EP0341261A1

EP0341261A1 - Anti-smoking agent

Info

Publication number: EP0341261A1
Application number: EP88901252A
Authority: EP
Inventors: Vladimir Dr. Badmajew
Original assignee: Individual
Current assignee: Individual
Priority date: 1987-01-15
Filing date: 1988-01-15
Publication date: 1989-11-15
Also published as: JPH03502092A; US5130132A; WO1988005305A1

Abstract

Un agent anti-tabagique possédant une action biochimique se compose des ingrédients végétaux suivants: radix bupleuri, radix peucedani, rhizoma cimicifugae et tubera pinelliae.An anti-smoking agent with biochemical action consists of the following plant ingredients: radix bupleuri, radix peucedani, rhizoma cimicifugae and tubera pinelliae.

Description

Name: Remedy for smoking

The invention relates to an anti-smoking agent with a biochemical effect.

The health-related disadvantages associated with smoking and caused by smoking are given even more attention. In the meantime, it has also become generally known that even non-smokers who, in the company of smokers, become smoke through the smoke become passive smokers, have to fear harmful effects on their health in the long run. Therefore, it has long been tried, procedure or Mitt ^ ¹ . to indicate different types, all of which aim to act against smoking by denying smoking to the smoker, motivating him psychologically against smoking, shifting the smoking pleasure to other physical pleasures or the like.

A disadvantage of the known chemical or biochemical agents against smoking are, in particular, their side effects, which occur when the known agents are taken. Furthermore, their effects are not as successful. The intake, in particular the continued intake of the known means, presupposes a determined and constant will of the patient, which experience shows that the patient applies during an initial phase of the intake, but often - after a certain weaning time - often no longer applies able. This is especially true when the first withdrawal symptoms occur and side effects, such as. B. weight gain etc. occur. It is at this stage that the willpower of many people wishing to quit waning. At this stage, however, the known biochemicals do not adequately support the person wishing to quit.

The invention is therefore based on the object of avoiding the disadvantages of the known biochemical weaning agents and of providing a bio-chemical agent which within a relatively short period of time, for example a few days (two to five days), spoils the person weaning from smoking so that he the therapy also in the following days perseveres. During the first few days of taking the drug, the drug should evoke such a strong aversion to smoking that the person wishing to withdraw it feels physical discomfort, especially nausea, if he smokes after taking the drug or even smokes a smoke as a passive smoker another smoker inhales. The invention aims at a strong anti-nicotine effect. The aim is to achieve an incompatibility between the smoking products and the agent according to the invention.

This object is achieved by an anti-smoking agent with a bio-chemical effect, which is composed of the following, non-toxic plant components:

RADIX BUPLEURI, RADIX PEUCEDANI, RHIZQMA CIMICIFUGAE and TUBERA PINELLIAE. Either Rhizcma phragmites or a mixture of Pinellia ternata and Liquiritiae can be added to these components, whereby Liquiritiae can be replaced by Robiniae pseudoacaciae.

These components can be in any dosage form, e.g. B. as a chewable tablet, normal, oral tablet or as a suitable tea preparation substance. The dosage form is preferred as a chewable tablet. As a chewable tablet, however, the very bitter taste comes into full effect, but it can be modified, suppressed or changed by suitable additives (sugar, flavorings or the like).

The combination of the components mentioned causes an aversion to smoke and to smoking, which is triggered when a cigarette is lit. This aversion also occurs when you as a passive smoker inhale the smoke of other smokers. In active or passive smoking, a bitter taste is produced in the mouth after taking the pharmaceutical, which initially spoils the enjoyment of smoking. In addition and as an additional effect, a defense reaction of the central nervous system is brought about. This is attributed to a change in the taste sensation in the brain. Furthermore, the parasymphatic nervous system is stimulated, which in turn triggers nausea, nausea, through which smoke nausea or nausea is increased. The herbal mixture according to the invention strengthens the nerves and the organs of the body. The anti-smoking effect sets in after a few days, for example two to four days. It first makes itself felt in an uncomfortable situation when a cigarette is lit.

The herbal ingredients used have a strong antinicotic effect, while smoking a cigarette or passive smoking causes nausea that can lead to vomiting. In terms of taste, there is an incompatibility between the smoking products and the components of the herbal active ingredients.

The pharmaceutical according to the invention causes weight loss when ingested. This is a particular advantage, because due to the nicotine, a person who wants to withdraw usually buzzes with weight, in any case with conventional anti-smoking therapies a weight gain is found a few days after the cessation of smoking. This increase in weight is counteracted by the agent according to the invention due to its slimness.

Overall, the effect of the pharmaceutical according to the invention directed against the enjoyment of smoking is not a psychological but a sensory contrast (incompatibility) that is noticeable both at the local sensory level and in the area of the central brain.

In addition, the agent has proven to be effective in reducing the enjoyment of drinking coffee. This is attributed in particular to Pinellia ternata. A taste incompatibility with coffee is achieved, a tingling, tingling, biting or burning sensation occurs in the mouth or throat when drinking coffee after taking the agent. When the agent was taken for a long time, it was found in test subjects that daily coffee consumption erroneously. In addition, there are indications that the drug also spoils the use of drugs. Initial, quite preliminary trials have shown that the drug can also be used in other drug and toxic cases Substances have an effect, e.g. B. when smoking marijuana, with excessive alcohol consumption and also in the last stage of a cocaine addiction.

Radix bupleuri is the root of the BUPLEURUM falcatum L. from the Umbelliferae family. The herb is native to Southern and Central Europe, East Asia and especially Japan. Its use against fever is well known. The essential chemical components are 0.5% bupleurumol C-.H _fi4 0 ₂ , 2% A-spinasterol and rutin ₂ ^H 3o ⁰ i6 _'

Radix peucedani is the root of PEUCEDANUM praeruptorum thin, also from the Umbelliferae family. Its use in gastric medicine and skin diseases is known. The root contains, among other things, essential oils and bitter substances, in particular nodakenin ^C 20 ^H 24 ° 9 'sponsterol and nodakenetin C, .H, .0 ..

Rhizoma cimicifugae is the root of the CIMICIFUGAE foetida L. from the Ranunculaceae family. The plant is native to North America and has the active ingredient <^ Cimitin C _2Q H., .0-, and Cimicifugih.

Tubera pinelliae is the tuber, root or stem of the PINELLIA ternata Breitenbach (P. tuberiferarum triphyllum from the Araceae family). The plant is native to East Asia. The chemical composition shows u. a. 0.003 to 0.13% volatile oils, some alkaloids, fatty oils and starch, for example pinelin.

Rhizαna phragmites are the root and stem of PHRAGMUES ar-itunis L. Trinius of the family of the Gramineae, the German name is reed. Up to 77% silica is found in the ashes. Rhizoma Phragmites has a sweet taste, the medicinal effect extends to the lungs, stomach and liver. Some protein, fat and carbohydrates are found in the chemical composition.

The root of the Liquiritiae or Glycyrrhize contains steroid-like hormones which are said to have an anti-inflammatory effect. As the main active ingredient, the root contains the intensely sweet-tasting one Triterpensaponin Glycyrrhizinsäure, which forms a gelatin-like mixture with water, which forms a protective coating in the neck area. The licorice root Radix glycyrrhize gives the agent a pleasant taste. Essential ingredients are 10% glycyrrhizin, potassium, 12% terpenoid saponins, e.g. B. as the already mentioned Glycyrrhizin¬ acid, liquiritin, isoliquiritin (flavonoids), 1 to 2% asparagine and 6% glycymarin (bitter taste).

Pinellia ternata from the Araceae family has pinelin, starch and volatile oils as active ingredients.

In a preferred further development of the invention, it is proposed that the vegetable components are present in the following weight percentages:

(Example 1): Radix bupleuri 25%, Radix peucedani 20%, Rhizαna cimicifugae 25%, Tubera pinelliae 20% and Rhizcma phragmites 10%. The starting point is fully dosed (saturated) aqueous solutions of Radix bupleuri 3-5 g, Radix peucedani 5-10 g, Rhizαna cimicifugae 3-5 g, Tubera pinelliae 5-10 g and Rhizcma phragmites 15-30 g.

(Example 2): Peucedanum praeruptorum from the Ranunculaceae family 30%, Gentiana barbata from the Gentianaciae family 24%, Cimicifugae foetida from the Ranunculaceae family 12%, Liquiritiae from the Leguminosae family or Robiniae pseudoacaciae 4 from the Leguminosae family %, Bupleurum falcatum from the Umbelliferae family 12% and Pinellia ternata from the Araceae family 18%

The plant constituents are simply mixed together during production; it is possible, but not necessary, to use special binders. A gum material, for example chicle gurriii, polyvinyl ester or polyethylene, is used in the manufacture of chewable tablets, that is to say materials such as are also used for the production of chewing gums. Sugar obtained from honey is preferably added. The chewable tablet formulation has a very long-lasting effect; the individual active ingredients are stig and open to the longer chewing time and therefore develop their effect to the desired extent.

A tea can also be prepared instead. The preparation takes place like with a tea preparation with normal tea leaves. Hot water is poured into a cup over at least one tablet of the pha ____ a.zeut__kums according to the invention, the preparation is allowed to stand for a few minutes and is drunk while it is still hot.

With a weight of a single tablet of 0.5 grams, three tablets per day are recommended as a normal dose, which are taken with a little water. For heavy smokers, it is recommended to double the dose. The tablets are taken with meals, they can be taken before, during or after meals.

The treatment should be continued until an effect is felt, but should not be given for more than five days. If after this time no effect, i.e. no aversion to smoking and smoking, is found, it is recommended to pause for two to three days and then to start a five-day course again.

The effective chemical components of these plants for the anti-smoking effect are considered:

Nödakenin in the Peucedanum, Gentioside in the Gentian (Gentiana), Cimitin in the Ci icifuga, Saponine and A-Spinasterol in the Bupleurum.

Claims

Name: Remedy for smoking claims

1. Anti-smoking agent with a biochemical effect, composed of the following non-toxic, herbal ingredients: Radix bupleuri, Radix peucedani, Rhizoma cimicifugae and Tubera pinelliae.

2. Composition according to claim 1, characterized in that it additionally contains Rhizcma phragmites.

3. Composition according to claim 1 or 2, characterized in that it additionally has Gentiana barbata (gentian) and / or Liquiritiae (or Glycyrrhize), Liquiritiae can be replaced by Robiniae pseudoacaciae.

4. Composition according to claim 2, characterized in that the components are present in the following relative weight ratio:

Radix bupleuri 25%, Radix peucedani 20%, Rhizoma cimicifugae 25%, Tubera pinelliae 20% and Rhizcma phragmites 10%.

5. Composition according to claim 3, characterized in that the components are present in the following relative weight ratio:

Peucedanum praeruptorum from the Ranunculaceae family 30%, Gentiana barbata from the Gentianaciae family 24%, Cimicifugae foetida from the Ranunculaceae family 12%, Liquiritiae from the Leguminosae family or Robiniae pseudoacaciae from the Leguminupurum family 4% the family of the Umbelli¬ ferae 12% and Pinellia ternata from the family of the Araceae 18%.

6. Composition according to one of claims 1 to 5, characterized in that the constituents are pressed dry and optionally with a binder to form a tablet.

7. Composition according to one of claims 1 to 6, characterized in that the components are open to each with water, in particular by cooking, and that manufactured from the thus obtained gene wässri- solution, a tablet, particularly in the form of a chewable tablet, ^' becomes.

8. Composition according to one of claims 1 to 7, characterized in that a Kaugurr_rtibasismaterial such as Chiclegurπmi, polyvinyl ester or polyethylene is added to the components.

9. Use of a mixture of the following herbal ingredients:

Radix bupleuri, Radix peucedani, Rhizcma cimicifugae and Tubera pinelliae as anti-smoking agents.