EA201790134A3 - Соединения имидазопирролидинонов - Google Patents

Соединения имидазопирролидинонов

Info

Publication number
EA201790134A3
EA201790134A3 EA201790134A EA201790134A EA201790134A3 EA 201790134 A3 EA201790134 A3 EA 201790134A3 EA 201790134 A EA201790134 A EA 201790134A EA 201790134 A EA201790134 A EA 201790134A EA 201790134 A3 EA201790134 A3 EA 201790134A3
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
imidazopirrolidinonov
mdm2
disorder
treating
Prior art date
Application number
EA201790134A
Other languages
English (en)
Other versions
EA201790134A2 (ru
Inventor
Паскаль Фюре
Вито Гуаньяно
Филипп Хольцер
Йорг Каллен
Лв Ляо
Роберт Мах
Лян Мао
Кеиити Масуя
Ахим Шлапбах
Штефан Штутц
Андреа Фаупель
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201790134(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201790134A2 publication Critical patent/EA201790134A2/ru
Publication of EA201790134A3 publication Critical patent/EA201790134A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к описанным здесь соединениям формулы (I), фармацевтическим препаратам, содержащим такие соединения, применению и способам применения таких соединений при лечении расстройства или заболевания, опосредованного активностью MDM2 и/или MDM4, и комбинациям, содержащим такие соединения.
EA201790134A 2012-01-26 2013-01-25 Соединения имидазопирролидинонов EA201790134A3 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591001P 2012-01-26 2012-01-26
US201261669902P 2012-07-10 2012-07-10
CNPCT/CN2012/086703 2012-12-14

Publications (2)

Publication Number Publication Date
EA201790134A2 EA201790134A2 (ru) 2017-05-31
EA201790134A3 true EA201790134A3 (ru) 2017-08-31

Family

ID=47997596

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201790134A EA201790134A3 (ru) 2012-01-26 2013-01-25 Соединения имидазопирролидинонов
EA201491423A EA027130B1 (ru) 2012-01-26 2013-01-25 Соединения имидазопирролидинонов

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201491423A EA027130B1 (ru) 2012-01-26 2013-01-25 Соединения имидазопирролидинонов

Country Status (44)

Country Link
US (2) US8815926B2 (ru)
EP (3) EP2807164B1 (ru)
JP (3) JP5865519B2 (ru)
KR (2) KR101694383B1 (ru)
CN (1) CN104203952B (ru)
AP (1) AP2014007810A0 (ru)
AR (1) AR089807A1 (ru)
AU (1) AU2013213260B2 (ru)
BR (1) BR112014018475B1 (ru)
CA (1) CA2860951C (ru)
CL (1) CL2014001855A1 (ru)
CO (1) CO7010838A2 (ru)
CR (1) CR20140354A (ru)
CU (1) CU24336B1 (ru)
CY (1) CY1119058T1 (ru)
DK (1) DK2807164T3 (ru)
DO (1) DOP2014000170A (ru)
EA (2) EA201790134A3 (ru)
EC (1) ECSP14015553A (ru)
ES (2) ES2632430T3 (ru)
GE (1) GEP20166438B (ru)
GT (1) GT201400164A (ru)
HK (2) HK1198761A1 (ru)
HR (1) HRP20171005T1 (ru)
IL (1) IL233739A (ru)
JO (1) JO3357B1 (ru)
LT (1) LT2807164T (ru)
MA (1) MA35869B1 (ru)
MX (1) MX353315B (ru)
MY (1) MY177242A (ru)
NI (1) NI201400083A (ru)
NZ (1) NZ627277A (ru)
PE (1) PE20141655A1 (ru)
PH (1) PH12014501702A1 (ru)
PL (1) PL2807164T3 (ru)
PT (1) PT2807164T (ru)
RS (1) RS56197B1 (ru)
SG (1) SG11201403935VA (ru)
SI (1) SI2807164T1 (ru)
TN (1) TN2014000319A1 (ru)
TW (2) TW201713644A (ru)
UA (1) UA115231C2 (ru)
UY (1) UY34591A (ru)
WO (1) WO2013111105A1 (ru)

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