EA201071269A1 - 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина - Google Patents

3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина

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Publication number
EA201071269A1
EA201071269A1 EA201071269A EA201071269A EA201071269A1 EA 201071269 A1 EA201071269 A1 EA 201071269A1 EA 201071269 A EA201071269 A EA 201071269A EA 201071269 A EA201071269 A EA 201071269A EA 201071269 A1 EA201071269 A1 EA 201071269A1
Authority
EA
Eurasian Patent Office
Prior art keywords
renin inhibitors
replaced
piperidine derivatives
relates
compounds
Prior art date
Application number
EA201071269A
Other languages
English (en)
Other versions
EA020853B1 (ru
Inventor
Остин Чих-Юй Чэнь
Даниель Дюб
Пьер-Андре Фурнье
Эрих Л. Гримм
Патрик Лякомб
Себастьен Лалиберт
Дуайт Макдональд
Д. Брюс Маккей
Дэниел Джеймс Маккей
Том Яо-Сиан Ву
Луи-Шарль Кампо
Джереми Петер Скотт
Надин Бремейер
Original Assignee
Мерк Фросст Кэнада Лтд.
Мерк Шарп Энд Домэ Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Мерк Фросст Кэнада Лтд., Мерк Шарп Энд Домэ Лимитед filed Critical Мерк Фросст Кэнада Лтд.
Publication of EA201071269A1 publication Critical patent/EA201071269A1/ru
Publication of EA020853B1 publication Critical patent/EA020853B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Hydrogenated Pyridines (AREA)

Abstract

Настоящее изобретение относится к ингибиторам ренина, представляющим собой 3,4-замещенные соединения на основе пиперидинила, которые содержат оксопиридин в положении 4 и имеют формулу (I). Изобретение также относится к фармацевтическим композициям, содержащим указанные соединения, а также к их применению для лечения сердечно-сосудистых заболеваний и почечной недостаточности.
EA201071269A 2008-05-05 2009-05-04 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина EA020853B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12652908P 2008-05-05 2008-05-05
US18830308P 2008-08-07 2008-08-07
PCT/CA2009/000611 WO2009135299A1 (en) 2008-05-05 2009-05-04 3, 4 - substituted piperidine derivatives as renin inhibitors

Publications (2)

Publication Number Publication Date
EA201071269A1 true EA201071269A1 (ru) 2011-06-30
EA020853B1 EA020853B1 (ru) 2015-02-27

Family

ID=41264366

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071269A EA020853B1 (ru) 2008-05-05 2009-05-04 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина

Country Status (23)

Country Link
US (1) US8889714B2 (ru)
EP (1) EP2274295B1 (ru)
JP (3) JP4790871B2 (ru)
KR (2) KR20130029116A (ru)
CN (1) CN102015682B (ru)
AU (1) AU2009243875B2 (ru)
BR (1) BRPI0912388A2 (ru)
CA (1) CA2722734C (ru)
CO (1) CO6311081A2 (ru)
CR (1) CR11809A (ru)
DO (1) DOP2010000329A (ru)
EA (1) EA020853B1 (ru)
ES (1) ES2548134T3 (ru)
IL (1) IL208467A (ru)
MA (1) MA32296B1 (ru)
MX (1) MX2010012067A (ru)
MY (1) MY152042A (ru)
NI (1) NI201000188A (ru)
NZ (1) NZ589019A (ru)
PL (1) PL2274295T3 (ru)
SG (1) SG192543A1 (ru)
SV (1) SV2010003723A (ru)
WO (1) WO2009135299A1 (ru)

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ES2548134T3 (es) 2015-10-14
JP5653842B2 (ja) 2015-01-14
JP2011225579A (ja) 2011-11-10
KR20130029116A (ko) 2013-03-21
MX2010012067A (es) 2010-12-06
JP2011225580A (ja) 2011-11-10
CO6311081A2 (es) 2011-08-22
NZ589019A (en) 2012-10-26
US20110053940A1 (en) 2011-03-03
CR11809A (es) 2011-01-10
CN102015682B (zh) 2014-07-16
US8889714B2 (en) 2014-11-18
BRPI0912388A2 (pt) 2017-09-26
EP2274295A1 (en) 2011-01-19
JP2011519871A (ja) 2011-07-14
CA2722734C (en) 2013-11-05
SG192543A1 (en) 2013-08-30
EP2274295B1 (en) 2015-08-05
AU2009243875A1 (en) 2009-11-12
CA2722734A1 (en) 2009-11-12
KR20100131007A (ko) 2010-12-14
NI201000188A (es) 2012-02-02
JP5587246B2 (ja) 2014-09-10
KR101403311B1 (ko) 2014-06-05
AU2009243875B2 (en) 2011-12-01
MA32296B1 (fr) 2011-05-02
CN102015682A (zh) 2011-04-13
SV2010003723A (es) 2011-01-24
PL2274295T3 (pl) 2016-01-29
WO2009135299A1 (en) 2009-11-12
JP4790871B2 (ja) 2011-10-12
MY152042A (en) 2014-08-15
IL208467A (en) 2014-07-31
IL208467A0 (en) 2010-12-30
EA020853B1 (ru) 2015-02-27
DOP2010000329A (es) 2011-01-15
EP2274295A4 (en) 2012-03-28

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