EA201691866A1 - Проникающие в опухоль лимфоциты для адоптивной клеточной терапии - Google Patents
Проникающие в опухоль лимфоциты для адоптивной клеточной терапииInfo
- Publication number
- EA201691866A1 EA201691866A1 EA201691866A EA201691866A EA201691866A1 EA 201691866 A1 EA201691866 A1 EA 201691866A1 EA 201691866 A EA201691866 A EA 201691866A EA 201691866 A EA201691866 A EA 201691866A EA 201691866 A1 EA201691866 A1 EA 201691866A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cell therapy
- lymphocytes
- permitting
- tumor
- methods
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 210000004698 lymphocyte Anatomy 0.000 title abstract 4
- 230000003044 adaptive effect Effects 0.000 title 1
- 238000002659 cell therapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 238000011467 adoptive cell therapy Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
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- Tropical Medicine & Parasitology (AREA)
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Abstract
В заявке описываются композиции и способы наращивания проникающих в опухоль лимфоцитов ex vivo с целью их применения при адоптивной клеточной терапии (АКТ). Также описываются композиции и способы идентификации агента для наращивания проникающих в опухоль лимфоцитов ex vivo с целью их применения при АКТ. Также в изобретении предлагаются способы лечения рака с применением проникающих в опухоль лимфоцитов, нарощенных с помощью описанных в настоящем документе способов.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461955970P | 2014-03-20 | 2014-03-20 | |
US201461973002P | 2014-03-31 | 2014-03-31 | |
PCT/US2015/021759 WO2015143328A1 (en) | 2014-03-20 | 2015-03-20 | Tumor-infiltrating lymphocytes for adoptive cell therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201691866A1 true EA201691866A1 (ru) | 2017-01-30 |
EA036386B1 EA036386B1 (ru) | 2020-11-03 |
Family
ID=54145388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201691866A EA036386B1 (ru) | 2014-03-20 | 2015-03-20 | Проникающие в опухоль лимфоциты для адоптивной клеточной терапии |
Country Status (11)
Country | Link |
---|---|
US (3) | US20170081635A1 (ru) |
EP (2) | EP3698850A1 (ru) |
JP (3) | JP2017511375A (ru) |
KR (2) | KR20230085225A (ru) |
CN (2) | CN106659913A (ru) |
AU (3) | AU2015231041B2 (ru) |
CA (1) | CA2943389C (ru) |
EA (1) | EA036386B1 (ru) |
ES (1) | ES2776407T3 (ru) |
MX (2) | MX2016012176A (ru) |
WO (1) | WO2015143328A1 (ru) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2016012176A (es) * | 2014-03-20 | 2017-04-13 | H Lee Moffitt Cancer Ct & Res | Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. |
EP3154350B1 (en) | 2014-04-10 | 2024-03-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
EP3328399B1 (en) | 2015-07-31 | 2023-12-27 | Regents of the University of Minnesota | Modified cells and methods of therapy |
EP3228701A1 (en) * | 2016-04-05 | 2017-10-11 | Fundación Centro Nacional de Investigaciones Oncológicas Carlos III | Method for preparing lymphocytes capable of infiltrating a solid tumor, lymphocytes obtainable by said method and uses thereof |
BR112019000185A2 (pt) | 2016-07-07 | 2019-04-16 | Iovance Biotherapeutics, Inc. | proteína, ácido nucleico, célula, e, métodos para produzir um linfócito citotóxico geneticamente modificado, para tratar um indivíduo que tem ou é suspeito de ter câncer e para reduzir a interação entre pd-l1 em uma primeira célula e pd-1 em uma segunda célula. |
GB2605883B (en) | 2016-10-18 | 2023-03-15 | Univ Minnesota | Tumor infiltrating lymphocytes and methods of therapy |
BR112019008305A2 (pt) | 2016-10-26 | 2019-08-06 | Iovance Biotherapeutics Inc | métodos para expansão de linfócitos infiltrantes de tumor, para avaliação da atividade metabólica de uma população de células til, para tratamento de um sujeito com câncer e para ensaiar tils, e, população de tils expandidos |
TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
KR102618948B1 (ko) | 2016-11-17 | 2023-12-27 | 이오반스 바이오테라퓨틱스, 인크. | 잔유 종양 침윤 림프구 및 그의 제조 및 사용 방법 |
WO2018129336A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
KR20190121773A (ko) | 2017-03-01 | 2019-10-28 | 넥타르 테라퓨틱스 | 입양 세포 이식 요법과 조합된 인터루킨-2 수용체 알파, 베타 선택성 효현제를 이용한 면역 요법적 종양 치료 방법 |
JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
EA201992765A1 (ru) | 2017-05-24 | 2020-03-25 | Новартис Аг | Белки на основе антител с привитым цитокином и способы их применения в лечении рака |
TW201919662A (zh) | 2017-06-05 | 2019-06-01 | 美商艾歐凡斯生物治療公司 | 對雙重難治性黑色素瘤使用腫瘤浸潤性淋巴細胞之方法 |
CN111511375A (zh) | 2017-06-30 | 2020-08-07 | 因提玛生物科学公司 | 用于基因治疗的腺相关病毒载体 |
US12104172B2 (en) | 2018-01-08 | 2024-10-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific t-cells |
US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
GB201801067D0 (en) * | 2018-01-23 | 2018-03-07 | Price Nicola Kaye | Biomarkers predictive of tumour infiltrating lymphocyte therapy and uses thereof |
EP3765094A4 (en) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | GENE REGULATION COMPOSITIONS AND METHODS FOR IMPROVING IMMUNOTHERAPY |
KR20210005138A (ko) | 2018-04-27 | 2021-01-13 | 이오반스 바이오테라퓨틱스, 인크. | 종양 침윤 림프구의 확장 및 유전자 편집을 위한 폐쇄 방법 및 면역요법에서의 그의 용도 |
CN108486120B (zh) * | 2018-04-28 | 2019-12-06 | 新乡医学院 | 一种新型CpG ODN序列及其在抗黑色素瘤上的应用 |
GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
AU2021258257A1 (en) | 2020-04-22 | 2022-11-10 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
JP2023524435A (ja) | 2020-04-28 | 2023-06-12 | アキレス セラピューティクス ユーケー リミテッド | T細胞療法 |
AU2021368569A1 (en) * | 2020-10-27 | 2023-06-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Oncolytic virus boosts t cell response for effective til therapy |
GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
US20240210396A1 (en) | 2021-04-09 | 2024-06-27 | Achilles Therapeutics Uk Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
EP4359511A1 (en) | 2021-06-22 | 2024-05-01 | Achilles Therapeutics UK Limited | A method for producing antigen-specific t cells |
WO2023108003A2 (en) * | 2021-12-07 | 2023-06-15 | Memgen, Inc. | Oncolytic virus boosts t cell response for effective til therapy |
WO2023201369A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5331573A (en) | 1990-12-14 | 1994-07-19 | Balaji Vitukudi N | Method of design of compounds that mimic conformational features of selected peptides |
US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
US5631280A (en) | 1995-03-29 | 1997-05-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5811515A (en) | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
EP1680443B9 (en) | 2003-11-05 | 2014-09-03 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides and uses thereof |
US7858743B2 (en) * | 2004-09-09 | 2010-12-28 | Ludwig Institute For Cancer Research | SSX-4 peptides presented by HLA class II molecules |
EP1910521B1 (en) * | 2005-08-05 | 2010-10-13 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Generation of allorestricted antigen specific t cells |
AU2006328944B2 (en) * | 2005-12-21 | 2011-08-25 | Sentoclone International Ab | Method for treating disseminated cancer |
KR101623985B1 (ko) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
AU2008323853B8 (en) | 2007-11-08 | 2014-07-24 | Beth Israel Deaconess Medical Center | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-CD3/CD28 |
US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
BR112012009962A2 (pt) * | 2009-10-27 | 2015-09-15 | Immunicum Ab | método para a proliferação de células tantígeno específicas. |
WO2012127464A2 (en) * | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
WO2013192628A1 (en) | 2012-06-22 | 2013-12-27 | University Of South Florida | Peptoid-peptide hybrids and their use |
CN103243072B (zh) * | 2013-05-09 | 2016-03-02 | 杭州中赢生物医疗科技有限公司 | CD8α-白介素21片段-CD137复合物扩增激活淋巴细胞的方法 |
CN103396992A (zh) * | 2013-08-15 | 2013-11-20 | 中国人民解放军第二军医大学 | 寡克隆肝癌肿瘤浸润淋巴细胞的培养和应用 |
CN103520198B (zh) * | 2013-09-24 | 2016-01-20 | 彭光勇 | 一种制备用于阻止肿瘤细胞诱导t细胞老化并逆转其免疫抑制能力的药物的方法及其在抗肿瘤免疫治疗中的用途 |
MX2016012176A (es) * | 2014-03-20 | 2017-04-13 | H Lee Moffitt Cancer Ct & Res | Composiciones y metodos para mejorar los linfocitos infiltrantes de tumor para terapia celular adoptiva. |
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2015
- 2015-03-20 MX MX2016012176A patent/MX2016012176A/es active IP Right Grant
- 2015-03-20 EP EP19220121.8A patent/EP3698850A1/en active Pending
- 2015-03-20 AU AU2015231041A patent/AU2015231041B2/en active Active
- 2015-03-20 CN CN201580022690.3A patent/CN106659913A/zh active Pending
- 2015-03-20 CN CN202010876959.7A patent/CN112080467A/zh active Pending
- 2015-03-20 EP EP15765854.3A patent/EP3119477B1/en active Active
- 2015-03-20 US US15/126,436 patent/US20170081635A1/en not_active Abandoned
- 2015-03-20 ES ES15765854T patent/ES2776407T3/es active Active
- 2015-03-20 JP JP2017501131A patent/JP2017511375A/ja active Pending
- 2015-03-20 CA CA2943389A patent/CA2943389C/en active Active
- 2015-03-20 KR KR1020237018885A patent/KR20230085225A/ko not_active Application Discontinuation
- 2015-03-20 KR KR1020167029042A patent/KR20160146713A/ko active Application Filing
- 2015-03-20 EA EA201691866A patent/EA036386B1/ru unknown
- 2015-03-20 WO PCT/US2015/021759 patent/WO2015143328A1/en active Application Filing
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2016
- 2016-09-20 MX MX2020005634A patent/MX2020005634A/es unknown
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2019
- 2019-02-11 US US16/272,524 patent/US11518980B2/en active Active
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2020
- 2020-07-15 JP JP2020121328A patent/JP2020182477A/ja active Pending
- 2020-10-15 AU AU2020256412A patent/AU2020256412A1/en not_active Abandoned
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2022
- 2022-05-24 US US17/752,481 patent/US20220282215A1/en active Pending
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2023
- 2023-01-20 AU AU2023200308A patent/AU2023200308A1/en not_active Abandoned
- 2023-07-10 JP JP2023113229A patent/JP2023123877A/ja active Pending
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EP3119477A4 (en) | 2018-03-07 |
US20220282215A1 (en) | 2022-09-08 |
MX2016012176A (es) | 2017-04-13 |
AU2020256412A1 (en) | 2020-11-26 |
AU2015231041B2 (en) | 2020-07-16 |
EP3698850A1 (en) | 2020-08-26 |
EP3119477B1 (en) | 2020-01-01 |
US11518980B2 (en) | 2022-12-06 |
JP2023123877A (ja) | 2023-09-05 |
US20170081635A1 (en) | 2017-03-23 |
CN106659913A (zh) | 2017-05-10 |
KR20160146713A (ko) | 2016-12-21 |
CN112080467A (zh) | 2020-12-15 |
BR112016021370A2 (pt) | 2017-08-15 |
BR112016021370A8 (pt) | 2021-07-20 |
MX2020005634A (es) | 2020-08-20 |
ES2776407T3 (es) | 2020-07-30 |
WO2015143328A1 (en) | 2015-09-24 |
JP2020182477A (ja) | 2020-11-12 |
US20190177693A1 (en) | 2019-06-13 |
CA2943389A1 (en) | 2015-09-24 |
AU2023200308A1 (en) | 2023-03-02 |
EP3119477A1 (en) | 2017-01-25 |
EA036386B1 (ru) | 2020-11-03 |
JP2017511375A (ja) | 2017-04-20 |
CA2943389C (en) | 2023-10-31 |
AU2015231041A1 (en) | 2016-11-03 |
NZ762786A (en) | 2024-05-31 |
KR20230085225A (ko) | 2023-06-13 |
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