EP0303233A3 - Human reg protein - Google Patents

Human reg protein Download PDF

Info

Publication number
EP0303233A3
EP0303233A3 EP88112942A EP88112942A EP0303233A3 EP 0303233 A3 EP0303233 A3 EP 0303233A3 EP 88112942 A EP88112942 A EP 88112942A EP 88112942 A EP88112942 A EP 88112942A EP 0303233 A3 EP0303233 A3 EP 0303233A3
Authority
EP
European Patent Office
Prior art keywords
human reg
reg protein
gln
ala
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP88112942A
Other languages
German (de)
French (fr)
Other versions
EP0303233A2 (en
Inventor
Hiroshi Dr. Med. Okamoto
Takako Itoh
Hiroshi Teraoka
Hiroshige Tsuzuki
Nobuo Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of EP0303233A2 publication Critical patent/EP0303233A2/en
Publication of EP0303233A3 publication Critical patent/EP0303233A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/474—Pancreatic thread protein; Reg protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A human reg protein is disclosed which comprises an amino acid sequence from Ala (1st), Gly (21st), Gln (22nd), Glu (23rd), Ala (24th), Gln (25th), Gln (30th), Ala (31st) or Ile (33rd) to Asn (165th) of the amino acid sequence shown in Fig. 1. Furthermore, a method for the production of said human reg proteins is disclosed.
EP88112942A 1987-08-10 1988-08-09 Human reg protein Withdrawn EP0303233A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20051487 1987-08-10
JP200514/87 1987-08-10

Publications (2)

Publication Number Publication Date
EP0303233A2 EP0303233A2 (en) 1989-02-15
EP0303233A3 true EP0303233A3 (en) 1989-06-14

Family

ID=16425579

Family Applications (1)

Application Number Title Priority Date Filing Date
EP88112942A Withdrawn EP0303233A3 (en) 1987-08-10 1988-08-09 Human reg protein

Country Status (8)

Country Link
EP (1) EP0303233A3 (en)
JP (1) JPH01137994A (en)
KR (1) KR940000199B1 (en)
AU (1) AU604147B2 (en)
CA (1) CA1339758C (en)
DK (1) DK174067B1 (en)
HU (1) HUT47640A (en)
NZ (1) NZ225738A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02200700A (en) * 1989-01-30 1990-08-08 Shionogi & Co Ltd New reg protein
ES2164634T3 (en) * 1989-10-18 2002-03-01 Us Health PRODUCTION AND USE OF HUMAN NM23-H2 PROTEIN AND ANTIBODIES INTENDED TO SUCH EFFECT.
JP3570557B2 (en) * 1992-12-01 2004-09-29 塩野義製薬株式会社 Drug containing reg protein as active ingredient
SK43197A3 (en) * 1994-10-13 1999-03-12 Amgen Inc Method of treating diabetes mellitus using kgf
US5866546A (en) * 1997-04-18 1999-02-02 Hadasit Medical Research Services And Development Company Ltd. Treatment for diabetes
EP1167974B1 (en) * 1999-04-07 2006-09-13 Hiroshi Okamoto METHOD FOR JUDGING AUTOIMMUNE DISEASE, METHOD FOR DETECTING ANTI-Reg PROTEIN AUTOANTIBODY AND DIAGNOSTICS FOR AUTOIMMUNE DISEASES
WO2006096565A2 (en) 2005-03-04 2006-09-14 Curedm Inc. Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions
EP2295066B1 (en) 2005-05-25 2016-04-27 CureDM Group Holdings, LLC Peptides, derivatives and analogs thereof, and methods of using same
WO2008064306A2 (en) 2006-11-22 2008-05-29 Curedm, Inc. Methods and compositions relating to islet cell neogenesis
CN101896499B (en) * 2007-08-30 2014-02-12 库尔Dm股份有限公司 Compositions and methods of using proislet peptides and analogs thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0258000A1 (en) * 1986-08-22 1988-03-02 Tohoku University Nucleotide sequence of gene specifically expressed by insulinoma and protein encoded thereby

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0258000A1 (en) * 1986-08-22 1988-03-02 Tohoku University Nucleotide sequence of gene specifically expressed by insulinoma and protein encoded thereby

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 5, 15th February 1988, pages 2111-2114, The American Society for Biochemistry and Molecular Biology, Inc., US; K. TERAZONO et al.: "A novel gene activated in regenerating islets" *
THE LANCET, vol. 1, no. 8533, 14th March 1987, pages 619-620, The Lancet Ltd, London, GB; Ph. VAGUE et al.: "Nicotinamide may extend remission phase in insulin-dependent diabetes" *

Also Published As

Publication number Publication date
HUT47640A (en) 1989-03-28
EP0303233A2 (en) 1989-02-15
NZ225738A (en) 1991-07-26
DK444288A (en) 1989-02-11
KR890003801A (en) 1989-04-18
AU2066188A (en) 1989-02-16
KR940000199B1 (en) 1994-01-12
JPH01137994A (en) 1989-05-30
AU604147B2 (en) 1990-12-06
CA1339758C (en) 1998-03-17
DK174067B1 (en) 2002-05-21
DK444288D0 (en) 1988-08-09

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