EA201690908A1 - Pyrazolopyrmidine compounds - Google Patents

Pyrazolopyrmidine compounds

Info

Publication number
EA201690908A1
EA201690908A1 EA201690908A EA201690908A EA201690908A1 EA 201690908 A1 EA201690908 A1 EA 201690908A1 EA 201690908 A EA201690908 A EA 201690908A EA 201690908 A EA201690908 A EA 201690908A EA 201690908 A1 EA201690908 A1 EA 201690908A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolopyrmidine
compounds
methods
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
EA201690908A
Other languages
Russian (ru)
Other versions
EA029372B1 (en
Inventor
Радослав Лауфер
Грейс Нг
Сцзе-Вань Ли
Хайнц В. Паулс
Юн Лю
Нарендра Кумар Б. Пател
Original Assignee
Юниверсити Хелс Нетуорк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2013/000957 external-priority patent/WO2014075168A1/en
Application filed by Юниверсити Хелс Нетуорк filed Critical Юниверсити Хелс Нетуорк
Publication of EA201690908A1 publication Critical patent/EA201690908A1/en
Publication of EA029372B1 publication Critical patent/EA029372B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем изобретении предложено соединение, представленное следующей структурной формулой:или его фармацевтически приемлемая соль. Также описаны фармацевтические композиции и способы их применения.The present invention provides a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Also described pharmaceutical compositions and methods for their use.

EA201690908A 2013-11-15 2014-11-14 Pyrazolopyrimidine compounds EA029372B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CA2013/000957 WO2014075168A1 (en) 2012-11-16 2013-11-15 Pyrazolopyrimidine compounds
PCT/CA2014/051091 WO2015070349A1 (en) 2012-11-16 2014-11-14 Pyrazolopyrimidine compounds

Publications (2)

Publication Number Publication Date
EA201690908A1 true EA201690908A1 (en) 2016-09-30
EA029372B1 EA029372B1 (en) 2018-03-30

Family

ID=56617958

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690908A EA029372B1 (en) 2013-11-15 2014-11-14 Pyrazolopyrimidine compounds

Country Status (2)

Country Link
JP (1) JP6095857B2 (en)
EA (1) EA029372B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102700233B1 (en) * 2016-07-18 2024-08-28 유니버시티 헬스 네트워크 Solid forms of TTK inhibitor
TW202003520A (en) * 2018-05-23 2020-01-16 加拿大健康網路大學 Biomarkers for TTK inhibition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003299651A1 (en) * 2002-12-11 2004-06-30 Merck And Co., Inc. Tyrosine kinase inhibitors
WO2004087707A1 (en) * 2003-03-31 2004-10-14 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
ES2339670T3 (en) * 2003-12-23 2010-05-24 Novartis Ag BICYCLE HYPERCYCLIC INHIBITORS OF QUINASA P-38.
CA2627623C (en) * 2005-10-06 2014-04-22 Schering Corporation Methods for inhibiting protein kinases
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
EP2178375B1 (en) * 2007-07-20 2014-09-24 Merck Sharp & Dohme Corp. Pyrazoloý1,5-a¨pyrimidine derivatives
WO2011151259A1 (en) * 2010-06-01 2011-12-08 Bayer Pharma Aktiengesellschaft Substituted imidazopyrazines
CA2821819A1 (en) * 2010-12-17 2012-06-21 Marcus Koppitz 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
CA2821829A1 (en) * 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US20140255392A1 (en) * 2011-04-06 2014-09-11 Bayer Intellectual Property Gmbh Substituted imidazopyridines and intermediates thereof
EP2920181B1 (en) * 2012-11-16 2019-01-09 University Health Network Pyrazolopyrimidine compounds

Also Published As

Publication number Publication date
JP2016537354A (en) 2016-12-01
EA029372B1 (en) 2018-03-30
JP6095857B2 (en) 2017-03-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM