EA200971141A1 - COMPOUNDS ACTIVATING TELOMERASE AND METHODS OF THEIR APPLICATION - Google Patents

COMPOUNDS ACTIVATING TELOMERASE AND METHODS OF THEIR APPLICATION

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Publication number
EA200971141A1
EA200971141A1 EA200971141A EA200971141A EA200971141A1 EA 200971141 A1 EA200971141 A1 EA 200971141A1 EA 200971141 A EA200971141 A EA 200971141A EA 200971141 A EA200971141 A EA 200971141A EA 200971141 A1 EA200971141 A1 EA 200971141A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
application
activating telomerase
compounds activating
compounds
Prior art date
Application number
EA200971141A
Other languages
Russian (ru)
Other versions
EA022472B1 (en
Inventor
Авив Гацит
Шимон Славин
Эстер Приель
Сара Йитцчак
Original Assignee
Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити
Шимон Славин
Авив Гацит
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити, Шимон Славин, Авив Гацит filed Critical Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити
Publication of EA200971141A1 publication Critical patent/EA200971141A1/en
Publication of EA022472B1 publication Critical patent/EA022472B1/en

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    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
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    • A61K31/055—Phenols the aromatic ring being substituted by halogen
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    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C215/80—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring containing at least two amino groups bound to the carbon skeleton
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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Abstract

Настоящее изобретение направлено на применение ряда соединений и включающих их композиций для активирования теломеразы и лечения связанных с ней заболеваний, расстройств и/или состояний.The present invention is directed to the use of a number of compounds and compositions comprising them for activating telomerase and treating related diseases, disorders and / or conditions.

EA200971141A 2007-06-04 2008-06-04 Telomerase activating compounds and methods of use thereof EA022472B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92487507P 2007-06-04 2007-06-04
US92952407P 2007-07-02 2007-07-02
US92952507P 2007-07-02 2007-07-02
US692408P 2008-02-06 2008-02-06
PCT/IL2008/000756 WO2008149353A2 (en) 2007-06-04 2008-06-04 Telomerase activating compounds and methods of use thereof

Publications (2)

Publication Number Publication Date
EA200971141A1 true EA200971141A1 (en) 2010-10-29
EA022472B1 EA022472B1 (en) 2016-01-29

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ID=40094272

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EA201401193A EA201401193A1 (en) 2007-06-04 2008-06-03 TRIAILARY COMPOUNDS AND COMPOSITIONS CONTAINING THEM
EA200971140A EA021544B1 (en) 2007-06-04 2008-06-03 Tri-aryl compounds and pharmaceutical compositions comprising the same
EA200971141A EA022472B1 (en) 2007-06-04 2008-06-04 Telomerase activating compounds and methods of use thereof
EA201500403A EA201500403A1 (en) 2007-06-04 2008-06-04 COMPOUNDS ACTIVATING TELOMERASE AND METHODS OF THEIR APPLICATION

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EA201401193A EA201401193A1 (en) 2007-06-04 2008-06-03 TRIAILARY COMPOUNDS AND COMPOSITIONS CONTAINING THEM
EA200971140A EA021544B1 (en) 2007-06-04 2008-06-03 Tri-aryl compounds and pharmaceutical compositions comprising the same

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