EE03873B1 - Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine - Google Patents

Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine

Info

Publication number: EE03873B1
Authority: EE; Estonia
Prior art keywords: alkyloxfuranone; preparation; compounds obtained; amine derivatives; amine
Prior art date: 1997-07-15

Application number

EEP200000024A

Other languages

English (en)

Inventor

Bouchet Rapha�l

Brion Francis

Colladant Colette

Lagouardat Jacques

Original Assignee

Hoechst Marion Roussel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-15

Filing date

1998-07-09

Publication date

2002-10-15

1998-07-09 Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel

2000-10-16 Publication of EE200000024A publication Critical patent/EE200000024A/et

2002-10-15 Publication of EE03873B1 publication Critical patent/EE03873B1/et

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

EEP200000024A 1997-07-15 1998-07-09 Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine EE03873B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9708932A FR2766188B1 (fr)	1997-07-15	1997-07-15	Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr)	1997-07-15	1998-07-09	Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number	Publication Date
EE200000024A EE200000024A (et)	2000-10-16
EE03873B1 true EE03873B1 (et)	2002-10-15

Family

ID=9509210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000024A EE03873B1 (et)	1997-07-15	1998-07-09	Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine

Country Status (34)

Country	Link
US (1)	US6235899B1 (et)
EP (1)	EP0998470B1 (et)
JP (1)	JP4450987B2 (et)
KR (1)	KR100519691B1 (et)
CN (1)	CN100363355C (et)
AP (1)	AP1071A (et)
AR (1)	AR015924A1 (et)
AT (1)	ATE239713T1 (et)
AU (1)	AU744272B2 (et)
BG (1)	BG64050B1 (et)
BR (1)	BR9810896A (et)
CA (1)	CA2296742C (et)
CZ (1)	CZ295312B6 (et)
DE (1)	DE69814395T2 (et)
DK (1)	DK0998470T3 (et)
EA (1)	EA002883B1 (et)
EE (1)	EE03873B1 (et)
ES (1)	ES2197489T3 (et)
FR (1)	FR2766188B1 (et)
HR (1)	HRP20000027B1 (et)
HU (1)	HU230148B1 (et)
ID (1)	ID23784A (et)
IL (1)	IL134031A (et)
ME (1)	ME01708B (et)
NO (1)	NO324508B1 (et)
NZ (1)	NZ502338A (et)
PL (1)	PL200820B1 (et)
PT (1)	PT998470E (et)
RS (1)	RS49832B (et)
SK (1)	SK284168B6 (et)
TR (1)	TR200000117T2 (et)
UA (1)	UA66364C2 (et)
WO (1)	WO1999003852A1 (et)
ZA (1)	ZA986203B (et)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7053056B2 (en)	1998-07-02	2006-05-30	Idun Pharmaceuticals, Inc.	C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
CA2402128A1 (en) *	2000-04-24	2001-11-01	Vertex Pharmaceuticals Incorporated	Process and intermediates for making substituted aspartic acid acetals
PE20011350A1 (es)	2000-05-19	2002-01-15	Vertex Pharma	PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) *	2000-09-20	2003-11-19	Kanegafuchi Chem Ind Co Ltd	光学活性β−アミノ酸誘導体の製造方法
WO2002055478A1 (fr) *	2001-01-16	2002-07-18	Kaneka Corporation	Procede de preparation de derives d'aminolactone optiquement actifs et intermediaires de ces derives
NZ549665A (en)	2004-02-27	2010-09-30	Vertex Pharma	Caspase inhibitors and uses thereof
SI2399915T1 (sl) *	2004-03-12	2015-05-29	Vertex Pharmaceuticals Incorporated	Postopek in intermediati za pripravo inhibitorjev asparagin-acetal-kaspaze

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) *	1994-06-17	1998-02-10	Vertex Pharmaceuticals, Inc.	Inhibitors of interleukin-1β converting enzyme

1997
- 1997-07-15 FR FR9708932A patent/FR2766188B1/fr not_active Expired - Lifetime
1998
- 1998-07-09 AT AT98937591T patent/ATE239713T1/de active
- 1998-07-09 DE DE69814395T patent/DE69814395T2/de not_active Expired - Lifetime
- 1998-07-09 TR TR2000/00117T patent/TR200000117T2/xx unknown
- 1998-07-09 DK DK98937591T patent/DK0998470T3/da active
- 1998-07-09 KR KR10-2000-7000398A patent/KR100519691B1/ko not_active IP Right Cessation
- 1998-07-09 SK SK30-2000A patent/SK284168B6/sk not_active IP Right Cessation
- 1998-07-09 AU AU86333/98A patent/AU744272B2/en not_active Expired
- 1998-07-09 EE EEP200000024A patent/EE03873B1/et unknown
- 1998-07-09 ID IDW20000067A patent/ID23784A/id unknown
- 1998-07-09 BR BR9810896-4A patent/BR9810896A/pt not_active Application Discontinuation
- 1998-07-09 ES ES98937591T patent/ES2197489T3/es not_active Expired - Lifetime
- 1998-07-09 CZ CZ200065A patent/CZ295312B6/cs not_active IP Right Cessation
- 1998-07-09 EA EA200000127A patent/EA002883B1/ru not_active IP Right Cessation
- 1998-07-09 JP JP2000503076A patent/JP4450987B2/ja not_active Expired - Lifetime
- 1998-07-09 ME MEP-2000-15A patent/ME01708B/me unknown
- 1998-07-09 PT PT98937591T patent/PT998470E/pt unknown
- 1998-07-09 NZ NZ502338A patent/NZ502338A/en not_active IP Right Cessation
- 1998-07-09 AP APAP/P/2000/001732A patent/AP1071A/en active
- 1998-07-09 RS YUP-15/00A patent/RS49832B/sr unknown
- 1998-07-09 HU HU0003857A patent/HU230148B1/hu unknown
- 1998-07-09 CA CA002296742A patent/CA2296742C/fr not_active Expired - Lifetime
- 1998-07-09 EP EP98937591A patent/EP0998470B1/fr not_active Expired - Lifetime
- 1998-07-09 WO PCT/FR1998/001480 patent/WO1999003852A1/fr active IP Right Grant
- 1998-07-09 IL IL13403198A patent/IL134031A/en not_active IP Right Cessation
- 1998-07-09 US US09/463,014 patent/US6235899B1/en not_active Expired - Lifetime
- 1998-07-09 CN CNB98808967XA patent/CN100363355C/zh not_active Expired - Lifetime
- 1998-07-09 PL PL338035A patent/PL200820B1/pl unknown
- 1998-07-13 ZA ZA9806203A patent/ZA986203B/xx unknown
- 1998-07-15 AR ARP980103455A patent/AR015924A1/es not_active Application Discontinuation
- 1998-09-07 UA UA2000020800A patent/UA66364C2/uk unknown
2000
- 2000-01-12 BG BG104073A patent/BG64050B1/bg unknown
- 2000-01-14 NO NO20000182A patent/NO324508B1/no not_active IP Right Cessation
- 2000-01-14 HR HR20000027A patent/HRP20000027B1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HRP20000027A2 (en)	2000-10-31
BR9810896A (pt)	2000-09-26
JP4450987B2 (ja)	2010-04-14
ZA986203B (en)	1999-08-18
US6235899B1 (en)	2001-05-22
CZ200065A3 (cs)	2000-07-12
AP2000001732A0 (en)	2000-03-31
DK0998470T3 (da)	2003-09-01
EA002883B1 (ru)	2002-10-31
TR200000117T2 (tr)	2000-07-21
RS49832B (sr)	2008-08-07
BG64050B1 (bg)	2003-11-28
JP2001510191A (ja)	2001-07-31
AP1071A (en)	2002-05-20
ES2197489T3 (es)	2004-01-01
EA200000127A1 (ru)	2000-08-28
DE69814395D1 (de)	2003-06-12
PL200820B1 (pl)	2009-02-27
IL134031A0 (en)	2001-04-30
NO20000182D0 (no)	2000-01-14
KR100519691B1 (ko)	2005-10-13
HRP20000027B1 (en)	2006-07-31
NZ502338A (en)	2001-09-28
WO1999003852A1 (fr)	1999-01-28
ID23784A (id)	2000-05-11
HUP0003857A2 (hu)	2001-04-28
NO20000182L (no)	2000-03-07
BG104073A (en)	2001-05-31
FR2766188A1 (fr)	1999-01-22
CA2296742A1 (fr)	1999-01-28
EP0998470B1 (fr)	2003-05-07
AU8633398A (en)	1999-02-10
CZ295312B6 (cs)	2005-07-13
NO324508B1 (no)	2007-11-05
FR2766188B1 (fr)	2000-02-11
EP0998470A1 (fr)	2000-05-10
UA66364C2 (uk)	2004-05-17
SK284168B6 (sk)	2004-10-05
EE200000024A (et)	2000-10-16
PL338035A1 (en)	2000-09-25
SK302000A3 (en)	2000-11-07
PT998470E (pt)	2003-09-30
CN1269795A (zh)	2000-10-11
CN100363355C (zh)	2008-01-23
YU1500A (sh)	2002-10-18
AU744272B2 (en)	2002-02-21
IL134031A (en)	2004-06-01
ME01708B (me)	2008-08-07
ATE239713T1 (de)	2003-05-15
CA2296742C (fr)	2009-12-08
KR20010021834A (ko)	2001-03-15
AR015924A1 (es)	2001-05-30
DE69814395T2 (de)	2003-12-11
HU230148B1 (hu)	2015-09-28
HUP0003857A3 (en)	2002-08-28

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2004-12-15	GB1A	Change in the ownership or in the address of the owner
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231

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FI951047A (fi)	1995-09-10	Menetelmä indolijohdannaisten valmistamiseksi