EP1494655A1 - Agent for producing a sensation of satiety and for weight loss - Google Patents
Agent for producing a sensation of satiety and for weight lossInfo
- Publication number
- EP1494655A1 EP1494655A1 EP03746298A EP03746298A EP1494655A1 EP 1494655 A1 EP1494655 A1 EP 1494655A1 EP 03746298 A EP03746298 A EP 03746298A EP 03746298 A EP03746298 A EP 03746298A EP 1494655 A1 EP1494655 A1 EP 1494655A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- aluminum
- agent according
- producing
- agent
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000036186 satiety Effects 0.000 title claims abstract description 11
- 235000019627 satiety Nutrition 0.000 title claims abstract description 11
- 230000004580 weight loss Effects 0.000 title abstract description 3
- 230000035807 sensation Effects 0.000 title abstract 2
- 235000019615 sensations Nutrition 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 39
- 229920006318 anionic polymer Polymers 0.000 claims abstract description 19
- 239000006260 foam Substances 0.000 claims abstract description 15
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 14
- 230000004060 metabolic process Effects 0.000 claims abstract 2
- 235000010443 alginic acid Nutrition 0.000 claims description 24
- 229920000615 alginic acid Polymers 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 23
- 235000010987 pectin Nutrition 0.000 claims description 18
- 239000001814 pectin Substances 0.000 claims description 18
- 229920001277 pectin Polymers 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 17
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 13
- 229910052782 aluminium Inorganic materials 0.000 claims description 13
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 12
- 229940072056 alginate Drugs 0.000 claims description 12
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 239000013585 weight reducing agent Substances 0.000 claims description 6
- 235000012000 cholesterol Nutrition 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 235000013619 trace mineral Nutrition 0.000 claims description 2
- 239000011573 trace mineral Substances 0.000 claims description 2
- 239000008298 dragée Substances 0.000 claims 1
- 159000000013 aluminium salts Chemical class 0.000 abstract 1
- 229910000329 aluminium sulfate Inorganic materials 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 19
- 150000001768 cations Chemical class 0.000 description 16
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 150000004781 alginic acids Chemical class 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000783 alginic acid Substances 0.000 description 7
- 229960001126 alginic acid Drugs 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 235000010413 sodium alginate Nutrition 0.000 description 6
- 239000000661 sodium alginate Substances 0.000 description 6
- 229940005550 sodium alginate Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- -1 polysaccharide alginic acid Chemical class 0.000 description 5
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 239000001110 calcium chloride Substances 0.000 description 4
- 229910001628 calcium chloride Inorganic materials 0.000 description 4
- 159000000007 calcium salts Chemical class 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 159000000003 magnesium salts Chemical class 0.000 description 4
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- 239000005017 polysaccharide Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 3
- 229910052788 barium Inorganic materials 0.000 description 3
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 239000004227 calcium gluconate Substances 0.000 description 3
- 229960004494 calcium gluconate Drugs 0.000 description 3
- 235000013927 calcium gluconate Nutrition 0.000 description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010014476 Elevated cholesterol Diseases 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 239000002830 appetite depressant Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000009194 citrus pectin Substances 0.000 description 2
- 229940040387 citrus pectin Drugs 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
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- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 description 2
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- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
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- 230000008569 process Effects 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
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- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 description 1
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- WNCAVNGLACHSRZ-KAMYIIQDSA-N Allithiamine Chemical compound C=CCSSC(/CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N WNCAVNGLACHSRZ-KAMYIIQDSA-N 0.000 description 1
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/231—Pectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a means for producing a satiety effect and for reducing weight. Furthermore, the agent according to the invention is also suitable for regulating the cholesterol balance.
- a means for oral administration which consists of a container which is detachable in the stomach and releases the contents. This is filled with a substance that increases its volume in the stomach after its release, thereby suggesting a feeling of satiety in the body.
- the disadvantage of this saturant is that there is a risk of intestinal obstructions.
- the object of the present invention is to provide an improved oral ingestion agent which has a longer gastric residence time than known agents of its kind and thus leads to a more effective satiety effect. It should also be suitable for weight loss. Its suitability for regulating the cholesterol level would also be advantageous, since obesity is usually accompanied by an elevated cholesterol level. In addition, simple manufacture from inexpensive raw materials that do not pose any health risks is desirable.
- the present object is achieved by a means for producing a saturation effect and for reducing the weight from dried porous gel or foam of at least one anionic polymer, the gel or the foam being present as an aluminum salt.
- Anionic polymers preferred according to the invention are polysaccharides and here polysaccharides containing polyuronic acid, such as alginic acids and their salts (alginates).
- polyuronic acid such as alginic acids and their salts (alginates).
- alginic acids and their salts alginates
- low-esterified pectins, xanthan, tragacanth, chondroitin sulfate and all other compounds containing uronic acid can also be used according to the invention.
- synthetic or semi-synthetic cellulose derivatives such as carboxymethyl cellulose or polyacrylates.
- Dried gels or foams containing mixtures of anionic polymers preferably the aforementioned anionic polysaccharides, particularly preferably mixtures of polyuronic acid-containing and low-esterified polysaccharides and in particular mixtures containing salts of alginic acid and pectin are advantageous according to the invention.
- Alginic acid is a linear polyuronic acid consisting of alternating proportions of D-mannuronic acid and L-guluronic acid, which are linked to one another by ⁇ -glycosidic bonds, the carboxyl groups not being esterified.
- One molecule of alginic acid can be composed of approximately 150-1050 uronic acid units, with the average molecular weight varying in a range of 30-200 kDa.
- the polysaccharide alginic acid is part of the cell walls of brown algae.
- the proportion of alginic acid in the dry mass of algae can make up to 40%.
- the alginic acid is obtained by alkaline extraction using methods known per se according to the prior art.
- the resulting powdered alginic acid is therefore purely vegetable and has a high level of biocompatibility. It can absorb 300 times its own weight of water, forming highly viscous solutions.
- alginic acid forms so-called gels.
- the formation of alginate gels in the presence of divalent cations, such as calcium or barium, is described in Shapiro I., et al. (Biomaterials, 1997, 18: 583-90).
- Pectins consist of chains of ⁇ -1, 4-glycosidically linked galacturonic acid units, the acid groups of which are 20-80% esterified with methanol. A distinction is made between high-esterified (> 50%) and low-esterified ( ⁇ 50%) pectins. The molar mass varies between 10-500 kDa.
- Pectins are obtained by acidic extraction using methods known per se according to the prior art from the inner portions of citrus fruit peels, fruit residues or sugar beet pulp.
- the resulting pectins (apple pectin, citrus pectin) are therefore purely vegetable and are highly biocompatible. They can form gels while absorbing water.
- divalent cations such as calcium or barium is known. The latter, however, is not suitable for use in biomedicine due to its toxicity.
- calcium gluconate also provides suitable divalent cations. It is also conceivable to use magnesium salts or a mixture of different physiologically harmless divalent cations.
- pectins according to the invention are advantageously characterized in that pectins have cholesterol-lowering properties. This property is advantageous in the sense of the present invention, since obesity is generally associated with an elevated cholesterol level.
- inorganic or organic calcium salts e.g. Calcium chloride or calcium gluconate
- magnesium salts and mixtures of different physiologically acceptable divalent cations is also conceivable.
- the addition of salts of physiologically acceptable trivalent cations, preferably of soluble aluminum salts is particularly preferred.
- the agents according to the invention can be prepared by adding soluble aluminum salts to an aqueous solution of anionic polymers, preferably alginates and / or pectins, using a manufacturing method of the type described above.
- Particularly suitable soluble aluminum salts are aluminum chloride or aluminum sulfate.
- the soluble aluminum salts can be used alone or in combination.
- salts of divalent cations such as.
- calcium or magnesium salts or a combination thereof can be used in the preparation of the agents according to the invention.
- the present invention thus also relates to a process for the preparation of an improved agent for achieving a saturation effect or for weight reduction, in which water-soluble salts containing trivalent cations, preferably aluminum salts, particularly preferably aluminum chloride or, are used to produce a dried gel or foam of at least one anionic polymer
- water-soluble salts containing trivalent cations preferably aluminum salts, particularly preferably aluminum chloride or
- Aluminum sulfate can be used.
- salts of physiologically harmless divalent cations can also be used, as well as conceivable combinations of salts of divalent and / or trivalent cations.
- anionic polymers is included individually or in combination according to the invention.
- the agent for oral administration according to the invention contains at least one anionic polymer in the form of its aluminum salt.
- the agent according to the invention advantageously contains alginate or pectin or a combination thereof as an anionic polymer.
- the agent according to the invention is preferably present as aluminum alginate or aluminum pectin or a mixture of aluminum alginate and aluminum pectin.
- the salt of trivalent cations preferably in the form of an aluminum salt, forms a more stable complex with the anionic polymers, preferably alginates or pectins, than salts of divalent cations used hitherto.
- aluminum is physiologically harmless compared to barium.
- the more stable interaction of the anionic polymers according to the invention with salts of trivalent cations gives the agent according to the invention the advantageous property that it is comparable on the one hand in solutions with a pH of 1 to 5, preferably from 1 to 4, particularly preferably in solutions with a pH of the stomach or in the stomach itself, is insoluble or only sparingly soluble and, on the other hand, completely in neutral to weakly acidic solutions with a pH of about 6 to 7, preferably with a pH comparable to that of the intestine or in the intestine itself dissolves.
- the dissolution of the agent according to the invention containing aluminum alginates begins, for example, at a pK value of about 3.3 to 3.7.
- the agents also have the advantageous property that they have an increased dimensional stability.
- This dimensional stability is particularly pronounced in compositions containing mixtures of anionic polymers in the form of their aluminum salts, preferably mixtures of aluminum alginate and aluminum pectinate.
- Dimensional stability in the sense of the invention means that the composition according to the invention containing aluminum salts of anionic polymers does not shrink in comparison with gels or foams containing only calcium salts of anionic polymers in solutions with a pH of about 1 to 5. That is, known agents from calcium salts of anionic polymers have the disadvantage that they lose at least a third of their volume, usually even more, in acidic solutions.
- the advantage of the dimensional stability of the agents according to the invention thus has a directly positive effect on their property for producing a satiety effect or for weight reduction, since there is no loss of volume when the agent according to the invention enters the stomach, as is the case with the agents known to date. In this case, compensation for the loss of volume, for example by taking an increased number of saturants, is not necessary according to the invention. This is a pleasant side effect for the consumer.
- the gel or the foam is preferably in compressed form during ingestion by the patient.
- the agent according to the invention can also be compressed during ingestion by chewing and / or swallowing movements. The absorption of liquid in the stomach then increases the volume of the agent according to the invention which has the desired effect the generation of a satiety effect, combined with a weight reduction.
- the agent according to the invention can be present, for example, in the form of tablets, capsules, coated tablets, granules or powder or other configurations.
- the agent according to the invention can have a coating as an outer layer.
- an outer layer referred to as a coating can be applied to the agent according to the invention, which may contain further auxiliaries or active ingredients, such as, for example, compounds which make swallowing or taking the agent according to the invention easier and known to the person skilled in the art under "coating"
- This outer layer can be a lacquer layer or other protective layer which makes it easier to take the agent according to the invention and which only dissolves in the gastrointestinal tract, for example under the influence of gastric fluid.
- the agent according to the invention can also contain further auxiliary substances and / or active substances.
- auxiliaries are understood to mean, for example, the following substances, which, however, are not limiting for the present invention: water-insoluble auxiliaries or mixtures thereof, such as lipids, including fatty alcohols, for example cetyl alcohol, stearyl alcohol and cetostearyl alcohol; glycerides, for example glycerol monostearate or mixtures of mono-, Di- and triglycerides of vegetable oils; hydrogenated oils, such as hydrogenated castor oil or hydrogenated cottonseed oil; waxes, for example beeswax or camauba wax; solid hydrocarbons, for example paraffin or earth wax; fatty acids, for example stearic acid; certain cellulose derivatives, for example ethyl cellulose or acetyl cellulose; polymers or copolymers, such as Polyalkylenes, for example polyethylene, polyvinyl compounds, for example polyvinyl chloride or polyvinyl acetate, and also vinyl chloride-vinyl acetate copoly
- Active ingredients are to be understood as meaning, for example, vitamins, trace elements or pharmaceutical active ingredients.
- the following substances are listed by way of example, but are not limiting for the present invention:
- appetite suppressants are: Amfepramon, Fenfluramin, Fenproporex, Levopropylhexedrin, Mazindol, Mefenorex, Metamfepramon, Norephedrin, Norpseudoephedrin.
- antivirals are: acyclovir, cidofovir, didanosine, famciclovir, foscarnet, ganciclovir, lamivudine, ritonavir, zalcitabine, zidovudine.
- vitamins are: alfacalcidol, allithiamine, ascorbic acid, biotin, calcifediol, calcitriol, colecalciferol, cyanocobalamin, ergocalciferol, folic acid, hydroxocobalamin, nicotinamide, pantothenic acid, phytomenadione, pyridoxine, retinol, riboflavocifone, thiolamine, transiolamine, thiolamine.
- the agent according to the invention can additionally contain fillers, disintegrants, binders and lubricants and carriers which have no decisive influence on the release of active ingredients.
- examples include bentonite (aluminum oxide-silicon oxide hydrate), silica, cellulose (usually microcrystalline cellulose) or cellulose derivatives, for example methyl cellulose, Sodium carboxymethyl cellulose, sugars such as lactose, starches, for example maize starch or derivatives thereof, for example sodium carboxymethyl starch, starch starch, phosphoric acid salts, for example di- or tricalcium phosphate, gelatin, stearic acid or suitable salts thereof, for example magnesium stearate or calcium stearate, talc, colloidal silicon oxide and similar auxiliaries.
- the present invention also relates to the use of the agent according to the invention for producing a saturation effect and for reducing weight.
- the use of the agent according to the invention for regulating the cholesterol balance is also included.
- the agent according to the invention for producing a composition for producing a saturation effect and for reducing weight is conceivable.
- a use of the agent according to the invention for the preparation of a composition for regulating the cholesterol balance is included.
- Dried aluminum alginate gels are placed in artificial gastric and intestinal juices and examined for their dissolution.
- the aluminum alginate dry gels according to the invention are insoluble in solutions with a pH between 1, 2 and 4.5.
- the solutions according to the invention are completely dissolved in solutions with pH 7
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- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
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- Epidemiology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
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Abstract
Description
Claims
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20205854U | 2002-04-15 | ||
DE10216551A DE10216551A1 (en) | 2002-04-15 | 2002-04-15 | Orally administered composition for obtaining satiation effect, reducing body weight and regulating cholesterol levels, comprising dried porous gel or foam of anionic polymer in aluminum salt form |
DE10216551 | 2002-04-15 | ||
DE20205854U DE20205854U1 (en) | 2002-04-15 | 2002-04-15 | Means for producing a satiety effect and for reducing weight |
PCT/EP2003/003910 WO2003086360A1 (en) | 2002-04-15 | 2003-04-15 | Agent for producing a sensation of satiety and for weight loss |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1494655A1 true EP1494655A1 (en) | 2005-01-12 |
Family
ID=29251758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EP03746298A Withdrawn EP1494655A1 (en) | 2002-04-15 | 2003-04-15 | Agent for producing a sensation of satiety and for weight loss |
Country Status (5)
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US (1) | US20050222082A1 (en) |
EP (1) | EP1494655A1 (en) |
CN (1) | CN1662224B (en) |
AU (1) | AU2003226811A1 (en) |
WO (1) | WO2003086360A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7695446B2 (en) | 2002-12-02 | 2010-04-13 | Gi Dynamics, Inc. | Methods of treatment using a bariatric sleeve |
EP1569582B1 (en) | 2002-12-02 | 2017-05-31 | GI Dynamics, Inc. | Bariatric sleeve |
US7678068B2 (en) | 2002-12-02 | 2010-03-16 | Gi Dynamics, Inc. | Atraumatic delivery devices |
US7608114B2 (en) | 2002-12-02 | 2009-10-27 | Gi Dynamics, Inc. | Bariatric sleeve |
US7025791B2 (en) | 2002-12-02 | 2006-04-11 | Gi Dynamics, Inc. | Bariatric sleeve |
DE10323794A1 (en) * | 2003-05-23 | 2004-12-09 | Dr. Suwelack Skin & Health Care Ag | Process for the production of alginate-containing porous moldings |
JP4512597B2 (en) | 2003-12-09 | 2010-07-28 | ジーアイ・ダイナミックス・インコーポレーテッド | Device fixed in gastrointestinal tract and fixing method |
US8057420B2 (en) | 2003-12-09 | 2011-11-15 | Gi Dynamics, Inc. | Gastrointestinal implant with drawstring |
US7837643B2 (en) | 2004-07-09 | 2010-11-23 | Gi Dynamics, Inc. | Methods and devices for placing a gastrointestinal sleeve |
EP1799145B1 (en) | 2004-09-17 | 2016-12-21 | GI Dynamics, Inc. | Gastrointestinal anchor |
US7976488B2 (en) | 2005-06-08 | 2011-07-12 | Gi Dynamics, Inc. | Gastrointestinal anchor compliance |
US20070082026A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for reducing food intake and controlling weight |
US20070082029A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R | Fiber satiety compositions |
US20070082107A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for reducing food intake and controlling weight |
US20070082085A1 (en) * | 2005-10-07 | 2007-04-12 | Catani Steven J | Compositions and methods for reducing food intake and controlling weight |
US20070082108A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Methods for reducing calorie intake |
AU2006326717B2 (en) * | 2005-12-16 | 2010-09-23 | Unilever Plc | Surface-active material and its application |
WO2007148197A2 (en) * | 2006-06-21 | 2007-12-27 | Fmc Biopolymer As | Gastro-activated dietary fibers |
MX2009001608A (en) * | 2006-08-24 | 2009-02-23 | Unilever Nv | Liquid satiety enhancing composition. |
CN101528054B (en) * | 2006-10-17 | 2013-03-13 | 荷兰联合利华有限公司 | Food composition comprising gas bubbles and process for preparing it |
WO2008046742A1 (en) * | 2006-10-17 | 2008-04-24 | Unilever N.V. | Food composition comprising gas bubbles and process for preparing it |
CA2665927A1 (en) * | 2006-10-17 | 2008-04-24 | Unilever Plc | Frozen aerated food products comprising surface-active fibres |
RU2009118467A (en) * | 2006-10-17 | 2010-11-27 | Юнилевер Н.В. (Nl) | FOOD COMPOSITION CONTAINING GAS BUBBLES AND METHOD FOR PREPARING IT |
MX2009003806A (en) * | 2006-10-17 | 2009-04-22 | Unilever Nv | Aerated food product and process for preparing it. |
US8801647B2 (en) | 2007-02-22 | 2014-08-12 | Gi Dynamics, Inc. | Use of a gastrointestinal sleeve to treat bariatric surgery fistulas and leaks |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
WO2014032676A1 (en) | 2012-09-03 | 2014-03-06 | S-Biotek Holding Aps | A solid oral formulation for treatment and/or prevention of overweight and/or for stabilizing blood sugar levels in an individual. |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1470890A1 (en) * | 1964-06-05 | 1969-02-20 | Sartorius Membranfilter Gmbh | Process for the production of alginate membranes |
GB1474891A (en) * | 1975-03-27 | 1977-05-25 | Inst Elementoorganiche Soedine | Synthetic caviar and method of preparing same |
FR2528279B1 (en) * | 1982-06-14 | 1985-10-18 | Pesche Bernard | PROCESS FOR THE MANUFACTURE OF A PRODUCT FOR THE DESTRUCTION OF PEST ANIMALS |
CN1097307A (en) * | 1993-07-16 | 1995-01-18 | 青岛海洋大学 | Marine alga food for decreasing fat |
CA2338337C (en) * | 1998-10-07 | 2008-12-02 | Giltech Limited | Foamable formulation and foam |
-
2003
- 2003-04-15 AU AU2003226811A patent/AU2003226811A1/en not_active Abandoned
- 2003-04-15 CN CN038139502A patent/CN1662224B/en not_active Expired - Fee Related
- 2003-04-15 US US10/511,518 patent/US20050222082A1/en not_active Abandoned
- 2003-04-15 WO PCT/EP2003/003910 patent/WO2003086360A1/en not_active Application Discontinuation
- 2003-04-15 EP EP03746298A patent/EP1494655A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO03086360A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003226811A1 (en) | 2003-10-27 |
US20050222082A1 (en) | 2005-10-06 |
CN1662224A (en) | 2005-08-31 |
WO2003086360A1 (en) | 2003-10-23 |
CN1662224B (en) | 2010-09-08 |
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