628 A EP 06290628A EP 1712272 A2 EP1712272 A2 EP 1712272A2
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EP
European Patent Office
Prior art keywords
tank
aqueous
vessel
closed
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP06290628A
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German (de)
French (fr)
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EP1712272A3 (en
Inventor
Michel Urbain
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Laboratoires SERB
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Laboratoires SERB
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Publication of EP1712272A2 publication Critical patent/EP1712272A2/en
Publication of EP1712272A3 publication Critical patent/EP1712272A3/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/54—Mixing liquids with solids wetting solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/53—Mixing liquids with solids using driven stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/10—Maintenance of mixers
    • B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
    • B01F35/146—Working under sterile conditions; Sterilizing the mixer or parts thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
    • B01F35/189—Venting, degassing or ventilating of gases, fumes or toxic vapours during mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/60—Safety arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/57—Mixing high-viscosity liquids with solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use

Definitions

  • the present invention relates to the chemical industry, and more particularly to the dispersion of finely powdered substances by avoiding spreading these powdery substances in the immediate environment.
  • the invention relates in particular to a container, such as for example a closed cylindrical vessel, in which, initially in a protected place, a finely powdered product is introduced and then in a second stage at another place, the wetting of this fine powder, not very soluble or insoluble in water, without fumes or splashes of product are released and can spread into the atmosphere and dirty containers, equipment and even the walls of premises.
  • a container such as for example a closed cylindrical vessel, in which, initially in a protected place, a finely powdered product is introduced and then in a second stage at another place, the wetting of this fine powder, not very soluble or insoluble in water, without fumes or splashes of product are released and can spread into the atmosphere and dirty containers, equipment and even the walls of premises.
  • the invention specifically relates to a tank having a removable closure device, in which one can introduce a particularly powdery product and a liquid for wetting the powder and ensuring the perfect homogeneity of the mixture without risk of spreading the finely powdered product in the working atmosphere.
  • the stirring can be carried out cold or hot either by external heating or by using a hot aqueous solution.
  • the density of the suspension of the aqueous solution can vary in large proportions and is generally of the order of 0.8 to 1.4 kg / dm 3 and preferably of the order of 1.2 to 1.4. kg / dm 3 .
  • the tank according to the invention is provided with a hatch held in place by a securing device, in particular by screwing or by a clamping lug. It can be detached by unscrewing the closure screw.
  • the tank according to the invention is preferably of cylindrical or ovoid shape. Such a tank is palletizable. Its capacity ranges from 700 to 1000 liters, but its capacity can be significantly reduced or increased without departing from the scope of the invention.
  • the tank according to the invention can be connected to the ground. It is provided at the base of the supply or discharge valves so as to allow the introduction of large volumes of aqueous phases and suspensions or, on the contrary, the emptying of such ingredients.
  • the tank according to the invention is also equipped with an adjustable speed stirring device, preferably from 50 to 500 revolutions / min.
  • aqueous phase of significant viscosity more or less thickened such as a solution of polyethylene glycol, polypropylene glycol, glycerol or poly glycerol.
  • the aqueous dispersion may contain significant proportions of insoluble or poorly water-soluble product.
  • the process according to the invention makes it possible to use the vessel as well to produce very fluid suspensions as very viscous suspensions.
  • the tank according to the invention is made of unalterable material, such as stainless steel, vitrified steel, brauthite steel, or polypropylene or anti-shock polystyrene.
  • the tanks according to the invention are placed on two supports on the ground. They comprise one or more pipes provided with valves for total drainage, one or more supply lines, a conical cover fitted on the tank and held in place by a securing means.
  • the upper part of the tank is crossed by the trap or the delivery line of the powdery product and this part of the tank comprises a pressure / vacuum valve.
  • Stirring is performed by means of an off-center stirring device provided with an electric motor.
  • the rod of the agitator comprises pallets or propellers, especially at several levels of the lower part to achieve better mixing.
  • the tank according to the invention comprises a lever door provided with two removable protective grids held in place by a sealing device.
  • the pipes passing through the dome of the tank serve one for the introduction of the aqueous phase and the others as a means of recycling the aqueous liquid. These pipes are equipped with a shut-off valve.
  • the stirring device is generally mounted on a flange.
  • the stirring power provided by the motor varies from 0.4 to 5 kW depending on the power to be applied.
  • the most suitable power ranges from 0.50 to 3 kW, for a stirring speed ranging from 50 to 500 rpm, and preferably from 100 to 300 rpm.
  • the stirring vanes have a diameter of the order of 100 to 500 mm and, preferably, of the order of 300 to 450 mm.
  • the device according to the invention thus finds its usefulness in the production of aqueous suspensions or aqueous solutions of powdery products likely to spread in the working environment and difficult to wettable. It is known that, in this case, the contact of the water with a powdery product gives rise to the formation of powder clouds and, moreover, that there may be a phenomenon of large gas evolution which, resulting in the powdery product. , can generate highly contaminating fumes for the surrounding space. Given the hydrophobicity of the powder, it can form lumps or blocks of powders difficult to use because of their size or the amount of powdery product included in such a formation of lumps. In addition, these blocks of powdery product, even if they become wet gradually, form networks of very different consistency, similar to those of lumps.
  • the problem is even more applicable to sweetening products, such as cellulose derivatives, or peptides.
  • the problem also concerns gelling agents of the alginate type, gelatin, ethylcellulose or carbomers.
  • the gelatinous mass blocks formed from such products do not moisten very easily and leave on the filters more or less hydrated raw material cores. They do not mix substantially with the liquid phase and retain a significant proportion of undispersed raw material.
  • the invention provides a valuable solution to such a situation.
  • the mass of powdery product is introduced, in a first step, into the tank in a dedicated place for this purpose (eg gray room), ie within a room protected against the risks of dissemination of the powder, then the hatch of the tank is sealed, then the tank is decontaminated externally.
  • the powdery product can be sterilized in the tank by the action of ionizing radiation (gamma rays).
  • the tank is then transported to the production site of the suspension, decontaminated externally again and then introduced into the suspension manufacturing facility (eg clean room). We can then, in a second time, manufacture the suspension without risk of external contamination.
  • a liquid mixture containing a stabilizing agent, a polysaccharide sweetening agent and a diluting agent is introduced into the tank which constitutes an enclosed space.
  • the mixture is then stirred until a homogeneous, ready-to-use aqueous suspension is formed which can subsequently be dried and / or granulated if desired.
  • the process according to the invention is further characterized by the fact that it comprises a second stage in which the removable lid of the tank is opened, the powdery product is introduced, the lid is carefully closed, the aqueous phase of viscous product while stirring and continue the introduction of aqueous phase and stirring until the suspension is completely homogeneous.
  • the process according to the invention is characterized by the fact that the pulverulent solid product is first introduced into the tank, which is itself placed in a room protected against any dissemination of the powder and which is then closed again. lid of the tank by securing it by a securing means before subsequently proceeding to the introduction of the aqueous phase in a second room.
  • the invention also relates to a method for preventing the occurrence of an overpressure in the tank while effectively retaining any particle likely to contaminate the environment of the tank which avoids producing projections or fumes of fumes in the environment of the tank.
  • the method according to the present invention consists of two pipes connected to the tank at one end and whose other end is connected to a flue gas cleaning system.
  • This flue gas cleaning system consists of a pipe that opens onto a diffuser immersed in the wash water of a tank properly sized to retain the powder particles.
  • the subject of the invention is also a process for the preparation of ready-to-use fluid compositions formed of activated charcoal, characterized in that a mass of coal is wetted. powder, sterilized, by an aqueous system containing a stabilizing agent, a polysaccharide sweetening agent and a diluting agent, in a closed system, and stirred until a homogeneous, ready-to-use suspension is formed which is can dry later and / or granulate if desired.
  • the pulverulent coal used is a very fine grade of coal with a particle size ranging from 8 to 15 microns. Such a powder has a high porosity.
  • this coal is subjected to steam activation.
  • the invention also relates to the production of catalysts by adsorption of metal salts, such as noble metals, on charcoal.
  • metal salts such as noble metals
  • the process according to the invention thus makes it possible to produce catalysts with palladium, platinum, ruthenium or rhodium on charcoal by impregnating the activated carbon with a salt solution of a metal such as a chloride, a sulphate or a nitrate, in evaporating the introduced water and then reducing the metal salt by calcination under a reducing atmosphere.
  • the present invention further serves to form a coal slurry in an aqueous medium for detoxification of a harmful or dangerous product or substance.
  • the coal thus prepared can be used inter alia for the adsorption of certain poisons, certain dyes, or certain bitter substances which render the ingestion of the active ingredients difficult to use.
  • Charcoal in suspension, thus prepared is particularly suitable for combating drug poisoning, phalloid poisoning, or for the elimination of toxins or harmful by-products, biological products, resulting from fermentation processes or biological transformations. under the influence of enzymes.
  • the activated charcoal prepared according to the invention is defined by its very fine homogeneous particle size, its porosity, its activation by steam and its ability to be sterilized.
  • the activated charcoal is suspended in a sweetening polysaccharide solution giving viscous solutions and, in particular, sucrose or maltose, or soluble cellulose derivatives such as ethylcellulose, carboxymethyl cellulose or hydroxypropyl methylcellulose.
  • the viscous diluent is a water-soluble polyol which contributes to high viscosity in the medium.
  • These are glycerol, poly-glycerol, erythritol, sorbitol, mannitol, poly (hydroxy methyl) or poly (hydroxyethyl) butane.
  • the stabilizing agent is a polyalkylene glycol, such as, for example, a polyethylene glycol having a molecular weight ranging from 1,000 to 3,000, or propylene glycol 1-2, or propylene glycol 1-3. Any water-soluble glycol such as glycerol is also suitable for stabilizing the suspension and retarding the re-deposition of the coal.
  • the suspension contains from 10 to 50 g of activated carbon per 100 ml of suspension and, preferably, from 15 to 35 g of activated charcoal.
  • a preferred preparation contains: activated charcoal 20.0 g liquid sugar (which helps to provide a pleasant flavor) 92.5 g glycerol 5.0 g propylene glycol 10.0 g per 100 ml of aqueous suspension
  • the suspension is distributed in polyethylene bottles closed with a polypropylene stopper.
  • the frame (C) on which the tank (1) rests has a grounding device (16).
  • the tank (1) thus shown has a height of about 945 cm, an inside diameter of about 955 cm and the conical lid has an angle of 5 ° and a thickness of 3 mm.
  • the stirring device is mounted on flange, the stirring power provided by the motor is 2 kW.
  • the stirring speed varies from 160 to 300 rpm.
  • the two pallets, mounted on the stirring rod, have a diameter of 400 mm.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Medicinal Preparation (AREA)

Abstract

A closed vessel for wetting fine powder which is insoluble or not very soluble in water, in which: (a) fine powder (I) is introduced into the vessel in a protected place; and (b) the vessel is moved to another place and stirred without releasing any product in the form of "fumes" or projections which might spread into the atmosphere and contaminate containers, apparatus or the walls of the room. Independent claims are included for (1) a method for the production of aqueous suspensions of poorly-wettable powder (I) by: (a) introducing (I) into a stirred vessel at a specific point in a place protected against the risk of dissemination of powder, tightly closing the trap, decontaminating the outside of the vessel, possibly sterilizing the powder in the vessel with ionizing radiation, moving the vessel to the production area, decontaminating the outside again, putting the vessel in the production workshop; and (b) making the suspension without risk of external contamination by adding (to the closed vessel) a liquid mixture containing a stabilizer, a polysaccharide sweetener and a diluent, and stirring to give a ready-to-use, homogeneous aqueous suspension which can then be dried and/or granulated if required; (2) a method as described for the production of ready-to-use fluid compositions of activated carbon; and (3) aqueous dispersions of activated carbon containing 10-50 g carbon/100 ml obtained by this method. ACTIVITY : Antidote; Antimicrobial. No biological data given. MECHANISM OF ACTION : None given.

Description

La présente invention se rapporte à l'industrie chimique, et plus particulièrement à la mise en dispersion de substances finement pulvérulentes en évitant de répandre ces substances pulvérulentes dans l'environnement immédiat.The present invention relates to the chemical industry, and more particularly to the dispersion of finely powdered substances by avoiding spreading these powdery substances in the immediate environment.

L'invention concerne en particulier un conteneur, comme par exemple une cuve cylindrique close, dans lequel, dans un premier temps dans un lieu protégé, on introduit un produit finement pulvérulent puis dans un deuxième temps en un autre lieu, on réalise par agitation le mouillage de cette poudre fine, peu soluble ou insoluble dans l'eau, sans que des fumées ou des projections de produit viennent à se dégager et puissent se répandre dans l'atmosphère et salir les contenants, les appareillages et même les parois des locaux.The invention relates in particular to a container, such as for example a closed cylindrical vessel, in which, initially in a protected place, a finely powdered product is introduced and then in a second stage at another place, the wetting of this fine powder, not very soluble or insoluble in water, without fumes or splashes of product are released and can spread into the atmosphere and dirty containers, equipment and even the walls of premises.

L'invention concerne précisément une cuve disposant d'un dispositif d'obturation amovible, dans laquelle on peut introduire un produit particulièrement pulvérulent et un liquide permettant le mouillage de la poudre et assurant la parfaite homogénéité du mélange sans risque de répandre le produit finement pulvérulent dans l'atmosphère de travail.The invention specifically relates to a tank having a removable closure device, in which one can introduce a particularly powdery product and a liquid for wetting the powder and ensuring the perfect homogeneity of the mixture without risk of spreading the finely powdered product in the working atmosphere.

L'agitation peut se réaliser à froid ou à chaud soit par chauffage externe, soit en utilisant une solution aqueuse chaude. La densité de la suspension de la solution aqueuse peut varier dans de larges proportions et est en général de l'ordre de 0,8 à 1,4 kg/dm3 et de préférence de l'ordre de 1,2 à 1,4 kg/dm3.The stirring can be carried out cold or hot either by external heating or by using a hot aqueous solution. The density of the suspension of the aqueous solution can vary in large proportions and is generally of the order of 0.8 to 1.4 kg / dm 3 and preferably of the order of 1.2 to 1.4. kg / dm 3 .

La cuve selon l'invention est pourvue d'une trappe maintenue en place par un dispositif de solidarisation, en particulier par vissage ou par une patte de serrage. Il peut être désolidarisé par dévissage de la vis d'obturation.The tank according to the invention is provided with a hatch held in place by a securing device, in particular by screwing or by a clamping lug. It can be detached by unscrewing the closure screw.

La cuve selon l'invention est de préférence de forme cylindrique ou ovoïde. Une telle cuve est palettisable. Sa contenance s'échelonne de 700 à 1 000 litres, mais sa capacité peut être sensiblement réduite ou augmentée sans sortir du cadre de l'invention.The tank according to the invention is preferably of cylindrical or ovoid shape. Such a tank is palletizable. Its capacity ranges from 700 to 1000 liters, but its capacity can be significantly reduced or increased without departing from the scope of the invention.

La cuve selon l'invention peut être raccordée à la terre. Elle est pourvue, à la base, de vannes d'alimentation ou d'évacuation de façon à permettre l'introduction de volumes importants de phases aqueuses et de suspensions ou, au contraire, la vidange de tels ingrédients.The tank according to the invention can be connected to the ground. It is provided at the base of the supply or discharge valves so as to allow the introduction of large volumes of aqueous phases and suspensions or, on the contrary, the emptying of such ingredients.

La cuve selon l'invention est également équipée d'un dispositif d'agitation de vitesse réglable, de préférence de 50 à 500 tours/min. Le dispositif d'agitation et un axe portant à la partie inférieure des palettes ou des hélices pour permettre l'agitation, le brassage et le maintien en suspension.The tank according to the invention is also equipped with an adjustable speed stirring device, preferably from 50 to 500 revolutions / min. The stirring device and an axle bearing at the bottom of the pallets or propellers to allow stirring, stirring and holding in suspension.

Le problème de l'agitation, et en particulier de la mise sous la forme d'une suspension homogène, est résolu en utilisant une phase aqueuse de viscosité importante plus ou moins épaissie, comme par exemple une solution de polyéthylène glycol, de polypropylène glycol, de glycérol ou de poly glycérol.The problem of stirring, and in particular the setting into the form of a homogeneous suspension, is solved using an aqueous phase of significant viscosity more or less thickened, such as a solution of polyethylene glycol, polypropylene glycol, glycerol or poly glycerol.

La dispersion aqueuse peut contenir des proportions importantes de produit insoluble ou peu soluble dans l'eau. Le processus selon l'invention permet d'utiliser la cuve aussi bien pour réaliser des suspensions très fluides que des suspensions très visqueuses.The aqueous dispersion may contain significant proportions of insoluble or poorly water-soluble product. The process according to the invention makes it possible to use the vessel as well to produce very fluid suspensions as very viscous suspensions.

La cuve selon l'invention est réalisée en matériau inaltérable, comme par exemple en acier inoxydable, en acier vitrifié, en acier brauthité, ou encore en polypropylène ou en polystyrène anti-choc.The tank according to the invention is made of unalterable material, such as stainless steel, vitrified steel, brauthite steel, or polypropylene or anti-shock polystyrene.

Les cuves selon l'invention sont posées sur deux supports au sol. Elles comportent une ou plusieurs canalisations pourvues de vannes pour vidange totale, une ou plusieurs canalisations d'amenée, un couvercle conique emboîté sur la cuve et maintenu en place par un moyen de solidarisation. La partie supérieure de la cuve est traversée par la trappe ou la conduite d'amenée du produit pulvérulent et cette partie de la cuve comporte une soupape de pression/dépression.The tanks according to the invention are placed on two supports on the ground. They comprise one or more pipes provided with valves for total drainage, one or more supply lines, a conical cover fitted on the tank and held in place by a securing means. The upper part of the tank is crossed by the trap or the delivery line of the powdery product and this part of the tank comprises a pressure / vacuum valve.

L'agitation est réalisée au moyen d'un dispositif d'agitation décentré, muni d'un moteur électrique. De préférence, la tige de l'agitateur comporte des palettes ou des hélices, notamment à plusieurs niveaux de la partie inférieure pour réaliser un meilleur brassage.Stirring is performed by means of an off-center stirring device provided with an electric motor. Preferably, the rod of the agitator comprises pallets or propellers, especially at several levels of the lower part to achieve better mixing.

La cuve selon l'invention comporte une trappe à levier munie de deux grilles de protection démontables maintenues en place par un dispositif d'étanchéité. Les canalisations qui traversent le dôme de la cuve servent les unes à l'introduction de la phase aqueuse et les autres comme moyen de recyclage du liquide aqueux. Ces canalisations sont équipées d'une vanne d'obturation.The tank according to the invention comprises a lever door provided with two removable protective grids held in place by a sealing device. The pipes passing through the dome of the tank serve one for the introduction of the aqueous phase and the others as a means of recycling the aqueous liquid. These pipes are equipped with a shut-off valve.

Le dispositif d'agitation est en général monté sur bride. La puissance d'agitation fournie par le moteur varie de 0,4 à 5 kW selon la puissance à appliquer. La puissance la plus appropriée s'échelonne de 0,50 à 3 kW, pour une vitesse d'agitation variant de 50 à 500 t/min, et de préférence, de 100 à 300 t/min Les palettes d'agitation ont un diamètre de l'ordre de 100 à 500 mm et, de préférence, de l'ordre de 300 à 450 mm.The stirring device is generally mounted on a flange. The stirring power provided by the motor varies from 0.4 to 5 kW depending on the power to be applied. The most suitable power ranges from 0.50 to 3 kW, for a stirring speed ranging from 50 to 500 rpm, and preferably from 100 to 300 rpm. The stirring vanes have a diameter of the order of 100 to 500 mm and, preferably, of the order of 300 to 450 mm.

Le dispositif selon l'invention trouve donc toute son utilité dans la réalisation de suspensions aqueuses ou de solutions aqueuses de produits pulvérulents risquant de se répandre dans l'environnement de travail et difficilement mouillables. On sait que, dans ce cas, le contact de l'eau avec un produit pulvérulent donne naissance à la formation de nuages de poudre et, en outre, qu'il peut se produire un phénomène de dégagement gazeux important qui, entraînant le produit pulvérulent, peut générer des fumées très contaminantes pour l'espace environnant. Compte tenu de l'hydrophobie de la poudre, il peut se former des grumeaux ou des blocs de poudres difficilement utilisables en raison de leur taille ou de la quantité de produit pulvérulent inclus dans une telle formation de grumeaux. En outre, ces blocs de produit pulvérulent, même s'ils se mouillent progressivement, forment des réseaux de consistance bien différents, semblables à celles des grumeaux.The device according to the invention thus finds its usefulness in the production of aqueous suspensions or aqueous solutions of powdery products likely to spread in the working environment and difficult to wettable. It is known that, in this case, the contact of the water with a powdery product gives rise to the formation of powder clouds and, moreover, that there may be a phenomenon of large gas evolution which, resulting in the powdery product. , can generate highly contaminating fumes for the surrounding space. Given the hydrophobicity of the powder, it can form lumps or blocks of powders difficult to use because of their size or the amount of powdery product included in such a formation of lumps. In addition, these blocks of powdery product, even if they become wet gradually, form networks of very different consistency, similar to those of lumps.

Le problème s'applique encore davantage aux produits édulcorants, comme les dérivés de la cellulose, ou des peptides. Le problème concerne aussi les agents gélifiants du type alginate, gélatine, l'éthylcellulose ou des carbomères. Les blocs de masse gélatineuse formés au départ de tels produits ne s'humectent que très difficilement et laissent sur les filtres des noyaux de matière première plus ou moins hydratés. Ils ne se mélangent pratiquement pas à la phase liquide et retiennent une proportion importante de matière première non dispersée.The problem is even more applicable to sweetening products, such as cellulose derivatives, or peptides. The problem also concerns gelling agents of the alginate type, gelatin, ethylcellulose or carbomers. The gelatinous mass blocks formed from such products do not moisten very easily and leave on the filters more or less hydrated raw material cores. They do not mix substantially with the liquid phase and retain a significant proportion of undispersed raw material.

Le problème se pose encore pour réaliser des compositions fluides prêtes à l'emploi, formées d'un produit pulvérulent très hydrophobe, comme, le carbonate de calcium léger, le phosphate de magnésium, le carbonate de bismuth ou le sous gallate de bismuth qui ne se mouillent que lentement et très difficilement et le charbon activé qui dégage rapidement de très importantes quantités d'air adsorbé en générant une épaisse fumée noire. Il peut en résulter une projection de produit qui peut souiller gravement les parois des locaux si l'on ne prend pas de grandes précautions pour y remédier. Le problème se pose également pour mettre en dispersion des produits peu solubles dans l'eau comme le permanganate de potassium, le bichromate de sodium ou surtout des produits colorés et colorants, comme le bleu de méthylène ou la fuchsine, surtout quand ces produits pulvérulents ont un caractère électrostatique et difficilement mouillable.The problem still arises for producing ready-to-use fluid compositions formed of a very hydrophobic powdery product, such as light calcium carbonate, magnesium phosphate, bismuth carbonate or bismuth wet only slowly and with great difficulty and activated charcoal which quickly releases very large amounts of adsorbed air generating a thick black smoke. This can result in a splash of product that can seriously soil the walls of the premises if we do not take great care to remedy it. The problem is also to disperse poorly water-soluble products such as potassium permanganate, sodium dichromate or especially colored products and dyes, such as methylene blue or fuchsin, especially when these powdery products have an electrostatic character and hardly wettable.

L'invention apporte une solution précieuse à une telle situation. Pour ce faire, la masse de produit pulvérulent est introduite, en un premier temps, dans la cuve en un lieu dédié à cet effet (par exemple salle grise), c'est à dire au sein d'un local protégé contre les risques de dissémination de la poudre, puis on referme la trappe de la cuve de façon étanche, ensuite la cuve est décontaminée extérieurement. Le produit pulvérulent peut être stérilisé dans la cuve par l'action de radiations ionisantes (rayons gamma). La cuve est ensuite transportée jusqu'au lieu de production de la suspension, décontaminée extérieurement à nouveau, puis introduite dans l'atelier de fabrication de la suspension (par exemple salle blanche). On peut alors, dans un deuxième temps, fabriquer la suspension sans risque de contamination extérieure. On introduit dans la cuve qui constitue un espace clos, un mélange liquide contenant un agent stabilisant, un agent polysaccharidique édulcorant et un agent diluant. On agite alors jusqu'à formation d'une suspension aqueuse homogène, prête à l'emploi, que l'on peut sécher ultérieurement et/ou granuler si désiré.The invention provides a valuable solution to such a situation. To do this, the mass of powdery product is introduced, in a first step, into the tank in a dedicated place for this purpose (eg gray room), ie within a room protected against the risks of dissemination of the powder, then the hatch of the tank is sealed, then the tank is decontaminated externally. The powdery product can be sterilized in the tank by the action of ionizing radiation (gamma rays). The tank is then transported to the production site of the suspension, decontaminated externally again and then introduced into the suspension manufacturing facility (eg clean room). We can then, in a second time, manufacture the suspension without risk of external contamination. A liquid mixture containing a stabilizing agent, a polysaccharide sweetening agent and a diluting agent is introduced into the tank which constitutes an enclosed space. The mixture is then stirred until a homogeneous, ready-to-use aqueous suspension is formed which can subsequently be dried and / or granulated if desired.

Le procédé selon l'invention est encore caractérisé par le fait qu'il comporte une seconde étape dans laquelle on effectue l'ouverture du couvercle amovible de la cuve, on y introduit le produit pulvérulent, on referme soigneusement le couvercle, on introduit progressivement la phase aqueuse de produit visqueux tout en mettant en route l'agitation et on poursuit l'introduction de phase aqueuse et l'agitation jusqu'à ce que la suspension soit totalement homogène.The process according to the invention is further characterized by the fact that it comprises a second stage in which the removable lid of the tank is opened, the powdery product is introduced, the lid is carefully closed, the aqueous phase of viscous product while stirring and continue the introduction of aqueous phase and stirring until the suspension is completely homogeneous.

Le procédé selon l'invention est caractérisé par le fait qu'on l'on introduit en premier lieu le produit solide pulvérulent dans la cuve, elle-même disposée dans un local protégé contre toute dissémination de la poudre et qu'on referme ensuite le couvercle de la cuve en l'assujettissant par un moyen de solidarisation avant de procéder ultérieurement à l'introduction de la phase aqueuse dans un second local.The process according to the invention is characterized by the fact that the pulverulent solid product is first introduced into the tank, which is itself placed in a room protected against any dissemination of the powder and which is then closed again. lid of the tank by securing it by a securing means before subsequently proceeding to the introduction of the aqueous phase in a second room.

L'invention a également pour objet un procédé permettant d'éviter l'apparition d'une surpression dans la cuve tout en retenant efficacement toute particule susceptible de contaminer l'environnement de la cuve ce qui évite de produire des projections ou des émanations de fumées dans l'environnement de la cuve. Le procédé selon la présente invention consiste en deux canalisations connectées à la cuve à une extrémité et dont l'autre extrémité est reliée à un système de lavage des fumées. Ce système de lavage des fumées consiste en une conduite qui débouche sur un diffuseur plongeant dans l'eau de lavage d'un bac correctement dimensionné pour retenir les particules pulvérulentes.The invention also relates to a method for preventing the occurrence of an overpressure in the tank while effectively retaining any particle likely to contaminate the environment of the tank which avoids producing projections or fumes of fumes in the environment of the tank. The method according to the present invention consists of two pipes connected to the tank at one end and whose other end is connected to a flue gas cleaning system. This flue gas cleaning system consists of a pipe that opens onto a diffuser immersed in the wash water of a tank properly sized to retain the powder particles.

L'invention a également pour objet un procédé de préparation de compositions fluides, prêtes à l'emploi, formées de charbon activé, caractérisé en ce que l'on mouille une masse de charbon pulvérulent, stérilisé, par un système aqueux contenant un agent stabilisant, un agent polysaccharidique édulcorant et un agent diluant, dans un système clos, et on agite jusqu'à formation d'une suspension homogène, prête à l'emploi, que l'on peut sécher ultérieurement et/ou granuler si désiré. Le charbon pulvérulent utilisé est une qualité de charbon très fine, dont la taille des particules s'échelonne de 8 à 15 microns. Une telle poudre présente une porosité élevée. En outre, ce charbon est soumis à une activation à la vapeur. On obtient ainsi un charbon en poudre extrêmement fine, très hydrophobe, ne se mouillant pratiquement pas à l'eau. Qui plus est, normalement, une telle qualité de charbon non seulement résiste au mouillage, mais en outre, a tendance à former des nuages, des fumerolles, et à projeter ainsi les particules de charbon dans l'atmosphère environnante. On connaît ainsi l'extrême difficulté de réaliser des préparations solides, à base de charbon, telles qu'un granulé ou des pilules, qui comportent des étapes de mouillage et d'agglomération.The subject of the invention is also a process for the preparation of ready-to-use fluid compositions formed of activated charcoal, characterized in that a mass of coal is wetted. powder, sterilized, by an aqueous system containing a stabilizing agent, a polysaccharide sweetening agent and a diluting agent, in a closed system, and stirred until a homogeneous, ready-to-use suspension is formed which is can dry later and / or granulate if desired. The pulverulent coal used is a very fine grade of coal with a particle size ranging from 8 to 15 microns. Such a powder has a high porosity. In addition, this coal is subjected to steam activation. This gives an extremely fine powder coal, very hydrophobic, practically not wetting with water. What is more, normally such a coal quality not only resists wetting, but also tends to form clouds, fumaroles, and thereby projecting the coal particles into the surrounding atmosphere. Thus, it is known that it is extremely difficult to produce solid, charcoal-based preparations such as granules or pills which include wetting and agglomeration steps.

L'invention concerne également la production de catalyseurs par adsorption de sels métalliques, comme les métaux nobles, sur du charbon. Le procédé selon l'invention permet ainsi de réaliser des catalyseurs au palladium, au platine, au ruthénium ou au rhodium sur charbon en imprégnant le charbon activé par une solution de sel d'un métal comme un chlorure, un sulfate ou un nitrate, en évaporant l'eau introduite puis en réduisant le sel métallique par calcination sous atmosphère réductrice.The invention also relates to the production of catalysts by adsorption of metal salts, such as noble metals, on charcoal. The process according to the invention thus makes it possible to produce catalysts with palladium, platinum, ruthenium or rhodium on charcoal by impregnating the activated carbon with a salt solution of a metal such as a chloride, a sulphate or a nitrate, in evaporating the introduced water and then reducing the metal salt by calcination under a reducing atmosphere.

Chacune de ses opérations est délicate à réaliser et nécessite normalement beaucoup de dextérité de la part des manipulateurs, pour éviter des projections de charbon ou des risques d'inflammation.Each of its operations is tricky to perform and usually requires a lot of dexterity on the part of the manipulators, to avoid coal splashes or risks of ignition.

La présente invention sert, en outre, à la mise sous forme d'une suspension de charbon dans un milieu aqueux en vue de la détoxification d'un produit ou d'une substance nocive ou dangereuse.The present invention further serves to form a coal slurry in an aqueous medium for detoxification of a harmful or dangerous product or substance.

Le charbon, ainsi préparé, peut servir entre autres à l'adsorption de certains poisons, de certains colorants, ou de certaines substances amères qui rendent l'ingestion des principes actifs difficiles à utiliser. Le charbon en suspension, ainsi préparé, convient tout particulièrement pour lutter contre les intoxications médicamenteuses, l'intoxication phalloïdienne, ou pour l'élimination de toxines ou de sous-produits nocifs, de produits biologiques, issus de processus de fermentation ou de transformations biologiques sous l'influence d'enzymes.The coal thus prepared can be used inter alia for the adsorption of certain poisons, certain dyes, or certain bitter substances which render the ingestion of the active ingredients difficult to use. Charcoal in suspension, thus prepared, is particularly suitable for combating drug poisoning, phalloid poisoning, or for the elimination of toxins or harmful by-products, biological products, resulting from fermentation processes or biological transformations. under the influence of enzymes.

Le charbon activé, préparé selon l'invention, se définit par sa granulométrie homogène très fine, sa porosité, son activation par la vapeur et par sa possibilité d'être stérilisé.The activated charcoal prepared according to the invention is defined by its very fine homogeneous particle size, its porosity, its activation by steam and its ability to be sterilized.

Le charbon activé est mis en suspension dans une solution de polysaccharide édulcorant donnant des solutions visqueuses et, notamment, du saccharose ou du maltose, ou des dérivés solubles de cellulose comme l'éthylcellulose, la carboxy méthyl cellulose ou l'hydroxy propyl méthyl cellulose.The activated charcoal is suspended in a sweetening polysaccharide solution giving viscous solutions and, in particular, sucrose or maltose, or soluble cellulose derivatives such as ethylcellulose, carboxymethyl cellulose or hydroxypropyl methylcellulose.

L'agent diluant visqueux est un polyol soluble dans l'eau contribuant à donner une viscosité élevée au milieu. Il s'agit en l'occurrence de glycérol, de poly-glycérol, d'erythritol, de sorbitol, de mannitol, de poly (hydroxy méthyl-) ou de poly (hydroxy ethyl-) butane.The viscous diluent is a water-soluble polyol which contributes to high viscosity in the medium. These are glycerol, poly-glycerol, erythritol, sorbitol, mannitol, poly (hydroxy methyl) or poly (hydroxyethyl) butane.

L'agent stabilisant est un polyalkylène glycol, comme par exemple, un polyéthylène glycol ayant un poids moléculaire variant de 1 000 à 3 000, ou le propylène glycol 1-2, ou le propylène glycol 1-3. Tout glycol soluble dans l'eau comme le glycérol convient également pour stabiliser la suspension et retarder la re-déposition du charbon.The stabilizing agent is a polyalkylene glycol, such as, for example, a polyethylene glycol having a molecular weight ranging from 1,000 to 3,000, or propylene glycol 1-2, or propylene glycol 1-3. Any water-soluble glycol such as glycerol is also suitable for stabilizing the suspension and retarding the re-deposition of the coal.

Selon l'invention, la suspension contient de 10 à 50 g de charbon activé pour 100 ml de suspension et, de préférence, de 15 à 35 g de charbon activé.According to the invention, the suspension contains from 10 to 50 g of activated carbon per 100 ml of suspension and, preferably, from 15 to 35 g of activated charcoal.

Selon l'invention, une préparation préférée contient : charbon activé 20,0 g sucre liquide (qui contribue à procurer une saveur agréable) 92,5 g glycérol 5,0 g propylène glycol 10,0 g pour 100 ml de suspension aqueuse According to the invention, a preferred preparation contains: activated charcoal 20.0 g liquid sugar (which helps to provide a pleasant flavor) 92.5 g glycerol 5.0 g propylene glycol 10.0 g per 100 ml of aqueous suspension

Après homogénéisation, la suspension est répartie en flacons de polyéthylène fermés par un bouchon de polypropylène.After homogenization, the suspension is distributed in polyethylene bottles closed with a polypropylene stopper.

Deux tailles de conditionnement sont envisageables pour le but recherché :

  • des flacons de 250 ml pour les adultes,
  • des flacons de 60 ml pour les enfants.
    Les suspensions de charbon selon l'invention trouvent un emploi tout à fait avantageux pour traiter les intoxications médicamenteuses ou les effets secondaires dus aux anti-dépresseurs, par les benzodiazépines, par les neuroleptiques, par les barbituriques ou par le paracétamol. Les suspensions selon l'invention servent également pour lutter contre les intoxications intestinales d'origine bactérienne, virale ou fongique. Leur administration intervient, en général, au plus tard de une à deux heures après la prise toxique.
    Les suspensions de charbon selon l'invention peuvent encore être séchées pour former des granulés qui pourront servir de moyen de lutte contre les empoisonnements, et aussi de moyen de lutte contre les gaz toxiques, surtout ceux solubles dans l'eau.
    Les suspensions selon l'invention pourront également servir de moyen de purification, de décoloration, de désodorisation des substances organiques ou minérales. Ces suspensions conviennent encore comme moyen de blanchiment comme par exemple dans les solutions brutes de sucre de betterave pour obtenir une mélasse incolore.
    L'invention concerne également les suspensions de charbon activé obtenues par le procédé de l'invention qui consiste en ce que le principe actif est mouillé et dispersé dans un véhicule visqueux qui maintient les particules très fines de charbon en suspension dans un véhicule aqueux.
    La suspension peut encore être stérilisée par tyndallisation ou par rayonnement pénétrant.
    Les figures ci-annexées fournissent une illustration de la cuve de mélange requise pour introduire le produit pulvérulent hydrophobe, le mouiller et le mettre en suspension, puis le soutirer.
Two sizes of packaging are conceivable for the desired purpose:
  • 250 ml bottles for adults,
  • bottles of 60 ml for children.
    The coal suspensions according to the invention find a use quite advantageous for treating drug poisoning or the side effects due to anti-depressants by benzodiazepines, neuroleptics, barbiturates or paracetamol. The suspensions according to the invention are also used to fight against intestinal intoxications of bacterial, viral or fungal origin. Their administration usually takes place at the latest one to two hours after the toxic intake.
    The coal suspensions according to the invention can be further dried to form granules which can serve as a means of combating poisoning, and also means of combating toxic gases, especially those soluble in water.
    The suspensions according to the invention may also be used as a means of purification, discoloration, deodorization of organic or mineral substances. These suspensions are still suitable as bleaching means, for example in crude solutions of beet sugar to obtain a colorless molasses.
    The invention also relates to the suspensions of activated charcoal obtained by the process of the invention which consists in that the active ingredient is wetted and dispersed in a viscous vehicle which keeps the very fine particles of coal suspended in an aqueous vehicle.
    The suspension can be further sterilized by tyndallization or penetrating radiation.
    The accompanying figures provide an illustration of the mixing tank required to introduce the hydrophobic powdery product, wet it and suspend it, and then withdraw it.

DESCRIPTION DES FIGURESDESCRIPTION OF THE FIGURES

  • - La figure 1 met en évidence la cuve de mélange utilisée pour réaliser la suspension de charbon selon l'invention. Elle comporte la cuve (1) posée sur deux supports au sol (2) (2'), une vanne de vidange totale (3), une plaque de firme (4) disposée à la partie supérieure, deux boules de lavage (5) (5') destinées à rincer la canalisation d'amenée (6), un couvercle conique (7) emboîté sur la cuve, traversé par la conduite d'amenée (6) en pente légère et une soupape de pression/dépression (7) montée dans le couvercle.- Figure 1 shows the mixing tank used to produce the coal suspension according to the invention. It comprises the tank (1) placed on two ground supports (2) (2 '), a total drain valve (3), a firm plate (4) arranged at the top, two washing balls (5) (5 ') for rinsing the supply line (6), a conical cover (7) fitted on the tank, traversed by the slightly sloping supply line (6) and a pressure / vacuum valve (7) mounted in the lid.
  • - La figure 2, montre la cuve (1) équipée d'un dispositif d'agitation pendulaire décentré (8) équipé d'un moteur électrique (16) portant deux palettes à la partie inférieure (9) (9'), monté sur un bâti (10) incliné par rapport à l'horizontale. Le couvercle conique (5) comporte une trappe à levier (11) avec deux grilles de protection démontables (12) (12') maintenue en place par un dispositif d'étanchéité (13). Le couvercle de la cuve est pourvu de deux canalisations d'amenée (14) et (15), l'une permettant l'introduction du sirop, l'autre le recyclage du liquide. Ces deux canalisations comportent une vanne d'obturation (17). La vanne de vidange (3) est située à la partie inférieure de la cuve (1). La cuve (1) montre également sur un coté une plaque de firme (4).FIG. 2 shows the tank (1) equipped with an off-center pendulum stirring device (8) equipped with an electric motor (16) carrying two vanes at the lower part (9) (9 '), mounted on a frame (10) inclined relative to the horizontal. The tapered lid (5) has a lever door (11) with two removable protective grids (12) (12 ') held in place by a sealing device (13). The lid of the tank is provided with two supply lines (14) and (15), one allowing the introduction of the syrup, the other the recycling of the liquid. These two pipes comprise a shutter valve (17). The drain valve (3) is located at the bottom of the tank (1). The tank (1) also shows on one side a firm plate (4).

Le bâti (C) sur lequel repose la cuve (1) comporte un dispositif de mise à la terre (16).The frame (C) on which the tank (1) rests has a grounding device (16).

La cuve (1) ainsi représentée, présente une hauteur d'environ 945 cm, un diamètre intérieur de l'ordre de 955 cm et le couvercle de forme conique présente un angle de 5° et une épaisseur de 3 mm.The tank (1) thus shown has a height of about 945 cm, an inside diameter of about 955 cm and the conical lid has an angle of 5 ° and a thickness of 3 mm.

Le dispositif d'agitation est monté sur bride, la puissance d'agitation fournie par le moteur est de 2 kW. La vitesse d'agitation varie de 160 à 300 t/min Les deux palettes, montées sur la tige d'agitation, ont un diamètre de 400 mm.The stirring device is mounted on flange, the stirring power provided by the motor is 2 kW. The stirring speed varies from 160 to 300 rpm. The two pallets, mounted on the stirring rod, have a diameter of 400 mm.

Claims (32)

Dispositif clos du type cuve destiné à réaliser par agitation le mouillage d'une poudre fine peu soluble ou insoluble dans l'eau
caractérisé en ce que
dans un premier temps dans un lieu protégé, on introduit un produit finement pulvérulent puis dans un deuxième temps en un autre lieu, on réalise par agitation le mouillage de cette poudre fine, peu soluble ou insoluble dans l'eau, sans que des fumées ou des projections de produit viennent à se dégager et puissent se répandre dans l'atmosphère et salir les contenants, les appareillages et même les parois des locauxClosed device of the tank type intended to perform, by agitation, the wetting of a fine powder that is slightly soluble or insoluble in water
characterized in that
firstly in a protected place, a finely powdered product is introduced and then, in a second stage at another place, the wetting of this fine, slightly soluble or insoluble powder in water is carried out by stirring, without any fumes or product splashes are released and can spread into the atmosphere and dirty containers, equipment and even the walls of the premises Dispositif clos selon la revendication 1,
caractérisé en ce qu'il
s'agit d'une cuve disposant d'un dispositif d'obturation amovible, dans laquelle on peut introduire un produit particulièrement pulvérulent et un liquide permettant le mouillage de la poudre tout en assurant la parfaite homogénéité du mélange sans risque de répandre le produit finement pulvérulent dans l'atmosphère de travail.Closed device according to claim 1,
characterized in that
is a tank with a removable closure device, in which we can introduce a particularly powdery product and a liquid for wetting the powder while ensuring the perfect homogeneity of the mixture without risk of spreading the product finely powdery in the working atmosphere. Dispositif clos selon la revendication 1 ou la revendication 2,
caractérisé en ce qu'il
comporte une cuve mobile comportant un dispositif d'obturation emboîtable dans laquelle on introduit un produit particulièrement pulvérulent par la trappe en position ouverte puis un liquide aqueux permettant le mouillage de la poudre tout en assurant la parfaite homogénéité du mélange grâce à un dispositif d'agitation mis en route après fermeture de la cuve.Closed device according to claim 1 or claim 2,
characterized in that
comprises a mobile vessel comprising a plug-in closure device in which a particularly powdery product is introduced through the hatch in the open position and then an aqueous liquid allowing the powder to be wetted while ensuring the perfect homogeneity of the mixture by means of a stirring device started after closing the tank. Dispositif clos selon la revendication 1,
caractérisé en ce que
la cuve est pourvue d'une ou plusieurs canalisations équipées de vannes pour assurer la vidange, l'amenée du liquide aqueux et/ou la vidange du milieu.Closed device according to claim 1,
characterized in that
the tank is provided with one or more pipes equipped with valves to ensure the emptying, the supply of the aqueous liquid and / or the emptying of the medium. Dispositif clos selon la revendication 1,
caractérisée en ce qu'
est équipé d'une trappe maintenue en place par un dispositif de solidarisation.Closed device according to claim 1,
characterized in that
is equipped with a hatch held in place by a securing device. Dispositif clos selon la revendication 5,
dans lequel
le dispositif de solidarisation consiste en une vis d'obturation ou une patte de serrage.Closed device according to claim 5,
in which
the securing device consists of a closure screw or a clamping lug. Dispositif selon l'une des revendications précédentes,
dans lequel
la trappe est traversée par une conduite d'amenée du produit pulvérulent.Device according to one of the preceding claims,
in which
the hatch is traversed by a conduit for supplying the powdery product. Dispositif clos selon l'une des revendications précédentes,
caractérisé en ce que
le couvercle de la cuve comporte une trappe à levier munie de deux grilles de protection maintenues en place par un dispositif d'étanchéité.Closed device according to one of the preceding claims,
characterized in that
the lid of the tank comprises a lever door provided with two protective grids held in place by a sealing device. Dispositif clos selon l'une des revendications précédentes,
caractérisé en ce que
le couvercle de la cuve comporte des canalisation d'introduction de la phase aqueuse et/ou des canalisations de recyclage du liquide aqueux.Closed device according to one of the preceding claims,
characterized in that
the lid of the tank comprises the introduction pipe of the aqueous phase and / or the recycling lines of the aqueous liquid. Dispositif clos selon l'une des revendications précédentes,
caractérisé en ce que
le dispositif est équipé d'un dispositif d'agitation ayant une puissance fournie par un moteur variant de 0,4 à 5 kW.Closed device according to one of the preceding claims,
characterized in that
the device is equipped with a stirring device having a power supplied by a motor varying from 0.4 to 5 kW. Dispositif selon la revendication 10,
caractérisé en ce que
le dispositif d'agitation est un axe portant à sa partie inférieure, des palettes ou des hélices, disposées de préférence à plusieurs niveaux de la partie inférieure.Device according to claim 10,
characterized in that
the stirring device is an axis carrying at its lower part, pallets or propellers, preferably arranged at several levels of the lower part. Dispositif selon l'une des revendications précédentes,
caractérisé en ce que
l'on introduit dans la cuve une phase aqueuse de viscosité importante, plus au moins épaisse.Device according to one of the preceding claims,
characterized in that
an aqueous phase of significant viscosity, more or less thick, is introduced into the vessel. Dispositif selon l'une des revendications précédentes,
caractérisé en ce que
la phase aqueuse de viscosité importante est une dispersion d'un polysaccharide, d'un agent diluant visqueux et d'un agent stabilisant, pour obtenir une viscosité appropriée.Device according to one of the preceding claims,
characterized in that
the aqueous phase of high viscosity is a dispersion of a polysaccharide, a viscous diluent and a stabilizing agent to obtain a suitable viscosity. Dispositif selon la revendication 11,
caractérisé en ce que
le polysaccharide est choisi parmi le saccharose, le maltose et les dérivés hydrosolubles de cellulose.Device according to claim 11,
characterized in that
the polysaccharide is chosen from sucrose, maltose and water-soluble cellulose derivatives. Dispositif selon la revendication 11,
caractérisé en ce que
l'agent diluant visqueux est un polyol soluble dans l'eau.Device according to claim 11,
characterized in that
the viscous diluent agent is a water-soluble polyol. Dispositif selon la revendication 13,
caractérisé en ce que
le polyol soluble dans l'eau est choisi parmi le glycérol, les polyglycérols, l'érythritol, le sorbitol, le mannitol, le tetra(hydroxymethyl)méthane et le tetra(hydroxyéthyl) propane.Device according to claim 13,
characterized in that
the water-soluble polyol is chosen from glycerol, polyglycerols, erythritol, sorbitol, mannitol, tetra (hydroxymethyl) methane and tetra (hydroxyethyl) propane. Dispositif selon la revendication 13,
caractérisé en ce que
l'agent stabilisant est choisi parmi les polyalkylèneglycols ayant un poids moléculaire allant de 1000 à 3000, le propylène glycol 1,2 et le propylène glycol 1,3.Device according to claim 13,
characterized in that
the stabilizing agent is chosen from polyalkylene glycols having a molecular weight ranging from 1000 to 3000, propylene glycol 1,2 and propylene glycol 1,3. Procédé de production de suspensions aqueuses de produits pulvérulents difficilement mouillables par l'eau dans le dispositif selon la revendication 1,
dans lequel on introduit la masse de produit pulvérulent en un premier temps, dans la cuve en un lieu dédié à cet effet au sein d'un local protégé contre les risques de dissémination de la poudre, puis on referme la trappe de la cuve de façon étanche, ensuite on décontamine la cuve extérieurement, on stérilise éventuellement le produit pulvérulent dans la cuve par l'action de radiations ionisantes, la cuve dans un second temps est transportée jusqu'au lieu de production de la suspension, décontaminée extérieurement à nouveau, puis on introduit dans l'atelier de fabrication de la suspension, la cuve et alors, dans un deuxième temps, on fabrique la suspension sans risque de contamination extérieure, en introduisant dans la cuve qui constitue un espace clos un mélange liquide contenant un agent stabilisant, un agent posysaccharidique édulcorant et un agent diluant, et agite alors jusqu'à formation d'une suspension aqueuse homogène, prête à l'emploi, que l'on peut sécher ultérieurement et/ou granuler si désiré.A process for producing aqueous suspensions of pulverulent products which are difficult to wetted with water in the device according to claim 1,
in which the mass of powdery product is initially introduced into the tank at a place dedicated for this purpose in a room protected against the risks of spreading the powder, then the trap door is closed in a manner watertight, then decontaminate the tank externally, optionally sterilize the powdery product in the tank by the action of ionizing radiation, the tank in a second time is transported to the production site of the suspension, decontaminated externally again, then the vessel is introduced into the suspension production workshop, and then, in a second step, the suspension is manufactured without any risk of external contamination, by introducing into the tank which constitutes an enclosed space a liquid mixture containing a stabilizing agent, a sweetening agent and a diluting agent, and then stirring until a homogeneous, ready-to-use aqueous suspension is formed which can be t dry later and / or granulate if desired. Procédé selon la revendication 18,
permettant d'éviter l'apparition d'une surpression dans la cuve tout en retenant efficacement toute particule susceptible de contaminer l'environnement de la cuve ce qui évite de produire des projections ou des émanations de fumées dans l'environnement de la cuve,
caractérisé en ce que la cuve comporte une canalisation qui lui est connectée à une extrémité et dont l'autre extrémité est reliée à un système de lavage des fumées, ce système de lavage des fumées consistant en une conduite qui débouche sur un diffuseur plongeant dans l'eau de lavage d'un bac dimensionné d'une manière appropriée pour retenir les particules pulvérulentesProcess according to claim 18,
to avoid the appearance of an overpressure in the tank while effectively retaining any particle likely to contaminate the environment of the tank which avoids producing projections or fumes of fumes in the environment of the tank,
characterized in that the tank has a pipe connected thereto at one end and the other end of which is connected to a flue gas cleaning system, said flue gas cleaning system consisting of a pipe which opens onto a diffuser plunging into the washing water of a tank sized appropriately to retain powder particles Procédé de préparation de compositions fluides, prêtes à l'emploi, formées de charbon activé, selon la revendication 18,
caractérisé en ce que l'on mouille une masse de charbon pulvérulent, stérilisé, préalablement introduit dans un dispositif clos du type cuve par un système aqueux contenant un agent stabilisant, un agent polysaccharidique édulcorant et un agent diluant, dans le système clos, on agite jusqu'à formation d'une suspension homogène, prête à l'emploi, que l'on peut sécher ultérieurement et/ou granuler si désiré.Process for the preparation of ready-to-use, ready-to-use, activated carbon compositions according to Claim 18,
characterized in that a mass of powdered, sterilized coal previously introduced into a closed vessel-type device is wetted by an aqueous system containing a stabilizing agent, a polysaccharide sweetening agent and a diluting agent, in the closed system, agitated until a homogeneous, ready-to-use slurry is formed which can subsequently be dried and / or granulated if desired. Procédé selon la revendication 20, dans lequel la qualité du charbon est une qualité de charbon très fine, dont la taille des particules s'échelonne de 8 à 15 microns et présente une porosité élevée.The method of claim 20, wherein the quality of the coal is a very fine grade of coal, the particle size of which ranges from 8 to 15 microns and has a high porosity. Procédé selon la revendication 19,
caractérisé en ce que
l'on introduit en premier lieu le produit solide pulvérulent dans la cuve et dans un local protégé contre toute dissémination de la poudre et qu'on referme ensuite le couvercle de la cuve en l'assujettissant par un moyen de solidarisation avant de procéder ultérieurement à l'introduction de la phase aqueuse dans un second local.Process according to claim 19,
characterized in that
first introduced solid powder product in the tank and in a room protected against any dissemination of the powder and then closed the lid of the tank by securing by a securing means before proceeding to later the introduction of the aqueous phase into a second room. Procédé selon la revendication 18,
caractérisé en ce qu'il comporte une seconde étape dans laquelle on effectue l'ouverture du couvercle amovible de la cuve, on y introduit le produit pulvérulent, on referme soigneusement le couvercle, on introduit progressivement la phase aqueuse de produit visqueux tout en mettant en route l'agitation et on poursuit l'introduction de la phase aqueuse et l'agitation, jusqu'à ce que la suspension soit totalement homogène.Process according to claim 18,
characterized in that it comprises a second step in which the opening of the removable lid of the tank is introduced, the powdery product is introduced therein, the cover is carefully closed, the aqueous phase of viscous product is introduced progressively while putting into stirring and continue the introduction of the aqueous phase and stirring, until the suspension is completely homogeneous. Procédé selon les revendications 18 et 19,
caractérisé en ce que le dispositif d'agitation est un dispositif décentré, équipé d'un moteur électrique.Process according to claims 18 and 19,
characterized in that the stirring device is an off-center device, equipped with an electric motor. Procédé selon la revendication 18,
dans lequel
le produit pulvérulent peut être stérilisé avant l'introduction dans la cuve.Process according to claim 18,
in which
the powdery product can be sterilized before introduction into the tank. Utilisation du procédé selon la revendication 18 à la réalisation de dispersions aqueuses de produits peu solubles dans l'eau, pulvérulents, hydrophobes.Use of the process according to claim 18 for producing aqueous dispersions of poorly water-soluble, pulverulent, hydrophobic products. Utilisation du procédé selon la revendication 18 à la réalisation de dispersions aqueuses de produits pulvérulents, hydrophobes, insolubles dans l'eau.Use of the process according to Claim 18 for producing aqueous dispersions of water-insoluble, hydrophobic powdery products. Utilisation du procédé selon la revendication 26 ou la revendication 27, dans laquelle
le produit pulvérulent est un produit finement pulvérulent hydrophobe, peu soluble ou insoluble dans l'eau et notamment un charbon.Use of the process according to claim 26 or claim 27, wherein
the powdery product is a finely powdered hydrophobic product, poorly soluble or insoluble in water and in particular a coal. Utilisation du procédé selon la revendication 27,
dans laquelle
le charbon est un charbon activé.Use of the process according to claim 27,
in which
coal is an activated carbon. Utilisation du procédé selon la revendication 27,
dans laquelle
la teneur en charbon activé dans la dispersion aqueuse varie de 10 à 50 g pour 100 ml de suspension aqueuse.Use of the process according to claim 27,
in which
the activated carbon content in the aqueous dispersion varies from 10 to 50 g per 100 ml of aqueous suspension. Utilisation du procédé selon la revendication 26 ou la revendication 27 dans laquelle on réalise une suspension aqueuse de charbon activé contenant de 15 à 35 g de charbon activé pour 100 ml de suspension.Use of the process according to claim 26 or claim 27 in which an aqueous suspension of activated charcoal containing 15 to 35 g of activated charcoal per 100 ml of suspension is produced. Les dispersions aqueuses de charbon activé obtenues selon le procédé de la revendication 18 comprenant de 10 à 50 g de charbon activé pour 100 ml de suspension aqueuse.The aqueous dispersions of activated charcoal obtained by the process of claim 18 comprising from 10 to 50 g of activated charcoal per 100 ml of aqueous suspension.
EP06290628A 2005-04-14 2006-04-14 Method of producing suspensions of powdery materials, apparatus therefor and pharmaceutical compositions containing said powdery materials Withdrawn EP1712272A3 (en)

Applications Claiming Priority (1)

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FR0503729A FR2904237A1 (en) 2005-04-14 2005-04-14 METHOD FOR PRODUCING SUSPENSIONS OF FINALLY PULVERULENT PRODUCTS, MEANS THEREFOR, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE FINALLY PULVERULENT PRODUCTS

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CN115089540A (en) * 2022-07-28 2022-09-23 厦门贝贝高生物科技有限公司 Refreshing and easily-washed skin-moistening shower gel and production method and production equipment thereof

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CN111790289B (en) * 2020-07-25 2022-03-18 淮北金岭石化有限公司 Uniform dilution device for concentrated solution additive for hydraulic support

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FR2904237A1 (en) 2008-02-01

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