EP0728020A1 - Contact lens care solutions - Google Patents
Contact lens care solutionsInfo
- Publication number
- EP0728020A1 EP0728020A1 EP94925504A EP94925504A EP0728020A1 EP 0728020 A1 EP0728020 A1 EP 0728020A1 EP 94925504 A EP94925504 A EP 94925504A EP 94925504 A EP94925504 A EP 94925504A EP 0728020 A1 EP0728020 A1 EP 0728020A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- weight
- ethyl
- care solution
- detergent
- care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003599 detergent Substances 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 7
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 10
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 10
- 229930182478 glucoside Natural products 0.000 claims description 5
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 4
- 229940123208 Biguanide Drugs 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 8
- 229960001484 edetic acid Drugs 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000305071 Enterobacterales Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000012487 rinsing solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/662—Carbohydrates or derivatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
Definitions
- the invention relates to the use of a biode ⁇ gradable detergent in contact lens care solutions, a care solution containing such detergent, and a method for the care of contact lenses.
- the use of a separate detergent and disinfectant complicates the care of contact lenses. It would therefore be highly desirable to provide a combined agent which is both an effective detergent and an effective disinfectant.
- Previous detergents have been toxic to the eyes, and so it has been necessary to use a separate rinsing solution after cleaning. It has now been unexpectedly found that when a biodegradable detergent is used in contact lens care solutions, the obtained solution is suitable for the cleaning, rinsing, disinfection and storage of contact lenses.
- the invention relates to the use of a bio- degradable detergent in contact lens care solutions.
- the invention also relates to a contact lens care solution which is characterized in that it contains a biodegradable detergent.
- the invention further relates to a method for the care of contact lenses. The method is character ⁇ ized by treating the contact lens by a care solution containing a biodegradable detergent.
- biodegradable detergent any biodegradable detergent can be used.
- preferred biodegrad ⁇ able detergents include 6-0-alkanoylglucosides, a particularly advantageous group consisting of those of the formula
- R represents alkyl with 7 to 17 carbon atoms
- R 1 represents ethyl or propyl.
- Preferred 6-0- alkanoylglucosides of formula I include ethyl-6-0- octanoylglucoside, ethyl-6-0-decanoylglucoside, ethyl- 6-0-dodecanoylglucoside, ethyl-6-0-tetradecanoyl- glucoside, propyl-6-0-decanoylglucoside and propyl-6- 0-dodecanoylglucoside.
- One particularly advantageous 6-0-alkanoylglucoside is ethyl-6-0-decanoylglucoside, which is sold by the company Novo Nordisk under the tradename BioSurfTM.
- a biodegradable detergent can be used in all types of contact lens care solutions. Preferably, however, it is used in care solutions containing biguanide, particularly chlorhexidine acetate.
- Chlorhexidine is a cationic ⁇ -substituted bibisguanide having a wide anti ⁇ bacterial spectrum.
- the advantageous effect of a biodegradable detergent, such as ethyl-6-0-decanoyl ⁇ glucoside is attributed to the fact that such a detergent, in addition to its own possible anti ⁇ bacterial effect, improves the antibacterial effect of other substances, such as chlorhexidine.
- a biodegradable detergent decomposes biofilms, which creates a suitable microenvironment for disinfectants.
- the amount of the antibacterial agent, such as biguanide, preferably chlorhexidine acetate, in the care solution is preferably between 0.000025 and 0.0025% by weight, most preferably about 0.00025% by weight.
- the care solution according to the invention may contain conventional additives, such as ethylene-diamine tetraacetic acid (EDTA), and a buffer.
- EDTA ethylene-diamine tetraacetic acid
- the care solution according to the invention typically contains 0.001 to 0.1% by weight, preferably about 0.005% by weight, of a biodegradable detergent.
- a contact lens care solution which contained ion-exchanged water and Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight
- the pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
- Example 2 Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight NaCl 0.47% by weight
- the pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
- Example 3 Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight NaCl 0.47% by weight
- the pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
- the pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
- the pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
- Example 6 Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight NaCl 0.47% by weight Na-tetraborate decahydrate 0.14% by weight
- the pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Detergent Compositions (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Eyeglasses (AREA)
Abstract
The invention relates to the use of a biodegradable detergent in contact lens care solutions. The invention also relates to a contact lens care solution containing the biodegradable detergent, and to a method for the care of contact lenses.
Description
Contact lens care solutions
The invention relates to the use of a biode¬ gradable detergent in contact lens care solutions, a care solution containing such detergent, and a method for the care of contact lenses.
An optimal contact lens disinfection method has not yet been developed. Hydrogen peroxide has been used widely for disinfection but its possible toxic effects have made it less popular. Disinfection systems using no peroxide have been suggested, but it has been found that such systems require careful cleaning and rinsing (see Shih et al. CLAO-J, 1991, 17, 165-168). It has also been found that biofilms formed by enterobacteria prevent efficient dis¬ infection (see Parment et al . , Acta Ophtalmol , 1986, 64, 456-462). Research on biofilms formed on contact lenses shows that hydrogen peroxide is more effective than other disinfectants, and that non-peroxide sub- stances require an effective method for the removal of biofilms (see Wilson et al . , Arch Ophtalmol , 1991, 109, 1155-1157).
The use of a separate detergent and disinfectant complicates the care of contact lenses. It would therefore be highly desirable to provide a combined agent which is both an effective detergent and an effective disinfectant. Previous detergents have been toxic to the eyes, and so it has been necessary to use a separate rinsing solution after cleaning. It has now been unexpectedly found that when a biodegradable detergent is used in contact lens care solutions, the obtained solution is suitable for the cleaning, rinsing, disinfection and storage of contact lenses. The invention relates to the use of a bio-
degradable detergent in contact lens care solutions.
The invention also relates to a contact lens care solution which is characterized in that it contains a biodegradable detergent. The invention further relates to a method for the care of contact lenses. The method is character¬ ized by treating the contact lens by a care solution containing a biodegradable detergent.
According to the invention any biodegradable detergent can be used. However, preferred biodegrad¬ able detergents include 6-0-alkanoylglucosides, a particularly advantageous group consisting of those of the formula
where R represents alkyl with 7 to 17 carbon atoms, and R1 represents ethyl or propyl. Preferred 6-0- alkanoylglucosides of formula I include ethyl-6-0- octanoylglucoside, ethyl-6-0-decanoylglucoside, ethyl- 6-0-dodecanoylglucoside, ethyl-6-0-tetradecanoyl- glucoside, propyl-6-0-decanoylglucoside and propyl-6- 0-dodecanoylglucoside. One particularly advantageous 6-0-alkanoylglucoside is ethyl-6-0-decanoylglucoside, which is sold by the company Novo Nordisk under the tradename BioSurf™.
According to the invention a biodegradable detergent can be used in all types of contact lens care solutions. Preferably, however, it is used in
care solutions containing biguanide, particularly chlorhexidine acetate. Chlorhexidine is a cationic ^^-substituted bibisguanide having a wide anti¬ bacterial spectrum. The advantageous effect of a biodegradable detergent, such as ethyl-6-0-decanoyl¬ glucoside, is attributed to the fact that such a detergent, in addition to its own possible anti¬ bacterial effect, improves the antibacterial effect of other substances, such as chlorhexidine. In addition, a biodegradable detergent decomposes biofilms, which creates a suitable microenvironment for disinfectants.
The amount of the antibacterial agent, such as biguanide, preferably chlorhexidine acetate, in the care solution is preferably between 0.000025 and 0.0025% by weight, most preferably about 0.00025% by weight.
In addition to a biodegradable detergent, water and antibacterial agents, the care solution according to the invention may contain conventional additives, such as ethylene-diamine tetraacetic acid (EDTA), and a buffer. The care solution according to the invention typically contains 0.001 to 0.1% by weight, preferably about 0.005% by weight, of a biodegradable detergent.
The following examples illustrate the invention.
Example 1
One litre of a contact lens care solution was prepared which contained ion-exchanged water and Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight
NaCl 0.47% by weight
Na-tetraborate decahydrate 0.14% by weight Ethyl-6-0-octanoylglucoside 0.005% by weight
The pH of the solution is adjusted between 7.0 and 8.0
with concentrated hydrochloric acid.
Example 2 Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight NaCl 0.47% by weight
Na-tetraborate decahydrate 0.14% by weight Ethyl-6-0-decanoylglucoside 0.005% by weight
The pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
Example 3 Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight NaCl 0.47% by weight
Na-tetraborate decahydrate 0.14% by weight Ethyl-6-0-dodecanoylglucoside 0.005% by weight
The pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
Example 4 Chlorhexidine acetate 0.00025% by weight
EDTA 0.1% by weight
NaCl 0.47% by weight
Na-tetraborate decahydrate 0.14% by weight
Ethyl-6-0-tetradecanoyl- glucoside 0.001% by weight
The pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
Example 5
Chlorhexidine acetate 0.00025% by weight
EDTA 0.1% by weight
NaCl 0.47% by weight
Na-tetraborate decahydrate 0.14% by weight
Propyl-6-0-decanoylglucoside 0.005% by weight
The pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
Example 6 Chlorhexidine acetate 0.00025% by weight EDTA 0.1% by weight NaCl 0.47% by weight Na-tetraborate decahydrate 0.14% by weight
Propyl-6-0-dodecanoylglucoside 0.005% by weight
The pH of the solution is adjusted between 7.0 and 8.0 with concentrated hydrochloric acid.
Claims
1. Use of a biodegradable detergent in contact lens care solutions.
2. Use according to claim 1, c h a r a c t e r¬ i z e in that the biodegradable detergent is a 6-0- alkanoylglucoside.
3. Use according to claim 2, c h a r a c t e r¬ i z e d in that the 6-0-alkanoylglucoside has the formula
where R represents alkyl with 7 to 17 carbon atoms, and R1 represents ethyl or propyl.
4. Use according to claim 3, c h a r a c t e r¬ i z e d in that the biodegradable detergent is ethyl- 6-0-octanoylglucoside, ethyl-6-0-decanoylglucoside, ethyl-6-0-dodecanoylglucoside, ethyl-6-0-tetradeca- noylglucoside, propyl-6-0-decanoylglucoside or propyl- 6-0-dodecanoylglucoside.
5. Use according to claim 4, c h a r a c t e r¬ i z e d in that the biodegradable detergent is ethyl- 6-0-decanoylglucoside.
6. Use according to any of the preceding claims, c h a r a c t e r i z e d in that the amount of the detergent is between 0.001 and 0.1% by weight, cal¬ culated on the care solution.
7. Use according to claim 6, c h a r a c t e r- i z e d in that the amount of the detergent is about
0.005% by weight, calculated on the care solution.
8. Use according to any of the preceding claims, c h a r a c t e r i z e d in that the care solution contains between 0.000025% and 0.0025% by weight of biguanide.
9. Use according to claim 8, c h a r a c t e r¬ i z e d in that the care solution contains about 0.00025% by weight of chlorhexidine acetate.
10. Contact lens care solution, c h a r a c- t e r i z e d in that it contains a biodegradable detergent.
11. Care solution according to claim 10, c h a r a c t e r i z e d in that the biodegradable detergent is a 6-0-alkanoylglucoside.
12. Care solution according to claim 11, c h a r a c t e r i z e d in that the 6-0-alkanoyl¬ glucoside has the formula
where R represents alkyl with 7 to 17 carbon atoms, and R1 represents ethyl or propyl.
13. Care solution according to claim 12, c h a r a c t e r i z e d in that the biodegradable detergent is ethyl-6-0-octanoylglucoside, ethyl-6-0- decanoylglucoside, ethyl-6-0-dodecanoylglucoεide, ethyl-6-0-tetradecanoylglucoside, propyl-6-0-decanoyl¬ glucoside or propyl-6-0-dodecanoylglucoside.
14. Care solution according to claim 13,
c h a r a c t e r i z e d in that the biodegradable detergent is ethyl-6-0-decanoylglucoside.
15. Care solution according to any of claims 10 to 14, c h a r a c t e r i z e d in that it contains between 0.001 and 0.1% by weight of the biodegradable detergent.
16. Care solution according to claim 15, c h a r a c t e r i z e d in that it contains about 0.005% by weight of the biodegradable detergent.
17. Care solution according to any of the preceding claims, c h a r a c t e r i z e d in that it contains between 0.000025% and 0.0025% by weight of biguanide.
18. Care solution according to claim 17, c h a r a c t e r i z e d in that it contains about
0.00025% by weight of chlorhexidine acetate.
19. Method for the care of contact lenses, c h a r a c t e r i z e d in that a contact lens is treated with a care solution according to any of claims 10 to 18.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI934199A FI93609C (en) | 1993-09-24 | 1993-09-24 | Use of a biodegradable detergent in contact lens care solutions, a treatment solution and a method for treating contact lenses |
| FI934199 | 1993-09-24 | ||
| PCT/FI1994/000392 WO1995008352A1 (en) | 1993-09-24 | 1994-09-05 | Contact lens care solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0728020A1 true EP0728020A1 (en) | 1996-08-28 |
Family
ID=8538656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP94925504A Ceased EP0728020A1 (en) | 1993-09-24 | 1994-09-05 | Contact lens care solutions |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0728020A1 (en) |
| JP (1) | JPH09503134A (en) |
| AU (1) | AU7538994A (en) |
| CA (1) | CA2172043A1 (en) |
| FI (1) | FI93609C (en) |
| WO (1) | WO1995008352A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2762849B1 (en) * | 1997-05-05 | 1999-06-18 | Essilor Int | AQUEOUS SOLUTION FOR MAINTAINING CONTACT LENSES |
| CN104138856B (en) * | 2014-07-16 | 2016-08-24 | 北京卫星制造厂 | The wiping arrangement in-orbit of a kind of mechanism seals circle and wiping method |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0055515B1 (en) * | 1980-12-18 | 1985-02-20 | Smith and Nephew Associated Companies p.l.c. | Lens sterilising solutions and their use |
| DE3626082A1 (en) * | 1986-07-31 | 1988-02-11 | Henkel Kgaa | DISINFECTANT AND CLEANER SYSTEM FOR CONTACT LENSES |
| CA2009118C (en) * | 1989-02-21 | 1996-02-27 | Mary F. Mowrey-Mckee | Method and composition for cleaning and disinfecting contact lenses |
| GB8922593D0 (en) * | 1989-10-06 | 1989-11-22 | Unilever Plc | Detergent composition |
| RU2067456C1 (en) * | 1990-12-27 | 1996-10-10 | Эллерган, Инк. | Method of contact lens disinfection and composition for contact lens disinfection |
| IE920838A1 (en) * | 1991-03-18 | 1992-09-23 | Allergan Inc | Contact lens disinfecting compositions |
| US5523012A (en) * | 1991-07-19 | 1996-06-04 | Ciba-Geigy Corporation | Hydrogen peroxide disinfection solutions |
-
1993
- 1993-09-24 FI FI934199A patent/FI93609C/en active
-
1994
- 1994-09-05 AU AU75389/94A patent/AU7538994A/en not_active Abandoned
- 1994-09-05 CA CA 2172043 patent/CA2172043A1/en not_active Abandoned
- 1994-09-05 WO PCT/FI1994/000392 patent/WO1995008352A1/en not_active Application Discontinuation
- 1994-09-05 JP JP7509579A patent/JPH09503134A/en active Pending
- 1994-09-05 EP EP94925504A patent/EP0728020A1/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9508352A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FI934199A0 (en) | 1993-09-24 |
| AU7538994A (en) | 1995-04-10 |
| CA2172043A1 (en) | 1995-03-30 |
| FI93609C (en) | 1995-05-10 |
| JPH09503134A (en) | 1997-03-31 |
| WO1995008352A1 (en) | 1995-03-30 |
| FI93609B (en) | 1995-01-31 |
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