EA201001858A1 - Гетероциклические производные мочевины для лечения бактериальных инфекций - Google Patents

Гетероциклические производные мочевины для лечения бактериальных инфекций

Info

Publication number
EA201001858A1
EA201001858A1 EA201001858A EA201001858A EA201001858A1 EA 201001858 A1 EA201001858 A1 EA 201001858A1 EA 201001858 A EA201001858 A EA 201001858A EA 201001858 A EA201001858 A EA 201001858A EA 201001858 A1 EA201001858 A1 EA 201001858A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
bacterial infections
urea
heterocyclic derivatives
heterocyclic
Prior art date
Application number
EA201001858A
Other languages
English (en)
Inventor
Памела Хилл
Джон Эруин Манчестер
Брайан Шерер
Эллисон Лора Чой
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40823415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201001858(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201001858A1 publication Critical patent/EA201001858A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Описываются соединения формулы (I) и их фармацевтически приемлемые соли. Также описываются способы их получения, содержащие их фармацевтические композиции, их применение в качестве лекарственных средств и их применение при лечении бактериальных инфекций.
EA201001858A 2008-06-04 2009-06-03 Гетероциклические производные мочевины для лечения бактериальных инфекций EA201001858A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5873608P 2008-06-04 2008-06-04
PCT/GB2009/050611 WO2009147433A1 (en) 2008-06-04 2009-06-03 Heterocyclic urea derivatives for the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
EA201001858A1 true EA201001858A1 (ru) 2011-08-30

Family

ID=40823415

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001858A EA201001858A1 (ru) 2008-06-04 2009-06-03 Гетероциклические производные мочевины для лечения бактериальных инфекций

Country Status (23)

Country Link
US (1) US8283361B2 (ru)
EP (1) EP2300463A1 (ru)
JP (1) JP2011522026A (ru)
KR (1) KR20110014710A (ru)
CN (1) CN102105469A (ru)
AR (1) AR072045A1 (ru)
AU (1) AU2009254930A1 (ru)
BR (1) BRPI0915471A2 (ru)
CA (1) CA2725568A1 (ru)
CL (1) CL2009001349A1 (ru)
CO (1) CO6382176A2 (ru)
CR (1) CR11825A (ru)
DO (1) DOP2010000373A (ru)
EA (1) EA201001858A1 (ru)
EC (1) ECSP10010664A (ru)
IL (1) IL209503A0 (ru)
MX (1) MX2010013310A (ru)
PE (1) PE20100155A1 (ru)
SV (1) SV2010003752A (ru)
TW (1) TW201000475A (ru)
UY (1) UY31864A (ru)
WO (1) WO2009147433A1 (ru)
ZA (1) ZA201008610B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1849465A4 (en) * 2005-02-18 2008-12-24 Takeda Pharmaceutical AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR
TW201102065A (en) * 2009-05-29 2011-01-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
WO2010142978A1 (en) * 2009-06-08 2010-12-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
US20130096119A1 (en) 2010-03-31 2013-04-18 Daniel Bur Isoquinolin-3-Ylurea Derivatives
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
CN105067814A (zh) * 2015-07-24 2015-11-18 中国科学院成都生物研究所 解旋酶水解atp活性测定方法
WO2018048882A1 (en) 2016-09-06 2018-03-15 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
WO2018074880A2 (ko) * 2016-10-20 2018-04-26 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
KR20190133667A (ko) 2017-03-24 2019-12-03 다이쇼 세이야꾸 가부시끼가이샤 2(1h)-퀴놀리논 유도체
CN111808089B (zh) * 2019-04-10 2023-04-11 四川大学华西医院 一种治疗糖尿病的药物依格列净或其衍生物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000342A1 (en) 1991-06-21 1993-01-07 Boehringer Mannheim Italia S.P.A. 2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
ES2294046T3 (es) 2000-12-15 2008-04-01 Vertex Pharmaceuticals Incorporated Inhibidores de girasa bacteriana y usos de los mismos.
AR042956A1 (es) 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
JP2008531671A (ja) * 2005-03-04 2008-08-14 アストラゼネカ アクチボラグ 化合物
US8022816B2 (en) 2005-03-21 2011-09-20 Vela Systems, Inc. System and method for field management using radio frequency tags
US7569907B2 (en) 2005-03-28 2009-08-04 Cooper Technologies Company Hybrid chip fuse assembly having wire leads and fabrication method therefor
CN101156207A (zh) 2005-04-13 2008-04-02 皇家飞利浦电子股份有限公司 在相位调制之前用水印进行编码
EP1991545A2 (en) * 2005-12-23 2008-11-19 AstraZeneca AB Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines
DE102006012337B3 (de) 2006-03-17 2007-11-29 Amphenol-Tuchel Electronics Gmbh Elektrischer Steckverbinder
CL2007003470A1 (es) * 2006-12-04 2008-08-22 Astrazeneca Ab Compuestos derivados de urea; composicion farmaceutica que comprende a dichos compuestos; y su uso como antibacterianos.
CN201038186Y (zh) 2007-03-08 2008-03-19 鹤山丽得电子实业有限公司 一种大功率led
TW200940537A (en) * 2008-02-26 2009-10-01 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof
WO2009110688A2 (ko) 2008-03-06 2009-09-11 Jang Gum Sik 태양광 발전 장치
WO2010142978A1 (en) * 2009-06-08 2010-12-16 Astrazeneca Ab Heterocyclic urea derivatives and methods of use thereof

Also Published As

Publication number Publication date
SV2010003752A (es) 2011-04-14
JP2011522026A (ja) 2011-07-28
US8283361B2 (en) 2012-10-09
BRPI0915471A2 (pt) 2017-06-27
CR11825A (es) 2011-02-04
ECSP10010664A (es) 2011-01-31
MX2010013310A (es) 2011-03-01
CA2725568A1 (en) 2009-12-10
AR072045A1 (es) 2010-08-04
CL2009001349A1 (es) 2010-12-31
PE20100155A1 (es) 2010-03-25
KR20110014710A (ko) 2011-02-11
ZA201008610B (en) 2012-08-29
CN102105469A (zh) 2011-06-22
DOP2010000373A (es) 2011-01-15
UY31864A (es) 2010-01-29
CO6382176A2 (es) 2012-02-15
TW201000475A (en) 2010-01-01
WO2009147433A1 (en) 2009-12-10
IL209503A0 (en) 2011-01-31
EP2300463A1 (en) 2011-03-30
US20100190745A1 (en) 2010-07-29
AU2009254930A1 (en) 2009-12-10

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