EA201590835A1 - Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием - Google Patents

Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием

Info

Publication number
EA201590835A1
EA201590835A1 EA201590835A EA201590835A EA201590835A1 EA 201590835 A1 EA201590835 A1 EA 201590835A1 EA 201590835 A EA201590835 A EA 201590835A EA 201590835 A EA201590835 A EA 201590835A EA 201590835 A1 EA201590835 A1 EA 201590835A1
Authority
EA
Eurasian Patent Office
Prior art keywords
digestive enzyme
dosage form
pancrelipase
compositions
low dose
Prior art date
Application number
EA201590835A
Other languages
English (en)
Other versions
EA030449B1 (ru
Inventor
Джованни Ортенци
Джузеппе Де Франца
Данило Клементи
Кристиан Столльберг
Луиджи Больтри
Original Assignee
Апталис Фарма Лимитид
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45044628&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590835(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Апталис Фарма Лимитид filed Critical Апталис Фарма Лимитид
Publication of EA201590835A1 publication Critical patent/EA201590835A1/ru
Publication of EA030449B1 publication Critical patent/EA030449B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение направлено на фармацевтическую композицию или лекарственную форму со стабильным низким содержанием пищеварительного фермента (разбавленным пищеварительным ферментом), содержащую по меньшей мере один пищеварительный фермент и по меньшей мере один носитель, или ее лекарственную форму. Настоящее изобретение также направлено на способ получения композиции или лекарственной формы. Кроме того, настоящее изобретение направлено на лечение и предупреждение расстройств или состояний, связанных с недостаточностью пищеварительного фермента, у пациента, нуждающегося в этом, включающие введение указанному пациенту фармацевтически приемлемого количества композиции со стабильным низким содержанием пищеварительного фермента или ее лекарственной формы.
EA201590835A 2010-10-01 2011-09-30 Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием EA030449B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38903710P 2010-10-01 2010-10-01

Publications (2)

Publication Number Publication Date
EA201590835A1 true EA201590835A1 (ru) 2015-11-30
EA030449B1 EA030449B1 (ru) 2018-08-31

Family

ID=45044628

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201590835A EA030449B1 (ru) 2010-10-01 2011-09-30 Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием
EA201590836A EA030450B1 (ru) 2010-10-01 2011-09-30 Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием
EA201390409A EA029101B1 (ru) 2010-10-01 2011-09-30 Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA201590836A EA030450B1 (ru) 2010-10-01 2011-09-30 Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием
EA201390409A EA029101B1 (ru) 2010-10-01 2011-09-30 Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием

Country Status (26)

Country Link
US (2) US11364205B2 (ru)
EP (2) EP2621476B8 (ru)
JP (2) JP6043929B2 (ru)
KR (2) KR101968457B1 (ru)
CN (2) CN103221036A (ru)
AR (1) AR093181A1 (ru)
AU (2) AU2011309763B2 (ru)
BR (1) BR112013007640A2 (ru)
CA (1) CA2812862C (ru)
CL (1) CL2011002432A1 (ru)
CO (1) CO6700848A2 (ru)
DK (1) DK2621476T4 (ru)
EA (3) EA030449B1 (ru)
ES (2) ES2657673T3 (ru)
HR (1) HRP20140995T1 (ru)
IL (1) IL225504A (ru)
MX (1) MX348118B (ru)
PL (1) PL2621476T5 (ru)
PT (1) PT2621476E (ru)
RS (1) RS53587B1 (ru)
SA (1) SA111320804B1 (ru)
SI (1) SI2621476T1 (ru)
SM (1) SMT201400149B (ru)
UA (1) UA111726C2 (ru)
WO (1) WO2012042372A1 (ru)
ZA (1) ZA201303087B (ru)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US20070053895A1 (en) 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
CN103933555B (zh) 2007-02-20 2018-06-01 阿普塔利斯制药有限公司 稳定的消化酶组合物
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
ES2578618T3 (es) 2009-01-06 2016-07-28 Curelon Llc Composiciones que comprenden proteasa, amilasa y lipasa para su uso en el tratamiento de infecciones por Staphylococcus aureus
EP2947100B1 (en) 2009-01-06 2019-05-08 Galenagen, LLC Oral compositions for the treatment or the prevention of infections by E. Coli
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2011050135A1 (en) 2009-10-21 2011-04-28 Curemark Llc Methods and compositions for the prevention and treatment of influenza
CN103221036A (zh) * 2010-10-01 2013-07-24 阿普塔利斯制药有限公司 肠溶包衣的低强度胰脂肪酶制剂
ES2726978T3 (es) 2011-04-21 2019-10-11 Curemark Llc Compuestos para el tratamiento de trastornos neuropsiquiátricos
US9976171B2 (en) 2011-08-08 2018-05-22 Allergan Pharmaceuticals International Limited Method for dissolution testing of solid compositions containing digestive enzymes
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
EP2996712B1 (en) 2013-03-15 2018-10-31 Allergan Pharmaceuticals International Limited Process for the preparation of a composition containing digestive enzymes and nutrients suitable for enteral administration
EP3639846B1 (en) * 2013-08-09 2022-09-28 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
JP2017500885A (ja) * 2013-11-05 2017-01-12 アラガン ファーマシューティカルズ インターナショナル リミテッド 高力価パンクレアチン医薬組成物
EP3157568A1 (en) 2014-06-19 2017-04-26 Aptalis Pharma Limited Methods for removing viral contaminants from pancreatic extracts
JP6442659B1 (ja) * 2017-12-28 2018-12-26 株式会社フクハラ 細菌増殖警報器付き除菌フィルタ
WO2020257802A1 (en) * 2019-06-21 2020-12-24 Das Aditya Spray dried oral pharmaceutical compositions for enteric hepatic or intestinal delivery
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751330A (en) 1952-08-27 1956-06-19 Armour & Co Use of a salt in the extraction slurry in recovering proteolytic enzymes from pancreas gland material
FR1484458A (ru) 1965-06-25 1967-09-15
GB1342409A (en) 1970-07-23 1974-01-03 Ciba Geigy Ag Flowable pancreatin preparation of low microorgan ism content and a process for its manufacture
DE2460334C3 (de) 1974-12-20 1979-09-06 Hoechst Ag, 6000 Frankfurt Verfahren zur Gewinnung von Insulin und Pankreatin aus Schweinepankreas
GB1509866A (en) 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4237229A (en) 1975-06-10 1980-12-02 W. R. Grace & Co. Immobilization of biological material with polyurethane polymers
GB1590432A (en) 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
JPS5535031A (en) 1978-09-04 1980-03-11 Shin Etsu Chem Co Ltd Enteric coating composition
DE2923279C2 (de) 1979-06-08 1987-07-09 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur Herstellung von Pankreatin-Pellets und diese enthaltende Arzneimittel
JPS5885159A (ja) 1981-11-17 1983-05-21 Furointo Sangyo Kk 溶出試験装置
EP0115023B1 (de) 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Verfahren zur Gewinnung von Pankreatin
US4447412A (en) 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US4704295A (en) 1983-09-19 1987-11-03 Colorcon, Inc. Enteric film-coating compositions
DE3445301A1 (de) 1984-12-12 1986-06-12 Hoechst Ag, 6230 Frankfurt Pankreasenzympraeparate und verfahren zu deren herstellung
DE3689727T2 (de) 1985-12-27 1994-07-07 Showa Denko Kk Granulierungsverfahren für enzyme.
US4849227A (en) 1986-03-21 1989-07-18 Eurasiam Laboratories, Inc. Pharmaceutical compositions
DE3750369T2 (de) 1986-03-21 1995-05-24 Eurasiam Lab Arzneimittelzusammensetzungen.
GB2189698A (en) 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
FR2603804B1 (fr) 1986-09-17 1989-10-27 Jouveinal Sa Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique
IT1205716B (it) 1987-01-21 1989-03-31 Samil Spa Procedimento per la preparazione di microsfere gastroresistenti ed enterosolubili di enzima digestivo e preparato faramceutico a microsfere cosi' prodotto
DK435687D0 (da) 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
US5733763A (en) 1988-08-19 1998-03-31 Novo Nordisk A/S Enzyme granulate formed of an enzyme-containing core and an enzyme-containing shell
DK78089D0 (da) 1989-02-20 1989-02-20 Novo Industri As Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
DK78189D0 (da) 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
DK306289D0 (da) 1989-06-21 1989-06-21 Novo Nordisk As Detergentadditiv i granulatform
DE3927286C2 (de) 1989-08-18 1997-07-24 Roehm Gmbh Wäßrige Enzym-Flüssigformulierungen
KR100229754B1 (ko) 1989-11-24 1999-11-15 샬러 한스, 하우스 한스 루돌프 판크레아틴구형입자, 이의 제조방법 및 이를 함유하는 약제학적 조성물
IT1246350B (it) 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
JPH0790565B2 (ja) 1991-08-06 1995-10-04 株式会社日本製鋼所 樹脂成形プレスのスライド制御方法及びその装置
US5225202A (en) 1991-09-30 1993-07-06 E. R. Squibb & Sons, Inc. Enteric coated pharmaceutical compositions
WO1993007859A1 (en) 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
SE9200858L (sv) 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
US5616483A (en) 1992-06-11 1997-04-01 Aktiebolaget Astra Genomic DNA sequences encoding human BSSL/CEL
US5260074A (en) 1992-06-22 1993-11-09 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5578304A (en) 1992-06-22 1996-11-26 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5460812A (en) 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5308832A (en) 1992-07-27 1994-05-03 Abbott Laboratories Nutritional product for persons having a neurological injury
DE4227385A1 (de) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pankreatinmikropellets
JP3264027B2 (ja) 1993-02-24 2002-03-11 ソニー株式会社 放電セル及びその製造方法
US5955448A (en) 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
RU94017352A (ru) 1994-05-11 1996-07-27 Товарищество с ограниченной ответственностью "Инвест" Способ лечения онкологических больных, перенесших операцию на желудочно-кишечном тракте
DE4422433A1 (de) 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
NZ291443A (en) 1994-08-05 1998-07-28 Smithkline Beecham Plc Container with puncturable seal carrying desiccant polymer
US5733575A (en) 1994-10-07 1998-03-31 Bpsi Holdings, Inc. Enteric film coating compositions, method of coating therewith, and coated forms
ES2236738T3 (es) 1995-05-31 2005-07-16 Medzyme N.V. Composicion para mejorar la digestibilidad y la utilizacion de nutrientes.
US6057139A (en) * 1995-06-29 2000-05-02 Mcneil-Ppc, Inc. Preblend of microcrystalline cellulose and lactase for making tablets
US5665428A (en) 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5750104A (en) 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
DE19622131A1 (de) 1996-06-01 1997-12-04 Solvay Enzymes Gmbh & Co Kg Neue Enzymgranulate
CA2257106C (en) 1996-06-04 2002-04-23 Euro-Celtique, S.A. Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
JPH1023888A (ja) 1996-07-10 1998-01-27 Kao Corp 酵素造粒物の製造方法
DE19724845A1 (de) 1996-08-28 1998-03-05 Solvay Pharm Gmbh Verwendung von komplexen Lipiden als stabilisierende Zusätze zu pharmazeutischen Zubereitungen von Verdauungsenzymgemischen
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
GB9623205D0 (en) 1996-11-07 1997-01-08 Eurand Int Novel pharmaceutical compositions
CA2198317C (en) 1997-02-24 2003-01-07 Mouhsine El Abboudi Method for preparing pancreatin which contains low amounts of residual organic solvent and product thereof
JPH10295374A (ja) 1997-04-30 1998-11-10 Amano Pharmaceut Co Ltd 安定な酵素顆粒の製造法
DE19721467A1 (de) 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
SE9702338D0 (sv) 1997-06-18 1997-06-18 Astra Ab An analytical method and industrial process including the same
ES2137862B1 (es) 1997-07-31 2000-09-16 Intexim S A Preparacion farmaceutica oral que comprende un compuesto de actividad antiulcerosa y procedimiento para su obtencion.
JP3611456B2 (ja) 1997-09-30 2005-01-19 日研化学株式会社 テオフィリン徐放性錠剤
KR19990072826A (ko) 1998-02-26 1999-09-27 우재영 판크레아틴장용코팅과립의제조방법
US7201923B1 (en) 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
JPH11315043A (ja) 1998-04-30 1999-11-16 Lion Corp ヒドロキシエーテル化合物の製造方法及び洗浄剤組成物
US7122207B2 (en) 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
US20010024660A1 (en) 1999-09-29 2001-09-27 Ismat Ullah Enteric coated pharmaceutical composition and method of manufacturing
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
IL142896A0 (en) 1998-11-02 2002-04-21 Elan Corp Plc Multiparticulate modified release composition
AU7405400A (en) 1999-10-01 2001-05-10 Novozymes A/S Enzyme granulate
US20010046493A1 (en) 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
WO2001070047A1 (en) 2000-03-24 2001-09-27 Société des Produits Nestlé S.A. Nutritional composition comprising hydrolysed protein
AU2001244093A1 (en) 2000-04-03 2001-10-15 Novozymes A/S Enzyme tablets for cleaning improvement
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
AR032392A1 (es) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
AUPR272901A0 (en) 2001-01-25 2001-02-22 Gainful Plan Limited Method of preparing biological materials and preparations produced using same
ATE346590T1 (de) 2001-07-26 2006-12-15 Ethypharm Sa Umgehüllte allylamine oder benzylamine enthaltende granulate, verfahren zur herstellung und in der mundhöhle dispergierbare tabletten enthaltend die umgehüllten granulate
JP4187085B2 (ja) 2001-08-24 2008-11-26 三菱電機株式会社 車両用乗員保護装置
US20040197321A1 (en) * 2002-03-19 2004-10-07 Tibor Sipos Composition and method to prevent or reduce diarrhea and steatorrhea in HIV patients
CN1156308C (zh) 2002-04-19 2004-07-07 北京世诺医药科技有限公司 多酶组合胶囊
US20040121010A1 (en) 2002-10-25 2004-06-24 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
AU2003288988A1 (en) * 2002-11-29 2004-06-23 Freund Corporation Water-based shellac coating material, process for producing the same, coated food obtained with the coating material, process for producing the same, coated medicine, process for producing the same, glazing composition for oily snack, method of glazing, and glazed oily snack
CA2419572A1 (en) 2003-02-18 2004-08-18 Axcan Pharma Inc. High dosage protease formulation
US20040213847A1 (en) 2003-04-23 2004-10-28 Matharu Amol Singh Delayed release pharmaceutical compositions containing proton pump inhibitors
ES2421538T3 (es) 2003-10-29 2013-09-03 Cystic Fibrosis Foundation Therapeutics Inc Proteasas no pancreáticas para controlar la concentración de colecistocinina (CCK) en plasma y para tratar el dolor
US7670624B2 (en) 2004-01-29 2010-03-02 Astella Pharma Inc. Gastrointestinal-specific multiple drug release system
PL1729797T3 (pl) 2004-03-22 2009-02-27 Abbott Laboratories Gmbh Doustne kompozycje farmaceutyczne produktów zawierających lipazę, a zwłaszcza pankreatynę, zawierające środki powierzchniowo czynne
US20050281876A1 (en) 2004-06-18 2005-12-22 Shun-Por Li Solid dosage form for acid-labile active ingredient
US20060013807A1 (en) * 2004-07-13 2006-01-19 Chapello William J Rapidly disintegrating enzyme-containing solid oral dosage compositions
US20060198838A1 (en) 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
PT2198880T (pt) 2004-10-14 2017-01-04 Lilly Co Eli Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática
CN1247106C (zh) * 2004-11-01 2006-03-29 广东溢多利生物科技股份有限公司 多色微丸型饲用复合酶及其制造方法
JP4891549B2 (ja) 2005-01-19 2012-03-07 富士フイルム株式会社 プラスチック成形用金型
US20070025977A1 (en) * 2005-07-21 2007-02-01 Mulberg Andrew E Method of treating steatorrhea in infants
KR101199196B1 (ko) 2005-07-25 2012-11-07 (주)다산메디켐 구형의 판크레아틴 과립의 제조방법
HUE031042T2 (en) 2005-07-29 2017-06-28 Abbott Laboratories Gmbh Methods for producing pancreatin powder with low viral content
NZ565960A (en) 2005-08-15 2012-03-30 Solvay Pharm Gmbh Controlled release pharmaceutical compositions for acid labile drugs
ES2320174T3 (es) 2005-08-15 2009-05-19 Solvay Pharmaceuticals Gmbh Microesferas de pancreatina adecuadas para el revestimiento enterico.
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
WO2007053619A2 (en) 2005-11-01 2007-05-10 Bio-Cat, Inc. A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
US20070141151A1 (en) 2005-12-20 2007-06-21 Silver David I Lansoprazole orally disintegrating tablets
US8486450B2 (en) 2005-12-28 2013-07-16 Takeda Pharmaceutical Company Limited Method of producing solid preparation disintegrating in the oral cavity
WO2007085024A2 (en) 2006-01-21 2007-07-26 Abbott Gmbh & Co. Kg Dosage form and method for the delivery of drugs of abuse
MY147954A (en) 2006-05-26 2013-02-15 Nestec Sa Methods of use and nutritional compositions of touchi extract
EP2051591B1 (en) 2006-08-07 2016-04-20 Novozymes A/S Enzyme granules for animal feed
KR100804096B1 (ko) 2006-08-31 2008-02-18 (주)아모레퍼시픽 고농도 계면활성제 계에서도 안정한 효소 캡슐 제제를포함하는 피부 세정용 조성물 및 그 제조방법
US9011843B2 (en) * 2006-12-14 2015-04-21 Master Supplements, Inc. Formulations including monovalent alginate to enhance effectiveness of administered digestive enzymes
US8066986B2 (en) 2007-02-01 2011-11-29 Master Supplements, Inc. Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms
US20080199448A1 (en) 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
US20090117180A1 (en) 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
RU2445952C2 (ru) 2007-02-20 2012-03-27 Юранд Фармасьютикалз Лимитед Стабильные композиции пищеварительных ферментов
CN103933555B (zh) 2007-02-20 2018-06-01 阿普塔利斯制药有限公司 稳定的消化酶组合物
AU2008239737A1 (en) 2007-04-13 2008-10-23 Beth Israel Deaconess Medical Center, Inc. Novel nutritional food products for improved digestion and intestinal absorption
CN101440361A (zh) * 2007-11-22 2009-05-27 珠海百康生物技术有限公司 一种制备稳定的包被颗粒酶的方法
US20110008423A1 (en) 2008-01-03 2011-01-13 Abbott Products Gmbh Pharmaceutical compositions comprising granules of purified microbial lipase and methods for preventing or treating digestive disorders
CN101249081A (zh) 2008-02-15 2008-08-27 南京大渊美容保健有限公司 口服控释给药药片
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
WO2010025126A1 (en) 2008-08-26 2010-03-04 Cystic Fibrosis Foundation Therapeutics, Inc. Rapidly disintegrating tablets comprising lipase, amylase, and protease
CN101430279A (zh) 2008-10-27 2009-05-13 江南大学 荧光分光光度法筛选催化非水相体系转酯化反应用酶的方法
CN101623269A (zh) * 2009-08-04 2010-01-13 南京大渊美容保健有限公司 口服缓释给药的颗粒
US8784884B2 (en) 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
JP2011093845A (ja) 2009-10-29 2011-05-12 宏之 ▲今▼西 胃瘻用注入剤及びその注入装置
US20110135728A1 (en) 2009-12-08 2011-06-09 Miller Jennifer L Gastric retentive pharmaceutical compositions for extended release of polypeptides
BR112012023518A2 (pt) 2010-03-19 2017-10-03 Aptalis Pharma Canada Inc Composição farmacêutica gastro- resistente compactada,monolítica, composição farmaceutica método para tratar um disturbio digestivo e método de controle da esteatorreia
EP2558216B1 (en) 2010-04-14 2020-03-18 Dow Global Technologies LLC Dispensing device for both froth and non-froth coatings
GB201006178D0 (en) 2010-04-14 2010-06-02 Ayanda As Composition
UY33548A (es) 2010-08-06 2012-02-29 Eurand Pharmaceuticals Inc Formula nutricional predigerida
TW201210517A (en) 2010-08-06 2012-03-16 Aptalis Pharma Ltd Predigested nutritional formula
CN103221036A (zh) 2010-10-01 2013-07-24 阿普塔利斯制药有限公司 肠溶包衣的低强度胰脂肪酶制剂
WO2012052853A2 (en) 2010-10-21 2012-04-26 Aptalis Pharma Limited Oral dosing device for administration of medication
PL2690951T3 (pl) 2011-03-27 2016-01-29 Cellresin Tech Llc Kompozycje cyklodekstryny, wyroby i sposoby
US9976171B2 (en) 2011-08-08 2018-05-22 Allergan Pharmaceuticals International Limited Method for dissolution testing of solid compositions containing digestive enzymes
CN103060296B (zh) 2012-12-30 2014-05-21 青岛九龙生物医药有限公司 从动物胰脏中提取胰蛋白酶的方法
EP2996712B1 (en) 2013-03-15 2018-10-31 Allergan Pharmaceuticals International Limited Process for the preparation of a composition containing digestive enzymes and nutrients suitable for enteral administration
ES2743212T5 (es) 2013-07-22 2023-04-25 Allergan Pharmaceuticals Int Ltd Métodos para preparar pancreatina
EP3639846B1 (en) 2013-08-09 2022-09-28 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
JP2017500885A (ja) 2013-11-05 2017-01-12 アラガン ファーマシューティカルズ インターナショナル リミテッド 高力価パンクレアチン医薬組成物
EP3157568A1 (en) 2014-06-19 2017-04-26 Aptalis Pharma Limited Methods for removing viral contaminants from pancreatic extracts
EP3035780A1 (de) 2014-12-18 2016-06-22 Siemens Aktiengesellschaft Kühlkörper
CN204811577U (zh) 2015-07-09 2015-12-02 佛山市南海中宇渔具有限公司 渔轮及其线壳

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